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#32746490   2020/08/03 To Up

Botulinum Toxin for Chronic Lateral Epicondylitis (LE).

Lateral epicondylitis is a common disease in orthopaedic practice. Although the majority of cases do not become chronic, patients who do not respond to the initial treatment may suffer from pain in the long term and effective treatment is challenging. The off-label use of botulinum toxin is one of the common potential indications for the substance in orthopaedics and traumatology. In a literature review of 2000 - 2019, eight EBM ≥ level 3 studies evaluating the use of botulinum toxin in lateral epicondylitis were found. Five of these studies evaluated botulinum toxin versus placebo in chronic cases; two other studies compared botulinum toxin with corticosteroids in acute cases and classic Hohmann surgery in chronic cases; the eighth study compared botulinum toxin in two different injection sites and corticosteroids by classic injection. Our findings suggest that the use of this substance may be a treatment option in refractory chronic cases before surgery is indicated. The working group on botulinum toxin in O & T of the International Musculoskeletal Pain Society (IMPS/IGOST) introduced an alternative injection schedule, which combines findings from the recent clinical literature with practical experience in order to reduce the risk of side effects while ensuring treatment effectiveness. Using 2 simple tests of function and, if necessary, sonographic verification, 2 separate injection sites in the extensor carpi radialis or the extensor digitorum can be identified by palpation. The tendon level on the lateral epicondyle acts as the third injection site. With optimal use of the ampoule content, the 3 injection sites can be infiltrated individually, depending on the muscle status. On the one hand, this enables treatment to take place after a dual therapy approach and, on the other hand, the risk of overdose in a muscle with subsequent unnecessary muscle weakening can be reduced.
Stephan Grüner, Axel Schulz, Klaus Schlüter-Brust, Marcela Lippert-Grüner

1603 related Products with: Botulinum Toxin for Chronic Lateral Epicondylitis (LE).

0.25 mg1 mL10 mg100 ug50 ml50 mL1 kit 1 G 2x5L1 mg1 ml

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#32746476   2020/08/03 To Up

Experience with Real-Time Continuous Glucose Monitoring in Newborns with Congenital Hyperinsulinemic Hypoglycemia.

Effective treatment and close monitoring of hypoglycemia in children with congenital hyperinsulinemic hypoglycemia (CHH) is vital to prevent brain damage. The current use of capillary sampling schedules does not provide a comprehensive assessment of glycemic status and fails to detect asymptomatic hypoglycemia episodes.
Ayşe Anık, Münevver Kaynak Türkmen, Abdullah Barış Akcan, Tolga Ünüvar, Sercan Öztürk, Ahmet Anık

1227 related Products with: Experience with Real-Time Continuous Glucose Monitoring in Newborns with Congenital Hyperinsulinemic Hypoglycemia.

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#32746363   2020/05/15 To Up

Bioluminescence Imaging Applications in Cancer: A Comprehensive Review.

Bioluminescence imaging (BLI), an optical preclinical imaging modality, is an invaluable imaging modality due to its low-cost, high throughput, fast acquisition times, and functional imaging capabilities. BLI is being extensively used in the field of cancer imaging, especially with the recent developments in genetic-engineering, stem cell, and gene therapy treatments. The purpose of this paper is to provide a comprehensive review of the principles, developments, and current status of BLI in cancer research. This paper covers the fundamental BLI concepts including BLI reporters and enzyme-substrate systems, data acquisition, and image characteristics. It reviews the studies discussing the use of BLI in cancer research such as imaging tumor-characteristic phenomena including tumorigenesis, metastasis, cancer metabolism, apoptosis, hypoxia, and angiogenesis, and response to cancer therapy treatments including chemotherapy, radiotherapy, immunotherapy, gene therapy, and stem cell therapy. The key advantages and disadvantages of BLI compared to other common imaging modalities are also discussed.
Nour Alsawaftah, Afifa Farooq, Salam Dhou, Amin F Majdalawieh

1768 related Products with: Bioluminescence Imaging Applications in Cancer: A Comprehensive Review.



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#32746186   2020/06/17 To Up

Enabling Real-Time Monitoring of Intrabody Networks through the Acoustic Discovery Architecture.

This paper proposes the first Acoustic Discovery Architecture (ADA) for Intrabody Networks (IN). The main objective of ADA is to discover and interrogate, in Real-Time (RT), all the Implanted Medical Devices (IMDs) that are part of an IN. This permits non-invasive RT diagnosis for patients with multiple IMDs. ADA will allow medical doctors to have vital information, on-the-go, for treating patients and to constantly monitor them. The architecture was implemented in a network simulator emulating a real life IN, based on preliminary experimental results. ADA is in charge of scanning the body volume, by exploiting the beam-forming and beam-steering capability of Piezoelectric Micro-Machined Ultrasonic Transducers (pMUTs) arrays, and efficiently interrogating all the reached devices for their status. As a result, a full IN map can be reconstructed together with all the vital signs of a patient. ADA shows very good RT capabilities, with a full scanning time from 1500ms down to 100ms and energy consumption from 2.6mJ down to 0.2mJ, depending on the scanning accuracy, for a body torso volume of 60x30x20cm3.
Flavius Pop, Bernard Herrera, Cristian Cassella, Matteo Rinaldi

1883 related Products with: Enabling Real-Time Monitoring of Intrabody Networks through the Acoustic Discovery Architecture.

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#32746016   2020/06/05 To Up

Non-contact assessment of peripheral artery haemodynamics using video infrared thermography.

Skin temperature has long been used as a natural indicator of vascular diseases in the extremities. Considerable correlation between oscillations in skin surface temperature and oscillations of skin blood flow has previously been demonstrated. We hypothesised that the impairment of blood flow in stenotic (subcutaneous) peripheral arteries would influence cutaneous temperature such that, by measuring gradients in the temperature distribution over skin surfaces, one may be able to diagnose or quantify the progression of vascular conditions in whose pathogenesis a reduction in subcutaneous blood perfusion plays a critical role (e.g. peripheral artery disease). As proof of principle, this study investigates the local changes in the skin temperature of healthy humans (15 male, 30.0 ± 5.2 years old, BMI 25.1 ± 2.2 kg/m ) undergoing two physical challenges designed to vary their haemodynamic status. Skin temperature was measured in four central regions (forehead, neck, chest, and left shoulder) and four peripheral regions (left upper arm, forearm, wrist, and hand) using an infrared thermal camera. We compare inter-region patterns. Median temperature over the peripheral regions decreased from baseline after both challenges (maximum decrease: -2.09 ± 0.41 °C at 60 s after exercise; p = 0.0001 and -0.58 ± 0.14 °C at 180 s of cold-water immersion; p = 0.0013). Median temperature over the central regions showed no significant changes. Our results show that the non-contact measurement of perfusion-related changes in peripheral temperature from infrared video data is feasible. Further research will be directed towards the thermographic study of patients with symptomatic peripheral vascular disease.
Joao Jorge, Mirae Harford, Mauricio Villarroel, Sitthichok Chaichulee, Shaun Davidson, Eoin Finnegan, Samuel H Clark, John Duncan Young, Peter J Watkinson, Lionel Tarassenko

2252 related Products with: Non-contact assessment of peripheral artery haemodynamics using video infrared thermography.

3x 500 ml1000 units100ug Lyophilized100ug1 mg1mg 5 G1.00 flask100ug Lyophilized2 mL100ug Lyophilized100ug

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#32745997   2020/07/31 To Up

Validity of self-reported cancer: Comparison between self-report versus cancer registry records in the Geelong Osteoporosis Study.

Determining the validity of self-reported data is important. The aim of this study was to assess the validity of self-reported cancer and investigate factors associated with accurate reporting in men and women.
Stephanie P Cowdery, Amanda L Stuart, Julie A Pasco, Michael Berk, David Campbell, Lana J Williams

2932 related Products with: Validity of self-reported cancer: Comparison between self-report versus cancer registry records in the Geelong Osteoporosis Study.



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#32745965   2020/07/31 To Up

KRAS inhibition in non-small cell lung cancer: Past failures, new findings and upcoming challenges.

Despite the high prevalence of Kirsten rat sarcoma (KRAS) mutations in non-small cell lung cancer (NSCLC), for a long time it has been defined as an 'undruggable target', with precision medicine not considered as an adequate approach to treat this subgroup of patients. After several years of efforts, preliminary data from early clinical trials have recently demonstrated that direct pharmacological inhibition of KRAS p.G12C mutation is possible, emerging as an effective targeted treatment for about 10-12% of patients with advanced NSCLC, with potential relevant impact on their long-term survival and quality of life. This review reports the current status of KRAS mutations detection in the Italian real-word scenario, summarises the biological basis of KRAS inhibition in NSCLC and provides an updated overview of therapeutic strategies, discussing the potential reasons for past failures and analysing the upcoming challenges related to the advent of new targeted agents in clinical practice.
Francesco Passiglia, Umberto Malapelle, Marzia Del Re, Luisella Righi, Fabio Pagni, Daniela Furlan, Romano Danesi, Giancarlo Troncone, Silvia Novello

2162 related Products with: KRAS inhibition in non-small cell lung cancer: Past failures, new findings and upcoming challenges.

1.00 flask

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#32745949   2020/07/26 To Up

Deep brain stimulation for the treatment of refractory and super-refractory status epilepticus.

Status epilepticus (SE) and super-refractory status epilepticus (SRSE) are life-threatening medical emergencies. The first-line treatment for SE or SRSE includes i. v. anesthetic agents with respiratory support, AEDs, and steroids. Surgical interventions are indicated if medical treatments fail to abrupt the seizures. Apart from resective epilepsy surgery employed for the treatment of SE and SRSE, deep brain stimulation (DBS) of thalamic nuclei is aimed at directly influencing the brain function.
Michał Sobstyl, Angelika Stapińska-Syniec, Marcin Rylski

1720 related Products with: Deep brain stimulation for the treatment of refractory and super-refractory status epilepticus.

200assays1 ml10 mg96T100ug 125 ml min 2 cartons10 ml 5 G 125 ml

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#32745921   2020/04/08 To Up

Trends in adult patients presenting to pediatric emergency departments.

Adults presenting to pediatric emergency departments (PEDs) include those with complex chronic conditions (CCCs) often still followed by pediatric providers, and those without CCCs (non-CCCs). This paper describes recent trends in adults seen within PEDs, both by age subgroups and CCC status.
Cherisse Mecham, Lucia Mirea, Ryan Bode, Jon McGreevy

2032 related Products with: Trends in adult patients presenting to pediatric emergency departments.

1 mg1 mg96 wells (1 kit) 1 G1mg1 kit100 μg100 mg

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