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#35045589   2022/01/19 To Up

Characterization of sleep-related neurochemicals in the different developmental stages and insomnia models of Drosophila melanogaster.

Neurotransmitters play an important role in regulating the physiological activity of the animal, especially in emotion and sleep. While nucleotides are involved in almost all cellular processes. However, the characteristics of sleep-related neurochemicals under different life cycles and environment remain poorly understood. A rapid and sensitive analytical method was established with LC-MS/MS to determine eight endogenous neurochemicals in Drosophila melanogaster and the levels of neurochemicals in the different developmental stages of Drosophila melanogaster were evaluated. The results indicated that there were significant discrepancies among different stages, especially from pupal stage to adult. The levels of these compounds in caffeine-induced insomnia model of Drosophila melanogaster were investigated. Compared with normal group the eight endogenous metabolites did not fluctuate significantly in insomnia Drosophila melanogaster, which may be due to the mechanism of caffeine-induced insomnia through other pathways, such as adenosine. The results provide a reference for decoding of neurochemicals involved in the development of the full cycle of mammalian life and exploration of insomnia even other mental diseases induced by exogenous substances in the future.
Yu Sun, Runhua Liu, Yuelin Bi, Xin Feng, Jiaqi Wang, Tianyi Li, Hao Wu, Chenning Zhang, Yikun Sun

1523 related Products with: Characterization of sleep-related neurochemicals in the different developmental stages and insomnia models of Drosophila melanogaster.

10 ug2 Pieces/Box12 Pieces/Box1 mg

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#35045586   2022/01/19 To Up

Identification of ginsenoside metabolites in plasma related to different bioactivities of Panax notoginseng and Panax Ginseng.

Although the chemical components of Panax notoginseng (PN) and Panax ginseng (PG) are similar, the bioactivities of them are different. In this study, the differential bioactivities of PN and PG were used as the research object. First, the different metabolites in the plasma after oral administration of PN and PG were analyzed by a UPLC-Q/TOF-MS-based metabolomics approach. Afterward, the metabolite-target- pathway network of PN and PG was constructed, thus the pathways related to different bioactivities were analyzed. As the results, 7 different metabolites were identified in PN group, and 10 different metabolites were identified in the PG group. In the PN group, the metabolite of N1 was related to hemostasis, N1 and N3 were related to inhibiting the nerve center, antihypertensive, and abirritation. The metabolites of N1, N3, N4, N5, and N6 were related to protecting the liver. The results showed that the metabolites of G1, G2, G3, G5, and G6 in PG group were related to anti-heart failure, and G1, G2, G6, and G9 were related to raising blood pressure. There were 13 signaling pathways related to different biological activities of PN (eight pathways) and PG (five pathways). These pathways further clarified the mechanism of action that caused the different bioactivities between PN and PG. In summary, metabolomics combined with network pharmacology could be helpful to clarify the material basis of different bioactivities between PN and PG, promoting the research on PN and PG.
Qinghai Dong, Yang An, Guangguang Du, Jia Wang, Jiayin Liu, Jun Su, Hongliu Xie, Chongyang Liang, Jihua Liu

1191 related Products with: Identification of ginsenoside metabolites in plasma related to different bioactivities of Panax notoginseng and Panax Ginseng.

2 Pieces/Box100.05 mg96T

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#35045574   2022/01/19 To Up

Safety-related outcomes of novel mRNA COVID-19 vaccines in pregnancy.

To describe the safety profile and demographic data for a cohort of pregnant individuals who received an mRNA COVID-19 vaccine.
Angela Nakahara, Joseph Biggio, Ardem Elmayan, Frank B Williams

1470 related Products with: Safety-related outcomes of novel mRNA COVID-19 vaccines in pregnancy.

2 Pieces/Box2 Pieces/Box2 Pieces/Box5 mg2 Pieces/Box2 Pieces/Box100 μg100ug Lyophilized100 μg1 Set

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#35045566   2022/01/14 To Up

Effectiveness of COVID-19 booster vaccines against covid-19 related symptoms, hospitalisation and death in England.

Booster vaccination with mRNA vaccines have been offered to adults in England starting on 14 September 2021. We used a test-negative case-control design to estimate the relative effectiveness of a booster dose of BNT162b2 (Pfizer-BioNTech) compared to only a 2-dose primary course (at least 175 days after the second dose) as well as compared to unvaccinated individuals from 13 September 2021 to 5 December 2021, when Delta variant was dominant in circulation. Outcomes were symptomatic COVID-19 and hospitalisation. The relative effectiveness against symptomatic disease 14-34 days after a BNT162b2 or mRNA-1273 (Moderna) booster after a ChAdOx1-S (Astrazeneca) and BNT162b2 as a primary course ranged from around 85 to 95%. Absolute VE ranged from 94-97% and was similar in all age groups. Limited waning was seen 10+ weeks after the booster. Against hospitalisation or death absolute effectiveness of a BNT162b2 booster ranged from around 97% to 99% in all age groups irrespective of the primary course with no evidence of waning up to 10 weeks. This study provides real world evidence of significant increased protection from the booster vaccine dose against mild and severe disease irrespective of the primary course.
Nick Andrews, Julia Stowe, Freja Kirsebom, Samuel Toffa, Ruchira Sachdeva, Charlotte Gower, Mary Ramsay, Jamie Lopez Bernal

2390 related Products with: Effectiveness of COVID-19 booster vaccines against covid-19 related symptoms, hospitalisation and death in England.

5 mg25 mg100ug Lyophilized 1 G1 g 100 UG100 MG 25 G 100 G1 g 25 G 1 G

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#35045563   2022/01/18 To Up

Comparison of Logarithmic Reading Charts for Visual Assessment in Normally Sighted Participants.

Logarithmic reading charts provide standardised measures of reading performance. Here we show that existing charts provide equivalent assessments of visual aspects of reading that are in good agreement with traditional measures of visual acuity and appear uninfluenced by cognitive (linguistic) factors.
Yahya A Maeni, Kevin B Paterson, John Maltby, Victoria A McGowan, Claire V Hutchinson

1506 related Products with: Comparison of Logarithmic Reading Charts for Visual Assessment in Normally Sighted Participants.

5 G500 MG 100 G250 mg 1 G 1 G5096 wells (1 kit)100

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#35045560   2022/01/18 To Up

How Broad Should Gram-Negative Coverage be for Febrile Parenteral Nutrition Dependent Short Bowel Syndrome Patients?

Broader spectrum gram-negative antibiotics are commonly utilized empirically for central line-associated bloodstream infections (CLABSI) in febrile short bowel syndrome (SBS) patients receiving home parenteral nutrition compared to those used empirically for inpatient-acquired CLABSI. This analysis reports 57 CLABSI in 22 patients with SBS admitted from the community and 78 inpatient-acquired CLABSI in 76 patients over a 5-year period. Proportional gram-negative CLABSI was similar between the SBS and inpatient-acquired cohorts (43.8% versus 42.3%, respectively, p = 0.78). 1.8% and 10.3% (p = 0.125) of gram-negative CLABSI were non-susceptible to ceftriaxone and 0% and 3.8% (p = 0.52) were non-susceptible to ceftazidime in the SBS and inpatient-acquired cohorts, respectively. In the SBS cohort, home ethanol lock therapy and prior culture results impacted gram-negative pathogen distribution. Broader empiric gram-negative coverage for CLABSI among SBS patients compared to inpatients is unnecessary. Third-generation cephalosporins represent appropriate empiric gram-negative agents for febrile SBS patients presenting from the community to our institution.
Jeremy S Stultz, James H Fly, Bindiya Bagga, Sandra R Arnold, Anushree Algotar, Kelley R Lee

2516 related Products with: How Broad Should Gram-Negative Coverage be for Febrile Parenteral Nutrition Dependent Short Bowel Syndrome Patients?

10 mg250 mg1 mL10 mg250 mg250 mg1 mg 100ul25 μg1 mg0.25 ml 100ul

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#35045557   2022/01/18 To Up

Trends and Disparities in Pediatric Nonalcoholic Fatty Liver Disease-Associated Hospitalizations in the United States.

Non-alcoholic fatty liver disease (NAFLD) represents a spectrum of disease characterized by accumulation of fat in the liver and is associated with co-morbidities linked to metabolic syndrome. The prevalence of NAFLD in children has increased in the U.S. over time and with marked racial differences observed in geographically limited studies. This study aims to provide a current, nation-wide analysis of temporal trends of pediatric NAFLD-related hospitalizations and associated co-morbidities as well as assess for racial/ethnic disparities.
Eric Dybbro, Deepa Dongarwar, Hamisu M Salihu, Faith D Ihekweazu

2925 related Products with: Trends and Disparities in Pediatric Nonalcoholic Fatty Liver Disease-Associated Hospitalizations in the United States.

900 tests 50 UG

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#35045553   2022/01/17 To Up

Predicting pathological response and overall survival in locally advanced gastric cancer patients undergoing neoadjuvant chemotherapy: the role of PET/computed tomography.

Gastric cancer is the second leading cause of cancer-related deaths, with a 5-year survival rate of about 20-25%. The ability to predict pathological response (PR) to neoadjuvant chemotherapy (NACT); hence, overall survival (OS) probability of patients can allow the clinician to individualize treatment strategies. We investigated the role of F-18 fluorodeoxyglucose PET-computed tomography (F-18 FDG PET/CT) in predicting histopathologic response and prognosis in locally advanced gastric cancer (LAGC) patients undergoing NACT.
Zeynep Gülsüm Güç, Bülent Turgut, Arzu Avci, Fevzi Cengiz, Mehmet Eren Kalender, Ahmet Alacacioğlu

1236 related Products with: Predicting pathological response and overall survival in locally advanced gastric cancer patients undergoing neoadjuvant chemotherapy: the role of PET/computed tomography.

100 UG

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