Only in Titles

           Search results for: serial    

paperclip

#32084404   // Save this To Up

A Color Vision Circuit for Non-Image-Forming Vision in the Primate Retina.

Melanopsin-expressing, intrinsically photosensitive retinal ganglion cells (ipRGCs) synchronize our biological clocks with the external light/dark cycle [1]. In addition to photoentrainment, they mediate the effects of light experience as a central modulator of mood, learning, and health [2]. This makes a complete account of the circuity responsible for ipRGCs' light responses essential to understanding their diverse roles in our well-being. Considerable progress has been made in understanding ipRGCs' melanopsin-mediated responses in rodents [3-5]. However, in primates, ipRGCs also have a rare blue-OFF response mediated by an unknown short-wavelength-sensitive (S)-cone circuit [6]. Identifying this S-cone circuit is particularly important because ipRGCs mediate many of the wide-ranging effects of short-wavelength light on human biology. These effects are often attributed to melanopsin, but there is evidence for an S-cone contribution as well [7, 8]. Here, we tested the hypothesis that the S-OFF response is mediated by the S-ON pathway through inhibitory input from an undiscovered S-cone amacrine cell. Using serial electron microscopy in the macaque retina, we reconstructed the neurons and synapses of the S-cone connectome, revealing a novel inhibitory interneuron, an amacrine cell, receiving excitatory glutamatergic input exclusively from S-ON bipolar cells. This S-cone amacrine cell makes highly selective inhibitory synapses onto ipRGCs, resulting in a blue-OFF response. Identification of the S-cone amacrine cell provides the missing component of an evolutionarily ancient circuit using spectral information for non-image forming visual functions.

2611 related Products with: A Color Vision Circuit for Non-Image-Forming Vision in the Primate Retina.

Colorectal carcinoma and FDA Standard Frozen Tissu  EpiQuik Superoxide Dism VisionBlue™ Quick Cell FDA Standard Frozen Tissu Breast invasive ductal ca Multiple organ tumor tiss  EpiQuik Superoxide Dism FDA Standard Frozen Tissu Frozen colorectal adenoca Thermal Shaker with cooli Lymphoma array, together

Related Pathways