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#32746055   2020/07/07 To Up

Flexible and Expandable Robot for Tissue Therapies - Modeling and Design.

Implantable technologies should be mechanically compliant with the tissue in order to maximize tissue quality and reduce inflammation during tissue reconstruction. We introduce the development of a flexible and expandable implantable robotic (FEIR) device for the regenerative elongation of tubular tissue by applying controlled and precise tension to the target tissue while minimizing the forces produced on the surrounding tissue.
Mohamed Atwya, Can Kavak, Elodie Alisse, YanQiang Liu, Dana Damian

2447 related Products with: Flexible and Expandable Robot for Tissue Therapies - Modeling and Design.

50 ug 200ug10 mg25 mg1000 tests100ug200ul100 mg10 mg10 mg100.00 ul

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#32745741   2020/07/26 To Up

High time-resolved PM composition and sources at an urban site in Yangtze River Delta, China after the implementation of the APPCAP.

In this study, hourly concentrations of PM water-soluble inorganic ions, bulk organic carbon (OC), and elemental carbon (EC) were monitored from 1/1/2017 to 12/31/2017 and validated using filter-based offline analysis at an urban site in Nanjing, China. Compared with 2013 or before, the annual average of PM concentration (36.5 ± 32.9 μg m) in 2017 decreased by more than 40%, NO (12.8 ± 11.4 μg m) became the most abundant water-soluble ion instead of SO (9.29 ± 6.07 μg m), and the relative contribution of OC (5.92 ± 3.40 μg m) and EC (2.95 ± 1.53 μg m) to bulk PM (24.9 ± 9.31%) increased substantially, indicating the effectiveness of the control policy for reducing gaseous precursor emissions. Based on the diurnal variations of water-soluble ions and gaseous pollutants, NH, SO, and NO were secondarily formed and NHNO dominated the composition of ammonium salts in PM. The diurnal changes of OC, EC, and OC/EC ratios reflected prominent influences from local traffic patterns. Positive matrix factorization was performed using hourly data of PM components (PMF), of which the results were justified by comparing to those using 23-h averaged data (PMF). Given that the secondary ion formation was still the dominant source (68.2%) of PM, and the average PM concentration in urban Nanjing remained higher than Tier II limit (35 μg m) of the Chinese National Ambient Air Quality Standard, controlling emissions of PM precursor gases should be continued after the completion of Air Pollution Prevention and Control Action Plan in 2017.
Yiyong Yu, Feng Ding, Yingfeng Mu, Mingjie Xie, Qin'geng Wang

1361 related Products with: High time-resolved PM composition and sources at an urban site in Yangtze River Delta, China after the implementation of the APPCAP.

4 Membranes/Box4 Membranes/Box4 Membranes/Box4 Arrays/Slide4 Arrays/Slide

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#32745423   // To Up

Solid-Liquid Transition of Deformable and Overlapping Active Particles.

Experiments and theory have shown that cell monolayers and epithelial tissues exhibit solid-liquid and glass-liquid transitions. These transitions are biologically relevant to our understanding of embryonic development, wound healing, and cancer. Current models of confluent epithelia have focused on the role of cell shape, with less attention paid to cell extrusion, which is key for maintaining homeostasis in biological tissue. Here, we use a multiphase field model to study the solid-liquid transition in a confluent monolayer of deformable cells. Cell overlap is allowed and provides a way for modeling the precursor for extrusion. When cells overlap rather than deform, we find that the melting transition changes from continuous to first order like, and that there is an intermittent regime close to the transition, where solid and liquid states alternate over time. By studying the dynamics of five- and sevenfold disclinations in the hexagonal lattice formed by the cell centers, we observe that these correlate with spatial fluctuations in the cellular overlap, and that cell extrusion tends to initiate near fivefold disclinations.
Benjamin Loewe, Michael Chiang, Davide Marenduzzo, M Cristina Marchetti

2202 related Products with: Solid-Liquid Transition of Deformable and Overlapping Active Particles.

1000 assays1 mg100 mg50 ug5 ug4 x 25 units20 1 mg5 mg50 ug5 μg

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#32745358   2020/08/03 To Up

Acute Recurrent and Chronic Pancreatitis in Children.

Acute recurrent pancreatitis (ARP) is defined as 2 distinct episodes of acute pancreatitis (AP), while chronic pancreatitis (CP) is caused by persistent inflammation of the pancreas. ARP and CP in children are caused by genetic mutations, autoimmune pancreatitis, congenital pancreatic abnormalities, and other conditions. ARP is frequently a precursor to CP, and both are thought to be on the same disease continuum. In particular, genetic factors are associated with early progression of ARP to CP. The diagnosis of CP, as in AP, is based on clinical findings, biochemical tests, and imaging studies. Findings of exocrine pancreatic dysfunction are also important in the diagnosis of CP. A step-up strategy has become increasingly standard for the treatment of patients with CP. This strategy starts with endoscopic treatment such as pancreatic sphincterotomy and stenting and progresses to surgery should endoscopic therapy fail or prove technically impossible. Non-opioid (e.g. ibuprofen/naproxen) and opioid (e.g. oxycodone) forms of analgesia are widely used in pediatric patients with AP or CP, while pancreatic enzyme replacement therapy may be beneficial for patients with abdominal pain, steatorrhea and malnutrition. Despite the disparity in the age of onset, pediatric CP patients display some similarities to adults in terms of disease progress. To reduce the risk of developing pancreatic exocrine inefficiency, diabetes and pancreatic cancer in the future, clinicians need to be aware of the current diagnostic approach and treatment methods for ARP and CP and refer on to a pediatric gastroenterologist in a timely manner.
Mitsuyoshi Suzuki, Kei Minowa, Hiroyuki Isayama, Toshiaki Shimizu

1426 related Products with: Acute Recurrent and Chronic Pancreatitis in Children.

50 UG8 x 25 ul96T100 μg100ug Lyophilized100 μgProtein100 ul (2 mM)100ug1.00 mg1 Set

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#32745356   2020/08/03 To Up

Mucins in pancreatic cancer: A well-established but promising family for diagnosis, prognosis and therapy.

Mucins are a family of multifunctional glycoproteins that mostly line the surface of epithelial cells in the gastrointestinal tract and exert pivotal roles in gut lubrication and protection. Pancreatic cancer is a lethal disease with poor early diagnosis, limited therapeutic effects, and high numbers of cancer-related deaths. In this review, we introduce the expression profiles of mucins in the normal pancreas, pancreatic precursor neoplasia and pancreatic cancer. Mucins in the pancreas contribute to biological processes such as the protection, lubrication and moisturization of epithelial tissues. They also participate in the carcinogenesis of pancreatic cancer and are used as diagnostic biomarkers and therapeutic targets. Herein, we discuss the important roles of mucins that lead to the lethality of pancreatic adenocarcinoma, particularly MUC1, MUC4, MUC5AC and MUC16 in disease progression, and present a comprehensive analysis of the clinical application of mucins and their promising roles in cancer treatment to gain a better understanding of the role of mucins in pancreatic cancer.
Shunda Wang, Lei You, Menghua Dai, Yupei Zhao

2442 related Products with: Mucins in pancreatic cancer: A well-established but promising family for diagnosis, prognosis and therapy.



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#32745311   2020/08/03 To Up

Accelerated Differentiation of Human Pluripotent Stem Cells into Neural Lineages via an Early Intermediate Ectoderm Population.

Differentiation of human pluripotent stem cells (hPSCs) [1-3] into ectoderm provides neurons and glia useful for research, disease modeling, drug discovery, and potential cell therapies. In current protocols, hPSCs are traditionally differentiated into an obligate rostro-dorsal ectodermal fate expressing PAX6 after 6 to 12 days in vitro when protected from mesendoderm inducers [4] [5-8]. This rate-limiting step has performed a long-standing role in hindering the development of rapid differentiation protocols for ectoderm-derived cell types, as any protocol requires 6 to 10 days in vitro to simply initiate. Here we report efficient differentiation of hPSCs into a naive early ectodermal intermediate within 24 hours using combined inhibition of bone morphogenic protein (BMP) and fibroblast growth factor (FGF) signaling. The induced population responds immediately to morphogen gradients to upregulate rostro-caudal neurodevelopmental landmark gene expression in a generally accelerated fashion. This method can serve as a new platform for the development of novel, rapid, and efficient protocols for the manufacture of hPSC-derived neural lineages. © AlphaMed Press 2020 SIGNIFICANCE STATEMENT: This submission reports a major advance in the ability to direct the differentiation human pluripotent stem cells (hPSCs) into neural precursors in culture. This study describes that inhibiting selected signaling pathways enables the immediate exit from pluripotency and converts the stem cells within 24 hours into precursor cells that can be rapidly directed to generate desired neural populations desirable for research and potential cell therapies. This work removes a historical bottleneck that has prevented improving the control and speed of making neural cells from hPSCs and will likely change the way human neurons are generated in the future.
Patrick Walsh, Vincent Truong, Sushmita Nayak, Marietta Saldías Montivero, Walter C Low, Ann M Parr, James R Dutton

2464 related Products with: Accelerated Differentiation of Human Pluripotent Stem Cells into Neural Lineages via an Early Intermediate Ectoderm Population.

100 ug/vial100 ug/vial0.1ml (1mg/ml)100ug Lyophilized200 200 0.5 ml100 ug/vial100 ug/vial1 x 10^6 cells/vial100 ug/vial1mg

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#32744957   2020/07/30 To Up

Natural Anti-inflammatory compounds as Drug candidates in Alzheimer's disease.

Alzheimer's disease (AD) is a chronic neurodegenerative brain disorder characterized by memory impairment, dementia, oxidative stress in elderly people. Currently, only a few drugs are available in the market with various adverse effects. So to develop new drugs with protective action against the disease, research is turning to the identification of plant products as a remedy. Natural compounds with anti-inflammatory activity could be good candidates for developing effective therapeutic strategies. Phytochemicals including Curcumin, Resveratrol, Quercetin, Huperzine-A, Rosmarinic acid, genistein, obovatol, and Oxyresvertarol were reported molecules for the treatment of AD. Several alkaloids such as galantamine, oridonin, glaucocalyxin B, tetrandrine, berberine, anatabine have been shown anti-inflammatory effects in AD models in vitro as well as in-vivo. In conclusion, natural products from plants represent interesting candidates for the treatment of AD. This review highlights the potential of specific compounds from natural products along with their synthetic derivatives to counteract AD in the CNS.
Reyaz Hassan Mir, Abdul Jalil Shah, Roohi Mohi-Ud-Din, Faheem Hyder Potoo, Mohd Akbar Dar, Sanjay M Jachak, Mubashir Hussain Masoodi

1110 related Products with: Natural Anti-inflammatory compounds as Drug candidates in Alzheimer's disease.

100 assays96 tests100 assays100 assays96 tests100 assays100 assays96 tests100 assays0.1ml (1mg/ml)

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#32744935   // To Up

From Rural Germany, Integrated Care Grows Into A Global Model.

Fifteen years after a precursor to the ACO formed in the Black Forest region, a value-based approach to health care gains traction.
Michele Cohen Marill

2989 related Products with: From Rural Germany, Integrated Care Grows Into A Global Model.

18 kgs48 assays

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#32744748   2020/08/03 To Up

FeIII48-Containing 96-Tungsto-16-Phosphate: Synthesis, Structure, Magnetism and Electrochemistry.

The 48-Fe III -containing 96-tungsto-16-phosphate, [Fe III 48 (OH) 76 (H 2 O) 16 (H P 2 W 12 O 48 ) 8 ] 36- ( Fe 48 ), has been synthesized and structurally characterized. This polyanion comprises eight equivalent {Fe III 6 P 2 W 12 } units which are linked in an end-on fashion forming a macrocyclic assembly that contains more iron centers than any other polyoxometalate (POM) known to date. The novel Fe 48 was synthesized by a simple one-pot reaction of an Fe 22 coordination complex with the hexalacunary {P 2 W 12 } POM precursor in water. The title polyanion was characterized by single-crystal XRD, FT-IR, TGA, magnetic and electrochemical studies.
Joydeb Goura, Bassem S Bassil, Jasleen K Bindra, Iwona A Rutkowska, Pawel J Kulesza, Naresh S Dalal, Ulrich Kortz

1555 related Products with: FeIII48-Containing 96-Tungsto-16-Phosphate: Synthesis, Structure, Magnetism and Electrochemistry.

100 assays50 ml 20 L 500 MG 5 G10 mg 1000 ml 25 mg 100 G0.1 mg1x5 ml10 mg

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#32743967   2020/08/02 To Up

Synthesis of Ultrahigh-Quality Monolayer Molybdenum Disulfide through In Situ Defect Healing with Thiol Molecules.

Monolayer transition metal dichalcogenides are 2D materials with many potential applications. Chemical vapor deposition (CVD) is a promising method to synthesize these materials. However, CVD-grown materials generally have poorer quality than mechanically exfoliated ones and contain more defects due to the difficulties in controlling precursors' distribution and concentration during growth where solid precursors are used. Here, thiol is proposed to be used as a liquid precursor for CVD growth of high quality and uniform 2D MoS . Atomic-resolved structure characterizations indicate that the concentration of sulfur vacancies in the MoS grown from thiol is the lowest among all reported CVD samples. Low temperature spectroscopic characterization further reveals the ultrahigh optical quality of the grown MoS . Density functional theory simulations indicate that thiol molecules could interact with sulfur vacancies in MoS and repair these defects during the growth of MoS , resulting in high-quality MoS . This work provides a facile and controllable method for the growth of high-quality 2D materials with ultralow sulfur vacancies and high optical quality, which will benefit their optoelectronic applications.
Simin Feng, Junyang Tan, Shilong Zhao, Shuqing Zhang, Usman Khan, Lei Tang, Xiaolong Zou, Junhao Lin, Hui-Ming Cheng, Bilu Liu

1718 related Products with: Synthesis of Ultrahigh-Quality Monolayer Molybdenum Disulfide through In Situ Defect Healing with Thiol Molecules.

100 assays10100 μg1 pce100 μg96 wells (1 kit)100 ul (2 mM)100ug Lyophilized1 Set

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