Only in Titles

           Search results for: paraffin    

paperclip

#32083130   // Save this To Up

Characterizations of Gene Alterations in Melanoma Patients from Chinese Population.

Melanoma is a human skin malignant tumor with high invasion and poor prognosis. The limited understanding of genomic alterations in melanomas in China impedes the diagnosis and therapeutic strategy selection. We conducted comprehensive genomic profiling of melanomas from 39 primary and metastatic formalin-fixed paraffin-embedded (FFPE) samples from 27 patients in China based on an NGS panel of 223 genes. No significant difference in gene alterations was found between primary and metastasis melanomas. The status of germline mutation, CNV, and somatic mutation in our cohort was quite different from that reported in Western populations. We further delineated the mutation patterns of 4 molecular subgroups (BRAF, RAS, NF1, and Triple-WT) of melanoma in our cohort. BRAF mutations were more frequently identified in melanomas without chromic sun-induced damage (non-CSD), while RAS mutations were more likely observed in acral melanomas. NF1 and Triple-WT subgroups were unbiased between melanomas arising in non-CSD and acral skin. BRAF, RAS, and NF1 mutations were significantly associated with lymph node metastasis or presence of ulceration, implying that these cancer driver genes were independent prognostic factors. In summary, our results suggest that mutational profiles of malignant melanomas in China are significantly different from Western countries, and both gene mutation and amplification play an important role in the development and progression of melanomas.

2766 related Products with: Characterizations of Gene Alterations in Melanoma Patients from Chinese Population.



Related Pathways

paperclip

#32081549   // Save this To Up

[EGFR molecular characterization in non-small cell bronchic cancer: comparative prospective study by NGS and Idylla platform technologies].

Detection of genetic alterations in the EGFR tyrosine kinase domain is a major concern in the management of non-small cell lung cancer because it conditions access to tyrosine kinase inhibitors. In practice, it is possible to characterize only well-documented mutations or to sequence all relevant EGFR exons and also other targets of theranostic interest. This prospective study compares the targeted EGFR characterization on Idylla platform (Biocartis) and a more extensive one by next generation sequencing using Ion Torrent technology.

2651 related Products with: [EGFR molecular characterization in non-small cell bronchic cancer: comparative prospective study by NGS and Idylla platform technologies].



Related Pathways

paperclip

#32081547   // Save this To Up

[Study of the Human Papillomavirus (HPV) prevalence in head and neck carcinomas in a French monocentric cohort of 372 patients].

French data about HPV role in head and neck carcinomas are sparse, although French patients are mostly heavy smokers. In this series of oropharyngeal et non-oropharyngeal tumors, we aimed to determine what were the clinicopathological features associated with HPV and evaluate survival of patients according to HPV status.

1781 related Products with: [Study of the Human Papillomavirus (HPV) prevalence in head and neck carcinomas in a French monocentric cohort of 372 patients].

Head and neck cancer tiss Head & Neck cancer tissue Multiple head and neck ca Head and neck cancer tiss Head and neck squamous ca Head & Neck cancer test t Head and Neck tumor and n Multiple head and neck tu Multiple head and neck ca Goat Anti-Human, Cow Argi Anti-human C1 Esterase In Goat Anti-Human RASSF7 HR

Related Pathways

  •  
  • No related Items
paperclip

#32080984   // Save this To Up

Immunohistochemical evidence of canine morbillivirus (canine distemper) infection in coatis (Nasua nasua) from Southern Brazil.

The pathological and immunohistochemical (IHC) findings associated with infection due to canine morbilivírus (canine distemper virus, CDV) are described in coatis (Nasua nasua). Tissue fragments of coatis (n = 13) that died at the Bela Vista Sanctuary, Paraná, Southern Brazil, were routinely processed for histopathology to identify the main histopathologic patterns as compared to that of the domestic dog. Selected formalin-fixed paraffin-embedded (FFPE) tissue fragments of the lungs, liver, urinary bladder and small intestine were used in IHC assays designed to identify the antigens of CDV, canine adenovirus (CAdV-1 and CAdV-2) and canine parvovirus type 2 (CPV-2). The main histopathologic patterns identified were interstitial pneumonia (n = 9), interstitial nephritis (n = 6), atrophic enteritis (n = 4) and ballooning degeneration of the uroepithelium (n = 3). Positive immunolabelling for intralesional antigens of CDV was identified in the lung with interstitial pneumonia (n = 3), in the intestine (n = 2) and in the degenerated epithelium of the urinary bladder (n = 2). Antigens of CPV-2, CAdV-1 and CAdV-2 were not identified in any FFPE tissue sections evaluated. These findings indicate that these wild carnivores were infected by a viral disease pathogen common to the domestic dog and develop similar histopathologic findings. Collectively, these findings suggest that these coatis were infected by CDV and can serve as a potential host for this infectious disease pathogen.

2397 related Products with: Immunohistochemical evidence of canine morbillivirus (canine distemper) infection in coatis (Nasua nasua) from Southern Brazil.



Related Pathways

paperclip

#32079464   // Save this To Up

Multispectral imaging technology: Visualize, analyze, phenotyping, and quantify immune cells in situ.

In the personalized medicine era, the field of immunohistopathology is evolving to provide even more precise diagnostic information to efficiently apply targeting therapies. In this regard, MultiSpectral fluorescence Imaging (MSI) is a powerful and reliable technique that provides a detailed and remarkable analysis of multiple biomarkers within their histological context. In particular, the analysis of the immune infiltrate in conjunction with the expression of immune checkpoint molecules could explain why the efficacy of the promising treatments based on immune modulator monoclonal antibodies is still limited. We analyzed the advantages and the pitfalls of applying MSI technology to investigate the immune infiltrate in correlation with programmed death-ligand 1 expression in paraffin embedded ovarian cancer samples.

2135 related Products with: Multispectral imaging technology: Visualize, analyze, phenotyping, and quantify immune cells in situ.

Nile Red, A lipophilic dy GLP 1 ELISA Kit, Rat Gluc superSf9-2 insect cells anti HSV (II) gB IgG1 (mo Cold Fusion Cloning Kit w Human Large Intestine Mic Sf9 insect cells Macrophage Colony Stimula Octyl â D 1 thioglucopyr Glucagon ELISA KIT, Rat G Rat Anti-Mouse Dendritic anti HCMV gB IgG1 (monocl

Related Pathways

paperclip

#32079442   // Save this To Up

Prognostic impact of PD-L1 in oropharyngeal cancer after primary curative radiotherapy and relation to HPV and tobacco smoking.

Incidence of oropharyngeal squamous cell carcinoma (OPSCC) is rising rapidly in many western countries due to (HPV) and tobacco smoking, with a considerable overlap. Immunotherapy directed at the PD1/PD-L1 axis have shown promise in head and neck cancer and other cancer types. PD-L1 expression may indicate a poorer prognosis, and at the same time indicate a possible benefit of anti-PD-L1 immunotherapeutic agents. The primary aim of this study was to establish the prognostic effect of PD-L1 expression after primary curative radiotherapy alone. A cohort of 303 OPSCC patients treated with primary, curative intended radiotherapy was established. PD-L1 expression was evaluated by immunohistochemistry on formalin fixed, paraffin embedded tissue sections. PD-L1 positivity was defined as a Combined Positive Score (CPS) ≥1, indicating staining of either tumor cells, lymphocytes or macrophages. Median follow-up was 5.3 years. With 199 deaths, there was no difference in overall survival between patients with PD-L1+ and PD-L1- tumors (adjusted hazard ratio [aHR] and 95% confidence interval [CI]: 1.0 [0.71-1.4]). Also, locoregional failure was similar between the two groups (aHR 1.1 [CI: 0.68 - 1.7]). Tumors were PD-L1+ in 76% of cases, significantly more among HPV p16+ tumors (82% vs. 70%,  = .01). Interestingly, higher prevalence of PD-L1+ expression was seen in HPV p16+ patients with <10 pack-years of tobacco-smoking (93%) compared to HPV p16+ smokers (76%) or HPV p16-negative patients (70%) ( = .003). PD-L1 expression had no prognostic significance in OPSCC patients treated with primary radiotherapy alone. A substantial proportion of OPSCC tumors show PD-L1 overexpression, especially in HPV p16+ tumors in patients with little or no smoking history.

1711 related Products with: Prognostic impact of PD-L1 in oropharyngeal cancer after primary curative radiotherapy and relation to HPV and tobacco smoking.



Related Pathways

paperclip

#32079384   // Save this To Up

The Prognostic Value of F-FDG PET/CT and KRAS Mutation in Colorectal Cancers

Prognostic effect of KRAS mutation and side of tumor in colorectal cancer is a highly controversial subject. Therefore, we evaluated the association between FDG uptake pattern in F-fluoro-2-deoxy-glucose positron emission tomography/computed tomography (F-FDG PET/CT) imaging and KRAS mutation and tumor localization in patients with a diagnosis of colon cancer and assessed the effects of these three factors on prognosis and survival.

2225 related Products with: The Prognostic Value of F-FDG PET/CT and KRAS Mutation in Colorectal Cancers

DVL1 & CTNNB1 Protein Pro Colorectal carcinoma and FDA Standard Frozen Tissu Thermal Shaker with cooli CD86 & CTLA4 Protein Prot MYLK & CTTN Protein Prote ACTN1 & CTNNA1 Protein Pr CASP3 & CTNNB1 Protein Pr PECAM1 & CTNNB1 Protein P Colorectal organ carcinom FDA Standard Frozen Tissu FLT1 & CTNNB1 Protein Pro

Related Pathways

paperclip

#32079266   // Save this To Up

Expanded Graphite/Paraffin/Silicone Rubber as High Temperature Form-stabilized Phase Change Materials for Thermal Energy Storage and Thermal Interface Materials.

In this work, expanded graphite/paraffin/silicone rubber composite phase-change materials (PCMs) were prepared by blending the expanded graphite (EG), paraffin wax (PW) and silicone rubber (SR) matrix. It has been shown that PW fully penetrates into the three dimensional (3D) pores of EG to form the EG/PW particles, which are sealed by SR and evenly embedded in the SR matrix. As a result of the excellent thermal stability of SR and the capillary force from the 3D pores of EG, the EG/PW/SR PCMs are found to have good shape stability and high reliability. After being baked in an oven at 150 °C for 24 h, the shape of the EG/PW/SR PCMs is virtually unchanged, and their weight loss and latent heat drop are only 7.91 wt % and 11.3 J/g, respectively. The latent heat of the EG/PW/SR composites can reach up to 43.6 and 41.8 J/g for the melting and crystallizing processes, respectively. The super cooling of PW decreased from 4.2 to 2.4 due to the heterogeneous nucleation on the large surface of EG and the sealing effect of the SR. Meanwhile, the thermal conductivity of the EG/PW/SR PCMs reaches 0.56 W·m·K, which is about 2.8 times and 3.73 times of pure PW and pristine SR, respectively. The novel EG/PW/SR PCMs with superior shape and thermal stabilities will have a potential application in heat energy storage and thermal interface materials (TIM) for electronic devices.

2737 related Products with: Expanded Graphite/Paraffin/Silicone Rubber as High Temperature Form-stabilized Phase Change Materials for Thermal Energy Storage and Thermal Interface Materials.



Related Pathways

paperclip

#32078828   // Save this To Up

miR-99a-5p as Possible Diagnostic and Prognostic Marker in Patients With Gastric Cancer.

The signet-ring cell carcinoma (SRC), one of the histological subtypes of gastric cancer, often exhibits aggressive behavior in clinical practice and is therefore a commonly found subtype in advanced gastric cancer. However, SRC, especially at the early stages, has recently been reported to show a lower potential for malignancy than other pathological subtypes. Because the detailed molecular mechanisms underlying SRC pathology remain unclear, we focused on microRNAs (miRs) and aimed to elucidate the molecular mechanisms involved in endowing early SRC with its characteristic properties.

2682 related Products with: miR-99a-5p as Possible Diagnostic and Prognostic Marker in Patients With Gastric Cancer.



Related Pathways

paperclip

#32077309   // Save this To Up

Steroids Inhibit Eosinophil Accumulation and Downregulate Hematopoietic Chemotaxic Prostaglandin D Receptor in Aspirin-Exacerbated Respiratory Disease.

Aspirin-exacerbated respiratory disease (AERD) is characterized by eosinophilic rhinosinusitis, nasal polyposis, aspirin sensitivity, and asthma. This study aims to identify a mechanism to target for the future treatment of AERD via the elucidation of the effect of systemic steroids on the expression of hematopoietic prostaglandin D synthase (HPGDS) and chemotaxic prostaglandin D (DP2) receptor relative to eosinophil activation in the nasal polyps of patients with AERD.

2032 related Products with: Steroids Inhibit Eosinophil Accumulation and Downregulate Hematopoietic Chemotaxic Prostaglandin D Receptor in Aspirin-Exacerbated Respiratory Disease.

DiscoveryPak™ Receptor DPP4 Inhibitor Screening  EpiQuik Superoxide Dism rHIV gp36, soluble Antige Dabrafenib Mesylate Mecha Caspase 3 Inhibitor Z DEV Beta Amyloid (42) ELISA K Tissue array of uterine c Human integrin aVb3, affi Caspase 5 Inhibitor Drug Breast disease spectrum t Pancreatic disease spectr

Related Pathways