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#33249766   2020/11/29 To Up

First expert elicitation of knowledge on drivers of emergence of influenza D in Europe.

The influenza D virus (IDV) was first identified and characterized in 2011. Considering the virus' zoonotic potential, its genome nature (segmented RNA virus), its worldwide circulation in livestock, and its role in bovine respiratory disease, an increased interest is given to IDV. However, few data are available on drivers of emergence of IDV. We first listed fifty possible drivers of emergence of IDV in ruminants and swine. As recently carried out for COVID19 in pets (Saegerman e,t al, 2020b), a scoring system was developed per driver and scientific experts (N = 28) were elicited to: (i) allocate a score to each driver, (ii) weight the drivers scores within each domain and (iii) weight the different domains among themselves. An overall weighted score was calculated per driver; and drivers were ranked in decreasing order. Drivers with comparable likelihoods to play a role in the emergence of IDV in ruminants and swine in Europe were grouped using a regression tree analysis. Finally, the robustness of the expert elicitation was verified. Eight drivers were ranked with the highest probability to play a key role in the emergence of IDV: current species specificity of the causing agent of the disease; influence of (il)legal movements of live animals (ruminants, swine) from neighbouring/European Union member states and from Third countries for the disease to (re-)emerge in a given country; detection of emergence; current knowledge of the pathogen; vaccine availability; animal density; and transport vehicles of live animals. As there is still limited scientific knowledge on the topic, expert elicitation of knowledge and multi-criteria decision analysis, in addition to clustering and sensitivity analyses, are very important to prioritize future studies, starting from the top eight drivers. The present methodology could be applied to other emerging animal diseases.
Claude Saegerman, Juana Bianchini, Chantal J Snoeck, Ana Moreno, Chiara Chiapponi, Siamak Zohari, Mariette F Ducatez

2342 related Products with: First expert elicitation of knowledge on drivers of emergence of influenza D in Europe.

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#33249714   2020/11/29 To Up

Which Inflammatory Marker is more reliable in Diagnosing Acute Septic Arthritis in Pediatric Population?

The present study aimed to investigate the levels of C-reactive protein (CRP), white blood cell (WBC), erythrocyte sedimentation rate (ESR), neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR) as possible indirect inflammatory markers in children with septic arthritis (SA) for diagnosis.
Serkan Bayram, Fuat Bilgili, Doğan Kiral, Taha Furkan Yağci, Ahmet Müçteba Yildirim, Mehmet Demirel

2054 related Products with: Which Inflammatory Marker is more reliable in Diagnosing Acute Septic Arthritis in Pediatric Population?

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#33249692   2020/11/29 To Up

Downregulation of DUSP6, a negative regulator of oncogenic ERK signaling, by ACA-28 induces apoptosis in NIH/3T3 cells overexpressing HER2/ErbB2.

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Yuki Kanda, Ayami Mizuno, Teruaki Takasaki, Ryosuke Satoh, Kanako Hagihara, Takashi Masuko, Yuichi Endo, Genzoh Tanabe, Reiko Sugiura

1990 related Products with: Downregulation of DUSP6, a negative regulator of oncogenic ERK signaling, by ACA-28 induces apoptosis in NIH/3T3 cells overexpressing HER2/ErbB2.

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#33249643   2020/11/29 To Up

Impact of genetic and pharmacologic inhibition of myostatin in a murine model of osteogenesis imperfecta.

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Catherine L Omosule, Victoria L Gremminger, Ashley M Aguillard, Youngjae Jeong, Emily N Harrelson, Lawrence Miloscio, Jason Mastaitis, Ashique Rafique, Sandra Kleiner, Ferris M Pfeiffer, Anqing Zhang, Laura C Schulz, Charlotte L Phillips

1577 related Products with: Impact of genetic and pharmacologic inhibition of myostatin in a murine model of osteogenesis imperfecta.

48 assays 0.1ml (1mg/ml)96 assays 48 assays 48 samples 5 G96 assays 48 assays48 assays 96 assays

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#33249617   2020/11/28 To Up

Ferritin as a key risk factor for nonalcoholic fatty liver disease in children with obesity.

The association between serum ferritin and nonalcoholic fatty liver disease (NAFLD) in children with obesity is not clear. This study was designed to investigate whether serum ferritin can be an independent predictor for NAFLD.
Junfeng Zhang, Jiajia Cao, Hui Xu, Guanping Dong, Ke Huang, Wei Wu, Jingjing Ye, Junfen Fu

1601 related Products with: Ferritin as a key risk factor for nonalcoholic fatty liver disease in children with obesity.

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#33249535   2020/11/28 To Up

Perceptual Assessment and Acoustic Voice Analysis as Screening Tests for Vocal Fold Paresis After Thyroid or Parathyroid Surgery.

The aim of this study was to evaluate the reliability of clinician-based perceptual assessment of voice and computerized acoustic voice analysis as screening tests for vocal fold paresis or paralysis (VFP) after thyroid and parathyroid surgery.
Maria Heikkinen, Elina Penttilä, Mari Qvarnström, Kimmo Mäkinen, Heikki Löppönen, Jussi M Kärkkäinen

1112 related Products with: Perceptual Assessment and Acoustic Voice Analysis as Screening Tests for Vocal Fold Paresis After Thyroid or Parathyroid Surgery.

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#33249523   2020/11/28 To Up

Endobronchial Ultrasound Improves Evaluation of Recurrent Laryngeal Nerve Lymph Nodes in Esophageal Squamous Cell Carcinoma Patients.

The bilateral recurrent laryngeal nerve (RLN) lymph nodes are the most common metastatic site for esophageal squamous cell carcinoma (ESCC); however, the RLNs are susceptible to injury during dissection. Clinically, there is an urgent need to determine an effective diagnostic method for RLN nodes to help achieve selective nodal dissection and avoid potential serious complications by performing more conservative surgery for those with nonmetastatic nodes. Here, we innovatively applied endobronchial ultrasonography (EBUS) and investigated its diagnostic performance for preoperative evaluation of RLN nodes in ESCC patients.
Xiayu Fu, Feixiang Wang, Xiaodong Su, Guangyu Luo, Peng Lin, Tiehua Rong, Guoliang Xu, Rong Zhang, Xinye Wang, Yaobin Lin, Jianhua Fu, Xu Zhang

2070 related Products with: Endobronchial Ultrasound Improves Evaluation of Recurrent Laryngeal Nerve Lymph Nodes in Esophageal Squamous Cell Carcinoma Patients.



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#33249518   2020/11/29 To Up

Improved detection of sentinel lymph node metastases allows reliable intraoperative identification of patients with extended axillary lymph node involvement in early breast cancer.

An improved procedure that allows accurate detection of negative sentinel lymph node (SLN) and of SLN macrometastases during surgery would be highly desirable in order to protect patients from further surgery and to avoid unnecessary costs. We evaluated the accuracy of an intraoperative procedure that combines touch imprint cytology (TIC) and subsequent frozen section (FS) analysis. 2276 SLNs from 1072 patients with clinical node-negative early breast cancer were evaluated during surgery using TIC. Only cytologically-positive SLN were subsequently analysed with a single FS, preserving cytologically-negative SLN for the final postoperative histological diagnosis. Sensitivity, specificity and the accuracy of this approach were analysed by comparing the results from intra- and postoperative SLN and axillary node evaluation. This intraoperative method displayed 100% specificity for SLN metastases and was significantly more sensitive for prognostically relevant macrometastases (85%) than for micrometastases (10%). Sensitivity was highest for patients with two or more positive LNs (96%) than for those with only one (72%). 98% of the patients with final pN2a-pN3a were already identified during surgery. Patients who received primary axillary lymph node dissection had significantly more frequent metastases in further LNs (44.6%). Sensitivity was highest for patients with luminal-B, HER2+ and triple negative breast cancer and for any subtype if Ki-67 > 40%. TIC and subsequent FS of cytologically-positive SLNs is highly reliable for detection of SLN macrometastases, and allows accurate identification of patients with a high risk of extended axillary involvement during surgery, as well as accurate histological diagnosis of negative SLN.
Cristina L Cotarelo, Annemarie Zschöck-Manus, Marcus Schmidt, Arno Schad, Christoph Brochhausen, Charles James Kirkpatrick, Sonja Thaler

2861 related Products with: Improved detection of sentinel lymph node metastases allows reliable intraoperative identification of patients with extended axillary lymph node involvement in early breast cancer.



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#33249470   2020/11/29 To Up

Identifying the best questions for rapid screening of secondhand smoke exposure among children.

Many children suffer from secondhand smoke exposure (SHSe), which leads to a variety of negative health consequences. However, there is no consensus on how clinicians can best query parents for possible SHSe among children. We employed a data-driven approach to create an efficient screening tool for clinicians to quickly and correctly identify children at risk for SHSe.
Albert J Ksinan, Yaou Sheng, Elizabeth K Do, Julia C Schechter, Junfeng Jim Zhang, Rachel L Maguire, Cathrine Hoyo, Susan K Murphy, Scott H Kollins, Bruce Rubin, Bernard F Fuemmeler

1551 related Products with: Identifying the best questions for rapid screening of secondhand smoke exposure among children.

400Tests1T x 10/Kit 1 G100ug 2x5L 96 Tests 50 IU 100 G0.25 mg

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#33249469   2020/11/29 To Up

Vitamin D-regulated gene expression profiles: species-specificity and cell-specific effects on metabolism and immunity.

Vitamin D has pleiotropic physiological actions including immune system regulation, in addition to its classical role in calcium homeostasis. Hormonal 1,25-dihydroxyvitamin D (1,25D) signals through the nuclear vitamin D receptor, and large-scale expression profiling has provided numerous insights into its diverse physiological roles. To obtain a comprehensive picture of vitamin D signaling, we analyzed raw data from 94 (80 human, 14 mouse) expression profiles of genes regulated by 1,25D or its analogs. This identified several thousand distinct genes directly or indirectly up- or downregulated in a highly cell-specific manner in human cells using a 1.5-fold cut-off. There was significant overlap of biological processes regulated in human and mouse but minimal intersection between genes regulated in each species. Disease ontology clustering confirmed roles for 1,25D in immune homeostasis in several human cell types, and analysis of canonical pathways revealed novel and cell-specific roles of vitamin D in innate immunity. This included cell-specific regulation of several components of NOD-like pattern recognition receptor signaling, and metabolic events controlling innate immune responses. Notably, 1,25D selectively enhanced catabolism of branched-chain amino acids (BCAAs) in monocytic cells. BCAA levels regulate the major metabolic kinase mTOR, and pretreatment with 1,25D suppressed BCAA-dependent activation of mTOR signaling. Furthermore, ablation of BCAT1 expression in monocytic cells blocked 1,25D-induced increases in autophagy marker LAMP1. In conclusion, the data generated represents a powerful tool to further understand the diverse physiological roles of vitamin D signaling and provides multiple insights into mechanisms of innate immune regulation by 1,25D.
Vassil Dimitrov, Camille Barbier, Aiten Ismailova, Yifei Wang, Katy Dmowski, Reyhaneh Salehi-Tabar, Babak Memari, Emilie Groulx-Boivin, John H White

2268 related Products with: Vitamin D-regulated gene expression profiles: species-specificity and cell-specific effects on metabolism and immunity.

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