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Search results for: serum

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#33096478   2020/10/20 To Up

Development and validation of MMR prediction model based on simplified clinicopathological features and serum tumour markers.

Although simplified clinicopathological features and serum tumour markers (STMs) were reported to be associated with the status of mismatch repair (MMR) in colorectal cancer (CRC) patients, their predictive value alone or in combination for MMR status remains unknown.
Yinghao Cao, Tao Peng, Han Li, Ming Yang, Liang Wu, Zili Zhou, Xudan Zhang, Shengbo Han, Haijun Bao, Kailin Cai, Ning Zhao

2593 related Products with: Development and validation of MMR prediction model based on simplified clinicopathological features and serum tumour markers.

96T10 mg500 mg100ug50 ug 25 mg100ul 5 G100ug25 mg 5 G100ug

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#33096350   2020/10/20 To Up

Pharmacodynamics of malondialdehyde as indirect oxidative stress marker after arrested-heart cardiopulmonary bypass surgery.

An unavoidable consequence of cardiac surgery is oxidative stress and resulting peroxidation of biological molecules, in particular unsaturated lipids. The detection of peroxidation metabolites in biological environments is difficult due to their large variety, small concentration, and high reactivity. One of the most studied lipid peroxidation products is malondialdehyde and as such an important marker of oxidative stress. The aim of this study was to monitor the perioperative serum concentration of malondialdehyde as an oxidative stress marker in patients undergoing arrested-heart cardiopulmonary bypass surgery.
Anže Djordjević, Petra Kotnik, Domen Horvat, Željko Knez, Miha Antonič

1505 related Products with: Pharmacodynamics of malondialdehyde as indirect oxidative stress marker after arrested-heart cardiopulmonary bypass surgery.

1200

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#33096343   2020/10/16 To Up

A common deletion in the growth hormone receptor gene (d3-GHR) in the offspring is related to maternal placental GH levels during pregnancy.

A common growth hormone receptor polymorphism with deletion of exon 3 (d3-GHR) has previously been linked to increased postnatal growth on the one hand and decreased fetal growth on the other. Regulation of fetal growth is positively dependent on secretion of placental GH (hGH-V).
Rikke Beck Jensen, Malene Boas, John E Nielsen, Lisa Leth Maroun, Anne Jørgensen, Torben Larsen, Katharina M Main, Anders Juul

2570 related Products with: A common deletion in the growth hormone receptor gene (d3-GHR) in the offspring is related to maternal placental GH levels during pregnancy.

100ug Lyophilized 100ul100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized

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#33096316   2020/10/16 To Up

Clinical and radiological characteristics of ultrasonic humidifier lung and summer-type hypersensitivity pneumonitis.

Ultrasonic humidifier lung is a rare form of hypersensitivity pneumonitis (HP), and its clinical and radiological features are unclear. This study examined the clinical and radiological characteristics of humidifier lung.
Susumu Sakamoto, Marie Furukawa, Hiroshige Shimizu, Muneyuki Sekiya, Shion Miyoshi, Yasuhiko Nakamura, Naohisa Urabe, Takuma Isshiki, Yusuke Usui, Kazutoshi Isobe, Yujiro Takai, Atsuko Kurosaki, Kazuma Kishi, Sakae Homma

2130 related Products with: Clinical and radiological characteristics of ultrasonic humidifier lung and summer-type hypersensitivity pneumonitis.

96T 5 G 5 G100ug25 mg100ul96 wells (1 kit)100ug

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#33096266   2020/10/20 To Up

Eosinophil-mast cell interaction: Mepolizumab leads to a reduction of clinical symptoms and serum tryptase in a patient with eosinophilic asthma and idiopathic mast cell activation.


Carole Guillet, Simona Steinmann, Claudia Lang, Julia-Tatjana Maul, Peter Schmid-Grendelmeier

1868 related Products with: Eosinophil-mast cell interaction: Mepolizumab leads to a reduction of clinical symptoms and serum tryptase in a patient with eosinophilic asthma and idiopathic mast cell activation.

20 200 1 kit1 kit

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#33096216   2020/10/20 To Up

Mortality Risk for Patients with Stage IV Cancer and Acute Illness Hospitalization.

Cancer prognosis data often comes from clinical trials which exclude patients with acute illness.
Laura C Hanson, Natalie C Ernecoff, Kathryn L Wessell, Feng-Chang Lin, Matthew I Milowsky, Frances A Collichio, William A Wood, Donald L Rosenstein

1925 related Products with: Mortality Risk for Patients with Stage IV Cancer and Acute Illness Hospitalization.



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#33096207   2020/10/20 To Up

Serum pooling for rapid expansion of anti-SARS-CoV-2 antibody testing capacity.

Examine possible pooling strategies designed to expand SARS-CoV-2 serological testing capacity.
Jerry William L Allen, Hans Verkerke, Joshua Owens, Bejan Saeedi, Darra Boyer, Sooncheon Shin, John D Roback, Andrew S Neish, Sean R Stowell

1010 related Products with: Serum pooling for rapid expansion of anti-SARS-CoV-2 antibody testing capacity.

100ug Lyophilized0.25 mg100ug Lyophilized100ug Lyophilized100ug Lyophilized 25UG200ul100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized

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#33096123   2020/10/20 To Up

Brain-targeted delivery of obidoxime, using aptamer-modified liposomes, for detoxification of organophosphorus compounds.

Effective intracerebral delivery acetylcholinesterase (AChE) reactivator is key for the acute organophosphorus (OPs) poison treatment. However, the blood-brain barrier (BBB) restricts the transport of these drugs from blood into the brain. Herein, we developed transferrin receptor (TfR) aptamer-functionalized liposomes (Apt-LP) that could deliver AChE reactivator (obidoxime) across the BBB to act against paraoxon (POX) poisoning. The aptamer had strong affinity for TfR and was modified with 3'-inverted deoxythymidine (dT) to improve serum stability. The uptake of Apt-LP by bEnd.3 cells was significantly higher than that of non-targeting liposomes. The ability of Apt-LP to penetrate intact BBB was confirmed in in vitro BBB mice model and in vivo biodistribution studies. Treatment of POX-poisoned mice with Apt-LP-LuH-6 reactivated 18% of the brain AChE activity and prevented brain damage to some extent. Taken together, these results showed that Apt-LP may be used as a promising brain-targeted drug delivery system against OPs toxicity.
Yadan Zhang, Junlin He, Liao Shen, Tao Wang, Jun Yang, Yao Li, Yongan Wang, Dongqin Quan

1386 related Products with: Brain-targeted delivery of obidoxime, using aptamer-modified liposomes, for detoxification of organophosphorus compounds.

5 G10 200 mg 1 kit(s) 2000 rxn0.1 mg25 g96T250 ml

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#33096092   2020/10/20 To Up

IMBALANCES IN CIRCULATING ANGIOGENIC FACTORS IN THE PATHOPHYSIOLOGY OF PREECLAMPSIA AND RELATED DISORDERS.

Preeclampsia is a devastating medical complication of pregnancy that can lead to significant maternal and fetal morbidity and mortality. It is currently believed that there is abnormal placentation as early as the first trimester in women destined to develop preeclampsia. While the etiology of the abnormal placentation is being debated, numerous epidemiological and experimental studies suggest imbalances in circulating angiogenic factors released from the placenta are responsible for the maternal signs and symptoms of preeclampsia. In particular, circulating levels of soluble fms-like tyrosine kinase 1, an anti-angiogenic factor, are markedly increased in women with preeclampsia, while free levels of its ligand placental growth factor are markedly diminished in preeclampsia. Alterations in these angiogenic factors precede the onset of clinical signs of preeclampsia and correlate with disease severity. Recently, availability of automated assays for the measurement of angiogenic biomarkers in plasma, serum and urine has helped investigators around the world to demonstrate a key role for these factors in the clinical diagnosis and prediction of preeclampsia. Numerous studies have shown that circulating angiogenic biomarkers have a very high negative predictive value to rule out clinical disease among women with suspected preeclampsia. These blood-based biomarkers have provided a valuable tool to clinicians to accelerate time to clinical diagnosis and minimize maternal adverse outcomes in women with preeclampsia. Angiogenic biomarkers have also been useful to elucidate the pathogenesis of related disorders of abnormal placentation such as fetal growth restriction, intrauterine fetal death, twin-to-twin transfusion syndrome, and fetal hydrops. In summary, discovery and characterization of angiogenic proteins of placental origin have provided clinicians a non-invasive blood-based tool to monitor placental function and health and for early detection of disorders of placentation. Uncovering the mechanisms of altered angiogenic factors in preeclampsia and related disorders of placentation may provide insights into novel preventive and therapeutic options.
Sarosh Rana, Suzanne D Burke, S Ananth Karumanchi

1549 related Products with: IMBALANCES IN CIRCULATING ANGIOGENIC FACTORS IN THE PATHOPHYSIOLOGY OF PREECLAMPSIA AND RELATED DISORDERS.

100 units2 Pieces/Box2 Pieces/Box12 Pieces/Box

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