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#33249773   2020/11/29 To Up

Does the definition of chronic active T-cell mediated rejection need revisiting?

Similar to what is observed in native kidneys, tubulo-interstitial inflammation in scarred areas (i-IFTA) is commonly found in kidney allografts, and here independently associated with impaired outcome. Along with the observation that i-IFTA is preceded by acute T cell mediated rejection (TCMR) and/or suboptimal immunosuppression in a subset of cases, these data formed the basis for the introduction of the category of tubulointerstitial (grade I) chronic active TCMR (CA-TCMR) in the 2017 Banff classification.
Maarten Naesens, Mark Haas, Alexandre Loupy, Candice Roufosse, Michael Mengel

2466 related Products with: Does the definition of chronic active T-cell mediated rejection need revisiting?

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#33249770   2020/11/29 To Up

Histologic effects of MicroPulse™ transscleral cyclophotocoagulation in normal equine eyes.

Determine the immediate post-operative effects of MicroPulse transscleral cyclophotocoagulation (MP-TSCPC) in healthy equine eyes.
Braidee C Foote, Jodi D Smith, Rachel A Allbaugh, Lionel Sebbag

1906 related Products with: Histologic effects of MicroPulse™ transscleral cyclophotocoagulation in normal equine eyes.



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#33249748   2020/11/29 To Up

Beyond energy storage: roles of glycogen metabolism in health and disease.

Beyond storing and supplying energy in the liver and muscles, glycogen also plays critical roles in cell differentiation, signaling, redox regulation and stemness under various physiological and pathophysiological conditions. Such versatile functions have been revealed by various forms of glycogen storage diseases. Here, we outline the source of carbon flux in glycogen metabolism and discuss how glycogen metabolism guides CD8 T cell memory formation and maintenance. Likewise, we review how this affects macrophage polarization and inflammatory responses. Furthermore, we dissect how glycogen metabolism supports tumor development by promoting tumor-repopulating cell growth in hypoxic tumor microenvironments. This review highlights the essential role of the gluconeogenesis-glycogenesis-glycogenolysis-PPP metabolic chain in redox homeostasis, thus providing insights into potential therapeutic strategies against major chronic diseases including cancer.
Huafeng Zhang, Jingwei Ma, Ke Tang, Bo Huang

2453 related Products with: Beyond energy storage: roles of glycogen metabolism in health and disease.

96 tests96 tests1-99 mg/ml/ea price x 2

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#33249724   2020/11/29 To Up

Serum YKL-40 and IL 17 in Psoriasis: Reliability as Prognostic Markers for Disease severity and Responsiveness to treatment.

YKL-40, a mammalian chitinase 3- like protein that was associated with multiple inflammatory and immune diseases. Previous studies have suggested a role for YKL-40 in psoriasis based on its significantly higher levels in the serum of psoriatic patient compared to healthy controls.
S A Khashaba, E M Attwa, N M Said, S Ahmed, F Khattab

1175 related Products with: Serum YKL-40 and IL 17 in Psoriasis: Reliability as Prognostic Markers for Disease severity and Responsiveness to treatment.

100 mg2.5 mg1 kit400Tests100 1 mg96T430 tests1 kit100 mg500 MG

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#33249720   2020/11/29 To Up

International Council for Standardization in Haematology (ICSH) laboratory guidance for the evaluation of haemostasis analyser-reagent test systems. Part 1: Instrument-specific issues and commonly used coagulation screening tests.

Before a new method is used for clinical testing, it is essential that it is evaluated for suitability for its intended purpose. This document gives guidance for the performance of verification, validation and implementation processes required by regulatory and accreditation bodies. It covers the planning and execution of an evaluation of the commonly performed screening tests (prothrombin time, activated partial thromboplastin time, thrombin time and fibrinogen assay), and instrument-specific issues. Advice on selecting an appropriate haemostasis analyser, planning the evaluation, and assessing the reference, interval, precision, accuracy, and comparability of a haemostasis test system are also given. A second companion document will cover specialist haemostasis testing.
Chris Gardiner, Robyn Coleman, Moniek P M de Maat, Akbar Dorgalaleh, Marión Echenagucia, Robert C Gosselin, Masahiro Ieko, Steve Kitchen

1735 related Products with: International Council for Standardization in Haematology (ICSH) laboratory guidance for the evaluation of haemostasis analyser-reagent test systems. Part 1: Instrument-specific issues and commonly used coagulation screening tests.

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#33249704   2020/11/29 To Up

Does Interleukin-33 level correlate with the activity of Pemphigus vulgaris?: A case-control study.

Pemphigus is a group of immune mediated blistering diseases of skin and mucus membrane caused by destruction of the intercellular junction (desmosomes) by autoantibodies. Pemphigus vulgaris (PV) is considered the most common type of all pemphigus family. Various cytokines play a major role in pemphigus pathogenesis. Interleukin-33 (IL-33) role has been studied in various autoimmune diseases as; psoriasis and rheumatoid arthritis, yet it has not been studied in Egyptian patients with PV.
Radwa M Bakr, Doaa S Sayed, Alaa S Abd-Elkader, Amira A Kamal, Aya Y Badran

1969 related Products with: Does Interleukin-33 level correlate with the activity of Pemphigus vulgaris?: A case-control study.

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#33249703   2020/11/29 To Up

ADFP promotes cell proliferation in lung adenocarcinoma via Akt phosphorylation.

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Xia Meng, Ruiying Sun, Wei Wang, Na Zhang, Shiguang Cao, Boxuan Liu, Ping Fang, Shanshan Deng, Shuanying Yang

2359 related Products with: ADFP promotes cell proliferation in lung adenocarcinoma via Akt phosphorylation.

2 Pieces/Box25 ml.2 Pieces/Box2 Pieces/Box

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#33249698   2020/11/29 To Up

Post-interventional antithrombotic management after venous stenting of the iliofemoral tract in acute and chronic thrombosis: a systematic review.

Venous stenting has become a common treatment option for central deep-venous outflow obstructions and post-thrombotic syndrome. Following successful recanalization and stenting, stent patency is endangered by in-stent thrombosis and recurrent venous thromboembolism. Antithrombotic therapy might reduce patency-loss. This systematic review summarizes the literature on antithrombotic therapy following (post-)thrombotic venous stenting. A systematic PubMed, MEDLINE, EMBASE, and Cochrane-search was performed for studies addressing antithrombotic therapy prescribed following venous stenting of the iliofemoral tract indicated by acute or chronic thrombotic pathology. A total of 277 articles was identified of which 64 (56 original studies) were selected. Overall, a mean primary patency rate of 82,3% was seen one year after the intervention which decreased to 73,3% after two years. In the majority (43 of 56 studies, 77%) treatment was based on use of vitamin-K-antagonists, either with (18%) or without (59%) use of antiplatelet drugs. Only two studies (4%) directly assessed the effect of antithrombotic therapy on treatment outcomes. The impact of post-interventional antithrombotic therapy on stent patency remains unknown due to limited and insufficient data available in current literature. Further clinical research should more clearly address the role of antithrombotic therapy for preservation of long-term patency following venous stenting.
Pascale Notten, Hugo Ten Cate, Arina J Ten Cate-Hoek

2341 related Products with: Post-interventional antithrombotic management after venous stenting of the iliofemoral tract in acute and chronic thrombosis: a systematic review.

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#33249665   2020/11/29 To Up

Transcriptional and signaling regulation of skin epithelial stem cells in homeostasis, wounds, and cancer.

The epidermis and skin appendages are maintained by their resident epithelial stem cells, which undergo long-term self-renewal and multi-lineage differentiation. Upon injury, stem cells are activated to mediate re-epithelialization and restore tissue function. During this process, they often mount lineage plasticity and expand their fates in response to damage signals. Stem cell function is tightly controlled by transcription machineries and signaling transductions, many of which derail in degenerative, inflammatory, and malignant dermatologic diseases. Here, by describing both well-characterized and newly emerged pathways, we discuss the transcriptional and signaling mechanisms governing skin epithelial homeostasis, wound repair, and squamous cancer. Throughout, we highlight common themes underscoring epithelial stem cell plasticity and tissue-level crosstalk in the context of skin physiology and pathology.
Yinglu Guan, Youn Joo Yang, Priyadharsini Nagarajan, Yejing Ge

2882 related Products with: Transcriptional and signaling regulation of skin epithelial stem cells in homeostasis, wounds, and cancer.

96 wells1 mg10 ug

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#33249657   2020/11/29 To Up

Histological Characteristics of Lung Adenocarcinoma with Uncommon Actionable Alterations: Special Emphasis on MET exon 14 Skipping Alterations.

In the evolving era of precision medicine, increasing emphasis is placed on detecting molecular alterations driving the development of specific cancers and targeting them with matched therapies that can yield the best outcomes for patients. Lung adenocarcinomas with uncommon actionable alterations, including MET exon 14 skipping (METex14), ERBB2 and BRAF mutations, are rare and poorly characterized cancers.
Takuo Hayashi, Shinji Kohsaka, Kazuya Takamochi, Satsuki Kishikawa, Daiki Ikarashi, Kei Sano, Kieko Hara, Hiroko Onagi, Yoshiyuki Suehara, Fumiyuki Takahashi, Tsuyoshi Saito, Tetsuya Nakatsura, Shigehisa Kitano, Kenji Suzuki, Takashi Yao

2580 related Products with: Histological Characteristics of Lung Adenocarcinoma with Uncommon Actionable Alterations: Special Emphasis on MET exon 14 Skipping Alterations.

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