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#32473571   2020/05/27 To Up

PIK3R3 regulates ZO-1 expression through the NF-kB pathway in inflammatory bowel disease.

Inflammatory bowel disease (IBD) are the major risk factor for developing colitis associated cancer (CAC). Previously, we have reported that Phosphoinositide-3-kinase regulatory subunit 3 (PIK3R3) was overexpressed in colorectal cancer (CRC), but we don't know the role of PIK3R3 in IBD.
Sidikjan Ibrahim, Xu Zhu, Xuelai Luo, Yongdong Feng, Jing Wang

1630 related Products with: PIK3R3 regulates ZO-1 expression through the NF-kB pathway in inflammatory bowel disease.

100ug Lyophilized100ug Lyophilized100ug Lyophilized10ug100ug100ug Lyophilized1000 100ug Lyophilized2 Pieces/Box50 mg100ug Lyophilized

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#32473552   2020/05/27 To Up

Epispadias associated with urethral duplication: Our practice.

Urethral duplication and epispadias are one of the rare anomalies of the genitourinary system. Sometimes, urethral duplication can also be associated with anorectal malformations, epispadias, hypospadias, bladder doubling, bladder exstrophy and other urinary excretory system anomalies.
Ramiz Polukhov, Vugar Mahammadov, Madina Baghirli

2417 related Products with: Epispadias associated with urethral duplication: Our practice.



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#32473549   2020/05/12 To Up

Association between gastrin-releasing peptide receptor expression as assessed with [Ga]Ga-RM2 PET/CT and histopathological tumor regression after neoadjuvant chemotherapy in primary breast cancer.

The gastrin-releasing peptide receptor is overexpressed in breast cancer (BC) tissue and can be visualized by positron emission tomography (PET) using the GRPR antagonist [Ga]Ga-RM2. This study assessed tumor binding of RM2 before and after neoadjuvant chemotherapy (NAC) in primary BC with reference to residual tumor size in the resected specimen.
Kerstin Michalski, Christian Stoykow, Peter Bronsert, Ingolf Juhasz-Böss, Philipp T Meyer, Juri Ruf, Thalia Erbes, Jasmin Asberger

2004 related Products with: Association between gastrin-releasing peptide receptor expression as assessed with [Ga]Ga-RM2 PET/CT and histopathological tumor regression after neoadjuvant chemotherapy in primary breast cancer.



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#32473543   2020/05/25 To Up

Targeting and deep-penetrating delivery strategy for stented coronary artery by magnetic guidance and ultrasound stimulation.

Stent placement is an effective treatment for atherosclerosis, but is suffered from in-stent restenosis (ISR) caused by stent mechanical damage. Conventional ISR treatment such as drug-eluting stents (DES) is challenged by the low therapeutic efficacy and severe complications, unchangeable drug dosage for individuals, and limited drug penetration in the vascular tissue. We hypothesize that magnetic targeting and deep-penetrating delivery strategy by magnetic guidance and ultrasound stimulation might be an effective approach for ISR treatment. In the present study, antiproliferative drug (paclitaxel, PTX) loaded poly (lactide-co-glycolide) (PLGA) nanoparticles (PLGA-PTX) were embedded within the shells of the magnetic nanoparticle coated microbubbles (MMB-PLGA-PTX). Once being targeted to the stent under a magnetic field, a low intensity focused ultrasound (LIFU) is applied to activate stable microbubble oscillations, thereby triggering the release of PLGA-PTX. The generated mechanical force and microstreaming facilitate the penetration of released PLGA-PTX into the thickened vascular tissue and enhance their internalization by smooth muscle cells (SMCs), thereby reducing the clearance by blood flow. In an ex vivo experiment, magnetic targeting improved the accumulation amount of MMB-PLGA-PTX by 10 folds, while the LIFU facilitated the penetration of released PLGA-PTX into the tunica media region of the porcine coronary artery, resulting in prolonged retention time at the stented vascular tissue. With the combination effects, this strategy holds great promise in the precision delivery of antiproliferative drugs to the stented vascular tissue for ISR treatment.
Siyu Wang, Xixi Guo, Lili Ren, Bo Wang, Lixin Hou, Hao Zhou, Qinchang Gao, Yu Gao, Lianhui Wang

1315 related Products with: Targeting and deep-penetrating delivery strategy for stented coronary artery by magnetic guidance and ultrasound stimulation.

2.5 mg10 mg50 ug 5 G1,000 tests100ul1 mg100ug100ug100 mg1000 tests

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