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#32970055   // To Up

New catalytically active conjugated microporous polymer bearing ordered salen-Cu and porphyrin moieties for Henry reaction in aqueous solution.

A catalytically active conjugated microporous polymer (SP-CMP-Cu) was facilely constructed with condensation polymerization of salen-Cu (salen = N,N'-bis(3-tertbutyl-5-formylsalicylidene) ethylenediamine) and pyrrole. The as-synthesized SP-CMP-Cu was completely characterized by powder X-ray diffraction (PXRD), Fourier transform infrared (FT-IR) spectroscopy, thermogravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS), and energy-dispersive X-ray (EDX) analysis. The morphological features of SP-CMP-Cu were revealed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). According to the N2 adsorption/desorption isotherm, the Brunauer-Emmett-Teller (BET) surface area of SP-CMP-Cu was calculated to be 252 m2 g-1 with a total pore volume of 0.178 cm3 g-1. SP-CMP-Cu exhibited an outstanding catalytic performance for the Henry reaction in aqueous solutions with excellent conversion and good selectivity. Moreover, SP-CMP-Cu can be reused for up to five consecutive runs without any significant loss in its catalytic efficiency.
Xiaoman Sun, Fanyu Meng, Qing Su, Kexin Luo, Pengyao Ju, Ziqian Liu, Xiaodong Li, Guanghua Li, Qiaolin Wu

2057 related Products with: New catalytically active conjugated microporous polymer bearing ordered salen-Cu and porphyrin moieties for Henry reaction in aqueous solution.

2000 Units1000 Units1000 Units250 Units250 Units250 Units100ug100ug Lyophilized100ug Lyophilized 1 G100ug Lyophilized

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#32485968   2020/05/29 To Up

Series of Near-IR-Absorbing Transition Metal Complexes with Redox Active Ligands.

New soluble and intensely near-IR-absorbing transition metal (Ti, Zr, V, Ni) complexes were synthesized using a redox non-innocent ,'-bis(3,5-di-tertbutyl-2-hydroxy-phenyl) -1,2-phenylenediamine (HL) as a ligand precursor. In all the complexes, ([Ti(L), [Zr(L)], [V(L)(HL)] and [Ni(HL)], two organic molecules coordinate to the metal center as tri- or tetradentate ligands. The solid-state structures of the complexes were determined using single crystal XRD, and the compounds were further characterized with Electrospray Ionisation Mass Spectrometry (ESI-MS). Thermoanalytical measurements indicated the thermal stabilities of the complexes. All compounds absorb strongly in the near-IR region and show very interesting magnetic and electrochemical properties. Moreover, it was shown that the V and Ni complexes can also convert absorbed near-IR photons to (un)paired electrons, which indicates great promise in photovoltaic applications.
Esko Salojärvi, Anssi Peuronen, Manu Lahtinen, Hannu Huhtinen, Leonid S Vlasenko, Mika Lastusaari, Ari Lehtonen

1698 related Products with: Series of Near-IR-Absorbing Transition Metal Complexes with Redox Active Ligands.

100μg100μg100 100μg5 ug100ug5 ug0.1 mg5 ug1 unit100ug

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#32057422   2019/11/21 To Up

NMR for screening and a biochemical assay: Identification of new FPPS inhibitors exerting anticancer activity.

Farnesyl pyrophosphate synthase (FPPS) is a crucial enzyme for the synthesis of isoprenoids and the key target of nitrogen-containing bisphosphonates (N-BPs). N-BPs are potent and selective FPPS inhibitors that are used in the treatment of bone-related diseases, but have poor pharmacokinetic properties. Given the key role played by FPPS in many cancer-related pathways and the pharmacokinetic limits of N-BPs, hundreds of molecules have been screened to identify new FPPS inhibitors characterized by improved drug-like properties that are useful for broader therapeutic applications in solid, non-skeletal tumours. We have previously shown that N6-isopentenyladenosine (i6A) and its related compound N6-benzyladenosine (2) exert anti-glioma activity by interfering with the mevalonate pathway and inhibiting FPPS. Here, we report the design and synthesis of a panel of N6-benzyladenosine derivatives (compounds 2a-m) incorporating different chemical moieties on the benzyl ring. Compounds 2a-m show in vitro antiproliferative activity in U87MG glioma cells and, analogous to the bisphosphonate FPPS inhibitors, exhibit immunogenic properties in ex vivo γδ T cells from stimulated peripheral blood mononuclear cells (PBMCs). Using saturation transfer difference (STD) and quantitative H nuclear magnetic resonance (NMR) experiments, we found that 2f, the N6-benzyladenosine analogue that includes a tertbutyl moiety in the para position of the benzyl ring, is endowed with increased FPPS binding and inhibition compared to the parent compounds i6A and 2. N6-benzyladenosine derivatives, characterized by structural features that are significantly different from those of N-BPs, have been confirmed to be promising chemical scaffolds for the development of non N-BP FPPS inhibitors, exerting combined cytotoxic and immunostimulatory activities.
Manuela Grimaldi, Rosario Randino, Elena Ciaglia, Mario Scrima, Michela Buonocore, Ilaria Stillitano, Mario Abate, Verdiana Covelli, Alessandra Tosco, Patrizia Gazzerro, Maurizio Bifulco, Manuela Rodriquez, Anna Maria D'Ursi

1718 related Products with: NMR for screening and a biochemical assay: Identification of new FPPS inhibitors exerting anticancer activity.

400Tests100 assays1 kit100 Tests40 assays100tests1 kit 96 Tests 100 assays1 kit

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#31922239   2020/01/09 To Up

Combining antioxidant astaxantin and cholinesterase inhibitor huperzine A boosts neuroprotection.

Oxidative stress is a pathophysiological condition resulting in neurotoxicity, which is possibly associated with neurodegenerative disorders. In this study, the antioxidative effects of the antioxidant astaxanthin (AXT) in combination with huperzine A (HupA), which is used as a cholinesterase inhibitor for the treatment of Alzheimer's disease, were investigated. PC12 cells were treated with either tert‑butyl hydroperoxide (TBHP), or with the toxic version of β‑amyloid, Aβ25‑35, to induce oxidative stress and neurotoxicity. Cell viability, morphology, lactate dehydrogenase (LDH) release, intracellular accumulation of reactive oxygen species (ROS), superoxide dismutase (SOD) activity and malondialdehyde (MDA) content were determined, while neuroprotection was also monitored using an MTT assay. It was found that combining AXT with HupA significantly increased the viability of PC12 cells, prevented membrane damage (as measured by LDH release), attenuated intracellular ROS formation, increased SOD activity and decreased the level of MDA after TBHP exposure when compared to these drugs administered alone. Pretreatment with HupA and AXT decreased toxic damage produced by Aβ25‑35. These data indicated that combining an antioxidant with a cholinesterase inhibitor increases the degree of neuroprotection; with future investigation this could be a potential therapy used to decrease neurotoxicity in the brain.
Xin Yang, Han-Mei Wei, Guo-Yan Hu, Jun Zhao, Li-Na Long, Chang-Jian Li, Zi-Jun Zhao, He-Kun Zeng, Hong Nie

2048 related Products with: Combining antioxidant astaxantin and cholinesterase inhibitor huperzine A boosts neuroprotection.

1 mg0.1 mg5 mg5mg100ul100 100ul0.1ml (1mg/ml)200 20 100.00 ug1 g

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#31681188   2019/09/27 To Up

From Cyanobacteria to Human, MAPEG-Type Glutathione-S-Transferases Operate in Cell Tolerance to Heat, Cold, and Lipid Peroxidation.

The MAPEG2 sub-family of glutathione-S-transferase proteins (GST) has been poorly investigated , even in prokaryotes such as cyanobacteria the organisms that are regarded as having developed glutathione-dependent enzymes to protect themselves against the reactive oxygen species (ROS) often produced by their powerful photosynthesis. We report the first analysis of a cyanobacterial MAPEG2-like protein (Sll1147) in the model cyanobacterium PCC 6803. While Sll1147 is dispensable to cell growth in standard photo-autotrophic conditions, it plays an important role in the resistance to heat and cold, and to n-butyl hydroperoxide (n-BOOH) that induces lipid peroxidation. These findings suggest that Sll1147 could be involved in membrane fluidity, which is critical for photosynthesis. Attesting its sensitivity to these stresses, the Δ mutant lacking Sll1147 challenged by heat, cold, or n-BOOH undergoes transient accumulation of peroxidized lipids and then of reduced and oxidized glutathione. These results are welcome because little is known concerning the signaling and/or protection mechanisms used by cyanobacteria to cope with heat and cold, two inevitable environmental stresses that limit their growth, and thus their production of biomass for our food chain and of biotechnologically interesting chemicals. Also interestingly, the decreased resistance to heat, cold and n-BOOH of the Δ mutant could be rescued back to normal (wild-type) levels upon the expression of synthetic MAPEG2-encoding human genes adapted to the cyanobacterial codon usage. These synthetic hmGST2 and hmGST3 genes were also able to increase the tolerance to heat and n-BOOH. Collectively, these finding indicate that the activity of the MAPEG2 proteins have been conserved, at least in part, during evolution from (cyano)bacteria to human.
Xavier Kammerscheit, Franck Chauvat, Corinne Cassier-Chauvat

2810 related Products with: From Cyanobacteria to Human, MAPEG-Type Glutathione-S-Transferases Operate in Cell Tolerance to Heat, Cold, and Lipid Peroxidation.

1 kit100 500 gm.1.00 flask100 μg1 kit25 One 96-Well Strip Micropl100

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#31538411   2019/10/21 To Up

tert-Butyl Nitrite (TBN), a Multitasking Reagent in Organic Synthesis.

The upsurge interest in the development of efficient methodologies for the construction of nitrogen-containing frameworks via the use of expedient reagents have been creating a renaissance in contemporary organic chemistry. In this perspective, tertbutyl nitrite (TBN) is an emerging building block. Due to its unique structural features, it shows differential reactivity under different reaction conditions. These diverse reactivities have resulted in the construction of a diverse array of complex N-containing molecules. The primary objective of the present review is to bring the latest findings of TBN in terms of its applications in reactions (oxidation, diazotization, nitrosation, nitration, oximation, N-synthon, and miscellaneous reactions) into the limelight. For simplicity and brevity, reactions in each section are explained with the mechanism of formation and selected examples are given.
Anjali Dahiya, Ashish Kumar Sahoo, Tipu Alam, Bhisma K Patel

2577 related Products with: tert-Butyl Nitrite (TBN), a Multitasking Reagent in Organic Synthesis.

5 G250 mg20 mg5 mg25 mg1 mg10 mg10 mg10 g1 g10 mg25 mg

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#31486264   2019/09/10 To Up

A Temperature-Sensitive Luminescent Ag Nanocluster Supported by TertButyl Thiol Ligands.

Compound [Ag S (StBu) (CF COO) (CO )](CO ) ⋅CH Cl ⋅4CH OH⋅9DMF (1) has been obtained and well defined. It consists of a multi-shell structure involving two Ag centres, one Ag S pentagram, two Ag S pentagons and one Ag S shell. Compound 1 has been characterized by XPS, FT-IR, PXRD, TGA, NMR, MS, UV/Vis spectrum, TEM and cyclic voltammetry. Temperature-sensitive luminescent property of 1 has also been investigated.
Yu-Hui Feng, Xiang-Ling Gao, Ju-Feng Shi, Kun Zhou, Jiu-Yu Ji, Yan-Feng Bi

2072 related Products with: A Temperature-Sensitive Luminescent Ag Nanocluster Supported by TertButyl Thiol Ligands.

100 plates100.00 ug500 g100ug Lyophilized100 μg0.1 mg100ug Lyophilized100ug100ul100ul100ug LyophilizedBox of 20 tubes

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#31151312   2019/05/31 To Up

Identification of a Quality Marker of Vinegar-Processed Curcuma Zedoaria on Oxidative Liver Injury.

Curcuma zedoaria (dry stenophora of Val., S. G. Lee et C. F. Liang, or Y. H. Chen et C.Ling) is a representative herb with clinical effects on liver diseases after being vinegar-processed. The crude Curcuma zedoaria and the processed Curcuma zedoaria (vinegar-boil) have been widely used as mixtures, but their equivalence has not been fully investigated. In this manuscript, quality markers of processed (vinegar-boil) Curcuma zedoaria were investigated by comparison of the compounds and hepatoprotective activities with the crude (three spices) ones. First, GC-MS-based untargeted metabolomics were applied to reveal the discriminatory components and discover potential markers. As a result, a total of six components were identified as potential markers. Then, the hepatoprotective activities were evaluated by dual cell damage models induced by a certain concentration of H2O2 or tertbutyl hydfroperoxide (t-BHP) (55 μM H2O2 or 40 μM t-BHP), which highlighted the potential of the processed Curcuma zedoaria on oxidative stress. Finally, epicurzerenone was identified as its quality marker on oxidative liver injury based on the above results and the cell-based biological assay. Overall, vinegar-processed Curcuma zedoaria was more suitable for the treatment of oxidative liver diseases, and epicurzerenone could be considered as its quality marker.
Herong Cui, Beibei Zhang, Guoping Li, Lei Li, Hongshan Chen, Jinchai Qi, Wenxue Liu, Jing Chen, Penglong Wang, Haimin Lei

2475 related Products with: Identification of a Quality Marker of Vinegar-Processed Curcuma Zedoaria on Oxidative Liver Injury.

50ul0.2 mg1.00 mg100ug100ug

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#31046156   2019/05/27 To Up

Two Types of σ-Allenyl Complexes from Reactions of Silylenes and Germylenes with Chromium Fischer Alkynyl(alkoxy)carbenes.

The reactivity of amidinatotetrylenes of the type E(tBu bzm)R (E=Si, Ge; tBu bzm=N,N'-bis(tertbutyl)benzamidinate; R =alkyl or aryl) with the chromium Fischer alkynylcarbene complexes [Cr{C(OEt)C R }(CO) ] (R =Ph; ferrocenyl, Fc) has been studied. At room temperature, two different reaction pathways have been identified: (a) attack of the amidinatotetrylene to the alkynyl C atom (γ-attack), which leads to σ-allenyl complexes in which the original C atom maintains its attachment to the Cr(CO) and OEt groups (compounds 3 ), and (b) attack of the amidinatotetrylene to the C atom (α-attack), which ends in σ-allenyl complexes in which the original C atom is not attached to the metal atom and has been inserted into an E-N bond of the amidinatotetrylene forming an E-C-N-C-N five-membered ring (compounds 4 ). It has been found that compounds 3 are thermodynamically less stable than their corresponding 4 isomers and that some of the former (E=Ge; R =CH SiMe ) can be transformed into the latter upon heating. At high temperatures (>70 °C) the reactions involving bulky amidinatotetrylenes (R =Mes, tBu) end in the carbene-substitution products [Cr{E(tBu bzm)R }(CO) ].
Javier A Cabeza, Pablo García-Álvarez, Mar Gómez-Gallego, Laura González-Álvarez, Alba D Merinero, Miguel A Sierra

1146 related Products with: Two Types of σ-Allenyl Complexes from Reactions of Silylenes and Germylenes with Chromium Fischer Alkynyl(alkoxy)carbenes.

5 G24 reactions500 reactions200 Reactions96 wells (1 kit)100 reactions4X1.25ml; 200 reactions (UniversALL Extract Buffer100 reactions

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#30825826   2019/02/23 To Up

Synergism of clay with zinc oxide as nanocatalyst for production of biodiesel from marine Ulva lactuca.

In the present work, Ulva lactuca, a marine macroalgae was used for the production of biodiesel. The ultrasound assisted extraction of oil from autoclaved algal biomass was found effective with maximum yield. The maximum oil was extracted at optimal conditions of 5% moisture content of algal biomass, 0.15 mm size of biomass, 6:1 solvent: solid ratio, at 55 °C in 140 min. The n-hexane with co-solvent methyl tertbutyl ether has shown higher oil when compared to other co-solvents. The extracted oil was transesterified into biodiesel using silica doped with zinc oxide as novel heterogeneous nanocatalyst. The maximum biodiesel yield of 97.43% was obtained at optimized conditions of 800 °C calcination temperature, 8% catalyst concentration, 9:1 methanol to oil ratio, 55 °C reaction temperature and 50 min reaction time. The kinetics of the transesterification reaction was also studied. The Ulva lactuca was found as a potential source for biodiesel production.
G Kalavathy, G Baskar

1799 related Products with: Synergism of clay with zinc oxide as nanocatalyst for production of biodiesel from marine Ulva lactuca.

100 assays50 assays100 5 G2.5 mg 1000 ml 100100Tests100 assays 500 ml 250

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