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Higher Postdialysis Lactic Acid Is Associated with Postdialysis Fatigue in Maintenance of Hemodialysis Patients.Postdialysis fatigue (PDF) is not an unusual symptom among hemodialysis (HD) patients; however, its causes remain unclear. The aim of this study was to analyze the factors responsible for PDF in maintenance HD patients.
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Effect of L-Carnitine on Amino Acid Metabolism in Elderly Patients Undergoing Regular Hemodialysis.Among patients regularly undergoing hemodialysis, hypocarnitinaemia often develops as a consequence of inadequate dietary intake, reduced synthesis in the body, and considerable losses during hemodialysis.
2391 related Products with: Effect of L-Carnitine on Amino Acid Metabolism in Elderly Patients Undergoing Regular Hemodialysis.11 (4,4 difluoro 5,7 dime N-Benzyloxycarbonyl Amino 3-Aminopicolinic Acid C6H 2 Amino 6 fluorobenzoic a 4-Amino-2-ethoxy-5-nitrob N-[[4-[[(4-Amino[1,1'-bip (R,S)-α-Amino-3-hydroxy- ε-Aminocaproic Acid Hydr 2 Amino 5 methoxybenzoic 9-(4’-Aminophenyl)-9H-p α-[(Aminocarbonyl)thio]- MEM Amino Acid Concentrat
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Home-based evaluation of executive function (Home-MET) for older adults with mild cognitive impairment.Executive function helps older adults maintain their activities of daily living by making plans, setting goals, and carrying them out successfully. It is important for their independence in community living.
1739 related Products with: Home-based evaluation of executive function (Home-MET) for older adults with mild cognitive impairment.MarkerGeneTM Fluorescent Calcium Home Test Human Mouse Rat Phospho-E Active human tPA function Cellufine Formyl Media Human Phospho-Stat 5 (Y69 Active Rabbit tPA Functio (5Z)-7-[(5-Acetyloxy-2-fo Bone Morphogenetic Protei Anti ADAM 12 (A Disintigr 4 (4 Formyl 3,5 dimethoxy Protein A (Liquid form)
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Ex Vivo Expanded 3D Human Kidney Spheres Engraft Long Term and Repair Chronic Renal Injury in Mice.End-stage renal disease is a worldwide epidemic requiring renal replacement therapy. Harvesting tissue from failing kidneys and autotransplantation of tissue progenitors could theoretically delay the need for dialysis. Here we use healthy and end-stage human adult kidneys to robustly expand proliferative kidney epithelial cells and establish 3D kidney epithelial cultures termed "nephrospheres." Formation of nephrospheres reestablishes renal identity and function in primary cultures. Transplantation into NOD/SCID mice shows that nephrospheres restore self-organogenetic properties lost in monolayer cultures, allowing long-term engraftment as tubular structures, potentially adding nephron segments and demonstrating self-organization as critical to survival. Furthermore, long-term tubular engraftment of nephrospheres is functionally beneficial in murine models of chronic kidney disease. Remarkably, nephrospheres inhibit pro-fibrotic collagen production in cultured fibroblasts via paracrine modulation, while transplanted nephrospheres induce transcriptional signatures of proliferation and release from quiescence, suggesting re-activation of endogenous repair. These data support the use of human nephrospheres for renal cell therapy.
2740 related Products with: Ex Vivo Expanded 3D Human Kidney Spheres Engraft Long Term and Repair Chronic Renal Injury in Mice.Human Kidney injury molec Goat Anti-Human GCNT3 (aa Goat Anti-Human Tissue Fa Goat Anti-Human Androgen Goat Anti-Human ACOX2, (i Goat Anti-Human TGM2, (in Goat Anti-Human FMR1, (in Goat Anti-Human, Mouse In Goat Anti-Human AOC3, (in Goat Anti-Human CES1, (in Goat Anti-Human INADL PAT Goat Anti-Human GAB2, (in
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Lack of association between amino acid sequences of the bovine leukemia virus envelope and varying stages of infection in dairy cattle.We collected 724 blood samples from dairy cattle from six Mexican states, and tested them for the presence of antibodies against BLV using a commercial ELISA test. Our study groups consisted of 32 samples: 12 asymptomatic cows, 12 cows with lymphocytosis and 8 samples of tumor tissue of the abomasum and heart of cattle with lymphoma. We designed three pairs of primers to amplify the complete BLV env gene, and obtained a fragment of 1548 nucleotides in length with the sequenced products. According to the phylogenetic tree we constructed to identify the viral genotype, 96.87% of the sequences grouped into genotype 1, while a single sample from a cow with lymphocytosis (3.13%) was associated with genotype 3 sequences. The similarity between the Mexican BLV sequences ranged from 0.985 to 1.00. In addition, the proportion of non-synonymous and synonymous mutations indicated negative selection. We did not identify any conserved residues in the viral protein sequences that could be related to BLV infection stage in cattle. Proviral quantification was performed using quantitative polymerase chain reaction, and we used Mood´s median test as statistical analysis. We found no significant association between proviral load and phase of infection. The sequences showed high similarity without any association between BLV surface glycoprotein and the different infection stages, nor differences in the proviral load. BLV genotype 1 was identified as prevalent in the studied samples, and for the first time in Mexico, we identified BLV genotype 3 in cattle.
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IMPACT OF TYPE 2 DIABETES ON NONALCOHOLIC STEATOHEPATITIS AND ADVANCED FIBROSIS IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE.Type 2 diabetes mellitus (T2DM) is a risk factor for nonalcoholic fatty liver disease (NAFLD). The aim of this study was to investigate the effect of T2DM on nonalcoholic steatohepatitis (NASH) and advanced fibrosis. A total of 221NAFLD patients who had undergone a liver biopsy were included in this study. Subjects were divided into a non-T2DM group and a T2DM group based on glycemic control. NASH was diagnosed by the joint presence of steatosis, ballooning and lobular inflammation. The steatosis, activity and fibrosis score (SAF) and NAFLD activity score (NAS) were used to evaluate the severity of NAFLD. The severity of liver fibrosis was evaluated based on the fibrosis stage. The total percentagesof NASH and advanced fibrosis in this study were 95.0% and 50.2%, respectively. The percentages of NASH and advanced fibrosis in NAFLD patients with T2DM were 96.1% and56.5%, respectively, which were higher than those in the non-T2DM group. SAF (especially activity and fibrosis stage) and NAS (especially ballooning) were higher in NAFLD patients with T2DM than in NAFLD patients without T2DM. Glycemic control and insulin resistance were positively associated with SAF, NAS, and fibrosis stage. Additionally, T2DM elevated the risk of a high NAS and advanced fibrosis. T2DM increases the risk of serious NASH and advanced fibrosis in patients with NAFLD. Liver biopsy can be performed in NAFLD patients with T2DM to confirm the stage of NAFLD. Screening of NASH and advanced fibrosis in NAFLD patients with T2DM is needed.
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EFFECT OF POST-SURGICAL RAI THERAPY ON PARATHYROID FUNCTION IN PATIENTS WITH DIFFERENTIATED THYROID CANCER.Radiotherapy with radioactive iodine (RAI) has become a common treatment for post-surgical differentiated thyroid carcinoma (DTC). The objective of this study was to determine the effect of RAI therapy following surgery on the function of parathyroid glands in DTC patients. A total of 81 DTC patients who received RAI therapy after surgery were enrolled in the study. The size of the residual thyroid was detected by Technetium-99m (Tc)-pertechnetate thyroid scan (Tc thyroid scan) before RAI therapy. The iodine uptake ability of residual thyroid was evaluated by iodine-131 (I) whole-body scan (WBS). All patients were treated with an activity of 3.7GBq (100mCi) I. Parathyroid hormone (PTH), serum calcium, phosphorus, and magnesium were evaluated at one day before treatment, one month and three months after. The study found that there was no statistically significant difference in blood PTH level was observed (P > 0.05) between three time points (pre-treatment, one month post-treatment and three months post-treatment). The serum calcium and phosphorus did not change significantly (P > 0.05), but serum magnesium level elevated after treatment (P < 0.05). There were no significant differences between PTH changes and sex, age, scores of Tc thyroid scan, scores of I WBS, T stage and N stage. RAI therapy following surgery did not significantly affect parathyroid function in DTC patients.
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TUMOR SIZE IS AN INDEPENDENT PREDICTOR OF MORTALITY RISK IN DIFFERENTIATED THYROID CANCER PATIENTS WITH T4 DISEASE.The 8th edition of the American Joint Committee on Cancer (AJCC) guideline on the tumor-node-metastasis staging system has been applied in clinical practice for thyroid cancer since 2018. However, using these criteria, a few studies have shown no significant difference between the stage III and IV diseases amongst the differentiated thyroid cancer (DTC) patients. Thus, in the current study we aim to study the underlying reason behind this observation.
1793 related Products with: TUMOR SIZE IS AN INDEPENDENT PREDICTOR OF MORTALITY RISK IN DIFFERENTIATED THYROID CANCER PATIENTS WITH T4 DISEASE.Thyroid cancer and adenom Thyroid cancer tissue arr Ovary disease spectrum (o Rabbit Anti-WT-1 Wilms Tu Rabbit Anti-TNIP2 ABIN2 T Rabbit Anti-Insulin Recep Rabbit Anti-G protein alp Oral squamous cell cancer Uterus cancer tissue arra Rabbit Anti-CD11b Integri Small intestine disease ( Breast cancer tissue arra
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DIABETIC RETINOPATHY, CLASSIFIED USING THE LESION-AWARE DEEP LEARNING SYSTEM, PREDICTS DIABETIC END-STAGE RENAL DISEASE IN CHINESE PATIENTS.To characterize the relationship between diabetic retinopathy (DR) and diabetic nephropathy (DN) in Chinese patients and to determine whether the severity of DR predicts end-stage renal disease (ESRD). Bilateral fundic photographs of 91 Chinese type 2 diabetic patients with biopsy-confirmed DN, not in ESRD stage, were obtained at the time of renal biopsy in this longitudinal study. The baseline severity of DR was determined using the Lesion-aware Deep Learning System (RetinalNET) in an open framework for deep learning and was graded using the Early Treatment Diabetic Retinopathy Study Severity Scale. Cox proportional hazard models were used to estimate the hazard ratio (HR) for the effect of the severity of diabetic retinopathy on ESRD. During a median follow-up of 15 months, 25 patients progressed to ESRD. The severity of retinopathy at the time of biopsy was a prognostic factor for progression to ESRD (HR 2.18, 95% confidence interval (CI) 1.05-4.53, = 0.04). At baseline, more severe retinopathy was associated with poor renal function, and more severe glomerular lesions. However, 30% patients with mild retinopathy and severe glomerular lesions had higher low-density lipoprotein-cholesterol and more severe proteinuria than those with mild glomerular lesions. Additionally, 3% of patients with severe retinopathy and mild glomerular changes were more likely to have had diabetes a long time than those with severe glomerular lesions. Although the severity of DR predicted diabetic ESRD in patients with T2DM and DN, the severities of DR and DN were not always consistent, especially in patients with mild retinopathy or microalbuminuria.
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