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#32947386   2020/09/16 To Up

Inflammatory induced astigmatism: acute changes in corneal curvature secondary to marginal keratitis and previous mitomycin-C treatment.

A 52-year-old man presented with left eye redness, blurred vision, and photophobia. Previous history included marginal keratitis and conjunctival squamous cell carcinoma treated with excision and topical MMC. Examination revealed current marginal keratitis, managed with topical antibiotic and corticosteroid. Regular assessments included high-resolution optical coherence corneal tomography, refraction, and blood tests to exclude other causes of peripheral infiltrate and thinning. Two weeks later visual acuity (VA) decreased and astigmatism increased. Significant refractive instability with astigmatism increased to 5.25 diopters with a corresponding decrease in VA. After 4 months of topical treatment, the marginal keratitis, astigmatism, and change in VA resolved. To the authors' knowledge, this is the first case report to describe an induced, and fluctuating high-magnitude corneal astigmatic change in response to marginal keratitis.
Ruhella R Hossain, James McKelvie

2310 related Products with: Inflammatory induced astigmatism: acute changes in corneal curvature secondary to marginal keratitis and previous mitomycin-C treatment.

500 gm.0.1 mg50 ul5ug100ug2ug2ug2ug96 assays 1 G

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#32947332   2020/09/17 To Up

A Novel Ciliated, Mucin-producing Variant of HPV-related Cervical Adenosquamous Carcinoma In Situ: A Case Report.

Uterine cervical adenosquamous carcinoma in situ was originally defined as having either a uniform population of cells with features intermediate in appearance between glandular and squamous cells, or a mixture of distinct glandular and squamous components within a single lesion. The former type would likely be reclassified today as stratified mucin-producing intraepithelial lesion, while the latter type is vanishingly rare. Here, we report a novel case of bona fide adenosquamous carcinoma in situ, which exhibits 2 morphologically and immunophenotypically distinct components: (1) an inner glandular component composed of a single layer of p40-negative, ciliated, mucin-producing dysplastic columnar cells and (2) an outer p40-positive, stratified dysplastic squamous component otherwise identical to cervical intraepithelial neoplasia-3. Both components show block-positive staining for p16 and are positive for high-risk human papillomavirus RNA by in situ hybridization. Our finding expands the histological spectrum of human papillomavirus-associated preinvasive cervical lesions while also providing further evidence that human papillomavirus-driven processes can exhibit ciliated morphology.
Jin Xu, Kay J Park, Paul Weisman

1978 related Products with: A Novel Ciliated, Mucin-producing Variant of HPV-related Cervical Adenosquamous Carcinoma In Situ: A Case Report.



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#32947298   2020/09/15 To Up

Cancer of the Vulva: A Review.

Vulvar cancers, although rare, are becoming an increasingly serious threat to women's health. Cancer of the vulva accounted for 0.3% of all new cancers in the United States in 2019, with 6,070 newly diagnosed cases. This review details the epidemiology, pathogenesis, diagnosis, staging, and treatment of vulvar malignancies.
Basia M Michalski, John D Pfeifer, David Mutch, M Laurin Council

2983 related Products with: Cancer of the Vulva: A Review.

100ul

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#32947166   2020/09/09 To Up

Combined treatment with acetazolamide and cisplatin enhances the chemosensitivity of human head and neck squamous cell carcinoma TU868 cells.

To investigate whether combination of acetazolamide and cisplatin can enhance the chemosensitivity of human head and neck squamous cell carcinoma (HNSCC) cell line TU868.
Tao Jia, Sen-Xiang Ming, Qing-Qing Cao, Feng-Lei Xu

2852 related Products with: Combined treatment with acetazolamide and cisplatin enhances the chemosensitivity of human head and neck squamous cell carcinoma TU868 cells.

96tests96tests200 1.00 flask1.00 flask1.00 flask100 ug/vial0.1 mg

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#32947165   2020/09/10 To Up

Biological role of epithelial-mesenchymal-transition-inducing transcription factors in head and neck squamous cell carcinoma: A systematic review.

The aim of this systematic review was to explore the biological functions and mechanisms of epithelial-mesenchymal transition-inducing transcription factors in head and neck squamous cell carcinoma-derived cell lines. In addition, we analyzed the possible usefulness of epithelial-mesenchymal transition-inducing transcription factors as a future therapeutic target.
Everton Freitas de Morais, Larissa Santos Amaral Rolim, Dennys Ramon de Melo Fernandes Almeida, Hannah Gil de Farias Morais, Lélia Batista de Souza, Roseana de Almeida Freitas

1334 related Products with: Biological role of epithelial-mesenchymal-transition-inducing transcription factors in head and neck squamous cell carcinoma: A systematic review.

100ug Lyophilized

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#32946785   // To Up

Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma.


Andrew L Ji, Adam J Rubin, Kim Thrane, Sizun Jiang, David L Reynolds, Robin M Meyers, Margaret G Guo, Benson M George, Annelie Mollbrink, Joseph Bergenstråhle, Ludvig Larsson, Yunhao Bai, Bokai Zhu, Aparna Bhaduri, Jordan M Meyers, Xavier Rovira-Clavé, S Tyler Hollmig, Sumaira Z Aasi, Garry P Nolan, Joakim Lundeberg, Paul A Khavari

1821 related Products with: Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma.

96tests96tests

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#32946621   2020/09/18 To Up

Supraglottic Carcinoma in Intravenous Opioid Drug Abusers: A Distinct Disease with Improved Survival.

Recent evidence indicates an increased prevalence of intravenous opioid drug abusers (IVDAs) among supraglottic squamous cell carcinoma (SG-SCC) patients. This study investigates whether the clinical course of SG-SCC in IVDA differs from SG-SCC in non-IVDA.
Dan Yaniv, Yonatan Reuven, Yonatan Lahav, Oded Cohen, Yaniv Hamzany, Assaf Moore, Olga G Rapana, Natan Argaman, Doron Halperin, Aron Popovtzer, Gideon Bachar, Hagit Shoffel-Havakuk

2787 related Products with: Supraglottic Carcinoma in Intravenous Opioid Drug Abusers: A Distinct Disease with Improved Survival.

100 assays100 assays

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#32946026   2020/09/19 To Up

Ussing Chamber Methods to Study the Esophageal Epithelial Barrier.

The Ussing chamber was developed in 1949 by Hans Ussing and quickly became a powerful tool to study ion and solute transport in epithelia. The chamber has two compartments strictly separating the apical and basolateral sides of the tissue under study. The two sides of the tissue are connected via electrodes to a modified electrometer/pulse generator that allows measurement of electrical parameters, namely, transepithelial voltage, current, and resistance. Simultaneously, permeability of the tissue to specific solutes or markers can be monitored by using tracers or isotopes to measure transport from one side of the tissue to the other. In this chapter, we will describe the use of the Ussing chamber to study the barrier properties of the mouse esophageal epithelium. We will also briefly describe the use of the modified Ussing chamber to simultaneously study transepithelial and cellular electrophysiology in the rabbit esophageal epithelium. Lastly, we will cover the use of the Ussing chamber to study bicarbonate secretion in the pig esophagus. These examples highlight the versatility of the Ussing chamber technique in investigating the physiology and pathophysiology of epithelia including human biopsies.
Solange M Abdulnour-Nakhoul, Nazih L Nakhoul

2726 related Products with: Ussing Chamber Methods to Study the Esophageal Epithelial Barrier.

25 G100.00 ul1 mg11 module1 mg1 module

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