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#32455469   2020/05/26 To Up

Primary stability and healing outcomes of apically tapered and straight implants placed into fresh extraction sockets. A pre-clinical in vivo study.

To compare the stability of apically tapered and straight (non-tapered cylindrical) implants at the time of immediate placement and to histologically evaluate the healing outcomes after 6 weeks.
Rebecca Ellis, Stephen Chen, Helen Davies, Wayne Fitzgerald, Junhua Xu, Ivan Darby

1630 related Products with: Primary stability and healing outcomes of apically tapered and straight implants placed into fresh extraction sockets. A pre-clinical in vivo study.

1000 tests100ug

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#32455448   2020/05/26 To Up

[Teleophthalmology Using Whole Slide Imaging (WSI): Clinical-Pathological Correlation Even Without Own Histological Laboratory].

Telepathology has experienced enormous growth over the last two decades due to significant advances in IT and has led to the introduction of innovative solutions for digital imaging in ophthalmology. Whole Slide Imaging (WSI), where conventional glass slides are fully scanned, offers a wide range of applications, including remote (conciliary) diagnostics, second opinions, (remote) teaching and research and presentation. In addition to qualified and experienced personnel, a comparatively expensive basic equipment has so far also been an essential requirement. The focus ophthalmology at the Eye Centre in Freiburg is able to involve a de facto unlimited number of users and consulting partners (also overseas) in the digital microscopy of identical sections independent of location, device and time. This is done simply by using the internet. This procedure has proven to be very successful and opens up completely new avenues, not only for correct diagnosis (clinical-pathological correlation), but also for education and training. Preparation and distribution of further histological slides in addition to the scanned slide is not required for small specimens with scant material, for example, nor is it necessary to purchase microscopes for the participants if funds are lacking or the infrastructure is unsuitable. When dealing with transferring data, it is essential to comply with data protection regulations.
Claudia Auw-Hädrich, Andreas Jedynak, Thomas Reinhard, Constanze Döring, Stefan J Lang

1814 related Products with: [Teleophthalmology Using Whole Slide Imaging (WSI): Clinical-Pathological Correlation Even Without Own Histological Laboratory].

70 Slides 1 kit 100 Slides 70 Slides 90 x 3 slides

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#32455137   2020/05/08 To Up

TRPV Subfamily (TRPV2, TRPV3, TRPV4, TRPV5, and TRPV6) Gene and Protein Expression in Patients with Ulcerative Colitis.

TRPVs are a group of receptors with a channel activity predominantly permeable to Ca. This subfamily is involved in the development of gastrointestinal diseases such as ulcerative colitis (UC). The aim of the study was to characterize the gene and protein expression of the TRPV subfamily in UC patients and controls.
Joel J Toledo Mauriño, Gabriela Fonseca-Camarillo, Janette Furuzawa-Carballeda, Rafael Barreto-Zuñiga, Braulio Martínez Benítez, Julio Granados, Jesus K Yamamoto-Furusho

2916 related Products with: TRPV Subfamily (TRPV2, TRPV3, TRPV4, TRPV5, and TRPV6) Gene and Protein Expression in Patients with Ulcerative Colitis.

100ul1000 TESTS/0.65ml100 μg300 units100 μg10 mg1 mg100ug Lyophilized100ug Lyophilized

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#32455113   2020/04/23 To Up

Multiple umbilical cord-derived MSCs administrations attenuate rat osteoarthritis progression via preserving articular cartilage superficial layer cells and inhibiting synovitis.

Articular cartilage erosion probably plays a substantial role in osteoarthritis (OA) initiation and development. Studies demonstrated that umbilical cord-derived mesenchymal stem cells (UCMSCs) could delay chondrocytes apoptosis and ameliorate OA progression in patients, but the detailed mechanisms are largely uncharacterised. In this study, we aimed to study the effects of UCMSCs on monosodium iodoacetate (MIA)-induced rat OA model, and explore the cellular mechanism of this effect.
Wei Tong, Xiaoguang Zhang, Quan Zhang, Jiarui Fang, Yong Liu, Zengwu Shao, Shuhua Yang, Dongcheng Wu, Xiaoming Sheng, Yingze Zhang, Hongtao Tian

1851 related Products with: Multiple umbilical cord-derived MSCs administrations attenuate rat osteoarthritis progression via preserving articular cartilage superficial layer cells and inhibiting synovitis.

1.00 flask1 vialOne Vial: 5 X 10^6 Cells1.00 flask100 ug/vial4 x 96-well plate100|uI x 10 vials1.00 flask1 x 10^6 cells/vial

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#32453807   2020/05/26 To Up

Effectiveness of electrical stimulation on nerve regeneration after crush injury: Comparison between invasive and non-invasive stimulation.

Several studies have investigated the use of invasive and non-invasive stimulation methods to enhance nerve regeneration, and varying degrees of effectiveness have been reported. However, due to the use of different parameters in these studies, a fair comparison between the effectiveness of invasive and non-invasive stimulation methods is not possible. The present study compared the effectiveness of invasive and non-invasive stimulation using similar parameters. Eighteen Sprague Dawley rats were classified into three groups: the iES group stimulated with fully implantable device, the tES group stimulated with transcutaneous electrical nerve stimulation (TENS), and the injury group (no stimulation). The iES and tES groups received stimulation for 6 weeks starting immediately after the injury. Motor function was evaluated using the sciatic functional index (SFI) every week. The SFI values increased over time in all groups; faster and superior functional recovery was observed in the iES group than in the tES group. Histological evaluation of the nerve sections and gastrocnemius muscle sections were performed every other week. The axon diameter and muscle fiber area in the iES group were larger, and the g-ratio in the iES group was closer to 0.6 than those in the tES group. To assess the cause of the difference in efficiency, a 3D rat anatomical model was used to simulate the induced electric fields in each group. A significantly higher concentration and intensity around the sciatic nerve was observed in the iES group than in the tES group. Vector field distribution showed that the field was orthogonal to the sciatic nerve spread in the tES group, whereas it was parallel in the iES group; this suggested that the tES group was less effective in nerve stimulation. The results indicated that even though rats in the TENS group showed better recovery than those in the injury group, it cannot replace direct stimulation yet because rats stimulated with the invasive method showed faster recovery and superior outcomes. This was likely attributable to the greater concentration and parallel distribution of electric field with respect to target nerve.
Chanyang Ju, Eunkyoung Park, Taewoo Kim, Taekyung Kim, Minhee Kang, Kyu-Sung Lee, Sung-Min Park

2384 related Products with: Effectiveness of electrical stimulation on nerve regeneration after crush injury: Comparison between invasive and non-invasive stimulation.

1 kit(96 Wells)

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#32453755   2020/05/26 To Up

Examination of ex-vivo viability of human adipose tissue slice culture.

Obesity is associated with significantly higher mortality rates, and excess adipose tissue is involved in respective pathologies. Here we established a human adipose tissue slice cultures (HATSC) model ex vivo. HATSC match the in vivo cell composition of human adipose tissue with, among others, mature adipocytes, mesenchymal stem cells as well as stroma tissue and immune cells. This is a new method, optimized for live imaging, to study adipose tissue and cell-based mechanisms of obesity in particular. HATSC survival was tested by means of conventional and immunofluorescence histological techniques, functional analyses and live imaging. Surgery-derived tissue was cut with a tissue chopper in 500 μm sections and transferred onto membranes building an air-liquid interface. HATSC were cultured in six-well plates filled with Dulbecco's Modified Eagle's Medium (DMEM), insulin, transferrin, and selenium, both with and without serum. After 0, 1, 7 and 14 days in vitro, slices were fixated and analyzed by morphology and Perilipin A for tissue viability. Immunofluorescent staining against IBA1, CD68 and Ki67 was performed to determine macrophage survival and proliferation. These experiments showed preservation of adipose tissue as well as survival and proliferation of monocytes and stroma tissue for at least 14 days in vitro even in the absence of serum. The physiological capabilities of adipocytes were functionally tested by insulin stimulation and measurement of Phospho-Akt on day 7 and 14 in vitro. Viability was further confirmed by live imaging using Calcein-AM (viable cells) and propidium iodide (apoptosis/necrosis). In conclusion, HATSC have been successfully established by preserving the monovacuolar form of adipocytes and surrounding macrophages and connective tissue. This model allows further analysis of mature human adipose tissue biology ex vivo.
Nikolas Schopow, Sonja Kallendrusch, Siming Gong, Felicitas Rapp, Justus Körfer, Martin Gericke, Nick Spindler, Christoph Josten, Stefan Langer, Ingo Bechmann

1594 related Products with: Examination of ex-vivo viability of human adipose tissue slice culture.

1 kit4/120 Packing /sleeve/bo50 reactions

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#32453636   // To Up

Deep-Learning-Based Characterization of Tumor-Infiltrating Lymphocytes in Breast Cancers From Histopathology Images and Multiomics Data.

Tumor-infiltrating lymphocytes (TILs) and their spatial characterizations on whole-slide images (WSIs) of histopathology sections have become crucial in diagnosis, prognosis, and treatment response prediction for different cancers. However, fully automatic assessment of TILs on WSIs currently remains a great challenge because of the heterogeneity and large size of WSIs. We present an automatic pipeline based on a cascade-training U-net to generate high-resolution TIL maps on WSIs.
Zixiao Lu, Siwen Xu, Wei Shao, Yi Wu, Jie Zhang, Zhi Han, Qianjin Feng, Kun Huang

2914 related Products with: Deep-Learning-Based Characterization of Tumor-Infiltrating Lymphocytes in Breast Cancers From Histopathology Images and Multiomics Data.



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#32452573   2020/05/26 To Up

Screening of plants from the Brazilian Atlantic Forest led to the identification of Athenaea velutina (Solanaceae) as a novel source of antimetastatic agents.

Plant biodiversity is a source of potential natural products for the treatment of many diseases. One of the ways of discovering new drugs is through the cytotoxic screening of extract libraries. The present study evaluated 196 extracts prepared by maceration of Brazilian Atlantic Forest trees with organic solvents and distilled water for cytotoxic and antimetastatic activity. The MTT assay was used to screen the extract activity in MCF-7, HepG2 and B16F10 cancer cells. The highest cytotoxic extract had antimetastatic activity, as determined in in vitro assays and melanoma murine model. The organic extract of the leaves of Athenaea velutina (EAv) significantly inhibited migration, adhesion, invasion and cell colony formation in B16F10 cells. The phenolic compounds and flavonoids in EAv were identified for the first time, using flow injection with electrospray negative ionization-ion trap tandem mass spectrometry analysis (FIA-ESI-IT-MS ). EAv markedly suppressed the development of pulmonary melanomas following the intravenous injection of melanoma cells to C57BL/6 mice. Stereological analysis of the spleen cross-sections showed enlargement of the red pulp area after EAv treatment, which indicated the activation of the haematopoietic system. The treatment of melanoma-bearing mice with EAv did not result in liver damage. In conclusion, these findings suggest that A velutina is a source of natural products with potent antimetastatic activity.
Alisson A Almeida, Graziela D A Lima, Marcos V R C Simão, Gabriela A Moreira, Raoni P Siqueira, Ana C Zanatta, Wagner Vilegas, Mariana Machado-Neves, Gustavo C Bressan, João P V Leite

1301 related Products with: Screening of plants from the Brazilian Atlantic Forest led to the identification of Athenaea velutina (Solanaceae) as a novel source of antimetastatic agents.

100ul430 tests1 kit(96 Wells)25 assays100 assays

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#32452510   2020/05/26 To Up

Design of nanomaterials for applications in maternal/fetal medicine.

Pregnancy complications are commonplace and the challenges of treatment during pregnancy with few options available pose a risk to the health of both the mother and baby. Patients suffering from conditions such as preeclampsia, placenta accreta, and intrauterine growth restriction have few treatment options apart from emergency caesarean section. Fortunately, researchers are beginning to develop nanomedicine-based therapies that could be utilized to treat conditions affecting the mother, placenta, or fetus to improve the prognosis for mothers and their unborn children. This review summarizes the field's current understanding of nanoparticle biodistribution and therapeutic effect following systemic or vaginal administration and overviews the design parameters researchers should consider when developing nanomedicines for maternal/fetal health. It also describes safety considerations for nanomedicines to limit undesirable maternal or fetal side effects and discusses future work that should be performed to advance nanomedicine for maternal/fetal health. With additional development and implementation, the application of nanomedicine to treat pregnancy complications may mitigate the need for emergency caesarean sections and allow pregnancies to extend to term.
N'Dea S Irvin-Choy, Katherine M Nelson, Jason P Gleghorn, Emily S Day

1161 related Products with: Design of nanomaterials for applications in maternal/fetal medicine.

5 G50 ml0.2 mg500 ml10 ml1 LITRE500 MG250 mg500 ml500 ml

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