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#35045574   2022/01/19 To Up

Safety-related outcomes of novel mRNA COVID-19 vaccines in pregnancy.

To describe the safety profile and demographic data for a cohort of pregnant individuals who received an mRNA COVID-19 vaccine.
Angela Nakahara, Joseph Biggio, Ardem Elmayan, Frank B Williams

2356 related Products with: Safety-related outcomes of novel mRNA COVID-19 vaccines in pregnancy.

2 Pieces/Box2 Pieces/Box2 Pieces/Box5 mg2 Pieces/Box2 Pieces/Box100 μg100ug Lyophilized100 μg1 Set

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#35045551   2022/01/17 To Up

Dosimetry in Lu-177-PSMA-617 prostate-specific membrane antigen targeted radioligand therapy: a systematic review.

177Lu-prostate-specific membrane antigen (PSMA) gained popularity as a choice of agent in the treatment of patients with advanced prostate cancer or metastatic castration-resistant stage of prostate carcinoma (mCRPC) diseases. However, this treatment may cause fatal effects, probably due to unintended irradiation of normal organs. We performed an extensive systematic review to assess the organs at risk and the absorbed dose received by tumor lesions in 177Lu-PSMA therapy.
Amit Nautiyal, Ashish K Jha, Sneha Mithun, Venkatesh Rangarajan

1652 related Products with: Dosimetry in Lu-177-PSMA-617 prostate-specific membrane antigen targeted radioligand therapy: a systematic review.

100 4 Membranes/Box4 Membranes/Box4 Membranes/Box 25 ml Ready-to-use 4 Membranes/Box4 Membranes/Box4 Membranes/Box1 kit(96 Wells)4 Membranes/Box 25 ml Ready-to-use

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#35045548   2022/01/17 To Up

Development of neutron-activated samarium-153-loaded polystyrene microspheres as a potential theranostic agent for hepatic radioembolization.

Hepatic radioembolization is an effective minimally invasive treatment for primary and metastatic liver cancers. Yttrium-90 [90Y]-labelled resin or glass beads are typically used as the radioembolic agent for this treatment; however, these are not readily available in many countries. In this study, novel samarium-153 oxide-loaded polystyrene ([153Sm]Sm2O3-PS) microspheres were developed as a potential alternative to 90Y microspheres for hepatic radioembolization.
Hun Yee Tan, Yin How Wong, Azahari Kasbollah, Mohammad Nazri Md Shah, Basri Johan Jeet Abdullah, Alan Christopher Perkins, Chai Hong Yeong

2949 related Products with: Development of neutron-activated samarium-153-loaded polystyrene microspheres as a potential theranostic agent for hepatic radioembolization.

10 plates96 Tests1 kit50 assays100 assays0.1ml (1mg/ml)1 kit100 plates1 kit

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#35045526   2022/01/17 To Up

Growth arrest-specific 5 lncRNA as a valuable biomarker of chemoresistance in osteosarcoma.

Osteosarcoma is the most common primary malignant bone tumour in children and teenagers, and it is characterised by drug resistance and high metastatic potential. Increasing studies have highlighted the critical roles of long noncoding RNAs (lncRNAs) as oncogenes or tumour suppressors as well as new biomarkers and therapeutic targets in osteosarcoma. The growth arrestspecific 5 (GAS5) lncRNA can function as a tumour suppressor in several cancers. The present study aimed to validate GAS5 and other chemoresistanceassociated lncRNAs as biomarkers in a cohort of primary osteosarcoma samples, to obtain predictive information on resistance or sensitivity to treatment. The GAS5 and a panel of lncRNAs related to chemoresistance [SNGH1, FOXD2-AS1, deleted in lymphocytic leukemia (DLEU2) and LINC00963] were evaluated in a cohort of osteosarcoma patients enrolled at the Careggi University Hospital. Total RNA was extracted from formalin-fixed paraffin-embedded (FFPE) tissue sections and the expression levels of the lncRNAs were quantified by qPCR. A bioinformatic analysis on deposited RNA-seq data was performed to validate the qPCR results. Clustering analysis shows that GAS5 could be linked to the expression of isoforms 02 and 04 of the lncRNA DLEU2, whereas the DLEU2 isoform 08 is linked to the lncRNA LINC00963. We found that GAS5 is significantly increased in patients with a good prognosis and is expressed differently between chemosensitive and chemoresistant osteosarcoma patients. However, the results obtained are not concordant with the in-silico analysis performed on the TARGET osteosarcoma dataset. In the future, we would enlarge the case series, including different disease settings.
Simone Polvani, Filippo Martignano, Guido Scoccianti, Adriano Pasqui, Anna Rita Palomba, Silvo Conticello, Andrea Galli, Ilaria Palchetti, Chiara Caporalini, Lorenzo Antonuzzo, Domenico Andrea Campanacci, Serena Pillozzi

2803 related Products with: Growth arrest-specific 5 lncRNA as a valuable biomarker of chemoresistance in osteosarcoma.

50ug50ug2 Pieces/Box400Tests100.00 ug0.1ml (1mg/ml)4 Membranes/Box2 Pieces/Box96 samples100 mg4 Membranes/Box

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#35045525   2022/01/17 To Up

Lidocaine hampers colorectal cancer process via circITFG2/miR-1204/SOCS2 axis.

Colorectal cancer (CRC) is a deadly disease with a poor prognosis. Lidocaine is preferred by surgical procedures due to the excellent anesthesia. Circular RNA integrin alpha FG-GAP repeat containing 2 (circITFG2) has been recognized as a momentous participator in CRC progression. The specific role of circITFG2 was further studied in this research.
Huashe Wang, Xuexia Zhang, Yi Li, Yanan Li, Ting Pang

2444 related Products with: Lidocaine hampers colorectal cancer process via circITFG2/miR-1204/SOCS2 axis.

Each1 kit(96 Wells)

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#35045465   // To Up

[Prognostic Analysis of Colorectal Cancer Patients by the Controlling Nutritional Status(CONUT)Score].

We examined the controlling nutritional status(CONUT)score and the long-term prognosis of colorectal cancer surgery cases. We retrospectively examined the prognosis of colorectal cancer patients who underwent surgery between January 2013 and December 2015. We targeted 449 patients who were able to calculate the CONUT score. A total of 266 patients (59.2%)had normal nutritional status(1 or less)and 183 patients(40.8%)had mildly poor or worse nutritional status (2 or more). The CONUT score was calculated through preoperative blood tests. The relationship between the CONUT score and overall survival was examined in the low and high groups. Overall survival was significantly shorter in the high group but relapse-free survival did not differ significantly between the 2 groups. There was no difference in cancer-specific survival between the 2 groups, but the survival time due to death from other diseases was significantly shorter in the high group. The CONUT score obtained from preoperative blood sampling suggested that the overall survival time was short in the malnourished group, and that it could be used as an index of prognosis due to death from other diseases.
Yasuhiro Fukui, Naoki Aomatsu, Kayo Sai, Ryoko Naka, Shigeaki Kurihara, Kenji Kuroda, Junya Nishimura, Katsunobu Sakurai, Takafumi Nishii, Akiko Tachimori, Yutaka Tamamori, Naoshi Kubo, Sadatoshi Shimizu, Akishige Kanazawa, Kiyoshi Maeda

1623 related Products with: [Prognostic Analysis of Colorectal Cancer Patients by the Controlling Nutritional Status(CONUT)Score].

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#35045421   2022/01/19 To Up

Osilodrostat for Cushing disease and its role in pediatrics.

Cushing disease is a very rare form of hypercortisolism caused by an adrenocorticotropic hormone-secreting pituitary adenoma. Clinical manifestations of Cushing disease can include central fat accumulation, arterial hypertension, glucose intolerance, skin atrophy with striae, and hypogonadism. Children are frequently diagnosed due to a growth stunt and excessive weight gain while classic cushingoid signs might be initially absent. Other children-specific presentations of Cushing disease are early or delayed puberty and hyperandrogenism in girls.
Urh Groselj, Jaka Sikonja, Tadej Battelino

1782 related Products with: Osilodrostat for Cushing disease and its role in pediatrics.

96 tests1-99 mg/ml/ea price x 2500 tests500 tests 5 G500 tests

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#35045418   2022/01/19 To Up

The Timing of Genital Surgery in Somatic Intersexuality: Surveys of Patients' Preferences.

In recent years, intersex advocates, medical ethicists, and lawmakers have increasingly demanded a delay of genital surgery that is not acutely medically necessary in patients with somatic intersexuality to the age of consent. This study provides a review of published surveys of affected patients' own opinions on this issue. In part with a search of PubMed 2000-2021, ten pertinent surveys of patients were identified: three from the U.S., four from European countries, and one each from Brazil, China, and Malaysia. All were based on samples of clinic patients, most of whom had previously undergone genital surgery. The majority of both XX and XY patients with somatic intersexuality favored early surgery, with somewhat more syndrome-specific variability in XY patients. The available survey data clearly indicate that a mandatory delay of genital surgery in all patients with somatic intersexuality to the age of consent would disregard the wishes of the majority of surveyed patients. A syndrome- and syndrome-severity-specific individualized approach to surgery decisions appears more appropriate.
Heino F L Meyer-Bahlburg

2890 related Products with: The Timing of Genital Surgery in Somatic Intersexuality: Surveys of Patients' Preferences.

1 5 G100 μg

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