Search results for: precursor
#38015465 
2023/11/28
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Laser-induced immobilization of an amorphous iron-phosphate/FeO composite on nickel foam for efficient water oxidation.
A laser-induced immobilization strategy is applied to prepare an amorphous iron-phosphate/FeO (L-FePO) composite on a nickel foam (NF) support. By laser-irradiating an iron hydrogen phosphate (FeHP) precursor, a melting and oxidation process leads to the generation of L-FePO with hierarchical pores and an amorphous structure. L-FePO shows exceptional electrocatalytic performance for the OER in an alkaline electrolyte, demonstrating an overpotential of 256 mV at 100 mA cm, a Tafel slope of 71 mV dec, and good stability over 100 h. The active FeO, partially dissolved phosphate, and newly formed FeOOH species provide abundant active sites, contributing to the excellent OER performance.Yan Zou, Man Jin, Dongdong Zhu, Yu-Jia Tang
2283 related Products with: Laser-induced immobilization of an amorphous iron-phosphate/FeO composite on nickel foam for efficient water oxidation.
50 ul 125 ml 100.00 ug 100ul 500 ml 50 mg100μg 100ul0.2 mg25 µg100ug
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#38015410 2023/11/28
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Akt/mTOR Pathway Agonist SC79 Inhibits Autophagy and Apoptosis of Oligodendrocyte Precursor Cells Associated with Neonatal White Matter Dysplasia.
White matter dysplasia (WMD) in preterm infants due to intrauterine inflammation is caused by excessive apoptosis of oligodendrocyte precursor cells (OPCs). In recent years, studies have found that excessive autophagy and apoptosis are highly interconnected and important in infection and inflammatory diseases in general. Therefore, in this study, we aimed to confirm whether regulation of autophagy by using the Akt phosphorylation agonist SC79 can inhibit abnormal apoptosis of OPCs and promote myelin maturation and white matter development in neonatal rats with WMD. We investigated the effect of inflammation on oligodendrocyte development in P0 neonatal rats by intracerebellar injection of LPS, and collected brain tissue at P2 and P5. Immunohistochemical and immunofluorescence staining were used to evaluate white matter damage, while immunofluorescence staining, terminal deoxynucleotidyl transferase dUTP nick end labeling analysis (TUNEL), and western blotting were used to evaluate autophagy and apoptosis. First, we observed that white matter development was arrested and white matter fiber maturation was impaired in LPS-inflicted pups compared with those in the sham-operated group. Second, treatment with SC79 reduced the levels of LC3II, caspase 3, caspase 9, and Bax/Bcl-2 and increased the levels of p62, p-Akt, and p-mTOR in the brain tissue of neonatal rats. Finally, SC79 treatment inhibited OPC apoptosis by increasing the binding of Beclin 1 to Bcl-2, which promoted OPC differentiation and maturation. However, the opposite results were observed after rapamycin administration. Taken together, our results suggest that SC79 can inhibit the abnormal apoptosis of OPCs caused by excessive autophagy through the Akt/mTOR pathway and that SC79 is a potential therapeutic agent for WMD in preterm infants.Zhongni Li, Feng Zhang, Li Huang, Jiehong Deng, Yutong Pan, Ting Xu, Jingyi Liu, Na Gao, Rongrong Duan, Chunyan Shao, Chan Wu, Minrong Wang, Liqun Lu
1576 related Products with: Akt/mTOR Pathway Agonist SC79 Inhibits Autophagy and Apoptosis of Oligodendrocyte Precursor Cells Associated with Neonatal White Matter Dysplasia.
1 mg2 Pieces/Box1.5x10(6) cells2 Pieces/Box1 mg1.5 x 10^6 cells100 µg11 inhibitors1.5x10(6) cells2 Pieces/Box500 1.5 x 10^6 cells
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#38015352 2023/11/28
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What Fosters School Connectedness? The Roles of Classroom Interactions and Parental Support.
Although research has identified the impact of school connectedness on a variety of outcomes for adolescents, much less work has focused on identifying its precursors. This study examined the relative influences of classroom interactions and parental support on elements of school connectedness among a sample of 4838 students (M = 15.84, SD = 0.29; 49.1% female) in the United States from the Programme for International Student Assessment (PISA) 2018 data. The results showed that three domains of classroom interactions (i.e., classroom management, instructional support, and emotional support) and parental support played unique roles in predicting school connectedness (i.e., teacher support and school belonging). Specifically, classroom management positively predicted both teacher support and school belonging; instructional support, especially directed instruction, positively predicted teacher support; emotional support was unrelated to teacher support and school belonging. Parental support positively predicted school belonging, but not teacher support. Overall, these findings highlight the roles of both teachers and parents in providing developmentally appropriate support to facilitate school connectedness.Anqi Peng, Meagan M Patterson, Sean Joo
1529 related Products with: What Fosters School Connectedness? The Roles of Classroom Interactions and Parental Support.
25 mg200 units11000 tests100 100 G100ug1100.00 ul 5 G500IU200
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#38015201 2023/11/28
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Chitosan-Grafted-Poly(-vinylcaprolactam)-Decorated FeO@SiO Core-Shell Nanoformulation as an Efficient Drug Delivery System for Poorly Soluble Drugs.
Hydrocortisone, a commonly used anti-inflammatory drug, has limited aqueous solubility and several side effects. To address this challenge, as a proof-of-concept, this article demonstrates the development of a controlled-release drug delivery system (DDS) for hydrocortisone using chitosan-grafted poly(-vinylcaprolactam) (CS--PNVCL)-coated core-shell FeO@SiO nanoformulations (NFs). Reported magnetic nanoparticles (NPs) were synthesized and modified with silica, PNVCL, and CS precursors to enhance the biocompatibility of DDS and drug-loading efficiency. The release rate of hydrocortisone from FeO@SiO@CS--PNVCL NFs was observed to be higher at lower pH values, and the smart polymer coating demonstrated temperature responsiveness, facilitating drug release at higher temperatures. FeO@SiO@CS--PNVCL NFs exhibited a cell viability of around 97.2 to 87.3% (5-100 μg/mL) after 24-48 h, while the hydrocortisone-NFs had a cell viability of around 93.2 to 82.3%. Our findings suggest that CS--PNVCL-coated FeO@SiO NPs effectively enhance the solubility, loading capacity, and targeted delivery of poorly soluble drugs, thereby improving their therapeutic efficacy and bioavailability.Sarah Asgari, Bahareh Farasati Far, Gholamreza Charmi, Parisa Haji Maghsoudi, Shadi Keihankhadiv, Mohammad Seyedhamzeh, Ajeet Kumar Kaushik
2234 related Products with: Chitosan-Grafted-Poly(-vinylcaprolactam)-Decorated FeO@SiO Core-Shell Nanoformulation as an Efficient Drug Delivery System for Poorly Soluble Drugs.
96 Tests50 assays100ug Lyophilized200 assays400 assays100μg100 μg100ug Lyophilized400 assays
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#38015013 2023/02/13
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Surgical outcome of a patient with Bertolotti's syndrome in whom the established Castellvi classification system failed: illustrative case.
Bertolotti's syndrome is a condition of the lower back and/or L5 distribution leg pain caused by a lumbosacral transitional vertebra (LSTV). Diagnosing the LSTV as the cause of the symptoms and condition is essential for accurate management of this syndrome. Castellvi's classification system is widely accepted for LSTV anatomy, but it measures only one aspect of transitional anatomy and was intended primarily to identify target-level disk herniations.Richard J Chung, Camryn Harvie, John O'Donnell, Sarah Jenkins, Arthur L Jenkins
1654 related Products with: Surgical outcome of a patient with Bertolotti's syndrome in whom the established Castellvi classification system failed: illustrative case.
4/120 Packing /sleeve/bocase4/120 Packing /sleeve/bocase100 μg
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#38014899 2023/11/28
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Catalyst-Free -Difluorination/Spirocyclization of Indole-2-carboxamides: Synthesis of C2-Spiroindoline Derivatives.
A catalyst-free -difluorination/spirocyclization reaction has been successfully developed for the synthesis of -difluorinated C2-spiroindoline derivatives from indole-2-carboxamides. The resulting -difluorinated C2-spiroindolines can be easily converted into 2-spiropseudoindoxyls through hydrolysis. This method offers the benefits of simple operation, convenient access to raw materials, and mild conditions. Dual function of Selectfluor in this reaction is noteworthy as it can serve as both a fluorinating agent and an alkaline accelerator precursor.Xiaotong Dong, Xiaonuo Liu, Lei Wang, Yixuan Zhang, Jiale Li, Laijin Tian, Yulei Zhao
2555 related Products with: Catalyst-Free -Difluorination/Spirocyclization of Indole-2-carboxamides: Synthesis of C2-Spiroindoline Derivatives.
5 G1 mg100ug25 mg 100 G1 mg96tests1 mg50 mL1 mg1 set
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#38014880 2023/11/28
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Nickel-Catalyzed Enantioselective Hydrothiocarbonylation of Cyclopropenes.
Hydrothiocarbonylation of olefins using carbon monoxide and thiols is a powerful method to synthesize thioesters from simple building blocks. Owing to the intrinsic challenges of catalyst poisoning, transition-metal-catalyzed asymmetric thiocarbonylation, particularly when utilizing earth abundant metals, remains rare in the literature. Herein, we report a nickel-catalyzed enantioselective hydrothiocarbonylation of cyclopropenes for the synthesis of a diverse collection of functionalized thioesters in good to excellent yields with high stereoselectivity. This new method employs an inexpensive, air-stable nickel(II) precursor, which provides enhanced catalyst fidelity against CO poisoning compared to nickel(0) catalysts.Song-Zhou Cai, Rongrong Yu, Can Li, Hongyu Zhong, Xichang Dong, Bill Morandi, Juntao Ye, Xianjie Fang
2921 related Products with: Nickel-Catalyzed Enantioselective Hydrothiocarbonylation of Cyclopropenes.
1 5 G25 ml1 l100 assays100 ml100 ml50 ml25 ml10 ml5 ml100 ml
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#38014497 2023/11/28
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Synthesis of -substituted phthalimides Pd-catalyzed [4+1] cycloaddition reaction.
A novel Pd-catalyzed assembly of -substituted phthalimides by merging of [4+1] cycloaddition and difluorocarbene transfer carbonylation from 2-iodo--phenylbenzamides and difluorocarbene precursors is disclosed. Difluorocarbene acts as a carbonyl source and simultaneously forms one C-C bond, one C-N bond and one CO bond to produce -substituted phthalimides in high yields.Chengxian Hu, Lu Wang, Yuanyuan Wu, Yonglong Zheng, Ying Fu, Zhengyin Du
2632 related Products with: Synthesis of -substituted phthalimides Pd-catalyzed [4+1] cycloaddition reaction.
25 Rxns Kit20 ml1 kit20000 Units500 Units80 ml100ug10000 Units1 kit112x5 reactions /200 react
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#38014295 2023/11/18
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Cardiac Molecular Analysis Reveals Aging-Associated Metabolic Alterations Promoting Glycosaminoglycans Accumulation Via Hexosamine Biosynthetic Pathway.
Age is a prominent risk factor for cardiometabolic disease, and often leads to heart structural and functional changes. However, precise molecular mechanisms underlying cardiac remodeling and dysfunction resulting from physiological aging per se remain elusive. Understanding these mechanisms requires biological models with optimal translation to humans. Previous research demonstrated that baboons undergo age-related reduction in ejection fraction and increased heart sphericity, mirroring changes observed in humans. The goal of this study was to identify early cardiac molecular alterations that precede functional adaptations, shedding light on the regulation of age-associated changes. We performed unbiased transcriptomics of left ventricle (LV) samples from female baboons aged 7.5-22.1 years (human equivalent ∼30-88 years). Weighted-gene correlation network and pathway enrichment analyses were performed to identify potential age-associated mechanisms in LV, with histological validation. Myocardial modules of transcripts negatively associated with age were primarily enriched for cardiac metabolism, including oxidative phosphorylation, tricarboxylic acid cycle, glycolysis, and fatty-acid β-oxidation. Transcripts positively correlated with age suggest upregulation of glucose uptake, pentose phosphate pathway, and hexosamine biosynthetic pathway (HBP), indicating a metabolic shift towards glucose-dependent anabolic pathways. Upregulation of HBP commonly results in increased glycosaminoglycan precursor synthesis. Transcripts involved in glycosaminoglycan synthesis, modification, and intermediate metabolism were also upregulated in older animals, while glycosaminoglycan degradation transcripts were downregulated with age. These alterations would promote glycosaminoglycan accumulation, which was verified histologically. Upregulation of extracellular matrix (ECM)-induced signaling pathways temporally coincided with glycosaminoglycan accumulation. We found a subsequent upregulation of cardiac hypertrophy-related pathways and an increase in cardiomyocyte width. Overall, our findings revealed a transcriptional shift in metabolism from catabolic to anabolic pathways that leads to ECM glycosaminoglycan accumulation through HBP prior to upregulation of transcripts of cardiac hypertrophy-related pathways. This study illuminates cellular mechanisms that precede development of cardiac hypertrophy, providing novel potential targets to remediate age-related cardiac diseases.Luís F Grilo, Kip D Zimmerman, Sobha Puppala, Jeannie Chan, Hillary F Huber, Ge Li, Avinash Y L Jadhav, Benlian Wang, Cun Li, Geoffrey D Clarke, Thomas C Register, Paulo J Oliveira, Peter W Nathanielsz, Michael Olivier, Susana P Pereira, Laura A Cox
1523 related Products with: Cardiac Molecular Analysis Reveals Aging-Associated Metabolic Alterations Promoting Glycosaminoglycans Accumulation Via Hexosamine Biosynthetic Pathway.
1 kit(96 Wells)5 x 2 ml100ug Lyophilized 1 ea. 1.5x10(6) cells3 modules 6 ml Ready-to-use 2x5L10μg/vial100ug Lyophilized100 ug/vial2 Pieces/Box
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#38014207 2023/11/13
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Tandem Duplications in Pediatric MDS and AML: Implications for Clinical Screening and Diagnosis.
Recent genomic studies in adult and pediatric acute myeloid leukemia (AML) demonstrated recurrent in-frame tandem duplications (TD) in exon 13 of upstream binding transcription factor ( ). These alterations, which account for ~4.3% of AMLs in childhood and up to 3% in adult AMLs under 60, are subtype-defining and associated with poor outcomes. Here, we provide a comprehensive investigation into the clinicopathological features of -TD myeloid neoplasms in childhood, including 89 unique pediatric AML and 6 myelodysplastic syndrome (MDS) cases harboring a tandem duplication in exon 13 of . We demonstrate that TD myeloid tumors are associated with dysplastic features, low bone marrow blast infiltration, and low white blood cell count. Furthermore, using bulk and single-cell analyses, we confirm that -TD is an early and clonal event associated with a distinct transcriptional profile, whereas the acquisition of or mutations is associated with more stem cell-like programs. Lastly, we report rare duplications within exon 9 of that phenocopy exon 13 duplications, expanding the spectrum of alterations in pediatric myeloid tumors. Collectively, we comprehensively characterize pediatric AML and MDS with TD and highlight key clinical and pathologic features that distinguish this new entity from other molecular subtypes of AML.Juan M Barajas, Masayuki Umeda, Lisett Contreras, Mahsa Khanlari, Tamara Westover, Michael P Walsh, Emily Xiong, Chenchen Yang, Brittney Otero, Marc Arribas-Layton, Sherif Abdelhamed, Guangchun Song, Xiaotu Ma, Melvin E Thomas, Jing Ma, Jeffery M Klco