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#33249770   2020/11/29 To Up

Histologic effects of MicroPulse™ transscleral cyclophotocoagulation in normal equine eyes.

Determine the immediate post-operative effects of MicroPulse transscleral cyclophotocoagulation (MP-TSCPC) in healthy equine eyes.
Braidee C Foote, Jodi D Smith, Rachel A Allbaugh, Lionel Sebbag

2340 related Products with: Histologic effects of MicroPulse™ transscleral cyclophotocoagulation in normal equine eyes.



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#33249736   2020/11/29 To Up

Assessing novel therapies for vulval neoplasia.

Vulval cancer is a potential outcome of two separate pathological processes. Human Papilloma Virus (HPV) infection and subsequent clearance is so common as to be normal, but it can sometimes persist and ultimately lead to invasive disease. Lichen sclerosus is a vulval dermatosis that is estimated to progress to vulval cancer in less than 5% of cases.
Amanda Tristram

1287 related Products with: Assessing novel therapies for vulval neoplasia.

2x5L1.0 mg 5 G0.1 mg500 ml100Tests 1 G1 g0.2 mg

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#33249717   2020/11/29 To Up

Insight into the hypercoagulable state of high-risk thrombotic APS patients: Contribution of aβ2GPI and aPS/PT antibodies.

Most high-risk thrombotic Antiphospholipid Syndrome (APS) patients test positive for anti-β2-Glycoprotein I (aβ2GPI) and anti-Phosphatidylserine/Prothrombin (aPS/PT) antibodies. Information on the influence of these antibodies on thrombin generation and activated protein C resistance (aPCr) is still sparse and contradictory.
Elena Pontara, Maria Grazia Cattini, Chunyan Cheng, Elisa Bison, Gentian Denas, Vittorio Pengo

1220 related Products with: Insight into the hypercoagulable state of high-risk thrombotic APS patients: Contribution of aβ2GPI and aPS/PT antibodies.

1000 0.5 ml0.1 ml0.1 ml100 μg100 μg100 μg50 50 100 μg0.1 ml

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#33249703   2020/11/29 To Up

ADFP promotes cell proliferation in lung adenocarcinoma via Akt phosphorylation.

Previously, we identified differentially expressed proteins, including ADFP, between lung adenocarcinoma (LAC) tissue and paired normal bronchioloalveolar epithelium. In this study, we investigated the role of ADFP in LAC. ADFP levels in the serum of patients with lung cancer and benign diseases were measured by enzyme-linked immunosorbent assays (ELISA). shRNA was used to knock-down or overexpress ADFP in A549 and NCI-H1299 cells. The biological function of ADFP and its underlying mechanisms was evaluated in vivo and in vitro. ADFP was highly expressed in the serum of lung cancer patients, especially those with LAC. ADFP promoted cell proliferation and up-regulated the p-Akt/Akt ratio in A549 and NCI-H1299 cells in vitro. Furthermore, in nude mice, ADFP promoted tumour formation with high levels of p-Akt/Akt, Ki67 and proliferating cell nuclear antigen (PCNA). Similar to the effect of ADFP knock-down, MK-2206 (a phosphorylation inhibitor of Akt) reduced A549 and NCI-H1299 cell proliferation. In ADFP-overexpressing A549 and NCI-H1299 cells, proliferation was suppressed by MK-2206 and returned to the control level. ADFP did not regulate invasion, migration or adhesion in LAC cells. Together, these results suggest that ADFP promotes LAC cell proliferation in vitro and in vivo by increasing Akt phosphorylation level.
Xia Meng, Ruiying Sun, Wei Wang, Na Zhang, Shiguang Cao, Boxuan Liu, Ping Fang, Shanshan Deng, Shuanying Yang

1369 related Products with: ADFP promotes cell proliferation in lung adenocarcinoma via Akt phosphorylation.

2 Pieces/Box25 ml.2 Pieces/Box2 Pieces/Box

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#33249687   2020/08/16 To Up

Postreflux swallow-induced peristaltic wave index from pH-impedance monitoring associates with esophageal body motility and esophageal acid burden.

Postreflux swallow-induced peristaltic wave (PSPW) on pH-impedance monitoring and contraction vigor on high-resolution manometry (HRM) both assess esophageal peristaltic response. We aimed to evaluate relationships between PSPW and esophageal peristalsis on HRM in the context of reflux disease in this multicenter cohort study.
Benjamin D Rogers, Arvind Rengarajan, Mentore Ribolsi, Matteo Ghisa, Farhan Quader, Roberto Penagini, Nicola de Bortoli, Aurelio Mauro, Michele Cicala, Edoardo Savarino, C Prakash Gyawali

1399 related Products with: Postreflux swallow-induced peristaltic wave index from pH-impedance monitoring associates with esophageal body motility and esophageal acid burden.

10 mg

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#33249666   2020/11/29 To Up

Role of pre-transplant MRD level detected by flow cytometry in recipients of allogeneic stem cell transplantation with AML.

We analyzed the impact of pre-transplant MRD level in bone marrow measured by flow cytometry using "different from normal" method on outcomes for 189 AML patients (108 males; median age, 58 (21-80) years). All patients were subdivided into negative (n=96), "low" (0.1-0.5%, n=32) and "high" MRD (>0.5%, n=61) groups.
Evgeny Klyuchnikov, Maximilian Christopeit, Anita Badbaran, Ulrike Bacher, Ulrike Fritsche-Friedland, Ute-Marie von Pein, Christine Wolschke, Nicolaus Kröger

1093 related Products with: Role of pre-transplant MRD level detected by flow cytometry in recipients of allogeneic stem cell transplantation with AML.

1 kit10 ug1 kit1 kit100ug Lyophilized1 kit100ug Lyophilized1 kit1 kit1 kit1 kit1 kit

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#33249648   2020/11/29 To Up

The Associations between Meeting 24-Hour Movement Guidelines and Adiposity in Asian Adolescents: The Asia-Fit Study.

Less is known about how compliance with 24-hour movement guidelines for physical activity (PA), sedentary behaviour, and sleep affects adiposity in young people. The purposes of this study were to compare compliance with 24-hour movement guidelines in Asian adolescents and to examine the associations between compliance with 24-hour movement guidelines and body fat percentage. A sample of 12,590 adolescents aged 13.63 (± 1.01) years from eight Asian metropolitan cities including Bangkok (Thailand), Hong Kong SAR, Kuala Lumpur (Malaysia), Seoul (South Korea), Shanghai (China), Singapore, Taipei (Taiwan), and Tokyo (Japan) completed interviewer-administered questionnaires to assess moderate-to-vigorous PA, recreational screen-time, sleep duration, and covariates. Body fat percentage was measured using bioelectrical impedance analysis. We found that compliance with 24-hour movement guidelines differed in Asian adolescents across the eight cities. Adjusting for covariates, there was a negative association between number of the guidelines being met and body fat percentage in Asian adolescents. In addition, meeting only the sleep guideline and both the PA and sleep guidelines had negative associations with body fat percentage compared with no guidelines being met. Our findings improve the understanding about how compliance with 24-hour movement guidelines benefit a healthy body weight in adolescents, as well as contribute to development of evidence-based 24-hour movement guidelines for Asian young people. Future research is needed to gain better insights into the directionality of the associations between compliance with 24-hour movement guidelines and adiposity, as well as the mechanisms underlying the associations in Asian adolescents.
Stanley Sai-Chuen Hui, Ru Zhang, Koya Suzuki, Hisashi Naito, Govindasamy Balasekaran, Jong Kook Song, Soo Yeon Park, Yiing Mei Liou, Dajiang Lu, Bee Koon Poh, Kallaya Kijboonchoo, Wiyada Thasanasuwan

1242 related Products with: The Associations between Meeting 24-Hour Movement Guidelines and Adiposity in Asian Adolescents: The Asia-Fit Study.

11100ug Lyophilized200 units

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#33249639   2020/11/29 To Up

Maternal body mass index, change in weight status from childhood to late adulthood and physical activity in older age.

This study aimed to examine the longitudinal associations of maternal body mass index (BMI), weight status in childhood and late adulthood and device-measured total physical activity (TPA) in older age. The study involves 552 participants from Helsinki Birth Cohort Study who were born in Helsinki, Finland in 1934-1944. TPA was measured with a multisensory body monitor at a mean age of 70 years and expressed in metabolic equivalent of task-hours/day (METh/d). Childhood overweight (BMI >85 percentile) was based on school health records at 6-7 years of age and late adulthood overweight (BMI ≥25 kg/m ) was based on clinical measurements at the mean age of 61 years. Childhood overweight was associated with lower TPA, particularly in older women (mean difference -3.2 METh/d, 95% confidence interval (CI) -4.6- -1.9), and late adulthood overweight was associated with lower TPA both in older women (mean difference -6.2, 95% CI (-7.2- -5.1) and in older men (mean difference -2.6 METh/d, 95% CI -3.7 - -1.5). TPA in older age was highest in participants who were normal weight both in childhood and adulthood and lowest in participants who were overweight in childhood and adulthood. In participants with childhood overweight, TPA was lower in participants who were overweight in childhood and adulthood, compared to those who were overweight only in childhood. There was a U-shaped distribution of TPA according to maternal BMI in older women (p=0.002), but not in older men. In conclusion, reaching normal weight after childhood predicted higher physical activity levels in older age.
Anna P Westberg, Niko Wasenius, Minna K Salonen, Mikaela B von Bonsdorff, Johan G Eriksson

2337 related Products with: Maternal body mass index, change in weight status from childhood to late adulthood and physical activity in older age.

900 tests1 kit1 kit48 assays 1 G400Tests1mg100 25

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