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#33080654   2020/10/20 To Up

[Lying synchronization in fattening cattle at different space allowances].

Lying synchronization is an important characteristic of the natural behavior in cattle. The guideline for the housing of fattening cattle published in 2018 in Lower Saxony, Germany, requests for the first time that the lying area should be large enough to enable all animals to lie down simultaneously. However, up to now, lying synchrony in fattening cattle has only been scientifically analyzed to a small extent and detailed data on lying space requirements of fattening bulls are lacking altogether. Therefore, this study aimed at analyzing the lying synchronization level in fattening bulls housed at different space allowances as well as at examining whether simultaneous lying of all animals per pen occurs.
Laura Schneider, Nina Volkmann, Birgit Spindler, Nicole Kemper

1471 related Products with: [Lying synchronization in fattening cattle at different space allowances].

1 Set100 μg100 μg100 100 20 µl (10 mM)100 μg1 mg100 μg

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#33080624   2020/10/20 To Up

Del17p without TP53 mutation confers poor prognosis in intensively treated newly diagnosed multiple myeloma patients.

Despite tremendous improvements in the outcome of patients with multiple myeloma (MM) in the past decade, high-risk patients have not benefited from the approval of novel drugs. The most important prognostic factor is the loss of parts of the short arm of chromosome 17, known as deletion 17p (del(17p)). A recent publication (on a small number of patients) suggested that these patients are at very high-risk only if del(17p) is associated with TP53 mutations, the so-called "double-hit" population. To validate this finding, we designed a much larger study on 121 patients presenting del(17p) in >55% of their plasma cells, and homogeneously treated by an intensive approach. For these 121 patients, we performed deep next generation sequencing targeted on TP53. The outcome was then compared to a large control population (2505 patients lacking del(17p)). Our results confirmed that the "double hit" situation is the worst (median survival = 36 months), but that del(17p) alone also confers a poor outcome compared with the control cohort (median survival = 52.8 months vs 152.2 months, respectively). In conclusion, our study clearly confirms the extremely poor outcome of patients displaying "double hit", but also that del(17p) alone is still a very high-risk feature, confirming its value as a prognostic indicator for poor outcome.
Jill Corre, Aurore Perrot, Denis Caillot, Karim Belhadj Merzoug, Cyrille Hulin, Xavier Leleu, Mohamad Mohty, Thierry Facon, Laure Buisson, Laura Do Souto, Romain Lannes, Stephanie Dufrechou, Nais Prade, Frederique Orsini Piocelle, Laurent Voillat, Arnaud Jaccard, Lionel Karlin, Margaret Macro, Sabine Brechignac, Mamoun Dib, Laurence Sanhes, Jean Fontan, Lauriane Filliatre-Clement, Jean-Pierre Marolleau, Stephane Minvielle, Philippe Moreau, Hervé Avet-Loiseau

2746 related Products with: Del17p without TP53 mutation confers poor prognosis in intensively treated newly diagnosed multiple myeloma patients.

1 Set1 Set5mg16 Arrays/Slide

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#33080593   2020/10/20 To Up

Sequential Minimally Invasive Fetal Interventions for Two Life-Threatening Conditions: A Novel Approach.

In utero interventions are performed in fetuses with "isolated" major congenital anomalies to improve neonatal outcomes and quality of life. Sequential in utero interventions to treat 2 anomalies in 1 fetus have not yet been described.
Rodrigo Ruano, Eniola R Ibirogba, Michelle A Wyatt, Karthik Balakrishnan, M Yasir Qureshi, Amy B Kolbe, Joseph A Dearani, R Paul Boesch, Leal Segura, Katherine W Arendt, Ellen Bendel-Stenzel, Shana S Salik, Denise B Klinkner

1934 related Products with: Sequential Minimally Invasive Fetal Interventions for Two Life-Threatening Conditions: A Novel Approach.

0.1 ml100μg 1 G500 250tests0.1 mg1,000 tests

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#33080592   2020/10/20 To Up

Importance of microRNAs in Skin Oncogenesis and Their Suitability as Agents and Targets for Topical Therapy.

Skin cancer is the most common cancer worldwide, with rapidly increasing incidence and consistent mortality. Skin cancer encompasses melanoma and non-melanoma skin cancer, which in turn is mainly divided into cutaneous squamous cell carcinoma and basal cell carcinoma. Small noncoding micro-RNAs (miRNAs) regulate protein expression after transcription and play a role in the development and progression of skin cancer. Deregulated expression of miRNAs in skin cancer is associated with cell proliferation, angiogenesis, metastasis, apoptosis, immune response, and drug resistance. Specific patterns of miRNAs in specific skin cancer types can be used as diagnostic markers. For therapeutic purposes, both miRNA and chemically modified variants thereof as well as miRNA antagonists (antagomiRs) or RNA inhibitors may be applied topically. Due to their specific physicochemical properties, physical or chemical diffusion promoters are used with varying degrees of success. There is no question by now that such preparations have a high potential for the treatment of epithelial skin tumors in particular.
Dennis Gerloff, Cord Sunderkötter, Johannes Wohlrab

1978 related Products with: Importance of microRNAs in Skin Oncogenesis and Their Suitability as Agents and Targets for Topical Therapy.

10 mg 100 G100ul96 samples1000 tests100 tests1 kit100ug

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#33080583   2020/10/20 To Up

Cone beam CT multisource configurations: evaluating image quality, scatter, and dose using phantom imaging and Monte Carlo simulations.

To compare various multisource configurations applied to cone beam CT (CBCT) using phantom imaging and Monte Carlo simulations.
Amy E Becker, Andrew M Hernandez, Paul R Schwoebel, John M Boone

1739 related Products with: Cone beam CT multisource configurations: evaluating image quality, scatter, and dose using phantom imaging and Monte Carlo simulations.

5mg1,000 tests200ug1 mg25 mg1000 tests100ug1000 TESTS/0.65ml 5 G2.5 mg2.5 mg

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#33080582   2020/10/20 To Up

Nitric oxide's physiologic effects and potential as a therapeutic agent against Covid-19.

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for COVID-19 pneumonia, a pandemic that precipitates huge pressures on the world's social and economic systems. Disease severity varies among individuals. SARS-CoV-2 infection can be associated with e.g. flu-like symptoms, dyspnoea, severe interstitial pneumonia, acute respiratory distress syndrome, multiorgan dysfunction, and generalized coagulopathy. Nitric oxide (NO), is a small signal molecule that impacts pleiotropic functions in human physiology, which can be involved in the significant effects of COVID-19 infection. NO is a neurotransmitter involved in the neural olfactory processes in the central nervous system, and some infected patients have reported anosmia as a symptom. Additionally, NO is a well-known vasodilator, important coagulation mediator, anti-microbial effector and inhibitor of SARS-CoV replication. Exhaled NO is strongly related to the type-2 inflammatory response found in asthma, which has been suggested to be protective against SARS-CoV-2 infection. Several reports indicate that the use of inhaled NO has been an effective therapy during this pandemic since the ventilation-perfusion ratio in COVID-19 patients improved afterwards and they did not require mechanical ventilation. The aim of this mini-review is to summarize relevant actions of NO that could be beneficial in the treatment of COVID-19.
Fabio Luigi Massimo Ricciardolo, Francesca Bertolini, Vitina Carriero, Marieann Högman

2378 related Products with: Nitric oxide's physiologic effects and potential as a therapeutic agent against Covid-19.

10010 plates100 100 100Tests100 plates100 200 assays10010 plates2 x 96 assays100 plates

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#33080551   2020/08/23 To Up

Association of baseline peripheral-blood eosinophil count with immune checkpoint inhibitor-related pneumonitis and clinical outcomes in patients with non-small cell lung cancer receiving immune checkpoint inhibitors.

Immune checkpoint inhibitors (ICIs) have revolutionized the oncologic treatment landscape, but have been accompanied by immune-related adverse events (irAEs). ICI-related pneumonitis (ICI-pneumonitis) is a potentially fatal irAE. However, the risk factors associated with ICI-pneumonitis remain unclear. There is an urgent need to identify risk factors for ICI-pneumonitis using reliable and accessible parameters. Here, we aimed to identify baseline peripheral-blood biomarkers correlated with ICI-pneumonitis and clinical outcomes in patients with advanced non-small cell lung cancer (NSCLC) who were treated with ICIs.
Xiangling Chu, Jing Zhao, Juan Zhou, Fei Zhou, Tao Jiang, Sen Jiang, Xiwen Sun, Xiaofang You, Fengying Fengying, Shengxiang Ren, Caicun Zhou, Chunxia Su

2556 related Products with: Association of baseline peripheral-blood eosinophil count with immune checkpoint inhibitor-related pneumonitis and clinical outcomes in patients with non-small cell lung cancer receiving immune checkpoint inhibitors.



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#33080547   2020/10/13 To Up

Antecedent Bile duct cutting in the glissonean pedicle technique (ABC technique) for extremely advanced perihilar cholangiocarcinoma.

In an increasing number of patients undergoing radical surgery for perihilar cholangiocarcinoma [1-3], the intrahepatic bile duct is conventionally transected after the vessels to be preserved or reconstructed are confirmed [3,4]. In patients with extremely advanced perihilar cholangiocarcinoma having massive vascular involvement, it is sometimes difficult to confirm the vessels for reconstruction because of restricted working space and/or anatomical variants, even after liver parenchymal dissection [4]. When the vessels cannot be confirmed, the tumor is usually unresectable [4].
Junichi Yoshikawa, Yutaro Kato, Atsushi Sugioka, Ichiro Uyama

2655 related Products with: Antecedent Bile duct cutting in the glissonean pedicle technique (ABC technique) for extremely advanced perihilar cholangiocarcinoma.

100 μg100 μg100 μg

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#33080545   2020/10/07 To Up

HSP90 expression and early recurrence in gastroenteropancreatic neuroendocrine tumors: Potential for a novel therapeutic target.

Heat shock protein (HSP)-90 promotes tumor growth and is overexpressed in many malignancies. HSP90 expression profile and its potential as a therapeutic target in primary and metastatic neuroendocrine tumors (NETs) are not known.
Adriana C Gamboa, Cecilia G Ethun, Lauren M Postlewait, Alexandra G Lopez-Aguiar, Kristen Zhelnin, Alyssa Krasinskas, Bassel F El-Rayes, Maria C Russell, David A Kooby, Charles A Staley, Kenneth Cardona, Shishir K Maithel

2823 related Products with: HSP90 expression and early recurrence in gastroenteropancreatic neuroendocrine tumors: Potential for a novel therapeutic target.

50ul (1mg/ml)1 ml0.1 mg1 LITRE0.1ml0.1ml1 Set0.1ml (1mg/ml)

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