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#33249794   // To Up

Highlights in Autoimmunity: 2020.

Innate and adaptive immune response dysregulations are equally involved in the induction of autoimmunity. Toll-like receptors play a leading role in the activation of innate immune cells, thus priming auto-reactive T cells. Th17 cells and related cytokines are widely involved in many immune-mediated diseases such as rheumatoid arthritis. Thus, the recent introduction of anti-IL-17 therapies should be further evaluated. Janus kinase inhibitors and Fc receptor-targeting drugs are some of the new therapeutic strategies that are being implemented when old classical therapies lack sufficient beneficial outcomes.
Elias Toubi, Zehava Vadasz

2624 related Products with: Highlights in Autoimmunity: 2020.

1 Set100 1 Set50 1 Set100ug Lyophilized1 Set20 1 mg1 kit(96 Wells)100 μg

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#33249783   2020/11/29 To Up

Plasma phosphorylated tau181 and neurodegeneration in Alzheimer's disease.

We examined if plasma phosphorylated tau is associated with neurodegeneration in Alzheimer's disease. We investigated 372 cognitively unimpaired participants, 554 mild cognitive impairment patients, and 141 Alzheimer's disease dementia patients. Tau phosphorylated at threonine 181, regional cortical thickness (using magnetic resonance imaging) and hypometabolism (using fluorodeoxyglucose positron emission tomography) were measured longitudinally. High plasma tau was associated with hypometabolism and cortical atrophy at baseline and over time, and longitudinally increased tau was associated with accelerated atrophy, but these associations were only observed in Aβ-positive participants. Plasma phosphorylated tau may identify and track processes linked to neurodegeneration in Alzheimer's disease.
Oskar Hansson, Nicholas Cullen, Henrik Zetterberg, , Kaj Blennow, Niklas Mattsson-Carlgren

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#33249764   2020/11/29 To Up

Type 2 MI induced by a single high dose of isoproterenol in C57BL/6J mice triggers a persistent adaptive immune response against the heart.

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Elvira Forte, Mona Panahi, Nicoleta Baxan, Fu Siong Ng, Joseph J Boyle, Jane Branca, Olivia Bedard, Muneer G Hasham, Lindsay Benson, Sian E Harding, Nadia Rosenthal, Susanne Sattler

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#33249751   2020/11/28 To Up

The regulation of gastric ghrelin secretion.

Ghrelin is a gastric hormone with multiple physiological functions, including the stimulation of food intake and adiposity. It is well established that circulating ghrelin levels are closely associated with feeding patterns, rising strongly before a meal, and lowering upon food intake. However, the mechanisms underlying the modulation of ghrelin secretion are not fully understood. The purpose of this review is to discuss current knowledge on the circadian oscillation of circulating ghrelin levels, the neural mechanisms stimulating fasting ghrelin levels, and peripheral mechanisms modulating postprandial ghrelin levels. Furthermore, the therapeutic potential of targeting the ghrelin pathway is discussed in the context of the treatment of various metabolic disorders, including obesity, type 2 diabetes, diabetic gastroparesis and Prader-Willi syndrome. Moreover, eating disorders, including anorexia nervosa, bulimia nervosa and binge-eating disorder are also discussed.
Maria Nunez-Salces, Hui Li, Christine Feinle-Bisset, Richard L Young, Amanda J Page

2672 related Products with: The regulation of gastric ghrelin secretion.

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#33249748   2020/11/29 To Up

Beyond energy storage: roles of glycogen metabolism in health and disease.

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Huafeng Zhang, Jingwei Ma, Ke Tang, Bo Huang

2365 related Products with: Beyond energy storage: roles of glycogen metabolism in health and disease.

96 tests96 tests1-99 mg/ml/ea price x 2

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#33249722   2020/11/28 To Up

ATF4-modified serum exosomes derived from osteoarthritic mice inhibit osteoarthritis by inducing autophagy.

Activating transcription factor 4 (ATF4) is critical for chondrocyte proliferation and bone formation. Exosomes are considered as promising gene-delivery vehicles for the treatment of osteoarthritis (OA). This study utilized the serum-derived exosomes from OA mice as the gene-delivery vehicles for ATF4 gene therapy and explored their therapeutic effects on OA. Meniscus injury-induced OA model was established by the excision of anterior part of medial meniscus in the right knee of C57BL/6J mice. Exosomes were isolated from serum samples of sham and OA mice, and were referred to as sham-Exo and OA-Exo, respectively. ATF4-overexpressing OA-Exo (ATF4-OA-Exo) was developed by introducing ATF4 mRNA into OA-Exo via electroporation. Four weeks after surgery, OA mice received intra-articular injections of sham-Exo, OA-Exo, and ATF4-OA-Exo, respectively. The results showed that intra-articular injection of ATF4-OA-Exo alleviated articular cartilage degeneration or damage and inflammatory response of OA mice. Autophagy was weakened in knee joint cartilage of OA mice, which was partially restored by intra-articular injection of ATF4-OA-Exo. Further in vitro assays revealed that ATF4-OA-Exo promoted chondrocyte autophagy and inhibited chondrocyte apoptosis in the TNF-α- or tunicamycin-treated chondrocytes. Together, ATF4-modified serum exosomes derived from OA mice protect cartilage and alleviate OA progression by inducing autophagy.
Yan Wang, Shi-Hao He, Xu Liang, Xin-Xin Zhang, Shan-Shan Li, Tian-Fang Li

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#33249719   2020/11/29 To Up

LGR5 induces β activation and augments tumor progression by activating STAT3 in human intrahepatic cholangiocarcinoma.

LGR5 enhances Wnt- β-catenin signaling; however, involvement of LGR5 or Wnt- β-catenin signaling in ICC progression has not been reported.
Keishi Kawasaki, Satoshi Kuboki, Katsunori Furukawa, Tsukasa Takayashiki, Shigetsugu Takano, Masayuki Ohtsuka

1073 related Products with: LGR5 induces β activation and augments tumor progression by activating STAT3 in human intrahepatic cholangiocarcinoma.

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#33249718   2020/11/29 To Up

Incidence and predictors of splanchnic vein thrombosis and mortality following hepatobiliary and pancreatic surgery.

Intraabdominal surgery is a known risk factor for splanchnic vein thrombosis (SVT). SVT incidence, management, and prognosis after hepatopancreatobiliary surgery are unknown.
Emmanuelle Duceppe, Jean-François Lauzon, Steven Galliger, Betty Zhang, Hannah Solomon, Pablo E Serrano

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#33249696   2020/11/29 To Up

Kawasaki disease mimickers.

Kawasaki disease (KD) is an acute systemic vasculitis that predominantly affects patients younger than five years. In the absence of an available affordable diagnostic test, detailed clinical history and physical examination are still fundamental to make a diagnosis.
Marimar Saez-de-Ocariz, Luisa Berenise Gámez-González, Francisco Rivas-Larrauri, Lina María Castaño-Jaramillo, Carla Toledo-Salinas, Luis Martín Garrido-García, Rolando Ulloa-Gutierrez, Maydeli Santamaría-Piedra, María de la Luz Orozco-Covarrubias, Selma Scheffler-Mendoza, Marco Yamazaki-Nakashimada

2885 related Products with: Kawasaki disease mimickers.

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#33249681   2020/11/29 To Up

BIOFILM OF Candida albicans: FORMATION, REGULATION AND RESISTANCE.

Candida albicans is the most common human fungal pathogen, causing infections that range from mucous membranes to systemic infections. The present article provides an overview of C. albicans, with the production of biofilms produced by this fungus, as well as reporting the classes of antifungals used to fight such infections, together with the resistance mechanisms to these drugs. C. albicans is highly adaptable, enabling the transition from commensal to pathogen due to a repertoire of virulence factors. Specifically, the ability to change morphology and form biofilms is central to the pathogenesis of C. albicans. Indeed, most infections by this pathogen are associated with the formation of biofilms on surfaces of hosts or medical devices, causing high morbidity and mortality. Significantly, biofilms formed by C. albicans are inherently tolerant to antimicrobial therapy, so the susceptibility of C. albicans biofilms to current therapeutic agents remains low. Therefore, it is difficult to predict which molecules will emerge as new clinical antifungals. The biofilm formation of C. albicans has been causing impacts on susceptibility to antifungals, leading to resistance, which demonstrates the importance of research aimed at the prevention and control of these clinical microbial communities.
Rafael Pereira, Raquel Oliveira Dos Santos Fontenelle, Erika Helena Salles de Brito, Selene Maia de Morais

2561 related Products with: BIOFILM OF Candida albicans: FORMATION, REGULATION AND RESISTANCE.

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