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#33249746   2020/11/29 To Up

Simulation of a detoxifying organ function: focus on hemodynamics modeling and convection-reaction numerical simulation in microcirculatory networks.

When modelling a detoxifying organ function, an important component is the impact of flow on the metabolism of a compound of interest carried by the blood. We here study the effects of red blood cells (such as the Fahraeus-Lindqvist effect and plasma skimming) on blood flow in typical microcirculatory components such as tubes, bifurcations and entire networks, with particular emphasis on the liver as important representative of detoxifying organs. In one of the plasma skimming models, under certain conditions, oscillations between states are found and analysed in a methodical study to identify their causes and influencing parameters. The flow solution obtained is then used to define the velocity at which a compound would be transported. A convection-reaction equation is studied to simulate the transport of a compound in blood and its uptake by the surrounding cells. Different types of signal sharpness have to be handled depending on the application to address different temporal compound concentration profiles. To permit executing the studied models numerically stable and accurate, we here extend existing transport schemes to handle converging bifurcations, and more generally multi-furcations. We study the accuracy of different numerical schemes as well as the effect of reactions and of the network itself on the bolus shape. Even though this study is guided by applications in liver micro-architecture, the proposed methodology is general and can readily be applied to other capillary network geometries, hence to other organs or to bioengineered network designs. This article is protected by copyright. All rights reserved.
Noemie Boissier, Dirk Drasdo, Irene E Vignon-Clementel

1420 related Products with: Simulation of a detoxifying organ function: focus on hemodynamics modeling and convection-reaction numerical simulation in microcirculatory networks.



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#33249671   2020/11/29 To Up

Long-distance stress and developmental signals associated with abscisic acid signaling in environmental responses.

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Takuya Yoshida, Alisdair R Fernie, Kazuo Shinozaki, Fuminori Takahashi

1304 related Products with: Long-distance stress and developmental signals associated with abscisic acid signaling in environmental responses.

1 G100ug Lyophilized 100 G 100 UG10 mg7 inhibitors 1 G 1 G100ug Lyophilized2 Pieces/Box

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#33249638   2020/11/29 To Up

Global pattern of interkinetic nuclear migration in tracheoesophageal epithelia of the mouse embryo: inter-organ and intra-organ regional differences.

Interkinetic nuclear migration (INM) is an apicobasal (AB) polarity-based regulatory mechanism of proliferation/differentiation in epithelial stem/progenitor cells. We previously documented INM in the endoderm-derived tracheal/esophageal epithelia at embryonic day (E) 11.5 and suggested that INM is involved in the development of both organs. We here investigated inter-organ (trachea vs. esophagus) and intra-organ regional (ventral vs. dorsal) differences in the INM mode in the tracheal and esophageal epithelia of the mouse embryo. We also analyzed convergent extension (CE) and planar cell movement (PCM) in the epithelia based on cell distribution. The pregnant C57BL/6J mice were intraperitoneally injected with 5-ethynyl-2'-deoxyuridine at E11.5 and E12.5 and were sacrificed 1, 4, 6, 8 and 12 hr later to obtain the embryos. The distribution of labeled cell nuclei along the AB axis was chronologically analyzed in the total, ventral and dorsal sides of the epithelia. The percentage distribution of the nuclei population was represented by histogram and the chronological change was analyzed statistically using multi-dimensional scaling. The inter-organ comparison of the INM mode during E11.5-E12.0, but not E12.5-E13.0, showed a significant difference. During E11.5-E12.0 the trachea, but not the esophagus, showed a significant difference between ventral and dorsal sides. During E12.5-E13.0 neither organ showed regional differences. CE appeared to occur in both organs during E11.5-E12.0 while PCM was unclear in both organs. These findings suggest a difference between the trachea and esophagus, and a regional difference in the trachea, not in the esophagus, in the INM mode, which may be related with the later differential organogenesis/histogenesis of these organs. This article is protected by copyright. All rights reserved.
Dereje Getachew, Akihiro Matsumoto, Yasuhiro Uchimura, Jun Udagawa, Nanako Mita, Noriko Ogawa, Shigeru Moriyama, Akiyasu Takami, Hiroki Otani

1032 related Products with: Global pattern of interkinetic nuclear migration in tracheoesophageal epithelia of the mouse embryo: inter-organ and intra-organ regional differences.



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#33249605   2020/11/29 To Up

Intracerebral endotheliitis and microbleeds are neuropathological features of COVID-19.

Coronavirus disease 19 (COVID-19), caused by infection with the severe acute respiratory syndrome coronavirus 2 (Sars-CoV-2), has become a worldwide pandemic (1). Symptoms of COVID-19 vary widely and range from asymptomatic disease to severe pneumonia and multiorgan failure (2). A severe disease course is more likely in older patients and patients with pre-existing respiratory and cardiovascular conditions (2). Patients with severe Sars-CoV-2 infection may present with ischaemic stroke (3, 4) or even fatal intracerebral haemorrhage (5). To date, little is known about the neuropathological sequelae of COVID-19. The largest published autopsy series of COVID-19 neuropathology reported microthrombi and acute haemorrhagic infarction in a significant number of patients (6), while another more recent study found evidence of lymphocytic encephalitis and meningitis (7). Endotheliitis of the brain and extraneural organs has been shown in Sars-CoV infected patients (8). Similarly, it is a recurrent feature in the lungs and other peripheral organs of Sars-CoV-2 infected patients (9) but has not yet been reported in the central nervous system. We speculated that cerebrovascular pathology in COVID-19 patients could be a direct consequence of hitherto unidentified cerebral endotheliitis caused by Sars-CoV-2.
Daniel Kirschenbaum, Lukas L Imbach, Elisabeth Jane Rushing, Katrin B M Frauenknecht, Dominic Gascho R T, Benjamin Victor Ineichen, Emanuela Keller, Sibylle Kohler, Mona Lichtblau, Regina R Reimann, Katharina Schreib, Silvia Ulrich, Peter Steiger, Adriano Aguzzi, Karl Frontzek

1140 related Products with: Intracerebral endotheliitis and microbleeds are neuropathological features of COVID-19.

10 mg5 per Sleeve, 100 Flasks/case200ul200ug25 mg200 1000 tests100ug10 mg200ul

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#33249527   2020/11/29 To Up

Structure and Function of the Blood-Brain Barrier (BBB).

The blood-brain barrier (BBB) protects the vertebrate central nervous system from harmful blood-borne, endogenous and exogenous substances to ensure proper neuronal function. The BBB describes a function that is established by endothelial cells of CNS vessels in conjunction with pericytes, astrocytes, neurons and microglia, together forming the neurovascular unit (NVU). Endothelial barrier function is crucially induced and maintained by the Wnt/β-catenin pathway and requires intact NVU for proper functionality. The BBB and the NVU are characterized by a specialized assortment of molecular specializations, providing the basis for tightening, transport and immune response functionality.The present chapter introduces state-of-the-art knowledge of BBB structure and function and highlights current research topics, aiming to understanding in more depth the cellular and molecular interactions at the NVU, determining functionality of the BBB in health and disease, and providing novel potential targets for therapeutic BBB modulation. Moreover, we highlight recent advances in understanding BBB and NVU heterogeneity within the CNS as well as their contribution to CNS physiology, such as neurovascular coupling, and pathophysiology, is discussed. Finally, we give an outlook onto new avenues of BBB research.
Fabienne Benz, Stefan Liebner

1210 related Products with: Structure and Function of the Blood-Brain Barrier (BBB).

100ug2ug

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#33249503   2020/11/29 To Up

Severe muscle damage with myofiber necrosis and macrophage infiltrates characterize anti-Mi2 positive dermatomyositis.

The aim of our study was to investigate clinical and histopathological findings in adult DM patients positive for anti-Mi2 (anti-Mi2+) antibodies compared with DM patients negative for anti-Mi2 (anti-Mi2-).
Marco Fornaro, Francesco Girolamo, Lorenzo Cavagna, Franco Franceschini, Margherita Giannini, Angela Amati, Anna Lia, Marilina Tampoia, Dario D'Abbicco, Lorenzo Maggi, Micaela Fredi, Giovanni Zanframundo, Liala Moschetti, Laura Coladonato, Florenzo Iannone

1049 related Products with: Severe muscle damage with myofiber necrosis and macrophage infiltrates characterize anti-Mi2 positive dermatomyositis.

100ul0.5 ml0.2 mL100ul0.5 ml100ul100100 μg1mg1000 100ul100ul

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#33249486   2020/11/29 To Up

Spatial variability in carbon and nitrogen related traits in apple trees: the effects of the light environment and crop load.

Photosynthetic carbon assimilation rates are highly dependent on environmental factors such as light availability and on metabolic limitations such as the demand for carbon by sink organs. The relative effects of light and sink demand on photosynthesis in perennial plants such as trees remain poorly characterised. The aim of the present study was therefore to characterize the relationships between light and fruit load on a range of leaf traits including photosynthesis, nonstructural carbohydrate (NSC) contents, leaf structure and nitrogen-related variables in fruiting ('ON') and nonfruiting ('OFF') 'Golden Delicious' apple trees. We show that crop status (at the tree scale) exerts a greater influence over leaf traits than the local light environment, or the local fruit load. High rates of photosynthesis were observed in the ON trees. This was correlated with a high leaf nitrogen content. In contrast, little spatial variability in photosynthesis rates was observed in the OFF trees. The lack of variation in photosynthesis rates was associated with high leaf NSC contents at the tree level. Taken together, these results suggest that low carbon demand leads to feedback limitations on photosynthesis resulting in a low level of within-tree variability. These findings provide new insights into carbon and nitrogen allocations within trees that are heavily dependent on carbon demand.
Jérôme Ngao, Sébastien Martinez, André Marquier, Sylvie Bluy, Brigitte Saint-Joanis, Evelyne Costes, Benoît Pallas

1007 related Products with: Spatial variability in carbon and nitrogen related traits in apple trees: the effects of the light environment and crop load.

1 25 G1 mg2 Pieces/Box

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#33249375   2020/11/16 To Up

Reverse regulation of hepatic ceruloplasmin production in rat model of myocardial ischemia.

Ceruloplasmin (Cp) is a major copper-binding protein produced in the liver and delivers copper to extrahepatic organs. Patients with myocardial infarction are often featured by an elevation of serum copper concentrations due to copper efflux from ischemic hearts. The present study was undertaken to test the hypothesis that serum copper elevation leads to up-regulation of hepatic Cp in myocardial infarction.
Dan Yang, Tao Wang, Jiaming Liu, Haitao Wang, Y James Kang

2423 related Products with: Reverse regulation of hepatic ceruloplasmin production in rat model of myocardial ischemia.

100 UG2 Pieces/Box300 units96 wells18 kgs

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#33249285   2020/11/26 To Up

Hypoxic preconditioning - a non-pharmacological approach in COVID-19 prevention.

Hypoxia is defined by low oxygen concentration in organs, tissues and cells. Maintaining oxygen homeostasis represents the essential cellular metabolic process for the structural integrity of tissues in different pathological conditions, including SARS-CoV-2 infection. Considering the role of hypoxia-inducible factor-1 (HIF-1) as regulator of cellular response to hypoxia and its involvement in angiogenesis, erythropoiesis, glucose metabolism, inflammation, we propose hypoxic preconditiong (HPC) as a novel prevention therapeutic approach on healthy contacts of COVID-19 patients. To date, several studies revealed the benefic effects of hypoxic preconditioning in ischemia, kidney failure and in pulmonary function recovery of lung surgery patients. HPC increases the expression of factors that promote cell survival and angiogenesis, induces an anti-inflammatory outcome, triggers coordinated hypoxia responses that promote erythropoiesis, and mobilizes the circulating progenitor cells. Futhermore, the mesenchymal stem cells (MSC) exposed to HPC show improvement of their regenerative capacities, and increases the effectiveness of stem cell therapy in different pathologies, including COVID-19. In conclusion, HPC should be considered an approach with beneficial outcomes and without significant side effects when the organism is severely exposed to the same stressor. HPC appears as a trigger to mechanisms that improve and maintain tissue oxygenation and repair, a main goal in different pathologies, including COVID-19 or other respiratory conditions.
Radu Gabriel Hertzog, Nicoleta Simona Bicheru, Diana Mihaela Popescu, Octavian Călborean, Ana-Maria Catrina

2064 related Products with: Hypoxic preconditioning - a non-pharmacological approach in COVID-19 prevention.

5 mg 100ul100 μg1 Set100 μg1 Set100 μg100ug

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#33249230   2020/11/26 To Up

Delay in puberty indices of Wistar rats caused by Cadmium. Focus on the redox system in reproductive organs.

Puberty is a transitional period from juvenile stage to adulthood, followed by the functional maturation of gonads and reproductive organs. This period is sensitive to environmental pollutants like cadmium (Cd), a heavy metal that represents a serious health risk. Cd is an endocrine disruptor that interferes with reproduction by causing oxidative stress in the reproductive organs, affecting the sexual function and decreasing testosterone (T) levels. However, little research has been done on the effects of Cd on puberty markers and antioxidant systems. In this study, we evaluated the effects of Cd on puberty markers: preputial separation, testes descent and T levels, and the antioxidant activity (SOD, CAT, GSH/GSSG and TAC) in the seminal vesicles, testis and epididymis. Male Wistar pups were treated with 1 mg/kg Cd or saline solution by i.p. injection from day 1 to 35; the other treatment was administrated for 49 days. At the end of treatment, the animals were sacrificed, and the tissues of interest dissected, weighed and prepared for the respective assays. Cd treated rats from birth to puberty showed a delay onset in the puberty markers and a low weight in reproductive organs. Also, Cd induced differential effects on the redox system in reproductive organs and decreased T levels, these effects played a pivotal role in the delay of puberty markers onset (testes descent and preputial separation), affecting the development and sexual maturity of the male rats.
Joel Hernández-Rodríguez, Ana Laura López, Sergio Montes, Herlinda Bonilla-Jaime, Ivis Morales, Ofelia Limón-Morales, Camilo Ríos, Marisela Hernández-González, Rosa María Vigueras-Villaseñor, Marcela Arteaga-Silva

1687 related Products with: Delay in puberty indices of Wistar rats caused by Cadmium. Focus on the redox system in reproductive organs.

25 ml.

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