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#32746167   2020/05/25 To Up

Compositional tuning of the Aurivillius phase material Bi5Ti3-2xFe1+xNbxO15 (0≤x≤0.4) grown by chemical solution deposition and its influence on the structural, magnetic and optical properties of the material.

A series of Aurivillius phase materials, Bi5Ti3-2xFe1+xNbxO15 (x = 0, 0.1, 0.2, 0.3 and 0.4), was fabricated by chemical solution deposition. The effects of aliovalent substitution for the successful inclusion of Fe3+ and Nb5+ by replacing Ti4+ was explored as a potential mechanism for increasing magnetic ion content within the material. The structural, optical, piezoelectric and magnetic properties of the materials were investigated. It was found that a limit of x = 0.1 was achieved before the appearance of secondary phases as determined by X-ray diffraction. Absorption in the visible region increased with increasing values of x corresponding to the transition from the valence band to the conduction band of the Fe-eg energy level. Piezoresponse force microscopy measurements demonstrated that the lateral piezoelectric response increased with increasing values of x. Magnetic measurements of Bi5Ti2.8Fe1.1Nb0.1O15 exhibited a weak ferromagnetic response at 2K, 150 and 300K of 2.2, 1.6, 1.5 emu/cm3 with Hc ∼ 40, 36, 34 Oe respectively. The remanent magnetisation, MR, of this sample was found to be higher than the range of reported values for the Bi5Ti3Fe1O15 parent phase. Elemental analysis of this sample by energy dispersive X-ray analysis did not provide any evidence for the presence of ironrich secondary phases. However, it is noted that a series of measurements at varying sample volumes and instrument resolutions is still required to in order to put a defined confidence level on the Bi5Ti2.8Fe1.1Nb0.1O15 material being a single-phase multiferroic.
Jennifer C Halpin, Michael Schmidt, Tuhin Maity, Martyn E Pemble, Lynette Keeney

2459 related Products with: Compositional tuning of the Aurivillius phase material Bi5Ti3-2xFe1+xNbxO15 (0≤x≤0.4) grown by chemical solution deposition and its influence on the structural, magnetic and optical properties of the material.

200 units200 units11mg50 IU100.00 ul500 Units1

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#32744173   2020/08/02 To Up

Death and Dying on the Social Network: An Italian Survey.

Death, bereavement, and grief are part of everyone's life experience. In the last few decades, media and social network platforms gradually began to influence people's ways of perceiving and coping with death and dying, and the research on the phenomenon of digital death is growing. Facebook is one of the most known and used social networks, and one of the few that developed specific measures to manage the profile pages of the deceased users. Based on these premises, this survey aimed to investigate how 1281 Italian participants, aged 14-77 years old, approach death on Facebook with respect to their opinions, attitudes, and emotional reactions, through an ad-hoc online survey. The results highlight how the participants seem to have different attitudes and emotions toward death, grief and mourning on the social network platform. The age of the participants seems to influence the use of the social network and the attitudes and the emotions toward the topic of investigation. Moreover, for this Italian sample, the custom of grieving and commemorating on social media is starting to spread along with the usual cultural practices without replacing them.
Andrea Bovero, Chiara Tosi, Rossana Botto, Irene Fonti, Riccardo Torta

1892 related Products with: Death and Dying on the Social Network: An Italian Survey.

100ul25 mg100ug Lyophilized100ug10 mg100ug Lyophilized100ul100.00 ul1 ml500 mg100ug

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#32743897   2020/08/02 To Up

Rational Design of Functional Peptide-Gold Hybrid Nanomaterials for Molecular Interactions.

Gold nanoparticles (AuNPs) have been extensively used for decades in biosensing-related development due to outstanding optical properties. Peptides, as newly realized functional biomolecules, are promising candidates of replacing antibodies, receptors, and substrates for specific molecular interactions. Both peptides and AuNPs are robust and easily synthesized at relatively low cost. Hence, peptide-AuNP-based bio-nano-technological approaches have drawn increasing interest, especially in the field of molecular targeting, cell imaging, drug delivery, and therapy. Many excellent works in these areas have been reported: demonstrating novel ideas, exploring new targets, and facilitating advanced diagnostic and therapeutic technologies. Importantly, some of them also have been employed to address real practical problems, especially in remote and less privileged areas. This contribution focuses on the application of peptide-gold hybrid nanomaterials for various molecular interactions, especially in biosensing/diagnostics and cell targeting/imaging, as well as for the development of highly active antimicrobial/antifouling coating strategies. Rationally designed peptide-gold nanomaterials with functional properties are discussed along with future challenges and opportunities.
Xiaohu Liu, Qingwen Zhang, Wolfgang Knoll, Bo Liedberg, Yi Wang

2255 related Products with: Rational Design of Functional Peptide-Gold Hybrid Nanomaterials for Molecular Interactions.

100ug Lyophilized 2x5L20 ug 1L10 50 ug50 ug50 ug100ug100ug Lyophilized100ug Lyophilized50

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#32741682   2020/07/14 To Up

Associations of meat consumption and changes with all-cause mortality in hypertensive patients during 11.4-year follow-up: Findings from a population-based nationwide cohort.

Accumulating evidence has linked distinct associations of red/processed and white meat consumption with chronic diseases and longevity among the general population. However, the associations of meat consumption and changes with mortality among hypertensive patients remain unknown. We aimed to assess the associations of red and white meat consumption with all-cause mortality among hypertensive patients in China.
Pan Zhuang, Jingjing Jiao, Fei Wu, Lei Mao, Yu Zhang

2909 related Products with: Associations of meat consumption and changes with all-cause mortality in hypertensive patients during 11.4-year follow-up: Findings from a population-based nationwide cohort.

100.00 ug1 Set1 Set100 μg1 Set1,000 tests100 μg100 μg100 ug100 μg

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#32741097   2020/08/02 To Up

Associations between cadence and knee loading in patients with knee osteoarthritis.

To test the hypothesis that higher walking cadence is associated with lower knee loading, while controlling for walking speed, in patients with medial compartment tibiofemoral osteoarthritis (OA).
Harvi F Hart, Trevor B Birmingham, Codie A Primeau, Ryan Pinto, Kristyn Leitch, J Robert Giffin

2701 related Products with: Associations between cadence and knee loading in patients with knee osteoarthritis.

20 1 mg5mg100 ug100μg1050μg

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#32740376   2020/07/27 To Up

New therapeutic strategies in lung vasculitis: Current Opinion in Pulmonary Medicine, invited review.

To summarize the latest publications and provide a practical overview of treatment strategies for lung vasculitis associated with antineutrophil cytoplasmic antibodies (ANCAs).
Mouhamad Nasser, Vincent Cottin

1726 related Products with: New therapeutic strategies in lung vasculitis: Current Opinion in Pulmonary Medicine, invited review.



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#32739045   2020/07/29 To Up

Minimising haemodynamic lability during changeover of syringes infusing norepinephrine in adult critical care patients: a multicentre randomised controlled trial.

Arterial pressure lability is common during the process of replacing syringes used for norepinephrine infusions in critically ill patients. It is unclear if there is an optimal approach to minimise arterial pressure instability during this procedures. We investigated whether 'double pumping' changeover (DPC) or automated changeover (AC) reduced blood pressure lability in critically ill adults compared with quick syringe changeover (QC).
Laurent Poiroux, Cyril Le Roy, Anne-Sylvie Ramelet, Mélaine Le Brazic, Leslie Messager, Amélie Gressent, Yolaine Alcourt, Carole Haubertin, Jean-François Hamel, Lise Piquilloud, Alain Mercat

1026 related Products with: Minimising haemodynamic lability during changeover of syringes infusing norepinephrine in adult critical care patients: a multicentre randomised controlled trial.

18 kgs1 Set100 μg1 Set100 μg1 Set100 μg100 μg100 μg

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#32738971   2020/06/19 To Up

MK-5204: An orally active β-1,3-glucan synthesis inhibitor.

Our previously reported efforts to produce an orally active β-1,3-glucan synthesis inhibitor through the semi-synthetic modification of enfumafungin focused on replacing the C2 acetoxy moiety with an aminotetrazole and the C3 glycoside with a N,N-dimethylaminoether moiety. This work details further optimization of the C2 heterocyclic substituent, which identified 3-carboxamide-1,2,4-triazole as a replacement for the aminotetrazole with comparable antifungal activity. Alkylation of either the carboxamidetriazole at C2 or the aminoether at C3 failed to significantly improve oral efficacy. However, replacement of the isopropyl alpha amino substituent with a t-butyl, improved oral exposure while maintaining antifungal activity. These two structural modifications produced MK-5204, which demonstrated broad spectrum activity against Candida species and robust oral efficacy in a murine model of disseminated Candidiasis without the N-dealkylation liability observed for the previous lead.
James M Apgar, Robert R Wilkening, Dann L Parker, Dongfang Meng, Kenneth J Wildonger, Donald Sperbeck, Mark L Greenlee, James M Balkovec, Amy M Flattery, George K Abruzzo, Andrew M Galgoci, Robert A Giacobbe, Charles J Gill, Ming-Jo Hsu, Paul Liberator, Andrew S Misura, Mary Motyl, Jennifer Nielsen Kahn, Maryann Powles, Fred Racine, Jasminka Dragovic, Weiming Fan, Robin Kirwan, Shu Lee, Hao Liu, Ahmed Mamai, Kingsley Nelson, Michael Peel

2945 related Products with: MK-5204: An orally active β-1,3-glucan synthesis inhibitor.

100ug Lyophilized100 ul1 ml200ul100ug Lyophilized100ug25 100 μg100μg50ug100 100ug Lyophilized

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#32738657   2020/07/15 To Up

Enzymatic protection and biocompatibility screening of enzyme-loaded polymeric nanoparticles for neurotherapeutic applications.

Polymeric nanoparticles provide a non-invasive strategy for enhancing the delivery of labile hydrophilic enzymatic cargo for neurological disease applications. One of the most common polymeric materials, poly(lactic-co-glycolic acid) (PLGA) copolymerized with poly(ethylene glycol) (PEG) is widely studied due to its biocompatible and biodegradable nature. Although PLGA-PEG nanoparticles are generally known to be non-toxic and protect enzymatic cargo from degradative proteases, different formulation parameters including surfactant, organic solvent, sonication times, and formulation method can all impact the final nanoparticle characteristics. We show that 30s sonication double emulsion (DE)-formulated nanoparticles achieved the highest enzymatic activity and provided the greatest enzymatic activity protection in degradative conditions, while nanoprecipitation (NPPT)-formulated nanoparticles exhibited no protection compared to free catalase. However, the same DE nanoparticles also caused significant toxicity on excitotoxicity-induced brain tissue slices, but not on healthy or neuroinflammation-induced tissue. We narrowed the culprit of toxicity to specifically sonication of PLGA-PEG polymer with dichloromethane (DCM) as the organic solvent, independent of surfactant type. We also discovered that toxicity was oxidative stress-dependent, but that increased toxicity was not enacted through increasing oxidative stress. Furthermore, no PEG degradation or aldehyde, alcohol, or carboxylic acid functional groups were detected after sonication. We identified that inclusion of free PEG along with PLGA-PEG polymer during the emulsification phases or replacing DCM with trichloromethane (chloroform) produced biocompatible polymeric nanoparticle formulations that still provided enzymatic protection. This work encourages thorough screening of nanoparticle toxicity and cargo-protective capabilities for the development of enzyme-loaded polymeric nanoparticles for the treatment of disease.
Rick Liao, Jessica Pon, Michael Chungyoun, Elizabeth Nance

2887 related Products with: Enzymatic protection and biocompatibility screening of enzyme-loaded polymeric nanoparticles for neurotherapeutic applications.

0.1 mg0.25 mg25 µg250 ml0.1 ml100 TESTS1 ml1 LITRE0.1 mg100 ml25 µg0.2 mg

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