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#33098686   2020/10/24 To Up

Neuromodulatory effect of curcumin on catecholamine systems and inflammatory cytokines in ovariectomized female rats.

Anti-inflammatory products may represent the future for depressive disorder therapies. Curcumin (CUR) is a polyphenol and an active component of the turmericplant Curcuma longa. The aim of this study was to investigate the impact of CUR,as a natural anti-inflammatory agent, on neuro-inflammation related to depression and compare it with the effects of fluoxetine (FLX) and estradiol (E ) in ovariectomized (OVX) rats.The experimental animals were divided into the following five treatment groups (n=10): sham-operated, OVX, OVX-E (100 μg/kg, i.m., every other day), OVX-FLX (20 mg/kg, i.p., daily), and OVX-CUR (100 mg/kg, p.o., daily). The results indicated that CUR improved the animals' performances in theopen field test and modulated dopamine (DA) and norepinephrine levels in several brain regions compared with the OVX group. CUR resulted in the down-regulation of monoamine oxidase b and up-regulation of tyrosine hydroxylase, as well asDA receptor mRNA in the limbic region. In addition, CURsignificantly attenuated the production of serum corticosterone hormone, tumor necrosis factor-alpha, interleukin-β1, interleukin-6, and nitric oxide in the limbic system. Furthermore, CUR normalized malondialdehyde levels and led to a significant upsurge in total antioxidant capacity, compared with the OVX group. Consequently, CUR, besides being harmless, was efficient against inflammation and oxidative-nitrosative stress, showing a greater effect on DA receptor expression than FLX and E in OVX rats.
Nashwa M Saied, Gehan S Georgy, Rokaya M Hussien, Wafaa A Hassan

2547 related Products with: Neuromodulatory effect of curcumin on catecholamine systems and inflammatory cytokines in ovariectomized female rats.

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#33098531   2020/10/24 To Up

Anthropogenic contaminants in freshwater from the northern Antarctic Peninsula region.

This study aimed to evaluate the presence of ultraviolet filters (UV-Fs), benzotriazoles, pyrethroids and per- and polyfluoroalkyl substances (PFASs) in freshwater and wastewater from the northern Antarctic Peninsula region. All water samples analyzed contained UV-Fs residues and high concentrations were detected in anthropogenic impacted sites (< LOD up to 1300 ng/L). Likewise, benzotriazoles were detected in all water samples (< LOQ-920 ng/L). Regarding suspended particulate matter, almost all UV-Fs and all benzotriazoles were measured at concentrations ranging from < LOQ to 33 µg/g dry weight. Pyrethroids were also detected (< LOQ-250 ng/L) and their presence implies the existence of a gateway to the Antarctica Peninsula from other regions. The data confirmed the presence of PFASs (< LOD-7500 ng/L) in this area, in agreement with previous studies. In light of these results, extended monitoring in Antarctica should be carried out to perform a reliable environmental risk assessment leading to propose recommendations to minimize the anthropic impact.
Noelia Domínguez-Morueco, Luis Moreno-Merino, Daniel Molins-Delgado, M Silvia Díaz-Cruz, Òscar Aznar-Alemany, Ethel Eljarrat, Marinella Farré, Jerónimo López-Martínez, Miren López de Alda, Adrián Silva, Juan José Durán Valsero, Yolanda Valcárcel

2901 related Products with: Anthropogenic contaminants in freshwater from the northern Antarctic Peninsula region.

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#33098516   2020/10/24 To Up

Vasoactive Intestinal Peptide Changes the Frequency and Force of Myocardial Contraction in Rats.

We studied the effect of non-selective agonist of VIP receptors of vasoactive intestinal polypeptide in different concentrations on the frequency, force, and duration of isometric contraction of myocardial strips of the right atrium under conditions of spontaneous activity, as well as the force and duration of contractions of the right ventricle in rats. It was found that the agonist produced a positive inotropic and chronotropic effect that depended on its concentration. The maximum effect was observed at vasoactive intestinal peptide concentration of 10 M.
A А Zverev, N V Leonov, Т А Аnikina, Т L Zefirov

2935 related Products with: Vasoactive Intestinal Peptide Changes the Frequency and Force of Myocardial Contraction in Rats.

20 96 assays100ug Lyophilized50 100ug200 100ug1 mg250 TESTS96tests50

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#33098505   2020/10/24 To Up

Activity of Antioxidant Enzymes in the Regional Blood Flow during Pelvic Venous Disorders in Women.

Activity of some antioxidant enzymes (superoxide dismutase, catalase, and glutathionedependent enzymes), as well as the level of LPO products in the region regional blood flow (collateral branches of the main trunks of ovarian veins) in women with pelvic venous disorders were studied. A compensatory increase in activity of superoxide dismutase, catalase, and glutathione peroxidase during stage I of the disease was found; during stage II, superoxide dismutase activity decreased and glutathione peroxidase increased, while during stage III, pronounced decrease in activities of all studied enzymes was observed. The level of lipid peroxidation products in the regional blood flow increased as the disease progressed, with maximum values in the third stage.
M A Darenskaya, A A Semendyaev, D A Stupin, L A Grebenkina, I N Danusevich, L I Kolesnikova, S I Kolesnikov

1181 related Products with: Activity of Antioxidant Enzymes in the Regional Blood Flow during Pelvic Venous Disorders in Women.

100ug Lyophilized100ug Lyophilized48 assays 1 kit1100ug Lyophilized

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