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[Systems Biology in Ophthalmology - Innovative Drug Identification for the Specific Prevention of Postoperative Fibrosis].The long-term success of fistulating therapies for the treatment of glaucoma is essentially limited by excessive scarring reactions (fibrosis). Cytostatic agents such as mitomycin C can prevent fibrosis, but are often associated with side effects. Specific antifibrotics are not currently in clinical use. Therefore, this study describes a systems biology approach using a dedicated bioinformatics technology platform, with which active substances can be identified and repositioned as antifibrotics.
2872 related Products with: [Systems Biology in Ophthalmology - Innovative Drug Identification for the Specific Prevention of Postoperative Fibrosis].Multiple organ tumor tiss Nuclear Membrane Receptor FDA Standard Frozen Tissu Angiogenesis (Mouse) Anti Rabbit Plasma US Origin I 10x ELISA WASH BUFFER, Pr Cytokine (Human) Antibody Rabbit Plasma US Origin I Inflammation (Human) Anti NATIVE HUMAN PROLACTIN, P Indole 3 carboxaldehyde ( Atherosclerosis (Human) A
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Dynamic Changes in the Localization of Neuronatin-Positive Cells during Neurogenesis in the Embryonic Rat Brain.Neuronatin (NNAT) was first identified as a gene selectively and abundantly expressed in the cytoplasm of the newborn mouse brain, and involved in neonatal neurogenesis. However, the particular roles of NNAT in the developing prenatal brain have not been identified, especially in mid to late stages. In this study, we performed immunohistochemical analyses of NNAT and SOX2 proteins, a nuclear transcription factor and neural stem/progenitor marker, in the rat brain on embryonic days 13.5, E16.5, and E20.5. NNAT signals were broadly observed across the developing brain on E13.5 and gradually more localized in later stages, eventually concentrated in the alar and basal parts of the terminal hypothalamus, the alar plate of prosomere 2 of the thalamus, and the choroid plexus in the lateral and fourth ventricles on E20.5. In particular, the mammillary body in the basal part of the terminal hypothalamus, a region with a high number of SOX2-positive cells, evidenced intense NNAT signals on E20.5. The intracellular localization of NNAT showed diverse profiles, suggesting that NNAT was involved in various cellular functions, such as cell differentiation and functional maintenance, during prenatal neurogenesis in the rat brain. Thus, the present observations suggested diverse and active roles of the NNAT protein in neurogenesis. Determining the function of this molecule may assist in the elucidation of the mechanisms involved in brain development.
1621 related Products with: Dynamic Changes in the Localization of Neuronatin-Positive Cells during Neurogenesis in the Embryonic Rat Brain.FDA Standard Frozen Tissu FDA Standard Frozen Tissu FDA Standard Frozen Tissu Multiple organ tumor tiss FDA Standard Frozen Tissu Thermal Shaker with cooli FDA Standard Frozen Tissu FDA Standard Frozen Tissu MultiGene Gradient therm Sf9 insect cells Rat Anti-Mouse Dendritic Goat Anti-Human CKB Brain
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Effects of spaceflight on the mouse submandibular gland.This study was conducted to determine if the morphology and biochemistry of the mouse submandibular gland is affected by microgravity and the spaceflight environment.
Normal mouse multiple org Mouse Anti-HPV 18 Oncopro Mouse anti human Oncostat Rat monoclonal anti mouse Mouse Anti-Bacteroides th Mouse Anti-HPV 16 Oncopro Mouse Anti-Human EPO Anti c-erbB-3 Oncoprotein; Cl Recombinant Mouse IL-17E Mouse anti human FGF basi Mouse Anti-Human P Glycop Purified Mouse Anti Human
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High-precision iron isotope analysis of whole blood, erythrocytes, and serum in adults.Iron isotopic composition serves as a biological indicator of Fe metabolism in humans. In the process of Fe metabolism, essential carriers of Fe circulate in the blood and pass through storage organs and intestinal absorptive tissues. This study aimed to establish an analytical method for high-precision Fe isotopic measurement, investigate Fe concentration and isotopic composition in different parts of whole blood, and explore the potential of Fe isotopic composition as an indicator for Fe status within individuals.
2250 related Products with: High-precision iron isotope analysis of whole blood, erythrocytes, and serum in adults.High density (495 cases 5 EnzyChrom™ Kinase Assay Sterile filtered fetal bo Sterile filtered fetal bo High density colon cancer Oral cavity squamous cell High density cervical can High density kidney cance High density ovarian canc High density breast invas High density liver cancer Sterile filtered fetal bo
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Comparative effects of Mancozeb and Disulfiram-induced striated muscle myopathies in Long-Evans rats.Dithiocarbamates (DTCs) like mancozeb (MZ) and disulfiram (DS) are used throughout agriculture and medicine and have been implicated in neurotoxicity. Little research has been studied on the reported myopathies caused by these compounds. Their pathogenesis and mechanism of muscle toxicity has not been fully studied. The aim of this study is to investigate if DTCs alter striated muscle tissues in vivo. Long-Evans rats were treated with either MZ or DS followed by analysis of muscle biomarkers and metal levels. DS resulted in increases in serum lactate dehydrogenase (LDH), cardiac troponin, and myoglobin levels. Creatine kinase-MB serum levels decreased. Mancozeb only showed an increase in serum LDH. Both MZ and DS-treatment resulted in altered metal levels in the myocardium but not skeletal muscle. Ultrastructural alterations included damaged mitochondria and myofibril splitting. The presence of multivesicular bodies, and alterations of the intercalated disc were also seen.
2773 related Products with: Comparative effects of Mancozeb and Disulfiram-induced striated muscle myopathies in Long-Evans rats.Anti AGO2 Mouse, Monoclon Mouse Epstein-Barr Virus Sarcoma tissue array of s Jurkat Cell Extract (Indu Anti AGO2 Mouse, Monoclon Anti AICDA(Activation ind Anti AGO2 Human, Monoclon Jurkat Cell Extract (Indu Zearalenone Mycotoxins EL Smooth muscle and striate Jurkat Cell Extract (Indu Anti AGO2 Human, Monoclon
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DNA methylation analysis validates organoids as a viable model for studying human intestinal aging.The epithelia of the intestine and colon turn over rapidly and are maintained by adult stem cells at the base of crypts. While the small intestine and colon have distinct, well-characterized physiological functions, it remains unclear if there are fundamental regional differences in stem cell behavior or region-dependent degenerative changes during aging. Mesenchyme-free organoids provide useful tools for investigating intestinal stem cell biology in vitro and have started to be utilized for investigating age-related changes in stem cell function. However, it is unknown whether organoids maintain hallmarks of age in the absence of an aging niche. Here we test whether stem cell enriched organoids preserve the DNA methylation-based aging profiles associated with the tissues and crypts from which they were derived.
2195 related Products with: DNA methylation analysis validates organoids as a viable model for studying human intestinal aging.Astra Blue 6GLL, Stain fo Human monkey anti-human t DNASE1L3 antibody Source DNAJC7 antibody Source Ra Human monkey anti-porcine Methylamp Global DNA Me Formate Assay Kit Human monkey anti-human t EpiQuik In Situ Histone H Single Donor Human Bronch NATIVE HUMAN PROLACTIN, P Mouse anti-human type II
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Characterization of the immune roles of cathepsin L in turbot (Scophthalmus maximus L.) mucosal immunity.Cathepsin L (CTSL) is one of the crucial enzymes in cathepsin family, which has been widely known for its involvement in the innate immunity. However, it still remains poorly understood how CTSL modulates the immune system of teleosts. In this study, we captured three cathepsin L genes (SmCTSL, SmCTSL.1 and SmCTSL1) from turbot (Scophthalmus maximus). The coding sequences of SmCTSL, SmCTSL.1 and SmCTSL1 are 1,026 bp, 1,005 bp and 1,017 bp in length and encode 341, 334 and 338 amino acids, respectively. In details, transcripts of CTSL genes share same domains as other CTSL genes, one signal peptide, one propeptide and one papain family cysteine protease domain. Protein interaction network analysis indicated that turbot CTSL genes may play important roles in apoptotic signaling and involve in innate immune response. Evidence from subcellular localization demonstrated that the three Cathepsin L proteins were ubiquitous in nucleus and cytoplasm. The cathepsin L genes were widely expressed in all the tested tissues with the highest expression level of SmCTSL in spleen, and SmCTSL.1 and SmCTSL1 in intestine. Following Vibrio anguillarum, Edwardsiella tarda and Streptococcus iniae challenge, these cathepsin L genes were significantly regulated in mucosal tissues in all the challenges, especially significantly down-regulated rapidly in intestine in all the three challenges. In addition, the three cathepsin L genes showed strong binding ability to all the examined microbial ligands (LPS, PGN and LTA). Further studies should be used to analyze the function of these three cathepsin L genes. Therefore, we can use their function to maintain the integrity of the mucosal barrier, thereby promoting the disease resistance line and family selection in turbot.
1577 related Products with: Characterization of the immune roles of cathepsin L in turbot (Scophthalmus maximus L.) mucosal immunity.Cathepsin B&L Inhibitor Z FDA Standard Frozen Tissu Multiple diseases of live Cathepsin F Blocking Pept Rabbit Anti-IAA (Indole-3 Lipoproteins, Human Plasm Goat Anti-Human LMO7 FBXO Rabbit Anti-Phospho-INPPL Rabbit Anti-Insulin Recep Breast invasive lobular c Calpain Inhibitor Z-LLY-F Caspase 9 Inhibitor Z LEH
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Interferon regulatory factor 2 plays a positive role in interferon gamma expression in golden pompano, Trachinotus ovatus (Linnaeus 1758).In fish, interferon (IFN) regulatory factor 2 (IRF2) is a regulator of the type I IFN-dependent immune response, thereby playing a crucial role in innate immunity. However, the specific mechanism by which IRF2 regulates type II IFN in fish remains unclear. In the present study, first, to analyse the potential role of golden pompano (Trachinotus ovatus) IRF2 (ToIRF2) in the immune response, the mRNA level of ToIRF2 was detected by quantitative real-time polymerase chain reaction (qRT-PCR) after parasite infection. ToIRF2 was upregulated at early time points in both local infection sites (skin and gill) and system immune tissues (liver, spleen, and head-kidney) after stimulation with Cryptocaryon irritans. Second, to investigate the modulation effect of ToIRF2 on type II IFN (interferon gamma, IFNγ) expression, a promoter analysis was performed using progressive deletion mutations of ToIFNγ. The expression level of IFNγ-5 was highest among the five truncated mutants in response to ToIRF2, indicating that the core promoter region was located from -189 bp to +120 bp, which included the IRF2 binding sites. Mutation analyses showed that the activity of the ToIFNγ promoter dramatically decreased after the targeted mutation of the M1, M2 or M3 binding sites. Additionally, electrophoretic mobile shift assay (EMSA) confirmed that IRF2 interacted with the M1 binding site in the ToIFNγ promoter region to dominate ToIFNγ expression. Finally, overexpressing ToIRF2 in vitro notably increased ToIFNγ and the transcription of several type II IFN/IRF-based signalling pathway genes. These results suggested that ToIRF2 might be involved in the host defence against C. irritans infection and contribute to a better understanding of the transcriptional mechanisms by which ToIRF2 regulates type II IFN in fish.
1889 related Products with: Interferon regulatory factor 2 plays a positive role in interferon gamma expression in golden pompano, Trachinotus ovatus (Linnaeus 1758).Rabbit Anti-Human Interfe Interferon-γ | Interfer Rat Interferon gamma IFN- Mouse Interferon gamma IF Interferon γ | Interfer Rat anti mouse Interferon Human Interferon-gamma IF Rat monoclonal anti mouse Polyclonal Antibody Inter Hamster anti mouse Interf Recombinant Human Interfe Anti beta3 AR Human, Poly
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Radiation-induced moyamoya syndrome in children with brain tumors: case series and literature review.Over the last decades, significant advancements have been achieved in the treatment of pediatric brain tumors thanks to radiation therapy (RT). With the increasing diffusion of this treatment, iatrogenic damages to cerebrovascular tissues contouring the radiation target volume have become subject of debate, especially radiation-induced moyamoya syndrome (RIMS).
2703 related Products with: Radiation-induced moyamoya syndrome in children with brain tumors: case series and literature review.Brain tumor tissue array Mid advanced stage brain Brain disease spectrum (b Brain cancer test tissue Brain tumor tissue array, Brain glioma and normal t Brain tumor and normal ti Brain tumor test tissue a Brain glioblastoma tissue Brain tumor tissue array, Brain cancer test tissue Brain tumor tissue array
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Whole Body Irradiation Induces Diabetes and Adipose Insulin Resistance in Non-human Primates.Diabetes mellitus (DM) is a delayed effect of radiation exposure in human and non-human primates. DM is characterized by peripheral tissue insulin resistance, and as a result, irradiation exposure may cause important changes in insulin-sensitive tissues such as muscle and adipose.
1572 related Products with: Whole Body Irradiation Induces Diabetes and Adipose Insulin Resistance in Non-human Primates.Insulin, human recombinan Human Insulin-like Growth Recombinant Human Insulin Recombinant Human Insulin Mouse Anti-Human Insulin Human Insulin-like Growth Recombinant Human Insulin Recombinant Human Insulin Human Insulin ELISA Kit insulin, human recombinan Mouse Anti-Human Insulin Goat Anti-Human Insulysin
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