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#32233322   // Save this To Up

[Hypereosinophilic syndromes].

Hypereosinophilic syndromes. Hypereosinophilic syndromes (HES) is a protean condition defined by chronic blood eosinophilia ≥ 1.5 G/L (> 1 month) leading to eosinophilic-related organ damage. HES subtypes includes neoplastic (clonal) disorders (HESN, that comprises FIP1L1-PDGFRA- related chronic eosinophilic leukemia and myeloproliferative and myelodysplastic syndromes associated with eosinophilia) and reactive HES (HESR, that aggregates all conditions e.g. parasitic infections, adverse drug reactions, inflammatory or neoplastic diseases that lead to the production of Th2-related cytokines and thereby to non-clonal hypereosinophilia). HESR also includes the lymphoid variant of HES (HESL), a chronic clonal indolent T-cell lymphoproliferative disorder in which mature peripheral T cells secrete high amounts of IL-5, leading to the polyclonal expansion of eosinophils. Despite an extensive etiological workup, approximately 50% of HES remain of undetermined cause. HES-related clinical manifestations are highly diverse, but dermatological, respiratory and gastro-intestinal symptoms are the most frequent. The long-term prognosis is driven by cardiac involvement and, for patients with HESN and HESL, by the risk of acute transformation into high-grade hematological malignancies. Treatment of HESN relies on tyrosine kinase inhibitors (e.g. imatinib mesylate), while oral glucocorticoids are the usual the fist-line therapy for HESR (including SHEL). In this setting, second-line treatments include hydroxyurea and Peg-interferon alfa-2a. IL-5-targeted therapies are very promising (except for HESN). Yet, to date, their use is restricted to clinical trials and to a compassionate use program dedicated to severe and refractory patients.

2860 related Products with: [Hypereosinophilic syndromes].



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Histomorphometrical changes in intestine structure and innervation following experimental fumonisins intoxication in male Wistar rats.

Fumonisins are highly toxic metabolites produced by Fusarium proliferatum and Fusarium verticillioides. Little is known about the effects of a chronic low level of fumonisins on intestinal structure and innervation in monogastric animals, even though the intestine is the first organ exposed to fumonisins. The influence of the most prevalent strains of fumonisins, FB1 and FB2, on intestinal and liver morphology, the enteric nervous system and intestinal epithelial cell prolif- eration was investigated in an experimental rat model of fumonisin intoxication. Adolescent (5-weeks-old), male Wistar rats were randomly divided into a control group (C group) not treated with fumonisins or intoxicated with fumonisins (FB group). FB1 together with FB2 were daily administered intragastrically at a dose of 90 mg/kg body weight for 21 days. The damaging effect was assessed by determination of the activity of ALAT and AspAT. Samples from the small intes- tine and liver were taken and blood samples were collected to determine the activity of gamma- -glutamyl transferase (GGT) and amylase. The exposure to FBs resulted in histopathological degenerative alterations in hepatocytes, including mild vacuolar degeneration and ballooning. FB exposure was also toxic in the duodenum and jejunum, where significant changes in morphology, cell proliferation, collagen wall fibres and innervation were observed. Taken together, the results obtained strengthen the hypothesis that chronic exposure to FBs could induce intestinal damage, including damage to the enteric nervous system and may have consequences for general health.

2048 related Products with: Histomorphometrical changes in intestine structure and innervation following experimental fumonisins intoxication in male Wistar rats.



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[Effect of low frequency pulsed electromagnetic field on peak bone mass in young rats].

To compare effects of low frequency pulsed electromagnetic fields on bone quality in growing rats between 1 h and 1.5 h.

1854 related Products with: [Effect of low frequency pulsed electromagnetic field on peak bone mass in young rats].

Rabbit Anti-FGF3 Oncogene Bone marrow tumor and nor Bone cancer test tissue a Human normal bone and ost Bone marrow tumor and adj Alkaline Phospatase (ALP) Bone and cartilage cancer Bone and cartilage tumor Rabbit Anti-Cell death in Interleukins Recombinant Rabbit Anti-ING1 p33 Poly Goat Anti-Human KLK2, (in

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[Role and regulatory mechanism of glycometabolism of Sertoli cells in spermatogenesis].

Testis has been reported to be a naturally oxygen-deprived organ. Lactate produced by glycolysis of Sertoli cells is an important source of energy in spermatogenic cells, which quickly provides adenosine triphosphate to meet the needs of rapidly proliferating spermatogenic cells for energy and substances. Wide attention has been drawn to the studies of energy metabolism and its regulatory mechanisms in normal spermatogenesis. It is essential to illuminate the regulation of glucose transport by glucose transporters in Sertoli cells, the catalysis of pyruvate to lactic acid by lactate dehydrogenase and the transport process of the single carboxylate transporter to lactic acid under the influence of different factors or diseases, which play important roles in ensuring the normal spermatogenesis and male reproductive function. This review summarizes the changes of energy metabolism in spermatogenesis and the mechanisms of endocrine factors, signaling pathways, miRNAs and protein acetylation regulating cell glycolysis, aiming to provide some important reference for the elucidation of the molecular metabolism of spermatogenesis and clinical treatment of relevant diseases.

2338 related Products with: [Role and regulatory mechanism of glycometabolism of Sertoli cells in spermatogenesis].



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Thiol/disulfide homeostasis in intensive care unit patients with sepsis and septic shock.

Sepsis is a condition caused by infection followed by unregulated inflammatory response which may lead to organ dysfunction. The aim of this studyis to be the first in the literature has been designed to show the thiol/disulfide changes in patients with sepsis and septic shock and their correlation with acute phase reactants.

1118 related Products with: Thiol/disulfide homeostasis in intensive care unit patients with sepsis and septic shock.

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Virtual Anatomical and Endoscopic Exploration Method of Internal Human Body for Training Simulator.

Virtual environments have brought the use of realistic training closer to many different fields of education. In medical education, several visualization methods for studying inside the human body have been introduced as a way to verify the structure of internal organs. However, these methods are insufficient for realistic training simulators because they do not provide photorealistic scenes or offer an intuitive perception to the user. In addition, they are used in limited environments within a classroom setting.

1923 related Products with: Virtual Anatomical and Endoscopic Exploration Method of Internal Human Body for Training Simulator.

Goat Anti-Human S3-12 KIA Goat Anti-Human ANKK1, (i Goat Anti-Human AGR2, (in Goat Anti-Human Histamine Human PAI-1 (stable mutan Goat Anti-Human TIM3 HAVC Goat Anti-Human, Mouse WN Goat Anti-Human Neurotrop Goat Anti-Human PTPRT, (i Goat Anti-Human Granulin Goat Anti-Human TOM1L1 SR Goat Anti-Human NAT10 hAL

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R-spondin-mediated WNT signaling potentiation in mammary and breast cancer development.

The mammary gland is a secretory organ, which develops as a network of growing epithelial ducts composed of luminal and basal cells that invade the surrounding adipose tissue through a series of developmental cycles. Mammary stem cells (MaSCs) maintain an accurate tissue homeostasis, and their proliferation and cell fate determination are regulated by multiple hormones and local factors. The WNT pathway plays a critical role in controlling the enormous tissue expansion and remodeling during mammary gland development through the maintenance and differentiation of MaSCs, and its deregulation has been implicated in breast cancer (BC) initiation and progression. The R-spondins (RSPOs) are four secreted proteins that strongly enhance target cell sensitivity to WNT ligands. Moreover, leucine-rich repeat-containing G-protein-coupled receptors (LGRs) 4-6 are considered obligate high-affinity receptors for RSPOs and have been described as stem cell markers. Importantly, elevated RSPO expression has been recently identified in several tumor types from patients, including BC, and it has been reported that they play a significant role in mammary tumor progression in experimental models. In this review, exploring our present knowledge, we summarize the role of the RSPO-LGR axis as a WNT-enhancing signaling cascade in the MaSC compartment and during the normal and neoplastic mammary gland development. In addition, we include an updated expression profile of the RSPOs and their action mediators at the cell membrane, the LGRs, and the ubiquitin-ligases ZNRF3/RNF43, in different BC subtypes. Finally and based on these data, we discuss the significance of tumor-associated alterations of these proteins and their potential use as molecular targets for detection and treatment of BC.

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Asymmetric cytokinin signalling opposes gravitropism in roots.

Plants deeply trust in gravity to provide the constant landmark for downward root growth and upward shoot growth. The phytohormone auxin and its cell-to-cell transport machinery are central determinants ensuring gravitropic growth. Statolith sedimentation towards gravity is sensed in specialised cells. This positional cue is translated into the polar distribution of PIN auxin efflux carriers at the plasma membrane, leading to asymmetric auxin distribution and, consequently, differential growth and organ bending. While we have started to understand the general principles of how primary organs execute gravitropism, we currently lack basic understanding of how lateral plant organs can defy gravitropic responses. Here we briefly review the establishment of the oblique gravitropic set point angle in lateral roots and particularly discuss the emerging role of asymmetric cytokinin signalling as a central anti-gravitropic signal. Differential cytokinin signalling is co-opted in gravitropic lateral and hydrotropic primary roots to counterbalance gravitropic root growth. This article is protected by copyright. All rights reserved.

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CMV myocarditis in solid organ transplant recipients: A case series and review of literature.

Cytomegalovirus (CMV) is a DNA-virus of the Herpesviridae family and is estimated to affect 15-30% of high-risk solid organ transplant recipients. Typical manifestations of CMV end-organ disease in this population include colitis, esophagitis, and pneumonitis, and myocarditis is a rarely reported manifestation. We describe two cases of CMV myocarditis in solid organ transplant recipients and review the literature regarding previously published cases of CMV myocarditis.

2991 related Products with: CMV myocarditis in solid organ transplant recipients: A case series and review of literature.

Multiple organ cancer tis Multiple organ cancer fro Multiple organ cancer tes Multiple organ cancer and Multiple organ tumor tiss Multiple organ tumor tiss High density (495 cases 5 Multiple organ cancer and Multiple organ carcinoma Multiple organ stromal tu Endocrine organ cancer te Multiple organ cancer and

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Review of early endoscopic findings in patients with local recurrence after definitive chemoradiotherapy for esophageal squamous cell carcinoma.

Local recurrence after definitive chemoradiotherapy, if diagnosed early, can be cured by salvage endoscopic therapy, which allows organ preservation and contributes to maintaining patient quality of life. This study aimed to investigate early endoscopic findings of local recurrence in post-definitive chemoradiotherapy patients.

1152 related Products with: Review of early endoscopic findings in patients with local recurrence after definitive chemoradiotherapy for esophageal squamous cell carcinoma.

Esophageal squamous cell Esophageal squamous cell Esophageal squamous cell Esophagus squamous cell c Cervix squamous cell carc Esophagus squamous cell c Lung squamous cell carcin Esophageal squamous cell Skin squamous cell carcin Multiple lung carcinoma ( Oral cavity squamous cell Esophagus squamous cell c

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