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#34525320   2021/09/15 To Up

How to make the use of recycled paperboard fit for food contact? A contribution to the discussion.

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1448 related Products with: How to make the use of recycled paperboard fit for food contact? A contribution to the discussion.

0.1 mg1 module 25 G600 Tests / Kit5 mg100 µg1 mg

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#34524915   2021/09/15 To Up

Foot-and-mouth disease virus VP3 protein acts as a critical proinflammatory factor by promoting toll-like receptor 4-mediated signaling.

Foot-and-mouth disease virus (FMDV) infection in cloven-hoofed animals causes severe inflammatory symptoms, including blisters on the oral mucosa, hoof, and breast; however, the molecular mechanism underlying the inflammatory response is unclear. In this study, we provide the first evidence that the FMDV protein VP3 activates lipopolysaccharide-triggered Toll-like receptor 4 (TLR4) signaling. FMDV VP3 increased the expression of TLR4 by downregulating the expression of the lysozyme-related protein Rab7b. Additionally, Rab7b can interact with VP3 to promote the replication of FMDV. Our findings suggested that VP3 regulates the Rab7b-TLR4 axis to mediate the inflammatory response to FMDV. Foot-and-mouth disease virus (FMDV) infection causes a severe inflammatory response in cloven-hoofed animals, such as pigs, cattle, and sheep, with typical clinical manifestations of high fever, numerous blisters on the oral mucosa, hoof, and breast, as well as myocarditis (tigroid heart). However, the mechanism underlying the inflammatory response caused by FMDV is enigmatic. In this study, we identified the VP3 protein of FMDV as an important proinflammatory factor. Mechanistically, VP3 interacted with TLR4 to promote TLR4 expression by inhibiting the expression of the lysozyme-related protein Rab7b. Our findings suggest that FMDV VP3 is a major proinflammatory factor in FMDV-infected hosts.
Jing Zhang, Dan Li, Wenping Yang, Yue Wang, Lulu Li, Haixue Zheng

2856 related Products with: Foot-and-mouth disease virus VP3 protein acts as a critical proinflammatory factor by promoting toll-like receptor 4-mediated signaling.

1 mg200 100 2 Pieces/Box961 mg4200ul200 1000 assays250ug50 Test

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#34524894   2021/09/15 To Up

The biosynthesis of ditropolonyl sulfide, an antibacterial compound produced by complex strain R-12632.

complex strain R-12632 produces ditropolonyl sulfide, an unusual sulfur-containing tropone, via a yet unknown biosynthetic pathway. Ditropolonyl sulfide purified from a culture of strain R-12632 inhibits the growth of various Gram-positive and Gram-negative multidrug resistant bacteria, with minimum inhibitory concentration (MIC) values as low as 16 μg/ml. In the present study we used a transposon mutagenesis approach combined with metabolite analyses to identify the genetic basis for antibacterial activity of strain R-12632 against Gram-negative bacterial pathogens. Fifteen of the 8304 transposon mutants investigated completely lost antibacterial activity against LMG 2095. In these loss-of-activity mutants, nine genes were interrupted. Four of those genes were involved in assimilatory sulfate reduction, two in phenylacetic acid (PAA) catabolism and one in glutathione metabolism. Via semipreparative fractionation and metabolite identification, it was confirmed that inactivation of the PAA degradation pathway or glutathione metabolism led to loss of ditropolonyl sulfide production. Based on earlier studies on the biosynthesis of tropolone compounds, the requirement for a functional PAA catabolic pathway for antibacterial activity in strain R-12632 indicated that this pathway likely provides the tropolone backbone for ditropolonyl sulfide. Loss of activity observed in mutants defective in assimilatory sulfate reduction and glutathione biosynthesis suggested that cysteine and glutathione are potential sources of the sulfur atom linking the two tropolone moieties. The demonstrated antibacterial activity of the unusual antibacterial compound ditropolonyl sulfide warrants further studies into its biosynthesis and biological role. bacteria are historically known for their biocontrol properties and have been proposed as a promising and underexplored source of bioactive specialized metabolites. complex strain R-12632 inhibits various Gram-positive and Gram-negative resistant pathogens and produces numerous specialized metabolites, among which ditropolonyl sulfide. This unusual antimicrobial has been poorly studied and its biosynthetic pathway remained unknown. In the present study, we performed transposon mutagenesis of strain R-12632 and performed genome and metabolite analyses of loss-of-activity mutants to study the genetic basis for antibacterial activity. Our results indicate that the phenylacetic acid catabolism, assimilatory sulfate reduction and glutathione metabolism are necessary for ditropolonyl sulfide production. These findings contribute to understanding the biosynthesis and biological role of this unusual antimicrobial.
Eliza Depoorter, Tom Coenye, Peter Vandamme

1995 related Products with: The biosynthesis of ditropolonyl sulfide, an antibacterial compound produced by complex strain R-12632.

1mg1 mg100ug100ug100ug100ul100ul100ug100ul100ul100ul50ug

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#34524798   2021/09/15 To Up

Linear Hydrocarbon Chain Growth from a Molecular Diruthenium Carbide Platform.

The formation of linear hydrocarbon chains by sequential coupling of C units on the metal surface is the central part of the Fischer-Tropsch (F-T) synthesis. Organometallic complexes have provided numerous models of relevant individual C-C coupling events but have failed to reproduce the complete chain lengthening sequence that transforms a linear C hydrocarbon chain into its C homologue in an iterative fashion. In this work, we demonstrate stepwise growth of linear C hydrocarbon chains and their conversion to their C homologues via consecutive addition of CH units on a molecular diruthenium carbide platform. The chain growth sequence is initiated by the formation of a μ-η:η-C═CH ligand from a C + CH coupling between the μ-carbido complex [(Cp*Ru)(η-NPh)(μ-C)] (; Cp* = η-CMe) and PhSCH. Then, the chain propagates via a general C═CHR + CH coupling and subsequent hydrogen-assisted isomerization of the resulting allene ligand μ-η:η-HC═C═CHR to a higher vinylidene homologue μ-η:η-C═CH(CH)R. By repeating this reaction sequence, up to C chains have been synthesized in a stepwise fashion. The key step of this chain homologation sequence is the selective hydrogenation of the μ-η:η-allene unit to the corresponding μ-alkylidene ligand. Isotope labeling and computational studies indicate that this transformation proceeds via the hydrogenation of the allene ligand to a terminal alkene form and its isomerization to the μ-alkylidene ligand facilitated by the coordinatively unsaturated diruthenium platform.
Jun Ohata, Akira Teramoto, Hiroaki Fujita, Shin Takemoto, Hiroyuki Matsuzaka

1641 related Products with: Linear Hydrocarbon Chain Growth from a Molecular Diruthenium Carbide Platform.

20 ug100 μg 100 UG2 mg500 100.00 ug50 ug100 1.5 mL100 10 1 mg

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#34524588   2021/09/15 To Up

Fibroadenoma in vulval ectopic breast tissue in a patient with PTEN Hamartoma Tumour Syndrome.

PTEN is a tumour suppressor gene involved in regulating cell division. Pathogenic germline variants in PTEN predispose to benign and malignant growths of numerous organs, including of the breast. In the following report, we describe the first documented case of a fibroadenoma developing in ectopic breast tissue of the vulva in a patient with a germline pathogenic variant in PTEN. This highlights the risk of hyperplasia developing in any breast tissue, including rare ectopic sites, particularly in patients with underlying germline variants in cancer susceptibility genes.
Hannah Dawson, Alannah Smrke, Peter M Ellery, Nafisa Wilkinson, Adam N Rosenthal, Terri P McVeigh

2352 related Products with: Fibroadenoma in vulval ectopic breast tissue in a patient with PTEN Hamartoma Tumour Syndrome.



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#34524567   2021/09/15 To Up

Factors Confounding the Athlete Biological Passport: A Systematic Narrative Review.

Through longitudinal, individual and adaptive monitoring of blood biomarkers, the haematological module of the athlete biological passport (ABP) has become a valuable tool in anti-doping efforts. The composition of blood as a vector of oxygen in the human body varies in athletes with the influence of multiple intrinsic (genetic) or extrinsic (training or environmental conditions) factors. In this context, it is fundamental to establish a comprehensive understanding of the various causes that may affect blood variables and thereby alter a fair interpretation of ABP profiles.
Bastien Krumm, Raphael Faiss

2688 related Products with: Factors Confounding the Athlete Biological Passport: A Systematic Narrative Review.

650mg100.00 ul1 ml96 100ul16 Arrays/Slide

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#34524531   2021/09/15 To Up

The influence of shade availability on the effectiveness of the Dairy Heat Load Index (DHLI) to predict lactating cow behavior, physiology, and production traits.

Numerous climatic indices have been utilized to predict the effect of hot, and cold, climatic conditions on animal production and welfare. To date, the dairy industry has relied extensively on the Temperature Humidity Index (THI) to predict adverse climatic conditions; however, neither solar radiation nor air movement is accounted for in the THI equation. The Dairy Heat Load Index (DHLI) was initially developed as an alternative climate index. In its current format, the DHLI does not account for the effects of heat load mitigation strategies, such as shade, which decreases the negative effects of hot climatic conditions on lactating cows. Therefore, this experiment aimed to determine the effectiveness of the DHLI as a predictor of heat load responses in both shaded and unshaded cows, as compared with the THI. Forty lactating Holstein Friesian (n = 40) cows were selected and paired based on live weight, milk yield, and days in milk. One cow from each pair was randomly allocated to one of two treatments: shaded (n = 20) or unshaded (n = 20). Cows were given 7 days to acclimate prior to the commencement of data collection. After 28 days, cows were transitioned into the alternate treatment in a crossover design and given 7 days to acclimate prior to data collection. Behavioral observations (0800, 1200, 1400, and 1800 h daily), daily milk yield (kg), milk composition (various days), and vaginal temperature (T, °C; 5 pairs/week, over a 4-week rotation) were recorded. Overall, data from this experiment indicated that the DHLI was a better predictor of standing and feeding behaviors in unshaded cows and drinking behaviors in shaded cows. Conversely, the THI was a better predictor of standing behavior and shade usage in shaded cows. Furthermore, the THI was a better predictor of mean panting score (MPS) in shaded cows, whereas the DHLI performed better in unshaded cows. Additionally the DHLI was a better predictor of T in these cows. Finally, when evaluating the 7-day average of each climatic index, the DHLI was a better predictor of change in milk yield. Incorporation of additional animal and management factors is required if the DHLI is to become an effective heat load management tool.
J C Lees, A M Lees, J B Gaughan

1962 related Products with: The influence of shade availability on the effectiveness of the Dairy Heat Load Index (DHLI) to predict lactating cow behavior, physiology, and production traits.

500 Units1 ml11mg11100.00 ul

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#34524469   2021/09/15 To Up

[Imaging diagnostics in acute pancreatitis].

Abdominal imaging is an important component of the diagnostics of acute pancreatitis. In addition to the clinical features and the laboratory constellation, it serves to establish the diagnosis or the exclusion of other diseases and also the identification and assessment of the course of local complications and vascular changes that can arise during the course of acute pancreatitis. Due to the numerous imaging examination methods that are available, their combination options and the different examination times, there are diverse application options that have to be taken into account, such as the severity and duration of the disease, concomitant diseases and complications of acute pancreatitis. A rational use of imaging is an important prerequisite for high quality and at the same time cost-effective patient care. This review summarizes the current importance of imaging in acute pancreatitis, with particular reference to the updated S3 guidelines on acute pancreatitis.
Ali A Aghdassi, Max Seidensticker

2126 related Products with: [Imaging diagnostics in acute pancreatitis].

1 Set100 μg5ug100 μg100ug Lyophilized100.00 ug2 1 mg96 assays

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#34524468   2021/09/15 To Up

[Pathogenesis of chronic pancreatitis].

Long-term alcohol consumption and gene mutations are the most important causes of chronic pancreatitis. In addition to mutations in acinar genes, such as digestive enzymes and their inhibitors, defects in genes that primarily or exclusively affect the duct cells have also been described in recent years. Genetic changes are found not only in patients with a positive family history (hereditary pancreatitis) but also in so-called idiopathic and, to a lesser extent, in alcoholic chronic pancreatitis. The coming years will likely show that there are very complex interactions between environmental influences and numerous genetic factors.
Jonas Rosendahl, Heiko Witt

2793 related Products with: [Pathogenesis of chronic pancreatitis].

50 UG 5 G

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