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#32272503   2020/04/09 To Up

Exploring Ways to Improve Access to and Minimize Risk from Lung Cancer Screening.


Humberto Choi, Nathan A Pennell

2186 related Products with: Exploring Ways to Improve Access to and Minimize Risk from Lung Cancer Screening.

96 Tests n1 mg430 Tests / Kit 1 G500 reactions1 module96 wells (1 kit)100

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#32272481   2020/04/09 To Up

Structure of M from COVID-19 virus and discovery of its inhibitors.

A new coronavirus (CoV) identified as COVID-19 virus is the etiological agent responsible for the 2019-2020 viral pneumonia outbreak that commenced in Wuhan. Currently there are no targeted therapeutics and effective treatment options remain very limited. In order to rapidly discover lead compounds for clinical use, we initiated a program of combined structure-assisted drug design, virtual drug screening and high-throughput screening to identify new drug leads that target the COVID-19 virus main protease (M). M is a key CoV enzyme, which plays a pivotal role in mediating viral replication and transcription, making it an attractive drug target for this virus. Here, we identified a mechanism-based inhibitor, N3, by computer-aided drug design and subsequently determined the crystal structure of COVID-19 virus M in complex with this compound. Next, through a combination of structure-based virtual and high-throughput screening, we assayed over 10,000 compounds including approved drugs, drug candidates in clinical trials, and other pharmacologically active compounds as inhibitors of M. Six of these compounds inhibited M with IC values ranging from 0.67 to 21.4 μM. Ebselen also exhibited promising antiviral activity in cell-based assays. Our results demonstrate the efficacy of this screening strategy, which can lead to the rapid discovery of drug leads with clinical potential in response to new infectious diseases for which no specific drugs or vaccines are available.
Zhenming Jin, Xiaoyu Du, Yechun Xu, Yongqiang Deng, Meiqin Liu, Yao Zhao, Bing Zhang, Xiaofeng Li, Leike Zhang, Chao Peng, Yinkai Duan, Jing Yu, Lin Wang, Kailin Yang, Fengjiang Liu, Rendi Jiang, Xinglou Yang, Tian You, Xiaoce Liu, Xiuna Yang, Fang Bai, Hong Liu, Xiang Liu, Luke W Guddat, Wenqing Xu, Gengfu Xiao, Chengfeng Qin, Zhengli Shi, Hualiang Jiang, Zihe Rao, Haitao Yang

2506 related Products with: Structure of M from COVID-19 virus and discovery of its inhibitors.

50 UG100 ug100 ug1 mg11 mg0.25 mg200 100ul 96 Tests 1 ml1 mg

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#32272456   2020/04/09 To Up

Single-channel oximetry monitor versus in-lab polysomnography oximetry analysis: does it make a difference?

Portable oximetry has been shown to be a promising candidate for large-scale obstructive sleep apnea screening. In polysomnography (PSG), the gold standard OSA diagnosis test, the oxygen desaturation index (ODI) is usually computed from desaturation events occurring during sleep periods only, i.e., overnight desaturations occurring during or overlapping with a wake state are excluded. However, for unattended home oximetry, all desaturations are taken into account since no reference electroencephalogram is available for sleep staging. We aim to evaluate the hypothesis that the predictive power of oximetry for OSA screening is not impaired when reference sleep stages are not available.
Joachim Behar, Niclas Palmius, Sroussi Zacharie, Armand Chocron, Thomas Penzel, Lia Bittencourt, Sergio Tufik

1824 related Products with: Single-channel oximetry monitor versus in-lab polysomnography oximetry analysis: does it make a difference?

1,000 tests100 25 100 1mg3 modules100 Tests25 Tests

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#32272443   2020/03/07 To Up

Pilot study of social cognitive theory variables as correlates of physical activity among adolescents with pediatric multiple sclerosis.

Adolescents with pediatric onset multiple sclerosis (MS) engage in low rates of physical activity. Behavioral interventions that target physical activity are most successful if grounded in theory. This study explored social cognitive theory (SCT) variables as correlates of physical activity among adolescents with pediatric onset MS.
Sikes Elizabeth Morghen, Motl Robert W

2370 related Products with: Pilot study of social cognitive theory variables as correlates of physical activity among adolescents with pediatric multiple sclerosis.

100 Tests100 assays1x96 well plate 96 Tests 100Tests100 assays1 kit100 assays100 assays1 kit100 assays1 kit

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#32272427   2020/03/31 To Up

Tunable photoluminescence and energy transfer of SrLiMg(PO): Ce/Tb/Mn phosphors.

The Ce/Tb/Mn activated color-tunable phosphors SrLiMg(PO) (SLMP) were prepared by solid-state reaction with post-annealing treatment. The structural, static and time-resolved luminescent properties are studied in detail. XRD pattern showed the pure trigonal phase of SrLiMg(PO) at an annealing temperature of 1300 °C. Ce-doped SLMP phosphor exhibits near-ultraviolet emission with peak-wavelength at 380 nm. Efficient Ce-Tb/Mn energy transfer process is demonstrated by luminescence spectrum and luminescence lifetimes of as-prepared samples. The emitting-color of SLMP: Ce/Tb/Mn was tunable through changing Ce/Tb/Mn ratio. Emission peak intensity of SLMP: Ce, Tb phosphor shows good thermal stability with rising temperature. These results suggest its great potential as luminescent materials with good performance for UV-excitable applications.
Jiabao Luo, Zishan Sun, Zhenpeng Zhu, Xinguo Zhang, Zhan-Chao Wu, Fuwang Mo

2128 related Products with: Tunable photoluminescence and energy transfer of SrLiMg(PO): Ce/Tb/Mn phosphors.

0.05 mg500 mg100ug Lyophilized200ul100ug Lyophilized 100ul250ul25 mg1 kit(96 Wells)100ug Lyophilized50 ug

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#32272373   2020/03/02 To Up

Rotating frame MRI relaxations as markers of diffuse white matter abnormalities in multiple sclerosis.

Even though MRI visualization of white matter lesions is pivotal for the diagnosis and management of multiple sclerosis (MS), the issue of detecting diffuse brain tissue damage beyond the apparent T2-hyperintense lesions continues to spark considerable interest. Motivated by the notion that rotating frame MRI methods are sensitive to slow motional regimes critical for tissue characterization, here we utilized novel imaging protocols of rotating frame MRI on a clinical 3 Tesla platform, including adiabatic longitudinal, T1ρ, and transverse, T2ρ, relaxation methods, and Relaxation Along a Fictitious Field (RAFF) in the rotating frame of rank 4 (RAFF4), in 10 relapsing-remitting multiple sclerosis patients and 10 sex- and age-matched healthy controls. T1ρ, T2ρ and RAFF4 relaxograms extracted from the whole white matter exhibited a significant shift towards longer relaxation time constants in MS patients as compared to controls. T1ρ and RAFF4 detected alterations even when considering only regions of normally appearing white matter (NAWM), while other MRI metrics such as T1w/T2w ratio and diffusion tensor imaging measures failed to find group differences. In addition, RAFF4, T2ρ and, to a lesser extent, T1ρ showed differences in subcortical grey matter structures, mainly hippocampus, whereas no functional changes in this region were detected in resting-state functional MRI metrics. We conclude that rotating frame MRI techniques are exceptionally sensitive methods for the detection of subtle abnormalities not only in NAWM, but also in deep grey matter in MS, where they surpass even highly sensitive measures of functional changes, which are often suggested to precede detectable structural alterations. Such abnormalities are consistent with a wide spectrum of different, but interconnected pathological features of MS, including the loss of neuronal cells and their axons, decreased levels of myelin even in NAWM, and altered iron content.
Pavel Filip, Alena Svatkova, Adam F Carpenter, Lynn E Eberly, Igor Nestrasil, Mikko J Nissi, Shalom Michaeli, Silvia Mangia

2317 related Products with: Rotating frame MRI relaxations as markers of diffuse white matter abnormalities in multiple sclerosis.

20 ul (10 mM)16 Arrays/Slide1 kit

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#32272362   2020/02/21 To Up

Malnutrition is associated with poor health-related quality of life in surgical patients with gastrointestinal cancer.

The aim of this study was to evaluate the association between preoperative nutritional status and health-related quality of life (HRQoL) in patients with gastrointestinal cancer who were admitted for elective surgical treatment.
Fernanda de Carvalho Pazzini Maia, Thales Antônio Silva, Simone de Vasconcelos Generoso, Maria Isabel Toulson Davisson Correia

1223 related Products with: Malnutrition is associated with poor health-related quality of life in surgical patients with gastrointestinal cancer.

100ug Lyophilized100ug Lyophilized25100ug Lyophilized0.1ml

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#32272349   2020/04/06 To Up

Patients with acute respiratory distress syndrome exhibit increased stromelysin1 activity in the blood samples.

Enzyme activity analyses in the blood are expected to be reliable, non-invasive diagnostic as well as prognostic markers to reflect disease progression in acute lung injury (ALI). The objective of the current study was to evaluate the enzymatic activity of stromelysin1 (matrix metalloprotease-3) in the plasma/serum samples collected from ALI patients compared to the samples collected from healthy controls. Gene expression omnibus (GEO) database analysis indicated a correlation between increased stromelysin1 gene expression and the incidence of ALI in various animal models. Our analysis of patient plasma/serum samples from healthy controls and ALI patients revealed a significant, 3-fold increase in stromelysin1 activity in ALI plasma/serum compared to healthy subjects with no difference in stromelysin1 activity between the serum and plasma samples. Interestingly, no significant difference in stromelysin1 activity between non-smoking and smoking subjects was observed. These findings provide fundamental information on the potential reliability of stromelysin1 activity analysis, combined with other biomarkers in development, in blood samples for the early detection of ALI.
Sandeep Artham, Arti Verma, Andrea Sikora Newsome, Payaningal R Somanath

1359 related Products with: Patients with acute respiratory distress syndrome exhibit increased stromelysin1 activity in the blood samples.

900 tests16 Arrays/Slide96 samples100 samples96 samples96 assays

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#32272344   2020/03/05 To Up

An integrated deep learning framework for joint segmentation of blood pool and myocardium.

Simultaneous and automatic segmentation of the blood pool and myocardium is an important precondition for early diagnosis and pre-operative planning in patients with complex congenital heart disease. However, due to the high diversity of cardiovascular structures and changes in mechanical properties caused by cardiac defects, the segmentation task still faces great challenges. To overcome these challenges, in this study we propose an integrated multi-task deep learning framework based on the dilated residual and hybrid pyramid pooling network (DRHPPN) for joint segmentation of the blood pool and myocardium. The framework consists of three closely connected progressive sub-networks. An inception module is used to realize the initial multi-level feature representation of cardiovascular images. A dilated residual network (DRN), as the main body of feature extraction and pixel classification, preliminary predicts segmentation regions. A hybrid pyramid pooling network (HPPN) is designed for facilitating the aggregation of local information to global information, which complements DRN. Extensive experiments on three-dimensional cardiovascular magnetic resonance (CMR) images (the available dataset of the MICCAI 2016 HVSMR challenge) demonstrate that our approach can accurately segment the blood pool and myocardium and achieve competitive performance compared with state-of-the-art segmentation methods.
Xiuquan Du, Yuhui Song, Yueguo Liu, Yanping Zhang, Heng Liu, Bo Chen, Shuo Li

2601 related Products with: An integrated deep learning framework for joint segmentation of blood pool and myocardium.

5 G10ml 5 G1 ml 50 UG25 mg100ug96 wells (1 kit)50 ug 100ug100 µg1

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