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#33453666   2021/01/06 To Up

Legacy and emerging per- and poly-fluoroalkyl substances in surface seawater from northwestern Pacific to Southern Ocean: Evidences of current and historical release.

Knowledge on distribution of per- and poly-fluoroalkyl substances (PFASs) in open oceans is limited. By taking part in the 32nd Chinese Antarctic Research Expedition, 41 surface seawater samples were collected in the northwestern Pacific Ocean (NW-PO), eastern Indian Ocean (E-IO) and Southern Ocean (SO), and 23 PFASs comprised of legacy perfluoroalkyl carboxylic acids, perfluoroalkyl sulfonate acids and some new emerging homologs such as 6:2 chlorinated polyfluorinated ether sulfonate (6:2 Cl-PFESA) were measured. The concentrations of the total PFASs decreased in the order of NW-PO>E-IO>SO. Perfluorooctanoic acid (PFOA) was the most dominant, followed by perfluorooctane sulfonate (PFOS). The PFOA concentration declined exponentially with the offshore distance, while such trend was not obvious for PFOS and other legacy PFASs, suggesting that PFOA was mainly derived from the ongoing land-based emissions, while PFOS was mainly from historical residues. 6:2 Cl-PFESA was identified (<11.1-170 pg/L) in the oceanic waters with relatively high level at the sites near Australia. Multiple receptor models indicated that PFASs in the SO were mainly contributed by atmosphere input, while those in the NW-PO and E-IO were originated from land sources. Isomeric profiles of PFOA showed that telomere-based source became more outstanding than electrochemical fluorinated production in recent years.
Guoqiang Shan, Xiang Qian, Xin Chen, Xuemin Feng, Minghong Cai, Liping Yang, Meng Chen, Lingyan Zhu, Shufeng Zhang

1340 related Products with: Legacy and emerging per- and poly-fluoroalkyl substances in surface seawater from northwestern Pacific to Southern Ocean: Evidences of current and historical release.

25 mg10 mg100ul500 mg 5 G 5 G25 mg1 g100ug96 wells (1 kit)100ug50 ug

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#33453599   2020/12/22 To Up

Study of photo induced charge transfer mechanism of PEDOT with nitro groups of RDX, HMX and TNT explosives using anti-stokes and stokes Raman lines ratios.

The paper reports the charge transfer mechanism between poly (3,4-ethylenedioxythiophene) (PEDOT) and high energy materials such as RDX, HMX and TNT, respectively in terms of ratios of anti-stokes (AS) and stokes(S) Raman lines of NO bands. Generally it works as an effective sensing medium for the detection of explosives when mixed in an equal proportion and are subjected to 532 nm wavelength without any chemical treatment [1]. The pristine PEDOT is less sensitive to 532 nm wavelength (2.33 eV) but influences the Raman S and AS lines of explosives in the mixture. The study also reveals that a small quantity (one milligram) of PEDOT is sufficient to initiate the positive charge transfer mechanism between its oxidized state to the lone pairs of electrons on the oxygen atoms of the nitro group of the explosive molecules. Consequently, the intensity of the Raman spectra of RDX, HMX and TNT is dropped by an order of 22.5, 11.45 and 17.2 times, respectively along with the shift of the NO vibrational modes. It is also attributed to Photon-electron-phonon interaction. Finally, we have estimated the reduced mass of the functional group to ascertain the force constant and the intensity ratios of AS /S lines to confirm the charge transfer mechanism. The effect of charge transfer mechanism is also reflected in drastic change in transmission /absorption characteristics of FTIR spectra of same PEDOT and explosive mixtures.
K Ramachandran, Archana Kumari, Jitendra Nath Acharyya, A K Chaudhary

1351 related Products with: Study of photo induced charge transfer mechanism of PEDOT with nitro groups of RDX, HMX and TNT explosives using anti-stokes and stokes Raman lines ratios.

200 1000 TESTS/0.65ml1000 5mg 5 G100.00 ul0.1 mg100ul1 ml100ul25 mg100ug Lyophilized

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#33453410   2021/01/13 To Up

Multi-sample mass spectrometry-based approach for discovering injury markers in chronic kidney disease.

Urinary proteomics studies have primarily focused on identifying markers of chronic kidney disease (CKD) progression. Here, we aimed to determine urinary markers of CKD renal parenchymal injury through proteomics analysis in animal kidney tissues and cells and in the urine of patients with CKD. Label-free quantitative proteomics analysis based on liquid chromatography-tandem mass spectrometry was performed on urine samples obtained from 6 normal controls and 9, 11, and 10 patients with CKD stages 1, 3, and 5, respectively, and on kidney tissue samples from a rat CKD model by 5/6 nephrectomy. Tandem mass tag-based quantitative proteomics analysis was performed for primary cultured glomerular endothelial cells (GECs) and proximal tubular epithelial cells (PTECs) before and after inducing 24-h hypoxia injury. Upon hierarchical clustering, out of 858 differentially expressed proteins (DEPs) in the urine of CKD patients, the levels of 416 decreased and 403 increased sequentially according to the disease stage, respectively. Among 2965 DEPs across 5/6 nephrectomized and sham-operated rat kidney tissues, 86 DEPs showed same expression patterns in the urine and kidney tissue. After cross-validation with two external animal proteome datasets, 38 DEPs were organized; only 10 DEPs, including serotransferrin, gelsolin, poly ADP-ribose polymerase 1, neuroblast differentiation-associated protein AHNAK, microtubule-associated protein 4, galectin-1, protein S, thymosin beta-4, myristoylated alanine-rich C-kinase substrate, and vimentin were finalized by screening human GECs and PTECs data. Among these ten potential candidates for universal CKD marker, validation analyses for protein S and galectin-1 were conducted. Galectin-1 was observed to have a significant inverse correlation with renal function as well as higher expression in glomerulus with chronic injury than protein S. This constitutes the first multi-sample proteomics study for identifying key renal-expressed proteins associated with CKD progression. The discovered proteins represent potential markers of chronic renal cell and tissue damage and candidate contributors to CKD pathophysiology.
Ji Eun Kim, Dohyun Han, Jin Seon Jeong, Jong Joo Moon, Hyun Kyung Moon, Sunhwa Lee, Yong Chul Kim, Kyung Don Yoo, Jae Wook Lee, Dong Ki Kim, Young Joo Kwon, Yon Su Kim, Seung Hee Yang

2258 related Products with: Multi-sample mass spectrometry-based approach for discovering injury markers in chronic kidney disease.

96T 50 UG250 mg16-22 Sample Kit96 tests

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#33453391   2021/01/13 To Up

Niraparib maintenance therapy in patients with platinum-sensitive recurrent ovarian cancer using an individualized starting dose (NORA): a randomized, double-blind, placebo-controlled phase 3 trial.

This study evaluated maintenance treatment with niraparib, a potent inhibitor of poly(ADP-ribose) polymerase 1/2, in patients with platinum-sensitive recurrent ovarian cancer.
X H Wu, J Q Zhu, R T Yin, J X Yang, J H Liu, J Wang, L Y Wu, Z L Liu, Y N Gao, D B Wang, G Lou, H Y Yang, Q Zhou, B H Kong, Y Huang, L P Chen, G L Li, R F An, K Wang, Y Zhang, X J Yan, X Lu, W G Lu, M Hao, L Wang, H Cui, Q H Chen, G Abulizi, X H Huang, X F Tian, H Wen, C Zhang, J M Hou, M R Mirza

2067 related Products with: Niraparib maintenance therapy in patients with platinum-sensitive recurrent ovarian cancer using an individualized starting dose (NORA): a randomized, double-blind, placebo-controlled phase 3 trial.

6 ml Ready-to-use

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#33453269   2021/01/13 To Up

Fundamentals of the logarithmic measure for revealing multimodal diffusion.

We develop a theoretical foundation for a time-series analysis method suitable for revealing the spectrum of diffusion coefficients in mixed Brownian systems, where no prior knowledge of particle distinction is required. This method is directly relevant for particle tracking in biological systems, where diffusion processes are often non-uniform. We transform Brownian data onto the logarithmic domain, where the coefficients for individual modes of diffusion appear as distinct spectral peaks in the probability density. We refer to the method as the logarithmic measure of diffusion, or simply as the logarithmic measure. We provide a general protocol for deriving analytical expressions for the probability densities on the logarithmic domain. The protocol is applicable for any number of spatial dimensions with any number of diffusive states. The analytical form can be fitted to data to reveal multiple diffusive modes. We validate the theoretical distributions and benchmark the accuracy and sensitivity of the method by extracting multi-modal diffusion coefficients from 2D Brownian simulations of poly-disperse filament bundles. Bundling the filaments allows us to control the system non-uniformity and hence quantify the sensitivity of the method. By exploiting the anisotropy of the simulated filaments, we generalize the logarithmic measure to rotational diffusion. By fitting the analytical forms to simulation data, we confirm the method's theoretical foundation. An error analysis in the single-mode regime shows that the proposed method is comparable in accuracy to the standard mean squared displacement approach for evaluating diffusion coefficients. For the case of multi-modal diffusion, we compare the logarithmic measure against other more sophisticated methods, showing that both model selectivity and extraction accuracy are comparable for small data sets. Therefore we suggest that the logarithmic measure, as a method for multi-modal diffusion coefficient extraction, is ideally suited for small data sets, a condition often confronted in the experimental context. Finally, we critically discuss the proposed benefits of the method and its information content.
Benjamin A Dalton, Ivo F Sbalzarini, Itsuo Hanasaki

1861 related Products with: Fundamentals of the logarithmic measure for revealing multimodal diffusion.

16 Arrays/Slide 1 G1.0 mg1 LITRE500 Units 100ul100μg16 Arrays/Slide

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#33453256   2021/01/13 To Up

Novel alginate-cellulose nanofiber-poly(vinyl alcohol) hydrogels for carrying and delivering nitrogen, phosphorus and potassium chemicals.

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Shiliang Liu, Qinglin Wu, Xiuxuan Sun, Yiying Yue, Brenda Tubana, Rongjie Yang, Huai N Cheng

1247 related Products with: Novel alginate-cellulose nanofiber-poly(vinyl alcohol) hydrogels for carrying and delivering nitrogen, phosphorus and potassium chemicals.

25 mg100ug100 mg 25 MG200ug1000 TESTS/0.65ml10 mg200ul200 25 mg1000 tests

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#33452755   2021/01/16 To Up

Statins attenuate antiviral IFN-β and ISG expression via inhibition of IRF3 and JAK/STAT signaling in poly(I:C)-treated hyperlipidemic mice and macrophages.

Viral infection is a significant burden to healthcare worldwide. Statins, 3-hydroxy-3-methyl glutaryl coenzyme A reductase inhibitors, are widely used as cholesterol-lowering drugs. Recently, long term statin therapy was shown to reduce the antiviral immune response; however, the underlying molecular mechanisms are unclear. Here, we found that simvastatin decreased polyinosinic-polycytidylic acid [poly(I:C)]-induced expression of antiviral interferon (IFN)-β and IFN-stimulated genes (ISGs) in the bronchoalveolar lavage fluid (BALF) and lungs of mice with high-fat diet-induced hyperlipidemia. Macrophages were the dominant cell type in the BALF of poly(I:C)-treated mice. We examined the effects of simvastatin in primary lung macrophages and found that simvastatin suppressed poly(I:C)-induced expression of IFN-β and ISGs. We examined the molecular mechanisms of statin-mediated inhibition of antiviral gene expression using murine macrophage-like cell line, J774.1/JA-4. Simvastatin and pitavastatin decreased poly(I:C)-induced expression of IFN-β and ISGs. Moreover, they repressed poly(I:C)-induced phosphorylation of IFN regulatory factor (IRF) 3 and signal transducers and activators of transcription (STAT) 1, which is involved in Janus kinase (JAK)/STAT signaling. Mevalonate and geranylgeranyl-pyrophosphate (GGPP), but not cholesterol, counteracted the negative effect of statins on IFN-β and ISG expression and phosphorylation of IRF3 and STAT1. The geranylgeranyl transferase inhibitor suppressed poly(I:C)-induced expression of IFN-β and ISGs and phosphorylation of IRF3 and STAT1. These results suggest that statins suppressed the expression of IFN-β and ISGs in poly(I:C)-treated hyperlipidemic mice and murine macrophages, and that these effects occurred through the inhibition of IRF3 and JAK/STAT signaling in macrophages. Furthermore, GGPP recovered the statin-suppressed IRF3 and JAK/STAT signaling in poly(I:C)-treated macrophages.
Atsushi Koike, Kaito Tsujinaka, Ko Fujimori

2379 related Products with: Statins attenuate antiviral IFN-β and ISG expression via inhibition of IRF3 and JAK/STAT signaling in poly(I:C)-treated hyperlipidemic mice and macrophages.

5 G100ul100ug2.5 mg10 mg50 ug 1,000 tests100ul1 mg1000 tests100ug

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#33452653   2021/01/15 To Up

From the laboratory to the end-user: a primary packaging study for microneedle patches containing amoxicillin sodium.

As microneedle (MN) patches progress towards commercialisation, there is a need to address issues surrounding their translation from the laboratory to the end-user. One important aspect of MN patches moving forward is appropriate primary packaging. This research focuses on MN patches containing amoxicillin (AMX) sodium for the potential treatment of neonatal sepsis in hot and humid countries. A MN patch consists of a hydrogel-forming MN array and a drug-containing reservoir. Improper primary packaging in hot and humid countries may result in degradation of active pharmaceutical ingredients, with the use of substandard medicines a major health concern. The research presented here, for the first time, seeks to investigate the integrity of MN patches in different primary packaging when stored under accelerated storage conditions, according to international guidelines. At pre-defined intervals, the performance of the MN patch was investigated. Major causes of drug instability are moisture and temperature. To avoid unnecessary degradation, suitable primary packaging was sought. After 168 days, the percentage of AMX sodium recovered from drug-containing reservoirs packaged in Protect™ 470 foil was 103.51 ± 7.03%. However, packaged in poly(ester) foil, the AMX sodium content decreased significantly (p = 0.0286), which is likely due to the degradation of AMX sodium by the imbibed moisture. Therefore, convincing evidence was provided as to the importance of investigating the stability of MN patches in primary packaging intended for MN-mediated transdermal delivery so that they are 'fit for purpose' when it reaches the end-user. Future work will include qualitative studies to assess MN patch usability.
Emma McAlister, Mary-Carmel Kearney, E Linzi Martin, Ryan F Donnelly

2725 related Products with: From the laboratory to the end-user: a primary packaging study for microneedle patches containing amoxicillin sodium.

100.00 ul100 100.00 ul

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#33452452   2021/01/15 To Up

Clinical implications of genomic alterations in metastatic prostate cancer.

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Takayuki Sumiyoshi, Kim N Chi, Alexander W Wyatt

2867 related Products with: Clinical implications of genomic alterations in metastatic prostate cancer.



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#33452397   2021/01/15 To Up

Semiconducting polymer nanoparticles for photothermal ablation of colorectal cancer organoids.

Colorectal cancer (CRC) treatment is currently hindered by micrometastatic relapse that cannot be removed completely during surgery and is often chemotherapy resistant. Targeted theranostic nanoparticles (NPs) that can produce heat for ablation and enable tumor visualization via their fluorescence offer advantages for detection and treatment of disseminated small nodules. A major hurdle in clinical translation of nanoparticles is their interaction with the 3D tumor microenvironment. To address this problem tumor organoid technology was used to evaluate the ablative potential of CD44-targeted polymer nanoparticles using hyaluronic acid (HA) as the targeting agent and coating it onto hybrid donor acceptor polymer particles (HDAPPs) to form HA-HDAPPs. Additionally, nanoparticles composed from only the photothermal polymer, poly[4,4-bis(2-ethylhexyl)-cyclopenta[2,1-b;3,4-b']dithiophene-2,6-diyl-alt-2,1,3-benzoselenadiazole-4,7-diyl] (PCPDTBSe), were also coated with HA, to form HA-BSe NPs, and evaluated in 3D. Monitoring of nanoparticle transport in 3D organoids revealed uniform diffusion of non-targeted HDAPPs in comparison to attenuated diffusion of HA-HDAPPs due to nanoparticle-matrix interactions. Computational diffusion profiles suggested that HA-HDAPPs transport may not be accounted for by diffusion alone, which is indicative of nanoparticle/cell matrix interactions. Photothermal activation revealed that only HA-BSe NPs were able to significantly reduce tumor cell viability in the organoids. Despite limited transport of the CD44-targeted theranostic nanoparticles, their targeted retention provides increased heat for enhanced photothermal ablation in 3D, which is beneficial for assessing nanoparticle therapies prior to in vivo testing.
Bryce McCarthy, Amit Cudykier, Ravi Singh, Nicole Levi-Polyachenko, Shay Soker

1657 related Products with: Semiconducting polymer nanoparticles for photothermal ablation of colorectal cancer organoids.

Each500U; 5U/ul1 kit(96 Wells)

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