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#33657709   2021/03/03 To Up

Comparative performance of Line Probe Assay (version 2) and Xpert® MTB/RIF assay for early diagnosis of rifampicin resistant pulmonary tuberculosis.

The emergence of drug resistant tuberculosis (TB), is a major menace to cast off TB worldwide. Line probe assay (GenoType MTBDRplus ver. 2) and Xpert® MTB/RIF assays are two rapid molecular TB detection/diagnostic tests.
Raj Narayan Yadav, Binit Kumar Singh, Rohini Sharma, Jigyasa Chaubey, Sanjeev Sinha, Pankaj Jorwal

2936 related Products with: Comparative performance of Line Probe Assay (version 2) and Xpert® MTB/RIF assay for early diagnosis of rifampicin resistant pulmonary tuberculosis.

100 plates10 plates10 plates100 platesFor 2 miRNA probes, each 100 Plates100 assays1,000 tests96 Tests10 plates50 assays

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#33657696   // To Up

[Analysis of five children with acquired thrombotic thrombocytopenic purpura].

To investigate the clinical characteristics, treatment and prognosis of children with acquired thrombotic thrombocytopenic purpura (TTP). The clinical manifestations, laboratory examination, treatment and prognosis of 5 children with acquired TTP hospitalized in Beijing Children's Hospital, Capital Medical University from January 2016 to July 2019 were analyzed retrospectively. There were 5 children with acquired TTP including 2 males and 3 females, with the onset age of 8.9(0.8-14.5) years, while 11 children with TTP in the same period. Thrombocytopenia and microangiopathic hemolytic anemia were found in all 5 patients. Only one patient had typical pentalogy of TTP, 3 patients had nervous system symptoms and 3 patients had fever, while renal impairment was relatively rare (1 case). Laboratory examination showed severe thrombocytopenia (7(4-14) ×10/L) and low level of hemoglobin (70(58-100)g/L) in all 5 children. Blood biochemical examination showed that total bilirubin (mainly indirect bilirubin) increased in 3 patients, lactate dehydrogenase increased in 5 patients, and urea nitrogen increased in 1 patient. Bone marrow smear showed megakaryocyte did not decrease. Plasma ADAMTS13 activity was 0 in all 5 patients while ADAMTS13 inhibitor was positive in 4 patients and negative in 1 patient. All 5 children received glucocorticoid therapy, rituximab was added in the early stage of the disease, and 3 children received plasma exchange. The time of platelet recovery to normal was 19 (9-29) days. One child had TTP recurrence after 9 months of treatment. The condition was stable after being treated with glucocorticoid and rituximab again. This case was finally diagnosed as systemic lupus erythematosus after more than 3 years followed up. By December 1, 2020, the follow-up time was 24(16-57) months.The clinical symptoms of all patients disappeared and the platelet level was stable at 159(125-269) ×10/L. Childhood acquired TTP is relatively rare, which can occur in all age groups. The clinical manifestations are mainly thrombocytopenia and microangiopathic hemolytic anemia, the plasma ADAMTS 13 activity and inhibitor test are helpful for the diagnosis of acquired TTP. Plasma exchange and rituximab are effective treatment. This disease requires long-term follow-up.
L L Fu, J Ma, J Y Ma, Y Y Wei, H Gu, R Zhang, R H Wu

2443 related Products with: [Analysis of five children with acquired thrombotic thrombocytopenic purpura].

15 ml 1 module1 module1 module1 module1 module 1 kit(s) 1 module1 module1 module1 module

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#33657695   // To Up

[Pseudohypoparathyroidism and GNAS gene defects: clinical evaluation and molecular analysis in 20 children].

To analyze the patients' clinical and genetic characteristics with pseudohypoparathyroidism (PHP) and investigate the correlation between clinical phenotypes and genotypes. Twenty PHP patients were ascertained at Children's Hospital Zhejiang University School of Medicine from January 2011 to July 2020. Clinical manifestation, laboratory examination and gene test results were retrospectively analyzed. In these twenty patients, eighteen cases showed resistance to parathyroid hormone (PTH) and thirteen cases had Albright's hereditary osteodystrophy (AHO) phenotype. Gene abnormalities were found in all the twenty PHP patients, which included seven patients with GNAS gene variations (six frameshifts and one missense) and thirteen patients with GNAS gene methylation defects. Moreover, twelve children with both PTH resistance and AHO phenotype were clinically diagnosed as PHP-Ⅰa, meanwhile, seven carried GNAS variations and five had methylation abnormalities with a correct diagnosis of PHP-Ⅰb. Patients with AHO phenotype and PTH resistance may have a high genetic diagnosis rate. Because PHP-Ⅰb clinical phenotype may be similar to PHP-Ⅰa, early genetic detection is required for the differential diagnosis. In addition, children without PTH resistance should also be followed up regularly, which may help the early diagnosis.
X Q Xu, X L Zhou, X F Chen, J N Yuan, Y L Dai, K Huang, G P Dong, W Wu, J F Fu

1053 related Products with: [Pseudohypoparathyroidism and GNAS gene defects: clinical evaluation and molecular analysis in 20 children].

200ul200ul200ug200ug200ul100ug25 mg50 ug

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#33657691   // To Up

[Reference values and growth curves of weight/length, body mass index, and ponderal index of Chinese newborns of different gestational ages].

To establish the reference values and growth curves of weight/length, body mass index, and ponderal index for Chinese newborns with gestational ages of 24 to 42 weeks, in order to provide a reference for the assessment of body proportionality and nutritional status at birth. Cross-sectional study design was applied. From June 2015 to November 2018, a total of 24 375 singleton live birth newborns with gestational ages of 24 to 42 weeks from 13 cities including Beijing, Harbin, Xi'an, Shanghai, Nanjing, Wuhan, Guangzhou, Fuzhou, Kunming, Tianjin, Shenyang, Changsha, and Shenzhen were selected, excluding those impacting the establishment of the reference values. The generalized additive model for location, scale, and shape (GAMLSS) was employed to establish percentile (P, P, P, P, P, P, P) reference values and growth curves of weight/length, body mass index, and ponderal index for male and female newborns with gestational ages of 24 to 42 weeks. The established growth standards in this study were compared with the standards from the 1988 Chinese data, the INTERGROWTH project, and the USA reference values. A total of 24 375 newborns with 12 264 preterm newborns (7 042 males and 5 222 females) and 12 111 full-term newborns (6 155 males and 5 956 females) were included in this study. The percentile reference values and growth curves of weight/length, body mass index, and ponderal index were obtained for male and female newborns with gestational ages of 24 to 42 weeks. Weight/length of males in all gestational ages at P, P and P was 0 to 0.2 kg/m higher than that of females, and body mass index of males in all gestational ages at the P, P and P was 0.1 to 0.3 kg/m higher than that of females. The established growth curves of weight/length and body mass index at the upper percentile and ponderal index at both upper and lower percentiles were greatly different from those of the 1988 Chinese data, which, for example, reported the difference ranges at P as -1.09 to 0.40 kg/m for weight/length, -1.19 to 0.92 kg/m for body mass index, and -0.64 to 0.81 kg/m for ponderal index. The established weight/length curves were generally consistent with the reference values from the INTERGROWTH project with a difference of -0.17 to 0.20 kg/m at P, while being 0.02 to 0.40 kg/m lower at P and 0.13 to 0.41 kg/m higher at P than that of the INTERGROWTH reference values at gestational ages of ≤32 weeks. The established body mass index curves differed from that of the USA reference values with a difference of -0.47 to 0.17 kg/m at P, while being 0.53 to 1.10 kg/m lower at gestational ages of ≥37 weeks but 0.17 to 0.45 kg/m higher at gestational ages of ≤28 weeks than that of the USA reference values at P. The establishment of the new standardized growth reference values of weight/length, body mass index, and ponderal index for Chinese newborns by different gestational ages are useful for clinical practice and scientific research.
X N Zong, H Li, Y Q Zhang, H H Wu

2838 related Products with: [Reference values and growth curves of weight/length, body mass index, and ponderal index of Chinese newborns of different gestational ages].

5 G1000 tests50 ug 100ug100 mg5ug10 mg500 MG25 mg100ug100ul96T

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#33657650   2021/03/03 To Up

IDDRRA: A novel platform, based on Geant4-DNA to quantify DNA Damage by Ionizing Radiation.

This study proposes a novel computational platform that we refer to as IDDRRA (DNA Damage Response to Ionizing RAdiation), which uses Monte Carlo (MC) simulations to score radiation induced DNA damage. MC simulations provide results of high accuracy on the interaction of radiation with matter while scoring the energy deposition based on state-of-the-art physics and chemistry models and probabilistic methods.
Konstantinos P Chatzipapas, Panagiotis Papadimitroulas, George Loudos, Niko Papanikolaou, George C Kagadis

2133 related Products with: IDDRRA: A novel platform, based on Geant4-DNA to quantify DNA Damage by Ionizing Radiation.

10 100ug Lyophilized100ug Lyophilized 100ul100ug Lyophilized100ug100 ul0.1 mg100ug Lyophilized100ug100ug100ug Lyophilized

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#33657638   2021/03/03 To Up

Umbilical Cord Separation Time and Influencing Factors in Very-Low-Birth-Weight Preterm Neonates.

 The average time for umbilical cord separation in term neonates is 7 to 10 days. Prematurity, phototherapy, prolonged duration of antibiotic treatment, and parenteral nutrition are other factors which were demonstrated to delay cord separation. In the previous studies including greater premature infants, the time of separation of the umbilical cord was shown to vary 2 to 3 weeks. We aimed to determine the cord separation time and associated factors in very-low-birth-weight (VLBW) infants.
Sezin Unal, Nihal Demirel, Zehra Arslan, Betül Tokgoz-Cuni, Dilek Ulubas-Isik, Ahmet Yagmur Bas

1444 related Products with: Umbilical Cord Separation Time and Influencing Factors in Very-Low-Birth-Weight Preterm Neonates.

2525500 gm.25100 units96 wells251

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#33657636   2021/03/03 To Up

Respiratory Syncytial Virus Immunoprophylaxis with Palivizumab: 12-Year Observational Study of Usage and Outcomes in Canada.

 This study aimed to evaluate palivizumab (PVZ) use, trends in indications, and outcomes of respiratory illness hospitalizations (RIH) and respiratory syncytial virus hospitalizations (RSVH).
Ian Mitchell, Abby Li, Candice L Bjornson, Krista L Lanctot, Bosco A Paes,

2649 related Products with: Respiratory Syncytial Virus Immunoprophylaxis with Palivizumab: 12-Year Observational Study of Usage and Outcomes in Canada.

100 μg1 mg100 100 1 mL10010 50 ug50 1 mg100

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#33657634   2021/03/03 To Up

The Development and Piloting of the Ambulatory Electronic Health Record Evaluation Tool: Lessons Learned.

 Substantial research has been performed about the impact of computerized physician order entry on medication safety in the inpatient setting; however, relatively little has been done in ambulatory care, where most medications are prescribed.
Zoe Co, A Jay Holmgren, David C Classen, Lisa P Newmark, Diane L Seger, Jessica M Cole, Barbara Pon, Karen P Zimmer, David W Bates

1342 related Products with: The Development and Piloting of the Ambulatory Electronic Health Record Evaluation Tool: Lessons Learned.

1mg11100.00 ul2000 IU500 Units10

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