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#32473510   2020/05/23 To Up

Are consumers satisfied with the use of prosthetic sports feet and the provision process? A mixed-methods study.

Special feet connected to a prosthesis, prosthetic sports feet, enable athletes with a lower limb amputation to run. The selection of a prosthetic sports feet is usually based on body weight and preferred sports performance. The selection of a prosthetic sport feet is also based on clinicians who likely have limited experience due to a small number of athletes with a lower limb amputation.
J Poonsiri, S W E van Putten, A T Ausma, J H B Geertzen, P U Dijkstra, R Dekker

2749 related Products with: Are consumers satisfied with the use of prosthetic sports feet and the provision process? A mixed-methods study.

100ul100.00 ul1100 100.00 ul

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#32473437   2020/05/11 To Up

Microbial sulfate reduction facilitates seasonal variation of arsenic concentration in groundwater of Jianghan Plain, Central China.

Bacterial sulfate reduction (BSR) plays a vital but complex role in regulating groundwater arsenic concentration. A quarterly hydro-biogeochemical investigation was conducted to clarify how BSR participated in arsenic dynamics in the geogenic As-contaminated alluvial aquifers of the Jianghan Plain, central Yangtze River Basin. Anthropogenic input of sulfate was identified in the transitional season with higher Cl concentrations and Cl/Br molar ratios compared to the monsoon season. Seasonal increase of S(-II) and Fe(II) concentrations in monsoon season suggests the co-occurrence of iron and sulfate reduction. Quantitative analysis of dsrB gene abundance revealed the corresponding variations between dsrB gene abundance (up to 1.2 × 10 copies L) and Fe(II) in groundwater. High-throughput sequencing of the dsrB gene identified a considerable proportion of sequences in the sulfate-reducing bacterial community was affiliated with Desulfobulbus (22.7 ± 20.8%) and Desulfocapsa (11.5 ± 11.9%). Moreover, the relative abundance of Desulfocapsa increased with the Fe(II) in the groundwater (R = 0.78, P < 0.01). These results suggest that microbially-mediated sulfate reduction facilitated the abiotic reduction of As-bearing Fe-oxides in the monsoon season after anthropogenic input of sulfate in the transitional season under oscillating redox conditions in the groundwater systems. The present research provides new insights into the critical role of BSR in the seasonal redox cycling of iron and variation of As in the aquifer systems, which are not only applicable in the central Yangtze River basin, but also to other similar As-rich alluvial aquifers worldwide.
Tianliang Zheng, Yamin Deng, Yanxin Wang, Hongchen Jiang, Xianjun Xie, Yiqun Gan

1827 related Products with: Microbial sulfate reduction facilitates seasonal variation of arsenic concentration in groundwater of Jianghan Plain, Central China.

100 UG1 mg 5 G10 mg100 μg10100ug100 μg0.1 mg100 μg100

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#32473415   2020/04/19 To Up

Evaluation of the Dual Path Platform (DPP) VetTB assay for the detection of Mycobacterium bovis infection in badgers.

Bovine tuberculosis (bTB), caused by Mycobacterium bovis, represents a major animal health issue. In the United Kingdom and the Republic of Ireland, European badgers (Meles meles) have been shown to act as a reservoir of M. bovis infection, hindering the eradication of bTB in livestock. The availability of suitable diagnostic assays, particularly those that may be applied in a "trap-side" setting, would facilitate the implementation of a wider range of disease control strategies. Here we evaluate the Dual Path Platform (DPP) VetTB assay, a lateral-flow type test for detecting antibodies to M. bovis antigens (MPB83 and ESAT-6/CFP-10). Both serum and whole blood were evaluated as diagnostic samples. Additionally, two methods were evaluated for interpretation of test results (qualitative interpretation by eye and quantitative measurement using an optical reader). The antibody response to MPB83 detected by the DPP VetTB assay increased significantly following experimental M. bovis infection of badgers, whilst the response to ESAT-6/CFP-10 showed no significant change. In sera from TB-free captive and naturally M. bovis infected wild badgers the MPB83 response exhibited a sensitivity of 55 % by eye and quantitative reader (95 % CI: 40-71 and 38-71, respectively), with slightly lower specificity when read by eye (93 % compared to 98 %; 95 % CI: 85-100 and 90-100, respectively). In whole blood, the DPP VetTB assay MPB83 response exhibited a sensitivity of 65 % (95 % CI: 50-80) when interpreted by eye and 53 % (95 % CI: 36-69) using quantitative values, whilst the specificity was 94 % and 98 % respectively (95 % CI: 88-100 and 90-100). Comparison with contemporaneous diagnostic test results from putatively naturally infected and TB-free badgers demonstrated varying levels of agreement. Using sera from naturally M. bovis infected and TB-free badgers, with post mortem confirmation of disease status, the DPP VetTB assay exhibited a sensitivity of 60 % (95 % CI: 41-77) when interpreted using quantitative values (specificity 95 %; 95 % CI: 76-100), and 67 % (95 % CI: 50-84) when read by eye (specificity 95 %; 95 % CI: 86-100). Further work is required to robustly characterize the DPP VetTB assay's performance in a wider selection of samples, and in the practical and epidemiological contexts in which it may be applied.
Roland T Ashford, Paul Anderson, Laura Waring, Dipesh Davé, Freya Smith, Richard J Delahay, Eamonn Gormley, Mark A Chambers, Jason Sawyer, Sandrine Lesellier

1316 related Products with: Evaluation of the Dual Path Platform (DPP) VetTB assay for the detection of Mycobacterium bovis infection in badgers.

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#32473396   2020/05/08 To Up

Psychological and cognitive factors related to prehospital delay in acute coronary syndrome: A systematic review.

In acute coronary syndrome the time elapsed between the start of symptoms and the moment the patient receives treatment is an important determinant of survival and subsequent recovery. However, many patients do not receive treatment as quickly as recommended, mostly due to substantial prehospital delays such as waiting to seek medical attention after symptoms have started.
Mercedes Arrebola-Moreno, Dafina Petrova, Rocio Garcia-Retamero, Ricardo Rivera-López, Laura Jordan-Martínez, Juan Pedro Arrebola, José Antonio Ramírez-Hernández, Andrés Catena

2007 related Products with: Psychological and cognitive factors related to prehospital delay in acute coronary syndrome: A systematic review.

100 μg100 1 mg2 Pieces/Box1 kit2 Pieces/Box1 kit2 Pieces/Box100

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#32473394   2020/04/28 To Up

Time-dependent accumulation of Cd, Co, Cu, Ni, and Zn in natural communities of mayfly and caddisfly larvae: Metal sensitivity, uptake pathways, and mixture toxicity.

Conceptual and quantitative models were developed to assess time-dependent processes in four sequential experimental stream studies that determined abundances of natural communities of mayfly and caddisfly larvae dosed with single metals (Cd, Co, Cu, Ni, Zn) or multiple metals (Cd + Zn, Co + Cu, Cu + Ni, Cu + Zn, Ni + Zn, Cd + Cu + Zn, Co + Cu + Ni, Cu + Ni + Zn). Metal mixtures contained environmentally relevant metal ratios found in mine drainage. Free metal ion concentrations, accumulation of metals by periphyton, and metal uptake by four families of aquatic insect larvae were either measured (Brachycentridae) or predicted (Ephemerellidae, Heptageniidae, Hydropsychidae) using equilibrium and biodynamic models. Toxicity functions, which included metal accumulations by larvae and metal potencies, were linked to abundances of the insect families. Model results indicated that mayflies accumulated more metal than caddisflies and the relative importance of metal uptake by larvae via dissolved or dietary pathways highly depended on metal uptake rate constants for each insect family and concentrations of metals in food and water. For solution compositions in the experimental streams, accumulations of Cd, Cu, and Zn in larvae occurred primarily through dietary uptake, whereas uptake of dissolved metal was more important for Co and Ni accumulations. Cd, Cu, and Ni were major contributors to toxicity in metal mixtures and for metal ratios examined. Our conceptual approach and quantitative results should aid in designing laboratory experiments and field studies that evaluate metal uptake pathways and metal mixture toxicity to aquatic biota.
Laurie S Balistrieri, Christopher A Mebane, Travis S Schmidt

2652 related Products with: Time-dependent accumulation of Cd, Co, Cu, Ni, and Zn in natural communities of mayfly and caddisfly larvae: Metal sensitivity, uptake pathways, and mixture toxicity.

100ug25 mg100ug1000 tests 5 G100ug2.5 mg1 ml2.5 mg10 mg1,000 tests

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#32473334   2020/05/27 To Up

Analyses of chemosensory genes provide insight into the evolution of behavioral differences to phytochemicals in Bactrocera species.

Insect olfactory systems have evolved to recognize phytochemicals and respond to olfactory-triggered cues that vary depending on needs. Several Bactrocera species are attracted explicitly to particular phytochemicals, including methyl eugenol (ME) and cue lure/raspberry ketone (CL/RK). The attraction of Bactrocerans to ME/RK is primarily driven by olfaction. Therefore, the divergent behavioral phenotypes are due to the differences in genes expressed in antennae. High quality transcriptomes were generated with mRNA from dissected antennae, to analyze the differences in olfaction-related genes of three ME-responders B. dorsalis, B. papayae and B. correcta and two RK-responders B. cucurbitae and B. tau. Many distinct quantitative and qualitative differences were identified in their respective chemosensory repertoires. Tissue- and sex-specific expression analyses identified antennae-predominant and sex-biased chemosensory genes. Sequence comparison revealed variations among family members of odorant-binding proteins and odorant-receptors between ME-responders and RK-responders. Differences in composition, expression levels, and sequence of proteins encoded by olfactory-related genes were identified between ME-responders and RK-responders. Some of the differences might contribute to the divergence in response to plant-derived odorants. Taken together, our results provide insights into the evolution of an olfactory system at molecular level in Bactrocera ME- and CL/RK-responding species.
Zhongzhen Wu, Yang Cui, Jun Ma, Mengqiu Qu, Jintian Lin

1026 related Products with: Analyses of chemosensory genes provide insight into the evolution of behavioral differences to phytochemicals in Bactrocera species.

96T 100ul50ul 100ul 100ul500 gm.96T 100ul

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#32473279   2020/05/27 To Up

Diverse styles of running-wheel behavior in antelope ground squirrels.

The running-wheel behavior of white-tailed antelope squirrels was studied in the laboratory by quantitative analysis of wheel revolutions and by visual inspection of video recordings with the assistance of Google Nest's detection algorithm. There was great interindividual diversity of running styles, although no systematic difference was found between male and female squirrels. Some animals ran on the outside of the wheel instead of inside, some ran consistently inside the wheel but alternating directions every few seconds, some ran on a virtual wheel while avoiding the actual wheel and doing back flips in the air instead, and some ran around the cage and occasionally hit the wheel thus generating a stable record of wheel revolutions. On average, the squirrels woke up an hour after lights-on, started activity on the running wheel about 40 minutes later, ran for 10 hours covering a distance of 2 km, and fell asleep about an hour after lights-off. This pattern of running-wheel behavior partially resembles that of laboratory mice, but its extreme diversity is unique to this species.
Roberto Refinetti

1191 related Products with: Diverse styles of running-wheel behavior in antelope ground squirrels.

200ul100ug100 100ug Lyophilized2.5 mg1 Set1 Set1 Set10 ml1 Set

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#32473269   2020/05/27 To Up

Relationship between multiple healthy lifestyles and serum lipids among adults in rural China: A population-based cross-sectional study.

Although several single lifestyles have been reported to meliorate serum lipid levels, there is little evidence of the relationship between multiple healthy lifestyles and lipid levels in Chinese adults. Cross-sectional data of 35,150 participants aged 18-79 years without dyslipidemia at baseline in the Henan Rural Cohort were collected from 2015 to 2017, to investigate the associations between individual and combinations of 6 healthy lifestyle factors and lipid levels. In multivariate linear regression analyses, non-current smoking, non-current alcohol consumption, regular physical exercise, healthy diet, lower body mass index, and lower waist-to-hip ratio were significantly associated with lower concentration of total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) and higher concentrations of high-density lipoprotein cholesterol (HDL-C) (all P < .001). There were positive quantitative correlations between the number of healthy lifestyle factors and the low levels of lipids (all P for linear trend <0.001). People with 6 healthy lifestyle factors had 0.72-mmol/L (95% confidence interval [CI]: 0.64 to 0.81) lower TC, 1.02-mmol/L (95% CI: 0.93 to 1.11) lower TG, 0.54-mmol/L (95% CI: 0.47 to 0.61) lower LDL-C, and 0.32-mmol/L (95% CI: 0.29 to 0.34) higher HDL-C, than people who had 0-1 healthy lifestyle factors. In this study, we found an association between an increased number of healthy lifestyle factors and better serum lipid profiles. The causality and temporality between maintenance of a healthy lifestyle and optimal lipid levels merit further investigations.
Yanting Zhao, Xiaotian Liu, Zhenxing Mao, Jian Hou, Wenqian Huo, Chongjian Wang, Sheng Wei

2318 related Products with: Relationship between multiple healthy lifestyles and serum lipids among adults in rural China: A population-based cross-sectional study.



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#32473213   2020/05/27 To Up

Quantitative Evaluation of the Crystallinity of Indomethacin Using H T Relaxation Behaviors Measured by Time Domain NMR.

We sought to demonstrate the usefulness of the T relaxation behaviors measured by time domain NMR (TD-NMR) for the quantitative evaluation of the crystallinity of an active pharmaceutical ingredient (API). This study used indomethacin as a model API. After blending amorphous and crystalline indomethacin powders at a designated ratio, T relaxation curves were measured by TD-NMR. Subsequently, we acquired a calibration curve to quantify crystallinity by curve fitting analysis. Validation demonstrated a good correlation between the theoretical and experimental percentage of crystallinity. Thus, this study succeeded in a precise estimation of crystallinity of indomethacin using TD-NMR. We also investigated whether the technique is practical by testing indomethacin powders with unknown proportion of crystallinity, and then compared their estimated crystallinity with that found using conventional evaluation techniques. The quantitative performance of the TD-NMR technique was comparable to that of Raman spectroscopy. Furthermore, indomethacin powder blended with excipients, which can be used to produce tablets, was tested. The TD-NMR technique was still able to quantify the crystallinity of indomethacin, even when excipients were incorporated into the sample. Therefore, the present study expands the horizon for evaluating the crystallinity of APIs in pharmaceutical sciences.
Kotaro Okada, Yoshihiro Hayashi, Shungo Kumada, Yoshinori Onuki

1811 related Products with: Quantitative Evaluation of the Crystallinity of Indomethacin Using H T Relaxation Behaviors Measured by Time Domain NMR.

1 kit216 Arrays/Slide251 kit25 100ul0.1ml (1mg/ml) 100ul1 mg16 Arrays/Slide

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#32473186   2020/05/27 To Up

The effects of GAMotion (a giant exercising board game) on physical capacity, motivation and quality of life among nursing home residents: A pilot interventional study.

In 2017, our team highlighted promising results of a giant exercising board game on physical activity level and a broader array of physical and psychological outcomes among nursing home residents. However, some improvements of this game were needed to make it more suitable for nursing homes and more challenging in terms of exercises. Therefore, we decided to develop a new version of a giant exercising board game: the GAMotion.
Fanny Buckinx, Olivier Bruyère, Laetitia Lengelé, Jean-Yves Reginster, Quentin Marchal, Paulin Hurtrez, Alexandre Mouton

2907 related Products with: The effects of GAMotion (a giant exercising board game) on physical capacity, motivation and quality of life among nursing home residents: A pilot interventional study.

100.00 ul96 wells (1 kit)100ug Lyophilized50 ug 1 g0.1 mg100tests100ug

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