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#32783418   // To Up

Effect of Topical Antibiotic Prophylaxis on Conjunctival Flora and Antibiotic Resistance Following Intravitreal Injections in Patients with Type 2 Diabetes.

We sought to determine changes in the conjunctival bacterial flora and antibiotic resistance after topical antibiotic drops for infection prophylaxis were administered following intravitreal injections in patients with type 2 diabetes.
Havva Kaldirim, Serpil Yazgan, Ahmet Kirgiz, Bilge Ozdemir, Ahu Yilmaz

1275 related Products with: Effect of Topical Antibiotic Prophylaxis on Conjunctival Flora and Antibiotic Resistance Following Intravitreal Injections in Patients with Type 2 Diabetes.

5 50200ul5 mg96 wells (1 kit)5/100 Packing /sleeve/bo5mg200ug100ug Lyophilized1 mg

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#32783415   2020/08/11 To Up

Histological Validation of Cardiovascular Magnetic Resonance T1 Mapping for Assessing the Evolution of Myocardial Injury in Myocardial Infarction: An Experimental Study.

To determine whether T1 mapping could monitor the dynamic changes of injury in myocardial infarction (MI) and be histologically validated.
Lu Zhang, Zhi Gang Yang, Huayan Xu, Meng Xi Yang, Rong Xu, Lin Chen, Ran Sun, Tianyu Miao, Jichun Zhao, Xiaoyue Zhou, Chuan Fu, Yingkun Guo

2804 related Products with: Histological Validation of Cardiovascular Magnetic Resonance T1 Mapping for Assessing the Evolution of Myocardial Injury in Myocardial Infarction: An Experimental Study.

100 μg

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#32782928   2020/07/24 To Up

National Board of Medical Examiners and Curriculum Change: What Do Scores Tell Us? A Case Study at the University of Balamand Medical School.

This study describes the results of NBME (National Board of Medical Examiners) implementation in Balamand Medical School (BMS) from 2015 to 2019, after major curricular changes were introduced as of 2012. BMS students' performance was compared with the international USMLE step 1 (United States Medical Licensing Examination, herein referred to as step 1) cohorts' performances. The BMS students' NBME results were analyzed over the successive academic years to assess the impact of the serial curricular changes that were implemented.
Mode Al Ojaimi, Megan Khairallah, Rayya Younes, Sara Salloum, Ghania Zgheib

1198 related Products with: National Board of Medical Examiners and Curriculum Change: What Do Scores Tell Us? A Case Study at the University of Balamand Medical School.

1ml

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#32782306   2020/08/11 To Up

Parallel in time dynamics with quantum annealers.

Recent years have witnessed an unprecedented increase in experiments and hybrid simulations involving quantum computers. In particular, quantum annealers. There exist a plethora of algorithms promising to outperform classical computers in the near-term future. Here, we propose a parallel in time approach to simulate dynamical systems designed to be executed already on present-day quantum annealers. In essence, purely classical methods for solving dynamics systems are serial. Therefore, their parallelization is substantially limited. In the presented approach, however, the time evolution is rephrased as a ground-state search of a classical Ising model. Such a problem is solved intrinsically in parallel by quantum computers. The main idea is exemplified by simulating the Rabi oscillations generated by a two-level quantum system (i.e. qubit) experimentally.
Konrad Jałowiecki, Andrzej Więckowski, Piotr Gawron, Bartłomiej Gardas

2512 related Products with: Parallel in time dynamics with quantum annealers.

252596 wells2596 wells2525200ul100 μg1 Set100 μg

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#32781869   // To Up

Serial locally applied water-filtered infrared a radiation in axial spondyloarthritis - a randomized controlled trial.

Aim of this randomized controlled trial was to evaluate the effects of serial locally applied water-filtered infrared A radiation (sl-wIRAR) in patients with axial spondyloarthritis (axSpA).
Philipp Klemm, Markus Eichelmann, Iris Aykara, Ole Hudowenz, Gabriel Dischereit, Uwe Lange

1170 related Products with: Serial locally applied water-filtered infrared a radiation in axial spondyloarthritis - a randomized controlled trial.

0,1 ML0,1 ML

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#32781635   2020/08/06 To Up

Relationship between Tube Parameters and Corneal Endothelial Cell Damage after Ahmed Glaucoma Valve Implantation: A Comparative Study.

We compared the clinical factors, including anterior chamber tube parameters, in patients with and without corneal endothelial cell damage after Ahmed glaucoma valve (AGV) implantation.
Han Min Lee, Kyoung Nam Kim, Kee Sup Park, Nam Ho Lee, Sung Bok Lee, Chang-Sik Kim

1803 related Products with: Relationship between Tube Parameters and Corneal Endothelial Cell Damage after Ahmed Glaucoma Valve Implantation: A Comparative Study.

2 ml0.5 ml96 tests50 assays1.00 flask96 assays100.00 ug1.00 flask1.00 flask0.2 mL0.5 ml1.00 flask

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#32781206   2020/08/08 To Up

Genome-wide analysis revealed the virulence attenuation mechanism of the fish-derived oral attenuated Streptococcus iniae vaccine strain YM011.

Streptococcus iniae has become one the most serious aquatic pathogens causing invasive diseases in farmed marine and freshwater fish worldwide, and orally attenuated vaccine is still the best option in protecting these invasive diseases. In this study, the safety, stability, immunogenicity of the S. iniae attenuated strain YM011 were evaluated, and comprehensively analyzed its virulence weakening mechanism at whole genome level. The results shown that attenuated S. iniae strain YM011 completely lost its pathogenicity to tilapia and had good immunogenicity with relative percent survival being 93.25% at 15 days and 90.31% at 30 days via IP injection, respectively, and 76.81% at 15 days and 56.69% at 30 days via oral gavage, respectively. Back-passage safety assay indicated that YM011 did not cause diseases or death in tilapia after 100 generations of serial passaging. Comparative genome-wide sequencing shown that YM011 had a 0.4 M large inversion fragment compared with its parental strain virulent strain GX005, which encoded 372 genes including drug resistance genes pbp2A and tet, as well as known virulence factors including hemolysin transport system gene, recA, and mutator family transposase. The attenuated S. iniae strain YM011 is an ideal attenuated oral vaccine candidate with good immunogenicity, safety and stability. Abnormal expression of important drug resistance genes as well as known virulence factors due to inversion of a 0.4 M large fragment is the leading mechanism underlying its attenuated virulence.
Yu Liu, Liping Li, Fangzhao Yu, Yongju Luo, Wanwen Liang, Qiong Yang, Rui Wang, Min Li, Jiayou Tang, Qunhong Gu, Zhiping Luo, Ming Chen

2204 related Products with: Genome-wide analysis revealed the virulence attenuation mechanism of the fish-derived oral attenuated Streptococcus iniae vaccine strain YM011.

100 Umin 2 cartons100.00 ul1 ml200 units100 500IU11

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#32781086   2020/08/08 To Up

Efficacy and Safety of Aldafermin, an Engineered FGF19 Analog, in a Randomized, Double-Blind, Placebo-Controlled Trial of Patients With Nonalcoholic Steatohepatitis.

Aldafermin, an engineered analog of FGF19, inhibits bile acid synthesis and regulates metabolic homeostasis. We report results from a 24-week, phase 2 study, with serial liver biopsies, of patients with non-alcoholic steatohepatitis (NASH).
Stephen A Harrison, Guy Neff, Cynthia D Guy, Mustafa R Bashir, Angelo H Paredes, Juan P Frias, Ziad Younes, James F Trotter, Nadege T Gunn, Sam E Moussa, Anita Kohli, Kristin Nelson, Mildred Gottwald, William C G Chang, Andrew Z Yan, Alex M DePaoli, Lei Ling, Hsiao D Lieu

1332 related Products with: Efficacy and Safety of Aldafermin, an Engineered FGF19 Analog, in a Randomized, Double-Blind, Placebo-Controlled Trial of Patients With Nonalcoholic Steatohepatitis.

100ug1 mg100ug Lyophilized2 Pieces/Box100 μg1 Set1 Set100ug Lyophilized1 Set100 μg

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#32780931   2020/08/11 To Up

Serial femtosecond zero dose crystallography captures a water-free distal heme site in a dye-decolourising peroxidase to reveal a catalytic role for an arginine in FeIV=O formation.

Obtaining structures of intact redox states of metal centres derived from  zero dose  X-ray crystallography can advance our mechanistic understanding of metalloenzymes. In dye-decolourising heme peroxidases (DyPs), controversy exists regarding the mechanistic role of the distal heme residues, aspartate and arginine, in the heterolysis of peroxide to form the catalytic intermediate compound I (Fe IV =O and a porphyrin cation radical). Using serial femtosecond X-ray (SFX) crystallography, we have determined the pristine structures of the Fe III  and Fe IV =O redox states of a B-type DyP. These structures reveal a water-free distal heme site, which together with the presence of an asparagine, infer the use of the distal arginine as a catalytic base. A combination of mutagenesis and kinetic studies corroborate such a role. Our SFX approach thus provides unique insight into how the distal heme site of DyPs can be tuned to select aspartate or arginine for the rate enhancement of peroxide heterolysis.
Marina Lucic, Dimitri Svistunenko, Michael Wilson, Amanda Chaplin, Bradley Davy, Ali Ebrahim, Danny Axford, Takehiko Tosha, Hiroshi Sugimoto, Shigeki Owada, Florian Dworkowski, Ivo Tews, Robin Owen, Michael Hough, Jonathan A R Worrall

2547 related Products with: Serial femtosecond zero dose crystallography captures a water-free distal heme site in a dye-decolourising peroxidase to reveal a catalytic role for an arginine in FeIV=O formation.

1 Set50 ul100 μg100μg

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#32780885   2020/08/11 To Up

Glucan rich nutrition does not increase gut translocation of Beta glucan.

(1-3)-b-D-glucan (BDG) is a fungal cell wall component and, in the absence of invasive fungal infection, a novel biomarker for microbial translocation of endogenous fungal products from the gastrointestinal tract into systemic circulation. However, its value as a marker of fungal translocation is limited by a concern that plant BDG-rich food influences blood BDG levels.
Martin Hoenigl, John Lin, Malcolm Finkelman, Yonglong Zhang, Maile Y Karris, Scott Letendre, Ronald J Ellis, Leah Burke, Byron Richard, Thaidra Gaufin, Stéphane Isnard, Jean-Pierre Routy, Sara Gianella

1158 related Products with: Glucan rich nutrition does not increase gut translocation of Beta glucan.

25 0.5 mg0.1 mg25 25 0.5 mg0.1 mg50 25 TESTS0.25 mg0.1 mg100 TESTS

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