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#33657697   // To Up

[Clinical follow-up and genetic analysis of six cases with hypophosphatasia].

To analyze the clinical, genetic characteristics and follow-up data of Chinese patients with hypophosphatasia (HPP). A retrospective analysis was conducted on six children with HPP admitted to the Department of Endocrinology, Genetics and Metabolism in Beijing Children's Hospital from October 2010 to January 2019. Summarized the clinical and follow-up data of all six patients, as well as the pathogenic variants of five children. The serum alkaline phosphatase levels of all six children (five males and one female) were significantly reduced (2-49 U/L). The 6 patients aged from 2 months to 6 years and 4 months, 4 infantile HPP, 1 childhood HIP and 1 odonto HPP. The four patients with infantile HPP presented with anorexia, slow weight gain and hypercalcemia, whereas the one patient with childhood HPP and the other patient with odonto HPP had tooth loss. The patient with childhood HPP also manifested with motor dysfunction. Genetic testing was conducted for five patients and 4 unrelated Chinese families and revealed 10 variations in ALPL gene, including 7 missense variation, 1 insertion variation, 1 frameshift variation, 1 deletion variation.Of which 3 were novel (p.Y28C, p.268, F>L, p.A176V).One of the infantile patients lost follow-up and the other three deceased. The clinical conditions were much improved with medical intervention for patients with childhood, orodonto HPP. While HPP patients with different ages of onset present with common features, the prognosis differ significantly. The prognosis is good for patients with childhood, orodonto HPP and poor for patients with infantile HPP. Genetic testing is the main method for definitive diagnosis.
M Liu, Y Zhao, X J Liang, B Y Cao, C Su, J J Chen, C X Gong

2547 related Products with: [Clinical follow-up and genetic analysis of six cases with hypophosphatasia].



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#33657670   2021/03/03 To Up

Lnc-RNA LINC01279 induces endometriosis via targeting of HOXA10.

To explore the regulatory role and molecular mechanism of lncRNA-LINC01279 in endometriosis (EMs).
Liling Liu, Junping Cheng, Fu Wei, Lihong Pang, Zhifu Zhi, Wenmei Yang, Weihong Tan

1824 related Products with: Lnc-RNA LINC01279 induces endometriosis via targeting of HOXA10.

1mg/vial100 μg250ul25μg/vial100ug/vial10 nmol100μg/vial100ug/vial5 X 1000 U100 μg1000pcs100 ug/vial

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#33657666   2021/03/03 To Up

Low androgen status inhibits erectile function by increasing pyroptosis in rat corpus cavernosum.

The mechanism of erectile dysfunction (ED) caused by low androgen status is not fully understood.
Zhi-Bin Chen, Ge Li, Haocheng Lin, Jun Jiang, Rui Jiang

1359 related Products with: Low androgen status inhibits erectile function by increasing pyroptosis in rat corpus cavernosum.

100 UG1 Set1 Set4/120 Packing /sleeve/bo20ug 1 G25 100 μg

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#33657656   2021/03/03 To Up

Oral dimethyl fumarate induces changes within the peripheral neutrophil compartment of psoriasis patients that are linked with skin improvement.

Dimethyl fumarate (DMF) is a treatment for moderate-to-severe psoriasis and multiple sclerosis. DMF therapy typically improves skin inflammation within the first 3 months of treatment. DMF is a prodrug that generates the hydroxycarboxylic acid receptor 2 (HCA2) agonist, monomethyl fumarate (MMF). Despite widespread clinical use, DMF's mechanism of action is not fully understood.
P J Morrison, I Suhrkamp, S Gerdes, U Mrowietz

1141 related Products with: Oral dimethyl fumarate induces changes within the peripheral neutrophil compartment of psoriasis patients that are linked with skin improvement.

1 mg 100 G1100 ul5 g 1 G 100 G 5 G100.00 ul2.5 mg1 mg

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#33657654   2021/03/03 To Up

The effects of valproate on serum leptin, insulin, and lipid levels in epileptic children.

Weight gain is an important adverse effect of valproate (VPA) therapy. Number of mechanisms have been proposed for its pathophysiology. The aim of the present study is evaluation of biochemical derangements in epileptic children on treatment with VPA.
Huseyin Kilic, Atalay Demirel, Serap Uysal

1100 related Products with: The effects of valproate on serum leptin, insulin, and lipid levels in epileptic children.

100ug100ug Lyophilized500 ml100ug100ml100mg10 mg100ug Lyophilized100mg100ug

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#33657638   2021/03/03 To Up

Umbilical Cord Separation Time and Influencing Factors in Very-Low-Birth-Weight Preterm Neonates.

 The average time for umbilical cord separation in term neonates is 7 to 10 days. Prematurity, phototherapy, prolonged duration of antibiotic treatment, and parenteral nutrition are other factors which were demonstrated to delay cord separation. In the previous studies including greater premature infants, the time of separation of the umbilical cord was shown to vary 2 to 3 weeks. We aimed to determine the cord separation time and associated factors in very-low-birth-weight (VLBW) infants.
Sezin Unal, Nihal Demirel, Zehra Arslan, Betül Tokgoz-Cuni, Dilek Ulubas-Isik, Ahmet Yagmur Bas

1057 related Products with: Umbilical Cord Separation Time and Influencing Factors in Very-Low-Birth-Weight Preterm Neonates.

2525500 gm.25100 units96 wells251

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#33657554   2021/03/03 To Up

Obesity Can Contribute to Severe Persistent Allergic Rhinitis in Children through Leptin and Interleukin-1β.

Obesity/overweight is associated with a higher risk of allergic rhinitis (AR) in children.
Myung Woul Han, Song Hee Kim, Inbo Oh, Yang Ho Kim, Jiho Lee

1565 related Products with: Obesity Can Contribute to Severe Persistent Allergic Rhinitis in Children through Leptin and Interleukin-1β.

96 wells (1 kit)96 wells (1 kit)5 100.00 ug10 5ug

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#33657534   2021/03/03 To Up

Therapeutic angiogenesis using zinc oxide nanoflowers for the treatment of hind limb ischemia in rat model.

Critical limb ischemia (CLI) is considered as a severe type of peripheral artery diseases (PADs) which occurs due to the inadequate supply of blood to the limb extremities. CLI patients often suffer from extreme cramping pain, impaired wound healing, immobility, cardiovascular complications, amputation of the affected limb and even death. The conventional therapy for the treatment of CLI includes surgical revascularization as well as restoring angiogenesis using growth factor therapy. However, surgical revascularization is suitable for only a minor percentage of CLI patients and it is associated with high perioperative mortality rate. The use of growth factors is also limited in terms of their poor therapeutic angiogenesis potential as observed by the earlier clinical studies, which could be attributed to their poor bio-availability and non-specificity issues. Therefore, to outweigh the aforesaid disadvantages of the conventional strategies, there is an utmost need for the advancement of new alternative therapeutic biomaterials to treat CLI. Since past few decades, various research groups including ours have been involved in developing different pro-angiogenic nanomaterials. Among them, zinc oxide nanoflowers (ZONF), established in our laboratory, are considered as one of the potent nanoparticles to induce therapeutic angiogenesis. In our earlier studies, we have depicted that ZONF promote angiogenesis by inducing the formation of reactive oxygen species (ROS) and nitric oxide (NO) as well as activating Akt/MAPK/eNOS cell signaling pathways in the endothelial cells. Recently, we have also reported the therapeutic potential of ZONF to treat cerebral ischemia through their neuritogenic and neuroprotective properties, exploiting angio-neural cross talk. Considering the excellent pro-angiogenic properties of ZONF and importance of revascularization for the recovery of CLI, in this present study, we have comprehensively explored the therapeutic potential of ZONF in a rat hind limb ischemia model (established by ligating the femoral artery of hind limb), an animal model that mimics CLI in humans. The behavioural studies, laser Doppler perfusion imaging, histopathology, immunofluorescence as well as estimation of serum NO level depicted that the administration of ZONF could ameliorate the ischemic conditions in rats at a faster rate by promoting therapeutic angiogenesis to the ischemic sites. Altogether, the present study offers an alternative nanomedicine approach employing ZONF for the treatment of PADs.
Ayan Kumar Barui, Susheel Kumar Nethi, Papia Basuthakur, Priya Jhelum, Vishnu Sravan Bollu, Bommana Raghunath Reddy, Sumana Chakravarty, Chitta Ranjan Patra

1288 related Products with: Therapeutic angiogenesis using zinc oxide nanoflowers for the treatment of hind limb ischemia in rat model.

100 50 assays4 Arrays/Slide 100 G

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#33657516   2021/02/18 To Up

Unveiling specific nanoparticle-protein interactions via evaporated drops: From molecular recognition to allergen identification.

Unveiling specific interactions between nanoparticles (NPs) and proteins could benefit a better control of NPs' performance in recognition-based detection, imaging and drug delivery. Herein, we investigated the specific recognition between an aptamer modified gold nanoparticle (Apt-AuNP) and its target protein arginine kinase (AK) through a coffee-ring effect (CRE)-based approach. The evaporated droplets of the Apt-AuNP with AK featured a ring-disk-ring transition with elevated AK concentration and a disk pattern was found when the Apt was saturated by AK. Moreover, the AK concentration versus ring thickness curve below the saturation point was proved to fit in an exponential function, indicating the strong association between the Apt-AuNP and AK. In contrast, the ring thickness above the saturation point fitted in a Gompertz growth model that was similar with the Apt-AuNPs incubated with the nonspecific protein (bovine serum albumin, BSA), suggesting that AK was nonspecifically adsorbed onto the AuNPs. The impact of the specific NP-protein interaction on the translation of CRE into macroscopic patterns was further utilized to identify target food allergen AK by the Apt-AuNPs over nontarget allergens (tropomyosin, ovalbumin and β-lactoglobulin). This work provided new insight into the general NP-protein association process and demonstrated the feasibility of employing CRE as an effective tool to profile the specific interactions between NPs and proteins.
Yanbo Wang, Huan Li, Linlin Cheng, Jinru Zhou, Linglin Fu

2833 related Products with: Unveiling specific nanoparticle-protein interactions via evaporated drops: From molecular recognition to allergen identification.

100ug/vial100 ug/vial1 mg51 kit(96 Wells)100ug100 1mg0.5mg2 Pieces/Box100ug/vial

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