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#35973801   2022/08/16 To Up

Prospective observational study of amino-terminal brain natriuretic peptide levels in obese and non-obese women during pregnancy.

NT-proBNP, a marker of ventricular dysfunction, varies by BMI outside of pregnancy. This study aimed to determine whether obesity affects NT-proBNP levels in pregnancy.
Anna Denoble, Julia Moyett, Sarah Goldstein, Cary C Ward, Tracy Truong, Alaattin Erkanli, Andra James, Chad Grotegut

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#35973713   2022/08/16 To Up

CaMKII as a Therapeutic Target in Cardiovascular Disease.

CaMKII (the multifunctional Ca and calmodulin-dependent protein kinase II) is a highly validated signal for promoting a variety of common diseases, particularly in the cardiovascular system. Despite substantial amounts of convincing preclinical data, CaMKII inhibitors have yet to emerge in clinical practice. Therapeutic inhibition is challenged by the diversity of CaMKII isoforms and splice variants and by physiological CaMKII activity that contributes to learning and memory. Thus, uncoupling the harmful and beneficial aspects of CaMKII will be paramount to developing effective therapies. In the last decade, several targeting strategies have emerged, including small molecules, peptides, and nucleotides, which hold promise in discriminating pathological from physiological CaMKII activity. Here we review the cellular and molecular biology of CaMKII, discuss its role in physiological and pathological signaling, and consider new findings and approaches for developing CaMKII therapeutics. Expected final online publication date for the , Volume 63 is January 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
Oscar E Reyes Gaido, Lubika J Nkashama, Kate L Schole, Qinchuan Wang, Priya Umapathi, Olurotimi O Mesubi, Klitos Konstantinidis, Elizabeth D Luczak, Mark E Anderson

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