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#33096558   2020/10/23 To Up

Genetics and genomics of root system variation in adaptation to drought-stress in cereal crops.

Cereals are important crops worldwide that help meet food demands and nutritional needs. In recent years, cereal production has been challenged globally by frequent droughts and hot spells. A plant's root is the most relevant organ during drought-stress adaptation, playing pivotal roles in anchorage and the acquisition of soil-based resources. Thus, dissecting root system variations and trait selection for enhancing yield and sustainability under drought-stress conditions should aid in future global food security. This review highlights the variations in root system attributes and their interplay with shoot architectural features for the yield and drought-stress adaptation of major cereal crops as determined by quantitative genetics and genomics approaches. Further, we compile the root-related drought-responsive quantitative trait loci (QTL)/genes in cereal crops including their inter-species comparisons using microsynteny to facilitate comparative genomic analyses. We then discuss the potential of an integrated strategy combining genomics and phenomics at genetic and epigenetic levels to explore natural genetic diversity as basis for knowledge-based genome editing. Finally, we present an outline to establish innovative breeding leads for the rapid and optimized selection of root traits necessary to develop resilient crop varieties.
Nurealam Siddiqui, Jens Léon, Ali A Naz, Agim Ballvora

1036 related Products with: Genetics and genomics of root system variation in adaptation to drought-stress in cereal crops.

1 kit 1 G1mg500 gm. 100 UG100 μg1 kit100 mg50

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#33096518   2020/10/20 To Up

Arabidopsis primary root growth: let it grow, can't hold it back anymore!

In multicellular organisms, growth is defined by those processes that allow an organ to increase in mass, namely cell proliferation - that increases the number of cells - and cell expansion - that increases their volume. For an organ to achieve a functional shape and a characteristic final size both these processes need to be tightly coordinated. In roots, these processes stand behind root primary growth, which results in lengthening of the root along its longitudinal axis, and secondary growth, which results in an increase of the root thickness. In this review, we will analyze latest advances in the study of the molecular mechanisms involved in root primary growth, focusing on the model species Arabidopsis thaliana, where some molecular factors and networks responsible for regulating its self-organized primary growth have been identified.
Noemi Svolacchia, Elena Salvi, Sabrina Sabatini

2344 related Products with: Arabidopsis primary root growth: let it grow, can't hold it back anymore!

100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100 μg100ug Lyophilized100ug Lyophilized100ug Lyophilized5 mL x 2100ug Lyophilized100ug Lyophilized

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#33096388   2020/10/13 To Up

Xenopus in revealing developmental toxicity and modeling human diseases.

The Xenopus model offers many advantages for investigation of the molecular, cellular, and behavioral mechanisms underlying embryo development. Moreover, Xenopus oocytes and embryos have been extensively used to study developmental toxicity and human diseases in response to various environmental chemicals. This review first summarizes recent advances in using Xenopus as a vertebrate model to study distinct types of tissue/organ development following exposure to environmental toxicants, chemical reagents, and pharmaceutical drugs. Then, the successful use of Xenopus as a model for diseases, including fetal alcohol spectrum disorders, autism, epilepsy, and cardiovascular disease, is reviewed. The potential application of Xenopus in genetic and chemical screening to protect against embryo deficits induced by chemical toxicants and related diseases is also discussed.
Juanmei Gao, Wanhua Shen

2022 related Products with: Xenopus in revealing developmental toxicity and modeling human diseases.

5 mg10 ug100 μg100 μg100 μg100 μg50ug100 μg100 μg100 μg96 wells (1 kit)100 μg

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#33096317   2020/10/17 To Up

Aquaporins in lung health and disease: Emerging roles, regulation, and clinical implications.

Aquaporins (AQPs) aka water channels are a family of conserved transmembrane proteins (~30 kDa monomers) expressed in various organ systems. Of the 13 AQPs (AQP0 through AQP12) in the human body, four (AQPs 1, 3, 4, and 5) are expressed in the respiratory system. These channels are conventionally known for mediating transcellular fluid movements. Certain AQPs (aquaglyceroporins) have the capability to transport glycerol and potentially other solutes. There is an emerging body of literature unveiling the non-conventional roles of AQPs such as in cell proliferation and migration, gas permeation, signal potentiation, etc. Initial gene knock-out studies established a physiological role for lung AQPs, particularly AQP5, in maintaining homeostasis, by mediating fluid secretion from submucosal glands onto the airway surface liquid (ASL) lining. Subsequent studies have highlighted the functional significance of AQPs, particularly AQP1 and AQP5 in lung pathophysiology and diseases, including but not limited to chronic and acute lung injury, chronic obstructive pulmonary disease (COPD), other inflammatory lung conditions, and lung cancer. AQP1 has been suggested as a potential prognostic marker for malignant mesothelioma. Recent efforts are directed toward exploiting AQPs as targets for diagnosis, prevention, intervention, and/or treatment of various lung conditions. Emerging information on regulatory pathways and directed mechanistic research are posited to unravel novel strategies for these clinical implications. Future considerations should focus on development of AQP inhibitors, blockers, and modulators for therapeutic needs, and better understanding the role of lung-specific AQPs in inter-individual susceptibility to chronic lung diseases such as COPD and cancer.
Ekta Yadav, Niket Yadav, Ariel Hus, Jagjit S Yadav

1368 related Products with: Aquaporins in lung health and disease: Emerging roles, regulation, and clinical implications.



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#33096290   2020/10/14 To Up

Factors associated with clinical outcomes in patients with Coronavirus Disease 2019 in Guangzhou, China.

Coronavirus Disease 2019 (COVID-19) is threatening billions of people. We described the clinical characteristics and explore virological and immunological factors associated with clinical outcomes.
Chunliang Lei, Weiyin Lin, Xilong Deng, Fengyu Hu, Fengjuan Chen, Weiping Cai, Yueping Li, Chunyan Wen, Yujuan Guan, Jian Wang, Xiaoting Chen, Yi Cao, Feng Li, Xiaoping Tang, Linghua Li

1200 related Products with: Factors associated with clinical outcomes in patients with Coronavirus Disease 2019 in Guangzhou, China.



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#33096264   2020/10/20 To Up

Stepwise Laparoendoscopic Single-Site Pectopexy for Pelvic Organ Prolapse.

To demonstrate stepwise techniques for the successful utilization of the LESS technique for safely performing pectopexy.
Qianqing Wang, Zhenkun Guan, Xiangcui Guo, Beibei Chen, Li Li, Juan Liu, Xiaoming Guan

1587 related Products with: Stepwise Laparoendoscopic Single-Site Pectopexy for Pelvic Organ Prolapse.

250ul96T100μg100 mg

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#33096228   2020/10/20 To Up

The Perfect Balance? Managing Heavy Menstrual Bleeding and Dysmenorrhea in a Patient with Hereditary Hemochromatosis and von Willebrand Disease.

Hereditary hemochromatosis typically presents in adulthood with organ damage secondary to iron overload. In females, menstrual periods are a protective mechanism allowing for monthly loss of iron stores.
Anne H Kalinowski, Elisabeth H Quint, Angela C Weyand

1622 related Products with: The Perfect Balance? Managing Heavy Menstrual Bleeding and Dysmenorrhea in a Patient with Hereditary Hemochromatosis and von Willebrand Disease.

1 mg100ug1,000 tests100ug100 mg1000 tests100.00 ul

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#33096199   2020/10/20 To Up

Thirty days oral Aframomum melegueta extract elicited analgesic effect but influenced cytochrome p4501BI, cardiac troponin T, testicular alfa-fetoprotein and other biomarkers in rats.

Pain is the commonest symptom of a disease and the percentage of persons manifesting one form of pain is growing globally. Aframomum melegueta (AM) is commonly used by traditional doctors as medication for many ailments such as body pains and rheumatism because it possesses anti-inflammatory, anti-allergenic, antiviral, anti-ageing and anti-tumour phytochemical agents.
K Talha Biobaku, O Mistura Azeez, S Adetayo Amid, T Nnaemeka Asogwa, A Abubakar Abdullahi, O Lukman Raji, J Atata Abdulhamid

1928 related Products with: Thirty days oral Aframomum melegueta extract elicited analgesic effect but influenced cytochrome p4501BI, cardiac troponin T, testicular alfa-fetoprotein and other biomarkers in rats.

25 G100ug Lyophilized96 tests50 1 mg1 mg500 tests100ug Lyophilized1mg1 mg100ug Lyophilized10

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#33096085   2020/10/20 To Up

Significant impact of COVID-19 on organ donation and transplantation in a low-prevalence country: Australia.


S J Chadban, M McDonald, K Wyburn, H Opdam, L Barry, P T Coates

1161 related Products with: Significant impact of COVID-19 on organ donation and transplantation in a low-prevalence country: Australia.

300 units5 mg

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