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#33249684   2020/11/29 To Up

Signals and signal transduction pathways in Entamoeba histolytica during the life cycle and when interacting with bacteria or human cells.

Entamoeba histolytica is the etiological agent of amoebiasis in humans. This amoeba parasite resides as a commensal in the intestine where it shares intestinal resources with the bacterial microbiome. In the intestinal ecosystem, the amoeba encysts and eventually develops disease by invading the tissues. E. histolytica possesses cell surface receptors for the proper sensing of signals involved in encystation or sustaining parasite interaction with bacteria and human cells. Among those receptors are the Gal/GalNAc lectin, G protein-coupled receptors, and transmembrane kinases. In addition there are recently discovered, promising proteins, including orthologs of Toll-type receptors and β-trefoil lectins. These proteins trigger a wide variety of signal transduction pathways; however, most of the players involved in the signaling pathways evoked in this parasite are unknown. This review provides an overview of amoebic receptors and their role in encystation, adherence to bacteria or human cells, as well as the reported intracellular signal transduction processes that they can trigger. This knowledge is essential for understanding the lifestyle of E. histolytica and its cytopathic effect on bacteria and human cells that are responsible for infection.
Nancy Guillen

1075 related Products with: Signals and signal transduction pathways in Entamoeba histolytica during the life cycle and when interacting with bacteria or human cells.

100ug Lyophilized100 μg1.00 flask 100ul1000 100 μg

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#33249553   2020/11/29 To Up

Strategies of desiccation tolerance vary across life phases in the moss Syntrichia caninervis.

Desiccation tolerance (DT) is a widespread phenomenon among land plants, and variable ecological strategies for DT are likely to exist. Using Syntrichia caninervis, a dryland moss and model system used in DT studies, we hypothesized that DT is lowest in juvenile (protonemal) tissues, highest in asexual reproductive propagules (gemmae), and intermediate in adults (shoots). We tested the long-standing hypothesis of an inherent constitutive strategy of DT in this species.
Kirsten K Coe, Joshua L Greenwood, Mandy L Slate, Theresa A Clark, John C Brinda, Kirsten M Fisher, Brent D Mishler, Matthew A Bowker, Melvin J Oliver, Sotodeh Ebrahimi, Lloyd R Stark

2702 related Products with: Strategies of desiccation tolerance vary across life phases in the moss Syntrichia caninervis.

1100 100 μg

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#33249476   2020/11/29 To Up

Nestin +/CD31 + Cells in the Hypoxic Perivascular Niche Regulate Glioblastoma Chemoresistance by Upregulating JAG1 and DLL4.

Failure of glioblastoma (GBM) therapy is often ascribed to different types of glioblastoma stem-like cells (GSLCs) niche, in particularly, a hypoxic perivascular niche (HPVN) is involved in GBM progression. However, the responsible cells for HPVN remained unclear.
Zong-Qing Zheng, Jin-Tao Chen, Ming-Cheng Zheng, Li-Juan Yang, Jun-Ming Wang, Quan-Li Liu, Lu-Fei Chen, Zu-Cheng Ye, Jin-Ming Lin, Zhi-Xiong Lin

2818 related Products with: Nestin +/CD31 + Cells in the Hypoxic Perivascular Niche Regulate Glioblastoma Chemoresistance by Upregulating JAG1 and DLL4.

1.00 flask-1x10e7 cells1.00 flask1

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#33249400   2020/11/12 To Up

KIAA1429 promotes the progression of lung adenocarcinoma by regulating the m6A level of MUC3A.

Lung adenocarcinoma (LUAD) is one of the most frequently occurring human malignancies worldwide, but its potential molecular mechanism has not yet been fully elucidated. N6-methyladenosine (m6A), the most common internal chemical modification of mRNAs, is implicated in diverse pathological processes in different human malignancies, but its functions in LUAD remain elusive. The current study aimed to investigate the function and molecular mechanism of KIAA1429 in LUAD.
Wenhua Zhao, Yuan Xie

2995 related Products with: KIAA1429 promotes the progression of lung adenocarcinoma by regulating the m6A level of MUC3A.

100 G11200 units500 Units1mg11 ml

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#33249353   2020/11/22 To Up

Effects of methyl farnesoate on Krüppel homolog 1 (Kr-h1) during vitellogenesis in the Chinese mitten crab (Eriocheir sinensis).

Methyl farnesoate (MF), a de-epoxidized form of juvenile hormone (JH) Ⅲ in insects, may regulate developmental processes such as reproduction and ovarian maturation in crustaceans. Krüppel homolog 1 (Kr-h1) is a target response gene for the methoprene-tolerant (Met) protein that is a component of the JH signaling pathway in insects. In the present study, Es-Kr-h1 was cloned from E. sinensis and characterized to ascertain whether JH/MF signaling in insects is conserved in crustaceans. The findings with molecular structure analysis indicated Es-Kr-h1 contains seven zinc finger motifs (Zn2-Zn8) commonly conserved in other crustaceans, but the Zn1 motif was not detected to be present. The PCR results indicated that relative abundance of Es-Kr-h1 mRNA transcript in the hepatopancreas was greatest in the Stage Ⅱ, followed by the Stage Ⅳ ovarian developmental categories. The relative abundance of Es-Kr-h1 mRNA transcript in vitro was greater after MF addition to the hepatopancreas, however, not the ovarian tissues. The results from in vivo and eyestalk ablation experiments indicated the relative abundance of Es-Kr-h1 mRNA transcript was greater after MF treatment and bilateral eyestalk removal in the hepatopancreas, however, not ovarian tissues. Notably, there were effects of MF on relative abundance of Es-Kr-h1 mRNA transcript pattern. The Es-Kr-h1 protein, therefore, may be involved in MF-mediated vitellogenesis resulting from the response to Es-Met in E. sinensis, and the JH/MF signaling pathway is potentially conserved in crustaceans.
Xilei Li, Tiantian Chen, Hucheng Jiang, Jiawei Huang, Mengting Huang, Ruihan Xu, Qiming Xie, Haojie Zhu, Shiping Su

1304 related Products with: Effects of methyl farnesoate on Krüppel homolog 1 (Kr-h1) during vitellogenesis in the Chinese mitten crab (Eriocheir sinensis).

10 mg25 mg10 mg25 mg25 mg 1 G1 mg100ug 5 G50 mg5 mg250 mg

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#33249285   2020/11/26 To Up

Hypoxic preconditioning - a non-pharmacological approach in COVID-19 prevention.

Hypoxia is defined by low oxygen concentration in organs, tissues and cells. Maintaining oxygen homeostasis represents the essential cellular metabolic process for the structural integrity of tissues in different pathological conditions, including SARS-CoV-2 infection. Considering the role of hypoxia-inducible factor-1 (HIF-1) as regulator of cellular response to hypoxia and its involvement in angiogenesis, erythropoiesis, glucose metabolism, inflammation, we propose hypoxic preconditiong (HPC) as a novel prevention therapeutic approach on healthy contacts of COVID-19 patients. To date, several studies revealed the benefic effects of hypoxic preconditioning in ischemia, kidney failure and in pulmonary function recovery of lung surgery patients. HPC increases the expression of factors that promote cell survival and angiogenesis, induces an anti-inflammatory outcome, triggers coordinated hypoxia responses that promote erythropoiesis, and mobilizes the circulating progenitor cells. Futhermore, the mesenchymal stem cells (MSC) exposed to HPC show improvement of their regenerative capacities, and increases the effectiveness of stem cell therapy in different pathologies, including COVID-19. In conclusion, HPC should be considered an approach with beneficial outcomes and without significant side effects when the organism is severely exposed to the same stressor. HPC appears as a trigger to mechanisms that improve and maintain tissue oxygenation and repair, a main goal in different pathologies, including COVID-19 or other respiratory conditions.
Radu Gabriel Hertzog, Nicoleta Simona Bicheru, Diana Mihaela Popescu, Octavian Călborean, Ana-Maria Catrina

2379 related Products with: Hypoxic preconditioning - a non-pharmacological approach in COVID-19 prevention.

5 mg 100ul100 μg1 Set100 μg1 Set100 μg100ug

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#33249230   2020/11/26 To Up

Delay in puberty indices of Wistar rats caused by Cadmium. Focus on the redox system in reproductive organs.

Puberty is a transitional period from juvenile stage to adulthood, followed by the functional maturation of gonads and reproductive organs. This period is sensitive to environmental pollutants like cadmium (Cd), a heavy metal that represents a serious health risk. Cd is an endocrine disruptor that interferes with reproduction by causing oxidative stress in the reproductive organs, affecting the sexual function and decreasing testosterone (T) levels. However, little research has been done on the effects of Cd on puberty markers and antioxidant systems. In this study, we evaluated the effects of Cd on puberty markers: preputial separation, testes descent and T levels, and the antioxidant activity (SOD, CAT, GSH/GSSG and TAC) in the seminal vesicles, testis and epididymis. Male Wistar pups were treated with 1 mg/kg Cd or saline solution by i.p. injection from day 1 to 35; the other treatment was administrated for 49 days. At the end of treatment, the animals were sacrificed, and the tissues of interest dissected, weighed and prepared for the respective assays. Cd treated rats from birth to puberty showed a delay onset in the puberty markers and a low weight in reproductive organs. Also, Cd induced differential effects on the redox system in reproductive organs and decreased T levels, these effects played a pivotal role in the delay of puberty markers onset (testes descent and preputial separation), affecting the development and sexual maturity of the male rats.
Joel Hernández-Rodríguez, Ana Laura López, Sergio Montes, Herlinda Bonilla-Jaime, Ivis Morales, Ofelia Limón-Morales, Camilo Ríos, Marisela Hernández-González, Rosa María Vigueras-Villaseñor, Marcela Arteaga-Silva

1509 related Products with: Delay in puberty indices of Wistar rats caused by Cadmium. Focus on the redox system in reproductive organs.

25 ml.

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#33249194   2020/11/26 To Up

TOX-expressing terminally exhausted tumor-infiltrating CD8 T cells are reinvigorated by co-blockade of PD-1 and TIGIT in bladder cancer.

Exhausted T cells in the tumor microenvironment are major targets of immunotherapies. However, the exhaustion status of CD8 tumor-infiltrating lymphocytes (TILs) in bladder cancer has not been comprehensively evaluated. Herein, we examined distinct exhaustion status of CD8 TILs based on the level of programmed cell death-1 (PD-1) and thymocyte selection-associated high mobility group box protein (TOX) expression in urothelial bladder cancer. We also evaluated the reinvigoration of exhausted CD8 TILs upon ex vivo treatment with inhibitory checkpoint blockers. TOX-expressing PD-1CD8 TILs had the highest expression of immune checkpoint receptors (ICRs), the most terminally exhausted features, and the highest tumor antigen reactivity among PD-1CD8 TILs. Bladder cancer patients with a high percentage of PD-1TOXCD8 TILs had more progressed T-cell exhaustion features and higher programmed death-ligand 1 expression in tumor tissues. TIGIT was the most frequent co-expressed ICR on PD-1CD8 TILs, and TIGIT blockade enhanced the PD-1 blockade-mediated cytokine production by CD8 TILs from bladder cancer patients. Our findings provide an improved understanding of the heterogeneous exhaustion status of CD8 TILs and additional immunotherapy strategies to improve outcomes of bladder cancer patients.
Hye Sook Han, Seongju Jeong, Hyunglae Kim, Hyung-Don Kim, A Reum Kim, Minsuk Kwon, Su-Hyung Park, Chang Gok Woo, Hee Kyung Kim, Ki Hyeong Lee, Sung Pil Seo, Ho Won Kang, Won Tae Kim, Wun-Jae Kim, Seok Joong Yun, Eui-Cheol Shin

1045 related Products with: TOX-expressing terminally exhausted tumor-infiltrating CD8 T cells are reinvigorated by co-blockade of PD-1 and TIGIT in bladder cancer.



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#33249190   2020/11/26 To Up

The bright and dark side of skin senescence. Could skin rejuvenation anti-senescence interventions become a "bright" new strategy for the prevention of age-related skin pathologies?

The number of senescent cells in the skin is increasing with age. Numerous studies have attempted to elucidate the role of these cells in normal aging of the skin as well as in age-related skin conditions. In recent years, attempts have also been made to find treatments that aim either to cleanse the skin tissues of senescent cells or to neutralize their effects (referred to as senolytics and senomorphics respectively) and thus prevent the consequences, particularly on the skin's appearance in advanced age. Through this review, we have tried to gather data on the role of senescent cells in the skin, in treatments aimed at removing them, and we are asking a reasonable question as to whether anti-senescence treatments may contribute to the protection against age-related skin pathologies, including skin cancer, such as non-melanoma skin cancer, in addition to their involvement in skin rejuvenation.
Eleni A Georgakopoulou, Christina Valsamidi, Dimitrios Veroutis, Sophia Havaki

2264 related Products with: The bright and dark side of skin senescence. Could skin rejuvenation anti-senescence interventions become a "bright" new strategy for the prevention of age-related skin pathologies?

1 ml

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