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Prescribing DNA Origami Patterns via Scaffold Decoration.DNA origami has rapidly emerged as a powerful technique to fabricate user-defined DNA nanostructures. However, the ability to custom-make patterns on DNA origami template is hampered by the heavy workload and high cost of changing staple DNA (up to several hundred strands per set). Here, a scaffold-decorated DNA origami method is developed by prescribing the pattern information to the scaffold DNA. For each pixel of an origami, a designed "pixel strand" (P-strand) is hybridized to the scaffold, strongly preoccupying a specific position and competing with invading staples in a mild origami assembly. To fabricate a new origami pattern, the P-strand set needs to be replaced with a universal staple set. The yield of thus-fabricated DNA origami patterns is comparable to a conventional DNA origami with canonical method. One-pot fabrication of three different nanopatterns in a single test-tube is further demonstrated. Also, dynamic switch of the pattern is shown. This method provides a generic approach and offers large flexibility for scaling up the nanofabrication with DNA origami by kinetically modulating the reaction pathway of the staples with the scaffold DNA, which represents a novel route in the self-assembly of complex biomolecular systems.
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Gas-phase action and fluorescence spectroscopy of mass-selected fluorescein monoanions and two derivatives.Gaseous fluorescein monoanions are weakly fluorescent; they display a broad fluorescence spectrum and a large Stokes shift. This contrasts with the situation in aqueous solution. One explanation of the intriguing behavior in vacuo is based on internal proton transfer from the pendant carboxyphenyl group to one of the xanthene oxygens in the excited state; another that rotation of the carboxyphenyl group relative to the xanthene leads to a partial charge transfer from one chromophore (xanthene) to the other (carboxyphenyl) when the π orbitals start to overlap. To shed light on the mechanism at play, we synthesized two fluorescein derivatives where the carboxylic acid group is replaced with either an ester or a tertiary amide functionality and explored their gas-phase ion fluorescence using the home-built LUminescence iNstrument in Aarhus (LUNA) setup. Results on the fluorescein methyl ester that has no acidic proton clearly disprove the former explanation: The spectrum remains broad, and the band center (at 605 nm) is shifted even more to the red than that of fluorescein (590 nm). Experiments on the other variant that contains a piperidino amide are also in favor of the second explanation as here the piperidino already causes the dihedral angle between the planes defining the xanthene and the benzene ring to be less than 90° in the ground state (i.e., 63°), according to density functional theory calculations. As a result of the closer similarity between the ground-state and excited-state structures, the fluorescence spectrum is narrower than those of the other two ions, and the band maximum is further to the blue (575 nm). In accordance with a more delocalized ground state of the amide derivative, action spectra associated with photoinduced dissociation recorded at another setup show that the absorption-band maximum for the amide derivative is redshifted compared to that of fluorescein (538 nm vs. 525 nm).
2249 related Products with: Gas-phase action and fluorescence spectroscopy of mass-selected fluorescein monoanions and two derivatives.Androgen Receptor Androgen Receptor Ab-1 An Andrographolide C20H30O5 Androgen Receptor (Phosph rac Androst-16-en-2,2,5,6 3-O-Acetyl 5,14-Androstad Rabbit Anti-Human Androge CAR,CAR,Constitutive acti Androgen Receptor (Phosph ∆2-Androstene-1α,17β- Androstenedione 19 Androgen Receptor Antibod
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Improved Thermoelectric Performance through Double Substitution in Shandite-Type Mixed-Metal Sulfides.Substitution of tin by indium in shandite-type phases, ASnS with mixed Co/Fe occupancy of the A-sites is used to tune the Fermi level within a region of the density of states in which there are sharp, narrow bands of predominantly metal d-character. Materials of general formula Co Fe SnIn S ( = 0, 0.167; 0.0 ≤ ≤ 0.7) have been prepared by solid-state reaction and the products characterized by powder X-ray diffraction. Electrical-transport property data reveal that the progressive depopulation of the upper conduction band as tin is replaced by indium increases the electrical resistivity, and the weakly temperature-dependent ρ() becomes more semiconducting in character. Concomitant changes in the negative Seebeck coefficient, the temperature dependence of which becomes increasingly linear, suggests the more highly substituted materials are n-type degenerate semiconductors. The power factors of the substituted phases, while increased, exhibit a weak temperature dependence. The observed reductions in thermal conductivity are principally due to reductions in the charge-carrier contribution on hole doping. A maximum figure-of-merit of () = 0.29 is obtained for the composition CoFeSnInS at 573 K: among the highest values for an n-type sulfide at this temperature.
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Gallbladder necrosis and small bowel ischaemia following fenestrated endovascular aneurysm repair for juxtarenal abdominal aortic aneurysm: a case report.Anatomical variation may result in unexpected complications after fenestrated endovascular aneurysm repair (FEVAR). We report a 78-year-old gentleman who was admitted for elective FEVAR procedure for a juxtarenal abdominal aortic aneurysm. Three days post-operatively, he deteriorated clinically. Computed tomography (CT) angiogram showed small bowel ischaemia and a replaced right hepatic artery originating from superior mesenteric artery. A necrotic gallbladder found during laparotomy required cholecystectomy following small bowel resection that required a relook for anastomosis and drainage of bile collection. He had prolonged ICU stay requiring treatment for multiple organ dysfunction then spent 4 weeks in hospital. Following multidisciplinary team approach in management of his complications during post-operative phase, he recovered well enough for rehabilitation and discharge home. Surveillance CT aorta at 1 month and 6 months post FEVAR showed satisfactory FEVAR appearance with no endoleak.
1179 related Products with: Gallbladder necrosis and small bowel ischaemia following fenestrated endovascular aneurysm repair for juxtarenal abdominal aortic aneurysm: a case report.Multiple lung carcinoma ( Non small cell lung carci Middle advanced stage lun Lung small cell carcinoma Non-small cell lung cance Non small cell lung carci Non small cell lung carci Small intestine adenocarc GI cancer (esophageal, ga Non small cell lung carci Non small cell lung carci Non small cell lung carci
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Development of a handheld dual-channel optical fiber fluorescence sensor based on a smartphone.In order to meet the needs of on-site, accurate, fast, and remote detection, we design a smartphone-based handheld dual-channel optical fiber fluorescence sensor (DOFFS), which is composed of a semiconductor laser for exciting fluorescence signals, a smartphone with a dual-bandpass filter for collecting fluorescence signals, a fiber coupler for transmitting light, and batteries for laser power supply. All the components are integrated into a 3D printed shell, on the side of which there are two fiber flanges used for fiber probe connection. The fluorescence signals of green and red quantum dots modified on the fiber probes can be captured by the smartphone camera and calculated by a self-developed Android application. The comparisons of single-channel and dual-channel fluorescence signals with pH show that the performance of the sensor is good. The proposed sensor not only can simultaneously detect dual-channel signals for fast detection needs, but it also is handheld with a small size of 79×57×154 and inner power supply, and the fiber probes can be easily replaced, supporting remote and on-site applications. It is a potential tool for many occasions in many fields.
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The First Application of Nanoelectrochemotherapy in Feline Oral Malignant Melanoma Treatment-Case Study.The aim of this study was to present the first domestic animal trial of nanosecond electroporation with chemotherapy and CO laser surgery.
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Prevents Oxidative Stress-Induced Apoptosis Blocking p53 Activation in Neuroblastoma Cells.Oxidative stress has been associated to neuronal cell loss in neurodegenerative diseases. Neurons are post-mitotic cells that are very sensitive to oxidative stress-especially considering their limited capacity to be replaced. Therefore, reduction of oxidative stress, and inhibiting apoptosis, will potentially prevent neurodegeneration. In this study, we investigated the neuroprotective effect of Ginkgo biloba extract (EGb 761) against HO induced apoptosis in SK-N-BE neuroblastoma cells. We analysed the molecular signalling pathway involved in the apoptotic cell death. HO induced an increased acetylation of p53 lysine 382, a reduction in mitochondrial membrane potential, an increased BAX/Bcl-2 ratio and consequently increased Poly (ADP-ribose) polymerase (PARP) cleavage. All these effects were blocked by EGb 761 treatment. Thus, EGb 761, acting as intracellular antioxidant, protects neuroblastoma cells against activation of p53 mediated pathway and intrinsic mitochondrial apoptosis. Our results suggest that EGb 761, protecting against oxidative-stress induced apoptotic cell death, could potentially be used as nutraceutical for the prevention and treatment of neurodegenerative diseases.
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Reversible Corneal Endothelial Abnormalities with Netarsudil.To report a case of reversible corneal endothelial abnormalities following treatment with netarsudil.
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A case of childhood glaucoma with a combined partial monosomy 6p25 and partial trisomy 18p11 due to an unbalanced translocation.: Chromosomal deletion involving the 6p25 region results in a clinically recognizable syndrome characterized by anterior eye chamber anomalies with risk of glaucoma and non-ocular malformations (6p25 deletion syndrome). We report a newborn infant case of childhood glaucoma with a combination of partial monosomy 6p25 and partial trisomy 18p11 due to an unbalanced translocation.: The patient was a 0-year-old girl. Both eyes showed aniridia and left eye Peters anomaly with multiple malformations. To identify the chromosomal aberrations in the patient with clinically suspected 6p25 deletion syndrome, we performed cytogenetic analysis (G-banding and multicolor fluorescent hybridization) and array-based comparative genomic hybridization (array-CGH) analysis.: Cytogenetic analyses revealed a derivative chromosome 6 with its distal short arm replaced by an extra copy of the short arm of chromosome 18. Array-CGH analysis detected a 4.6-Mb deletion at 6pter to 6p25.1 and 8.9-Mb duplication at 18pter to 18p11.22. To determine the breakpoint of the unbalanced rearrangement at the single-base level, we performed a long-range PCR for amplifying the junctional fragment of the translocation breakpoint. By sequencing the junctional fragment, we defined the unbalanced translocation as g.chr6:pter_4594783delinschr18:pter_8911541.: A phenotype corresponding to combined monosomy 6p25 and trisomy 18p11 presented as childhood glaucoma associated with non-acquired (congenital) ocular anomalies consist of aniridia and Peters anomaly and other systemic malformations. To the best of our knowledge, this is the first report which demonstrated the breakpoint sequence of an unbalanced translocation in a Japanese infant with childhood glaucoma.
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Effect of suprahyoid muscles on mouth opening with and without lateral pterygoid muscle: 3D inverse dynamic model analysis.: To evaluate the contribution of suprahyoid muscles to mouth opening in different hyoid bone positions.: The jaw-opening and closing movements were imposed on the 3D inverse dynamic jaw model with and without the lateral pterygoid muscle (LPM). The activation of the muscles was evaluated for eight different positions of the hyoid bone.: The muscles with 100% activation provided maximum mouth opening (MMO). When the hyoid bone was replaced, the muscles could achieve MMO at the 135º, 180º, and 225º points with the LPM. Mouth opening was estimated to be 36.8 mm in the absence of the LPM. A jaw opening greater than 36.8 mm was seen when the hyoid bone was repositioned at the 90º, 180º, and 135º points.: The contribution of suprahyoid muscles to mouth opening varies in different hyoid bone positions, with the inferior and anterior positions having a positive impact.
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