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#32942230   2020/09/03 To Up

Assessment of a long-term in vitro model to characterize the mechanical behavior and macrophage-mediated degradation of a novel, degradable, electrospun poly-urethane vascular graft.

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Marjan Enayati, Sarah Puchhammer, Jagoba Iturri, Christian Grasl, Christoph Kaun, Stefan Baudis, Ingrid Walter, Heinrich Schima, Robert Liska, Johann Wojta, José Luis Toca-Herrera, Bruno K Podesser, Helga Bergmeister

1747 related Products with: Assessment of a long-term in vitro model to characterize the mechanical behavior and macrophage-mediated degradation of a novel, degradable, electrospun poly-urethane vascular graft.

2 Pieces/Box4 Membranes/Box 0.1 mg 4 Arrays/Slide100 μg4 Arrays/Slide100 μg100 μg

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#32942173   2020/08/29 To Up

Mitochondrial Protrusions in Neuronal Cells.

Mitochondrial function relies on multiple quality control mechanisms, including the release of mitochondrial vesicles. To investigate the ultrastructure and prevalence of mitochondrial membranous protrusions (and, by extension, vesicles) in neurons, we surveyed mitochondria in rat and planarian brains using transmission electron microscopy (EM). We observed that mitochondrial protrusions mostly extend from the outer membrane. Leveraging available 3D EM datasets of the brain, we further analyzed mitochondrial protrusions in neurons of mouse and Drosophila brains, identifying high-resolution spatial views of these protrusions. To assess whether the abundance of mitochondrial protrusions and mitochondria-derived vesicles respond to cellular stress, we examined neurons expressing fluorescently tagged mitochondrial markers using confocal microscopy with Airyscan and found increased numbers of mitochondrial protrusions and vesicles with mild stress. Future studies using improved spatial resolution with added temporal information may further define the functional implications of mitochondrial protrusions and vesicles in neurons.
Pamela J Yao, Erden Eren, Ronald S Petralia, Jeffrey W Gu, Ya-Xian Wang, Dimitrios Kapogiannis

1156 related Products with: Mitochondrial Protrusions in Neuronal Cells.

1 mg96 tests10 ug1.00 flask1x10e7 cells96 tests1.00 flask1x10e7 cells10 rxns96 wells

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#32942156   2020/09/14 To Up

The analgesic effects of pioglitazone in the bone cancer pain rats via regulating the PPARγ/PTEN/mTOR signaling pathway in the spinal dorsal horn.

Bone cancer pain (BCP) remains a difficult clinical problem. This study examined whether pioglitazone, a peroxisome proliferator-activated receptor gamma (PPARγ) agonist, is effective for attenuating BCP, and investigated the interaction between activation of PPARγ and phosphatase and tensin homolog deleted from chromosome 10 (PTEN) / mammalian target of rapamycin (mTOR) signal in the spinal dorsal horn (SDH) of BCP rats.
Wei Gu, Yu'e Sun, Wanjie Gu, Yulin Huang, Jinhua Bo, Luyang Zhou, Zhengliang Ma, Xiaoping Gu, Wei Zhang

2863 related Products with: The analgesic effects of pioglitazone in the bone cancer pain rats via regulating the PPARγ/PTEN/mTOR signaling pathway in the spinal dorsal horn.

111 inhibitors1

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#32942150   2020/09/14 To Up

Pharmacokinetic-Pharmacodynamic Modeling of the Antioxidant Activity of Quzhou Fructus Aurantii Decoction in a Rat Model of Hyperlipidemia.

Quzhou Fructus Aurantii (QFA) is an herb that is commonly used to alleviate inflammation in individuals dealing with obesity.To date, however, no systematic pharmacokinetic (PK) or pharmacodynamic (PD) analyses of the clinical efficacy of QFA under hyperlipemia-associated oxidative stress conditions have been conducted. The present study, was therefore designed to construct a PK-PD model for this herb, with the goal of linking QFA PK profiles to key therapeutic outlines to guide the therapeutic use of this herb in clinical settings.
Yuqi Ying, Haoyu Wan, Xixi Zhao, Li Yu, Yu He, Weifeng Jin

1245 related Products with: Pharmacokinetic-Pharmacodynamic Modeling of the Antioxidant Activity of Quzhou Fructus Aurantii Decoction in a Rat Model of Hyperlipidemia.

5 G96 assays 100 UG196T48 assays 900 tests

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#32942130   2020/08/07 To Up

Effect of Lactobacillus plantarum HT121 on serum lipid profile, gut microbiota, and liver transcriptome and metabolomics in a high-cholesterol diet-induced hypercholesterolemia rat model.

The aim of this study was to evaluate effect of Lactobacillus plantarum HT121 on serum lipid profile, gut microbiota, and liver transcriptome and metabolomics.
Xianping Li, Yuchun Xiao, Liqiong Song, Yuanming Huang, Qiongfang Chu, Siyi Zhu, Shan Lu, Luwen Hou, Zhen Li, Jianguo Li, Jianguo Xu, Zhihong Ren

1726 related Products with: Effect of Lactobacillus plantarum HT121 on serum lipid profile, gut microbiota, and liver transcriptome and metabolomics in a high-cholesterol diet-induced hypercholesterolemia rat model.

96T1,000 tests0.1 mg10 mg100ul100 mg100.00 ul

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#32942121   2020/09/14 To Up

Modulating endothelial adhesion and migration impacts stem cell therapies efficacy.

Limited knowledge of stem cell therapies` mechanisms of action hampers their sustainable implementation into the clinic. Specifically, the interactions of transplanted stem cells with the host vasculature and its implications for their therapeutic efficacy are not elucidated. We tested whether adhesion receptors and chemokine receptors on stem cells can be functionally modulated, and consequently if such modulation may substantially affect therapeutically relevant stem cell interactions with the host endothelium.
Richard Schäfer, Matthias Schwab, Georg Siegel, Andreas von Ameln-Mayerhofer, Marine Buadze, Ali Lourhmati, Hans-Peter Wendel, Torsten Kluba, Marcel A Krueger, Carsten Calaminus, Eva Scheer, Massimo Dominici, Giulia Grisendi, Thorsten R Doeppner, Jana Schlechter, Anne Kathrin Finzel, Dominic Gross, Roland Klaffschenkel, Frank K Gehring, Gabriele Spohn, Anja Kretschmer, Karen Bieback, Eva-Maria Krämer-Albers, Kerstin Barth, Anne Eckert, Stefanie Elser, Joerg Schmehl, Claus D Claussen, Erhard Seifried, Dirk M Hermann, Hinnak Northoff, Lusine Danielyan

1464 related Products with: Modulating endothelial adhesion and migration impacts stem cell therapies efficacy.

1.00 flask1.00 flask0.5 ml1.00 flask1.00 flask 6 ml Ready-to-use 61.00 flask1.00 flask1.00 flask1.00 flask8 Modulators

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#32942106   2020/09/09 To Up

Heart-cutting two-dimensional liquid chromatography coupled to quadrupole-orbitrap high resolution mass spectrometry for determination of N,N-dimethyltryptamine in rat plasma and brain; Method development and application.

The orthogonal heart-cutting liquid chromatography (LC) modes coupled to high-resolution tandem mass spectrometry (HRMS/MS) provide a number of possibilities to enhance selectivity and sensitivity for the determination of targeted compounds in complex biological matricies. Here we report the development of a new fast 2D-LC-(HRMS/MS) method and its successful application for quantitative determination of the level of plasma and brain N,N-dimethyltriptamine (DMT) using α-methyltryptamine (AMT) as internal standard in an experimental model of cerebral ischemia/reperfusion using DMT administration. The 2D-LC separation was carried out by a combination of hydrophilic interaction liquid chromatography (HILIC) in the first dimension followed by second-dimensional reversed-phase (RP) chromatography within a total run time of 10 min. The enrichment of HILIC effluent of interest containing DMT was performed using a C18 trapping column. During method development several parameters of sample preparation procedures, chromatographic separation and mass spectrometric detection were optimised to achieve high DMT recovery (plasma: 90 %, brain: 88 %) and sensitivity (plasma: 0.108 ng/mL of LOD, brain: 0.212 ng/g of LOD) applying targeted analytical method with strict LC and HRMSMS confirmatory criteria. Concerning rat plasma sample, the concentration of DMT before hypoxia (49.3-114.3 ng/mL plasma) was generally higher than that after hypoxia (10.6-96.1 ng/mL plasma). After treatment, the concentration of DMT in brain was elevated up to the range of 2-6.1 ng/g. Overall, our analytical approach is suitable to detect and confirm the presence of DMT administered to experimental animals with therapeutic purpose in a reliable manner.
Tímea Körmöczi, Írisz Szabó, Eszter Farkas, Botond Penke, Tamás Janáky, István Ilisz, Róbert Berkecz

1603 related Products with: Heart-cutting two-dimensional liquid chromatography coupled to quadrupole-orbitrap high resolution mass spectrometry for determination of N,N-dimethyltryptamine in rat plasma and brain; Method development and application.

400Tests 100 UG100Tests0.1ml (1mg/ml)96T100ug1000 TESTS/0.65ml 25 MG4 Arrays/Slide2 Pieces/Box

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#32942017   2020/09/14 To Up

Therapeutic potential of cPLA2 inhibitor to counteract dilated-cardiomyopathy in cholesterol-treated H9C2 cardiomyocyte and MUNO rat.

The pathogenesis of cardiomyopathy in metabolically unhealthy obesity (MUO) has been well studied. However, the pathogenesis of cardiomyopathy typically associated with high cholesterol levels in metabolically unhealthy nonobesity (MUNO) remains unclear. We investigated whether cholesterol-generated LysoPCs contribute to cardiomyopathy and the role of cytosolic phospholipase A2 (cPLA2) inhibitor in cholesterol-induced MUNO.
Jiung-Pang Huang, Mei-Ling Cheng, Chao-Hung Wang, Shiang-Suo Huang, Po-Shiuan Hsieh, Chih-Chun Chang, Chao-Yu Kuo, Kuan-Hsing Chen, Li-Man Hung

2943 related Products with: Therapeutic potential of cPLA2 inhibitor to counteract dilated-cardiomyopathy in cholesterol-treated H9C2 cardiomyocyte and MUNO rat.

100 25 mg20 10mg100 assays100 10mg100

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#32942016   2020/09/14 To Up

GLP-1 improves adipose tissue glyoxalase activity and capillarization improving insulin sensitivity in type 2 diabetes.

Methylglyoxal was shown to impair adipose tissue capillarization and insulin sensitivity in obese models. We hypothesized that glyoxalase-1 (GLO-1) activity could be diminished in the adipose tissue of type 2 diabetic obese patients. Moreover, we assessed whether such activity could be increased by GLP-1-based therapies in order to improve adipose tissue capillarization and insulin sensitivity. GLO-1 activity was assessed in visceral adipose tissue of a cohort of obese patients. The role of GLP-1 in modulating GLO-1 was assessed in type 2 diabetic GK rats submitted to sleeve gastrectomy or Liraglutide treatment, in the adipose tissue angiogenesis assay and in the HUVEC cell line. Glyoxalase-1 activity was decreased in visceral adipose tissue of pre-diabetic and diabetic obese patients, together with other markers of adipose tissue dysfunction and correlated with increased HbA1c levels. Decreased adipose tissue GLO-1 levels in GK rats were increased by sleeve gastrectomy and Liraglutide, being associated with overexpression of angiogenic and vasoactive factors, as well as insulin receptor phosphorylation (Tyr1161). Moreover, GLP-1 increased adipose tissue capillarization and HUVEC proliferation in a glyoxalase-dependent manner. Lower adipose tissue GLO-1 activity was observed in dysmetabolic patients, being a target for GLP-1 in improving adipose tissue capillarization and insulin sensitivity.
Tiago Rodrigues, Patrícia Borges, Laura Mar, Daniela Marques, Miguel Albano, Hans Eickhoff, Catarina Carrêlo, Bruno Almeida, Salomé Pires, Margarida Abrantes, Beatriz Martins, Cristina Uriarte, Filomena Botelho, Pedro Gomes, Sónia Silva, Raquel Seiça, Paulo Matafome

1443 related Products with: GLP-1 improves adipose tissue glyoxalase activity and capillarization improving insulin sensitivity in type 2 diabetes.

5 96 wells (1 kit)100ug Lyophilized100ug250ul10mg100ug100ug Lyophilized100ug100ug Lyophilized100ug

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