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#33453655   2021/01/05 To Up

Development of the first universal mixture for use in system suitability tests for High-Performance Thin Layer Chromatography.

The use of chromatographic methods in routine analysis includes System Suitability Tests (SST). This paper presents a novel approach to SST in HPTLC, which allows qualification of the entire R range of an HPTLC plate independently of the samples. It is based on the Universal HPTLC mix (UHM), a pre-defined mixture of eight reference substances: guanosine, sulisobenzone, thymidine, paracetamol, phthalimide, 9-hydroxyfluorene, thioxanthen-9-one, and 2-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phenol, selected to cover a broad range of polarities and functional groups. The chromatographic behavior of the UHM was evaluated for 20 different mobile phases on Silica gel 60 F. At least three constituents were baseline separated. In a collaborative trial with four laboratories the reproducibility of R values for three representative mobile phases, was found to be within a confidence interval of 0.040 R units. The response characteristics of the UHM were assessed with respect to changes in chromatographic conditions, such as variation of the relative humidity, improperly employed saturation, or mistakes in the preparation of the mobile phase. Based on the R values of the individual constituents significant responses were found for most changes. This qualifies the UHM for use in SST.
Thi Kieu Tiên Do, Marco Schmid, Manjusha Phanse, Akshay Charegaonkar, Hanspeter Sprecher, Markus Obkircher, Eike Reich

2405 related Products with: Development of the first universal mixture for use in system suitability tests for High-Performance Thin Layer Chromatography.

1 G 5 G100 tests250 mg100 TESTS500 MG1,000 tests 100 G 1 G96 Tests

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#33453631   2021/01/05 To Up

Voxyvi: A system for long-term audio and video acquisitions in neonatal intensive care units.

In the European Union, 300,000 newborn babies are born prematurely every year. Their care is ensured in Neonatal Intensive Care Units (NICU) where vital signs are constantly monitored. In addition, other descriptors such as motion, facial and vocal activities have been shown to be essential to assess neurobehavioral development.
S Cabon, F Porée, G Cuffel, O Rosec, F Geslin, P Pladys, A Simon, G Carrault

1626 related Products with: Voxyvi: A system for long-term audio and video acquisitions in neonatal intensive care units.

0.1 mg 100 μg100 μg100 μg100 μg100 μg100 ug100 μg100 μg

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#33453609   2021/01/13 To Up

The C-sign in normal feet: a prospective study and novel imaging algorithm for subtalar joint tarsal coalition.

The C-sign on lateral radiographs has been subject to considerable debate with respect to its reliable association to subtalar joint tarsal coalition. The purpose of this study was to determine to what degree subtalar joint pronation factors into (a) the appearance of both complete and incomplete type A C-signs and (b) the conspicuity of the middle facet in both flatfeet and rectus feet.
Jill S Kawalec, Ashley Mariano, Shiloh Thoman, Lawrence S Osher

2703 related Products with: The C-sign in normal feet: a prospective study and novel imaging algorithm for subtalar joint tarsal coalition.

2 Pieces/Box

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#33453543   2020/12/26 To Up

Challenges of Combining Opioids and P2Y Inhibitors in Acute Coronary Syndrome: Should the Future Be Opioid Free?

Morphine has been long recognized as standard of care in the treatment of acute coronary syndrome (ACS) patients; however, its safety has recently been called into question due to a drug interaction with P2Y inhibitors. Opioids, given in combination with P2Y inhibitors, can reduce antiplatelet effects by slowing gastrointestinal motility and ultimately reducing drug absorption. While there are proposed benefits of opioids in ACS patients, conflicting data regarding clinical outcomes exist. The majority of clinical data slightly favors opioid use in ST-elevation myocardial infarction over non-ST-elevation myocardial infarction, although trends for increased myocardial infarction are present in both settings. Current practice should be aimed at discerning the need for routine opioid use in ACS. Alternative strategies may be needed to overcome these interactions; however, no robust data are currently available to support these treatment options. Future research should be aimed at non-opioid treatment options in ACS, as opioid use remains controversial in this population.
Catherine H Moore, Jack G Lukas, Brandon E Cave, Rami N Khouzam

2611 related Products with: Challenges of Combining Opioids and P2Y Inhibitors in Acute Coronary Syndrome: Should the Future Be Opioid Free?

1000 1 mg250 100 MG8 inhibitors2.5 mg96T 100 UG100ug100 mg

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#33453366   2021/01/13 To Up

Cardiovascular dysfunction in children exposed to preeclampsia during fetal life.

Keeping in view the Developmental Origin of Health and Disease hypothesis, this study aimed to assess differences in cardiac and vascular structure and function in children exposed to preeclampsia in-utero as compared to those of normotensive mothers. We hypothesized that children exposed to preeclampsia had altered cardiac and vascular structure and function as compared to the unexposed group.
Zahra Hoodbhoy, Nuruddin Mohammed, Shafquat Rozi, Nadeem Aslam, Shazia Mohsin, Salima Ashiqali, Hina Ali, Saima Sattar, Devyani Chowdhury, Babar Sultan Hasan

1668 related Products with: Cardiovascular dysfunction in children exposed to preeclampsia during fetal life.

100 ml100 ml1 mg100 ml500 ml1 mg10 ml100 ml

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#33453218   2021/01/13 To Up

An advanced method for propargylcholine phospholipid detection by direct-infusion mass spectrometry.

Phospholipids with a choline head group are an abundant component of cellular membranes and are involved in many important biological functions. For studies on the cell biology and metabolism of these lipids traceable analogues where propargylcholine replaces the choline head group have proven useful. We present a novel method to analyze propargylcholine phospholipids by mass spectrometry. The routine employs 1-radyl-2-lyso-sn-glycero-3-phosphopropargylcholines as labeled lysophosphatidylcholine (LPC) precursors, which upon cellular conversion direct the traceable tag with superb specificity and efficiency to the primary target lipid class. Using azido-palmitate as a click-chemistry reporter we introduce a highly specific, sensitive and robust mass spectrometry detection procedure for the propargylcholine phospholipids. In a first study we apply the new technique to investigate choline phospholipid metabolism in brain endothelial cells. These experiments reveal differences in the metabolism of phosphatidylcholine and its pendant, ether phosphatidylcholine. The novel method described here opens a new, quantitative and detailed view on propargylcholine phospholipid metabolism and will greatly facilitate future studies on choline phospholipid metabolism.
Mohamed H Yaghmour, Christoph Thiele, Lars Kuerschner

1190 related Products with: An advanced method for propargylcholine phospholipid detection by direct-infusion mass spectrometry.

0.2 mg 100 UG100μg100ug8 Array supply x 2400 assays100tests100tests100ug96 tests100μg25 µg

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#33453121   2021/01/16 To Up

Rapid implementation of telemedicine during the COVID-19 pandemic: Cancer patients' perspectives and preferences.

The use of telemedicine in oncology practice is rapidly expanding and is considered safe and cost effective. However, the implications of telemedicine on patient-physician interaction, patients' satisfaction and absence of personal touch have not been studied to date. Following the spread of COVID-19, telemedicine services were rapidly incorporated at the oncology division of Tel Aviv Medical Center (TLVMC). We aimed to evaluate patients' perspectives and preferences regarding telemedicine and assess whether this virtual communication platform affects the patient-physician relationship.
Shira Peleg Hasson, Barliz Waissengrin, Eliya Shachar, Marah Hodruj, Rochelle Fayngor, Mirika Brezis, Alla Nikolaevski-Berlin, Sharon Pelles, Tamar Safra, Ravit Geva, Ido Wolf

1373 related Products with: Rapid implementation of telemedicine during the COVID-19 pandemic: Cancer patients' perspectives and preferences.

Each25 mg 5 G 96 Tests

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#33453046   2021/01/16 To Up

Update on pituitary adenomas in the 2017 World Health Organization classification: innovations and perspectives.

The World Health Organization (WHO) classifications of tumors offer invaluable support in the diagnosis of tumors, with every new edition including novel information and diagnostic updates. The new 2017 WHO Classification of Tumors of Endocrine Organs, 4th edition, includes innovations in both terminology and diagnostic guidelines for pituitary adenomas, along with new entities, molecular information, and novel treatment modalities. The recommended reporting system of pituitary adenomas is based on morphology and assessment of the hormonal content by immunohistochemistry. Electron microscopy and immunohistochemistry for Ki-67 and p53 and transcription factors, while presenting additional information, are not recommended for routine diagnosis. Other markers may also yield information of prognostic and predictive significance. In sum, the 2017 WHO classification provides pathologists and clinicians with new and comprehensive information of great use for the diagnosis and treatment of pituitary tumors.
George Kontogeorgos

2761 related Products with: Update on pituitary adenomas in the 2017 World Health Organization classification: innovations and perspectives.

1100ug100 μg

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#33452964   2021/01/16 To Up

Utility of susceptibility weighted imaging (SWI) and pseudo-continuous arterial spin labeling (pCASL) in diagnosis of falcine venous thrombosis in a child with transient ischemic attack.

Pediatric stroke and transient ischemic attack (TIA) are uncommon but true emergencies with a wide differential diagnosis. Diagnostic imaging plays a critical role in differentiating the diverse range of etiologies. In this case, we report a 3-year-old female with no medical history who developed acute neurological deficits and demonstrate how adjunct advanced imaging including susceptibility weighted imaging (SWI) and pseudo-continuous arterial spin labeling (pCASL) can play a significant diagnostic role in the emergent setting. Imaging was performed with a Philips Ingenia 3.0T MRI. MRI brain, MR angiography (MRA), and phase contrast angiography MR Venography (PCA-MRV) were obtained. pCASL and SWI sequences were performed using SENSE (sensitivity encoding) parallel imaging techniques. MRI/MRA brain showed no restricted diffusion, abnormal T1/T2/FLAIR signal, arterial occlusion, or irregular angioarchitecture. SWI revealed increased susceptibility along the posterior falx cerebri and right posterior parietal and occipital lobes, and pCASL showed decreased blood flow within these same regions. No falcine sinus was visualized on PCA-MRV, but SWI and pCASL findings led to diagnosis of falcine sinus thrombosis and initiation of appropriate treatment. Repeat MRI one month later showed interval resolution of the abnormal SWI findings and a now patent persistent falcine sinus visualized on PCA-MRV imaging. Routine use of SWI imaging on all brain MRIs and addition of pCASL imaging when there is concern for ischemia or infarction in the emergent setting can limit the risk of missed occult diagnoses like a thrombosed falcine sinus.
Jeffrey D Spiro, William F James, Aaron A Cho

2344 related Products with: Utility of susceptibility weighted imaging (SWI) and pseudo-continuous arterial spin labeling (pCASL) in diagnosis of falcine venous thrombosis in a child with transient ischemic attack.

100 ul100 μg100 μg100μg100 μg1 Set100 μg1 Set

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#33452910   2021/01/16 To Up

Predicting the outcome of asymptomatic univesicular liver hydatids: diagnostic accuracy of unenhanced CT.

To establish the role of unenhanced CT in predicting the outcome of liver hydatid cysts. We sought to determine whether the presence of laminated membrane detachment (LMD) or pericyst degenerative changes (PDCs) detected on CT were reliable signs for predicting a favorable outcome of liver hydatids.
Farrokh Habibzadeh, Parham Habibzadeh, Alireza Shakibafard, Farrokh Saidi

2392 related Products with: Predicting the outcome of asymptomatic univesicular liver hydatids: diagnostic accuracy of unenhanced CT.

5 G

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