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#32652903   2020/07/11 To Up

Safely finishing a half marathon by an adult with type 1 diabetes using a commercially available hybrid closed-loop system.

Glycemic targets are often difficult to achieve in people with type 1 diabetes (T1D), especially during exercise. Consequently, many people with T1D avoid sports due to fear of hypoglycemia. Strenuous physical activity such as a half marathon imposes difficulties on people with T1D. A first commercial hybrid closed-loop (HCL) system with the potential to facilitates better diabetes management during exercise has been recently marketed. So far, no data on HCL performance during strenuous exercise has been published. A woman with well-controlled T1D participated in and safely finished a half marathon while undergoing HCL therapy. HCL could safely establish glycemic control without causing either hypo- or relevant hyperglycemia and without the need for rescue carbohydrates while running. In the days following the half marathon, there was no change in glycemic control compared to the period before. HCL use can safely manage diabetes during a half marathon in T1D.
Louisa van den Boom, Haris Ziko, Julia K Mader

2217 related Products with: Safely finishing a half marathon by an adult with type 1 diabetes using a commercially available hybrid closed-loop system.

100ug100ul100ug100ul100ug100μg100ul100ul100μg 100ul100ul100ul

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#32652899   // To Up

Muscle and serum myostatin expression in type 1 diabetes.

Type 1 diabetes (T1D) has been reported to negatively affect the health of skeletal muscle, though the underlying mechanisms are unknown. Myostatin, a myokine whose increased expression is associated with muscle-wasting diseases, has not been reported in humans with T1D but has been demonstrated to be elevated in preclinical diabetes models. Thus, the purpose of this study was to determine if there is an elevated expression of myostatin in the serum and skeletal muscle of persons with T1D compared to controls. Secondarily, we aimed to explore relationships between myostatin expression and clinically important metrics (e.g., HbA , strength, lean mass) in women and men with (N = 31)/without T1D (N = 24) between 18 and 72 years old. Body composition, baseline strength, blood sample and vastus lateralis muscle biopsy were evaluated. Serum, but not muscle, myostatin expression was significantly elevated in those with T1D versus controls, and to a greater degree in T1D women than T1D men. Serum myostatin levels were not significantly associated with HbA nor disease duration. A significant correlation between serum myostatin expression and maximal voluntary contraction (MVC) and body fat mass was demonstrated in control subjects, but these correlations did not reach significance in those with T1D (MVC: R = 0.64 controls vs. R = 0.37 T1D; Body fat: R = -0.52 controls/R = -0.02 T1D). Collectively, serum myostatin was correlated with lean mass (R = 0.45), and while this trend was noted in both groups separately, neither reached statistical significance (R = 0.47 controls/R = 0.33 T1D). Overall, while those with T1D exhibited elevated serum myostatin levels (particularly females) myostatin expression was not correlated with clinically relevant metrics despite some of these relationships existing in controls (e.g., lean/fat mass). Future studies will be needed to fully understand the mechanisms underlying increased myostatin in T1D, with relationships to insulin dosing being particularly important to elucidate.
Athan G Dial, Cynthia M F Monaco, Grace K Grafham, Nadya Romanova, Jeremy A Simpson, Mark A Tarnopolsky, Christopher G R Perry, Evangelia Kalaitzoglou, Thomas J Hawke

1481 related Products with: Muscle and serum myostatin expression in type 1 diabetes.

96T10 ml96T100 ml100 ml100 ml10 ml100 ml10ml100 ml96T

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#32652893   2020/07/11 To Up

Two novel mutations in the MCM8 gene shared by two Chinese siblings with primary ovarian insufficiency and short stature.

Minichromosome maintenance complex component 8 (MCM8) is responsible for homologous recombination and DNA double-strand breaks (DSBs) repair and is the cause of primary ovarian insufficiency (POI), which is seldom diagnosed in adolescents and children.
Fei Wang, Sheng Guo, Pin Li

1821 related Products with: Two novel mutations in the MCM8 gene shared by two Chinese siblings with primary ovarian insufficiency and short stature.

15ug100ug300 units96T

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#32652888   2020/07/11 To Up

Enzyme Instructed Self-assembly of Naphthalimide-dipeptide: Spontaneous Transformation from Nanosphere to Nanotubular Structures that Induces Hydrogelation.

Understanding the structure-morphology relationships of the self-assembled nanostructures is very crucial for developing the materials with the desired chemical and biological functions. Here, phosphate-based naphthalimide (NI) derivatives have been developed for the first time to study the enzyme instructed self-assembly process. Self-assembly of simple amino acid derivative NI-Y p resulted in non-specific amorphous aggregates in the presence of alkaline phosphatase enzyme. On the other hand, NI-FY p dipeptide forms spherical nanoparticles in the aqueous condition which slowly transformed into partially unzipped nanotubular structures during the enzymatic catalytic process through multiple stages which subsequently resulted in hydrogelation. The self-assembly is driven by the formation of β-sheet type structures stabilized by offset aromatic stacking of NI core and hydrogen bonding interactions which is confirmed with PXRD, Congo-red staining and molecular mechanical calculations. We propose a mechanism for the self-assembly process based on TEM and spectroscopic data. The nanotubular structures of NI-FY p precursor exhibited higher cytotoxicity to human breast cancer cells and human cervical cancer cells when compared to the nanofiber structures of the similar Fmoc-derivative. Overall this study provides a new understanding of the supramolecular self-assembly of small molecular weight hydrogelators.
Rajan Deepan Chakravarthy, Mohiuddin Mohammed, Hsin-Chieh Lin

1622 related Products with: Enzyme Instructed Self-assembly of Naphthalimide-dipeptide: Spontaneous Transformation from Nanosphere to Nanotubular Structures that Induces Hydrogelation.

100 Units1 mg100 mg 25 G480/kit0.1ml (1.3mg/ml)500 MG3 modules250 ul1 module

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#32652880   2020/07/11 To Up

Post dural puncture headache evolving to a subdural hematoma: A case report.

Cervical epidural corticosteroid injections are frequently used for the treatment of subacute cervicobrachial pain. This therapy isconsidered safe with the vast majority of the complications being minor and transient.
Seppe Dehaene, Jeroen Biesemans, Koen Van Boxem, Wesley Vidts, Joeri Sterken, Jan Van Zundert

1984 related Products with: Post dural puncture headache evolving to a subdural hematoma: A case report.



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#32652863   // To Up

Impact of interval walking training managed through smart mobile devices on albuminuria and leptin/adiponectin ratio in patients with type 2 diabetes.

Interval walking training has demonstrated more pronounced positive effects on physical fitness and metabolism in type 2 diabetes (T2D), compared to continuous walking. One of the pathogenic mechanisms of T2D is associated with derangements in leptin/adiponectin axis, which might predispose affected individuals to vascular inflammation and albuminuria. The aim of this study was to investigate the effects of interval walking training delivered through smart mobile devices upon albuminuria and leptin/adiponectin ratio in patients with T2D.
Jelizaveta Sokolovska, Karina Ostrovska, Leonora Pahirko, Gunita Varblane, Ksenija Krilatiha, Austris Cirulnieks, Inese Folkmane, Valdis Pirags, Janis Valeinis, Aija Klavina, Leo Selavo

2916 related Products with: Impact of interval walking training managed through smart mobile devices on albuminuria and leptin/adiponectin ratio in patients with type 2 diabetes.

96 wells (1 kit)20000 Units10200ug200ug 1 G200ul2000 Units 500 G5mg200ul

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#32652829   2020/07/11 To Up

Monitoring skin metastases during immuno- and targeted therapy using total-body 3D photography.

Eruptive skin metastases in melanoma are an uncommon manifestation of rapidly progressive, systemic disease . Type and kinetics of these lesions have not been analyzed before, because of the rarity of the event and technical restrictions of total-body photography. We present the first sequential total-body 3D photography-based analysis by a VECTRA 360WB imaging system of a melanoma patient suffering from disseminated, spreading skin metastases under treatment with immune checkpoint antibodies and subsequent BRAF/MEK inhibition.In April 2019 a 54-year-old male patient with BRAF V600E-mutated conjunctival melanoma developed pigmented skin (Fig. 1a), brain, pulmonary, and hepatic metastases. In addition to a cerebral stereotactic radiotherapy the patient received four cycles of a combined immunotherapy with ipilimumab (1mg/kg) and pembrolizumab (2mg/kg).
Michael Erdmann, Lucie Heinzerling, Gerold Schuler, Carola Berking, Stefan Schliep

1699 related Products with: Monitoring skin metastases during immuno- and targeted therapy using total-body 3D photography.

480/kit200ug1l1 mg9650µg1 kit100ug

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#32652824   2020/07/11 To Up

NAFLD is related to Postprandial Triglyceride-enrichment of HDL Particles in Association with Endothelial and HDL Dysfunction.

NAFLD is closely related with the metabolic syndrome (MetS) and increased risk of cardiovascular disease. Liver fat associates with postprandial hypertriglyceridemia, potentially contributing to triglyceride-enrichment of high-density-lipoproteins (HDL-TG), and subsequent HDL-dysfunction. We assessed liver fat by MR-spectroscopy, and its association with HDL physiochemical properties, and endothelial function, measured as flow-mediated dilation (FMD), before and following 3 consecutive meals, in 36 men with type 2 diabetes (T2DM), with the MetS, and controls. Plasma triglycerides increased significantly following the meals (P<.001). Fasting HDL-TG was highest in T2DM, relative to MetS and controls (P=.002), and increased postprandially in all groups (P<.001). HDL-function was negatively associated with HDL-TG following 3 meals (r=-0.32, P<.05). Liver fat associated with HDL-TG after 3 meals (r=.65, P<.001). HDL-TG was independently associated with FMD following 3 consecutive meals (r=-.477, P=.003). We conclude liver fat is associated with postprandial HDL-TG-enrichment which was closely related with endothelial and HDL-dysfunction.
Bart J Verwer, Peter G Scheffer, Rick P Vermue, Petra J Pouwels, Michaela Diamant, Maarten E Tushuizen

1489 related Products with: NAFLD is related to Postprandial Triglyceride-enrichment of HDL Particles in Association with Endothelial and HDL Dysfunction.

100 μg100ug Lyophilized100 μg100ug Lyophilized 100ul1 mg100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized100ug Lyophilized

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#32652820   2020/07/11 To Up

Does adjuvant treatment improve prognosis after curative resection of ampulla of Vater carcinoma? A multicenter retrospective study.

Ampulla of Vater (AoV) carcinoma is a rare tumor that accounts for approximately 0.2% of gastrointestinal malignancies. There are no clinical guidelines concerning the treatment of AoV carcinoma. This study aimed to investigate the effectiveness of adjuvant treatment in AoV carcinoma following curative resection and define the "high-risk" group.
Hyung Sun Kim, Jin Young Jang, Yoo Seok Yoon, Sang Jae Park, Wooil Kwon, Sun Whe Kim, Ho Seong Han, SungSik Han, Joon Seong Park, Dong Sup Yoon

2353 related Products with: Does adjuvant treatment improve prognosis after curative resection of ampulla of Vater carcinoma? A multicenter retrospective study.

96tests

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#32652807   2020/07/11 To Up

De novo mutation and skewed X-inactivation in girl with BCAP31-related syndrome.

Full genome analysis of a young girl with deafness, dystonia, central hypomyelination, refractory seizure, and fluctuating liver function impairment revealed a heterozygous, de novo variant in the BCAP31 gene on chromosome Xq28 (NM_001256447.2:c.92G>A), mutations of which caused the X-linked recessive severe neurologic disorder DDCH (Deafness, Dystonia, and Cerebral Hypomyelination). Reverse transcription-PCR (RT-PCR) of the patient's white blood cells showed the absence of wild-type BCAP31 mRNA but the presence of two novel BCAP31 mRNAs. The major alternatively-spliced mRNA is due to exon 2 skipping and the utilization of a new initiation site in exon 3 that leads to a frameshift and truncated transcript while the minor novel mRNA has a 110 nucleotide insertion to exon 2. Phasing studies showed that the de novo variant arose in the paternal X chromosome. X chromosome inactivation assay was done and confirmed that the patient's maternal X chromosome was preferentially inactivated, providing evidence that the mutated BCAP31 gene was the predominantly expressed. According to the ACMG guideline, this variant is deemed "pathogenic" (PS2, PS3, PM2, PP3, PP4) and deleterious. This is the first reported female patient in BCAP31-related syndrome resulted from skewed X-inactivation and a de novo mutation in the active X chromosome. This article is protected by copyright. All rights reserved.
Hsiao-Jung Kao, Hung-Lun Chiang, Hsiao-Huei Chen, Pi-Chuang Fan, Yi-Fang Tu, Yen-Yin Chou, Wuh-Liang Hwu, Chien-Ling Lin, Pui-Yan Kwok, Ni-Chung Lee

2697 related Products with: De novo mutation and skewed X-inactivation in girl with BCAP31-related syndrome.

300 units100ug Lyophilized100 2 Pieces/Box100ug Lyophilized10mg20 3 mg100ug

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