Search results for: vial
#34125086 2021/05/25 To Up
Gas Chromatography-Mass Spectrometry Paired with Total Vaporization Solid-Phase Microextraction as a Forensic Tool.Gas Chromatography - Mass Spectrometry (GC-MS) is a frequently used technique for the analysis of numerous analytes of forensic interest, including controlled substances, ignitable liquids, and explosives. GC-MS can be coupled with Solid-Phase Microextraction (SPME), in which a fiber with a sorptive coating is placed into the headspace above a sample or immersed in a liquid sample. Analytes are sorbed onto the fiber which is then placed inside the heated GC inlet for desorption. Total Vaporization Solid-Phase Microextraction (TV-SPME) utilizes the same technique as immersion SPME but immerses the fiber into a completely vaporized sample extract. This complete vaporization results in a partition between only the vapor phase and the SPME fiber without interference from a liquid phase or any insoluble materials. Depending upon the boiling point of the solvent used, TV-SPME allows for large sample volumes (e.g., up to hundreds of microliters). On-fiber derivatization may also be performed using TV-SPME. TV-SPME has been used to analyze drugs and their metabolites in hair, urine, and saliva. This simple technique has also been applied to street drugs, lipids, fuel samples, post-blast explosive residues, and pollutants in water. This paper highlights the use of TV-SPME to identify illegal adulterants in very small samples (microliter quantities) of alcoholic beverages. Both gamma-hydroxybutyrate (GHB) and gamma-butyrolactone (GBL) were identified at levels that would be found in spiked drinks. Derivatization by a trimethylsilyl agent allowed for conversion of the aqueous matrix and GHB into their TMS derivatives. Overall, TV-SPME is quick, easy, and requires no sample preparation aside from placing the sample into a headspace vial.
Kymeri E Davis, John V Goodpaster
2949 related Products with: Gas Chromatography-Mass Spectrometry Paired with Total Vaporization Solid-Phase Microextraction as a Forensic Tool.1 kit(96 Wells)100 assays1 kit1 kit(96 Wells)430 tests1 kit(96 Wells)1 kit(96 Wells)100 assays1 kit1 kit(96 Wells)
#34118253 2021/06/09 To Up
Near Infrared and Frequency Modulated Spectroscopy as Non-invasive methods for Moisture Assessment of Freeze-Dried Biologics.Near-infrared (NIR) and frequency modulated spectroscopy (FMS) were employed, for non-invasive moisture determination of a lyophilized biologic drug product (DP). Development of NIR and FMS provides a rapid non-invasive means of residual moisture measurement, and would be beneficial compared with traditional time consuming, product destructive methods such as Karl Fischer (KF). A model therapeutic enzyme in a sucrose-based formulation was employed for proof of concept studies, and NIR and FMS methods were compared side by side for residual moisture analysis. Moisture models were created using lyophilized vials and comparisons were made between the methods using different moisture preparation approaches:1) direct water droplet addition to the vial headspace, 2) use of elevated temperature (80Â°C), and 3) using various levels of moisture in stoppers generated during the washing and drying procedures, then lyophilizing using the stoppers and placing the sealed vials on stability. The results for direct water addition gave an average percent error for residual moisture of 5.7% for NIR and 9.4% for FMS when compared to KF. The elevated temperature method resulted in an average percent error for residual moisture of 54% for NIR and 43% for FMS compared to KF. The stopper moisture stability study, for FMS, provided an average percent error for residual moisture of 31% compared to KF. The error was greater for the elevated temperature and stopper methods, due to the low moisture values, which resulted in greater error. At this lower range of moisture (<1%) both NIR and FMS were less accurate, but from 1 to 5% their accuracy increased, based on the models used in this study. NIR and FMS methods can be used to complement KF at these lower moisture levels and models could be further improved with additional data points. NIR and FMS methods have advantages and disadvantages for residual moisture analysis when compared to each other, but both provided an accurate measurement of drug product moisture (depending on the method used for moisture increase), they can be used as process analytical technology (PAT), and both can be used for fast non-invasive moisture determination.
Richard P Affleck, Dikshitkumar Khamar, Katie M Lowerre, Nikoletta Adler, Sean Cullen, Mark Yang, Timothy R McCoy
1736 related Products with: Near Infrared and Frequency Modulated Spectroscopy as Non-invasive methods for Moisture Assessment of Freeze-Dried Biologics.100tests1,000 tests1 kit100Tests100Tests100tests100 tests100tests100tests1 kit
#34117546 2021/06/12 To Up
Impact of repeated irrigation of lettuce cultures with municipal wastewater on soil bacterial community diversity and composition.The effect of wastewater irrigation on the diversity and composition of bacterial communities of soil mesocosms planted with lettuces was studied over an experiment made of five cultivation campaigns. A limited effect of irrigation with either raw or treated wastewater was observed in both Î±-diversity and Î²-diversity of soil bacterial communities. However, the irrigation with wastewater fortified with a complex mixture of fourteen relevant chemicals at 10 Î¼g/L each, including pharmaceutical, biocide, and pesticide active substances, led to a drift in the composition of soil bacterial community. One hundred operational taxonomic units (OTUs) were identified as responsible for changes between treated and fortified wastewater irrigation treatments. Our findings indicate that under a realistic agronomical scenario, the irrigation of vegetables with domestic (treated or raw) wastewater has no effect on soil bacterial communities. Nevertheless, under the worst-case scenario tested here (i.e., wastewater fortified with a mixture of chemicals), non-resilient changes were observed suggesting that continuous/repeated irrigation with wastewater could lead to the accumulation of contaminants in soil and induce changes in bacterial communities with unknown functional consequences.
Sara Gallego, Monica Brienza, JÃ©rÃ©mie BÃ©guet, Serge Chiron, Fabrice Martin-Laurent
1038 related Products with: Impact of repeated irrigation of lettuce cultures with municipal wastewater on soil bacterial community diversity and composition.5 G10 mg0.2 mg100 ml1000 tests100ug 6 ml Ready-to-use 0.2 mg5 mg25 mg
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#34115918 2021/06/11 To Up
Kidney transplant recipient perspectives on telehealth during the COVID-19 pandemic.The COVID-19 pandemic has challenged the delivery of health services. Telehealth allows delivery of care without in-person contacts and minimizes the risk of vial transmission. We aimed to describe the perspectives of kidney transplant recipients on the benefits, challenges and risks of telehealth.
Brooke M Huuskes, Nicole Scholes-Robertson, Chandana Guha, Amanda Baumgart, Germaine Wong, John Kanellis, Steve Chadban, Katherine A Barraclough, Andrea K Viecelli, Carmel M Hawley, Peter G Kerr, P Toby Coates, Noa Amir, Allison Tong
1877 related Products with: Kidney transplant recipient perspectives on telehealth during the COVID-19 pandemic.1 g 1 G1 mg1540 tests 25 ml Ready-to-use 1 g1 Shaker/Unit100 µg200 units2
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#34111968 2021/06/11 To Up
Inspecting Insulin Products Using Water Proton NMR. I. Noninvasive vs Invasive Inspection.There is a clear need to transition from batch-level to vial/syringe/pen-level quality control of biologic drugs, such as insulin. This could be achieved only by noninvasive and quantitative inspection technologies that maintain the integrity of the drug product.
Marc B Taraban, Yilin Wang, Katharine T Briggs, Yihua Bruce Yu
2753 related Products with: Inspecting Insulin Products Using Water Proton NMR. I. Noninvasive vs Invasive Inspection.100ug1g 200 purifications2 mL100ug Lyophilized100ug Lyophilized100.00 ug1 g100ug Lyophilized100ug100ug
#34105167 2021/06/08 To Up
Multi-Site Multi-Vendor Validation of a Quantitative MRI and CT Compatible Fat Phantom.Chemical shift-encoded magnetic resonance imaging enables accurate quantification of liver fat content though estimation of proton density fat-fraction (PDFF). Computed tomography (CT) is capable of quantifying fat, based on decreased attenuation with increased fat concentration. Current quantitative fat phantoms do not accurately mimic the CT number of human liver. The purpose of this work was to develop and validate an optimized phantom that simultaneously mimics the MRI and CT signals of fatty liver.
Ruiyang Zhao, Diego Hernando, David T Harris, Louis A Hinshaw, Ke Li, Lakshmi Ananthakrishnan, Mustafa R Bashir, Xinhui Duan, Mounes Aliyari Ghasabeh, Ihab R Kamel, Carolyn Lowry, Mahadevappa Mahesh, Daniele Marin, Jessica Miller, Perry J Pickhardt, Jean Shaffer, Takeshi Yokoo, Jean H Brittain, Scott B Reeder
1296 related Products with: Multi-Site Multi-Vendor Validation of a Quantitative MRI and CT Compatible Fat Phantom.
#34104127 2021/06/03 To Up
Advanced packaging for distribution and storage of COVID-19 vaccines: a review.The outbreak of the coronavirus disease 2019 global pandemic (COVID-19)Â has affected billions of lives, posing critical challenges to the healthcare system, vaccine manufacturers, packaging scientists, and daily public activity. Biotechnological advances have allowed to create rapidly vaccines, yet the success of an efficient immunization mainly depends on the safe and timely delivery of vaccines. In particular, packaging plays a crucial role in protecting, preserving, transporting, and distributing vaccines. Here, we review advanced packaging for distribution and storage of COVID-19 vaccines, with focus on innovative hybrid packaging materials, cyclic olefin polymers with nanolayer glass, and vials for vaccines. We present vaccine packaging, auto-disable syringes, stoppers, and closures. We discuss the chronology of the packaging system, and the labeling of the vaccine packages, with emphasis on bar codes, quick response codes, vaccine vial monitors, anti-counterfeiting and traceability measures.
Dakuri Ramakanth, Suman Singh, Pradip K Maji, Youn Suk Lee, Kirtiraj K Gaikwad
2094 related Products with: Advanced packaging for distribution and storage of COVID-19 vaccines: a review.1 G 100 UG50 assays1,000 tests100ug50 mg100 mg200 mg100 mg 1 G
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#34101501 2021/06/08 To Up
Preparation of Rhenium-188-Lipiodol Using Freeze-Dried Kits for Transarterial Radioembolization: An Overview and Experience in a Hospital Radiopharmacy.Rhenium-188-lipiodol is a clinically effective, economically viable radiopharmaceutical for Selective Internal Radiation Therapy of liver cancer. Present study evaluates the performance of three freeze-dried kits with respect to the radiochemistry, quality control, and overall "ease of preparation" aspects in a hospital radiopharmacy. Freeze-dried kits of acetylated 4-hexadecyl-4,7-diaza-1,10-decanedithiol (AHDD), super six sulfur (SSS), and diethyl dithiocarbamate (DEDC), obtained commercially or received as gift, were used for the preparation of Rhenium-188-lipiodol using freshly eluted Re-sodium perrhenate from commercial Tungsten-188/Rhenium-188 generator following recommended procedures. The overall yield of Rhenium-188-lipiodol prepared using AHDD Kit, SSS Kit, and DEDC Kit was 74.82%âÂ±â3.3%, 87.55%âÂ±â4.8%, and 76.38%âÂ±â4.6%, respectively. Observed radiochemical purity (RCP) of Rhenium-188-lipiodol prepared using these kits was 88.65%âÂ±â2.8%, 92.92%âÂ±â3.0%, and 91.38%âÂ±â3.0%, respectively. Using a modified version of the DEDC Kits, overall yield of 87.17%âÂ±â2.7% and RCP of 95.43%âÂ±â2.3% could be achieved. While all three freeze-dried kits can be used for the preparation of Rhenium-188-lipiodol in >70% overall yield, the modified version of DEDC Kits has some advantages in terms of preparation time and volume of Rhenium-188 activity that can be added to the kit vial. The latter feature of the DEDC Kit is particularly useful for patient dose preparation with Rhenium-188 activity of low radioactive concentration.
Edathurutykalarickal Ramakurup Radhakrishnan, Viju Chirayil, Arun Pandiyan, Suresh Subramanian, Madhava B Mallia, Koramadai Karuppusamy Kamaleshwaran, Ajit Shinto
1083 related Products with: Preparation of Rhenium-188-Lipiodol Using Freeze-Dried Kits for Transarterial Radioembolization: An Overview and Experience in a Hospital Radiopharmacy.100 μg100ug Lyophilized100 μg100 μg100ug100 μg100ug Lyophilized1 Set1 Set100ug Lyophilized1 Set
#34095915 2021/06/07 To Up
Development of a high-throughput device for liquid-phase microextraction coupled with gas chromatography-mass spectrometry for the determination of benzene derivatives in environmental water.A device coupled with an automatic gas chromatography injection sampler for high-throughput liquid-liquid microextraction has been proposed in this study. This study's main objective was to devise a trap vial directly placed in an automatic liquid sampler (ALS) to collect and inject the extractant without a transfer step. Sixteen groups of microextraction procedures were performed simultaneously to increase the overall efficiency. The experimental parameters of the extraction method were optimized using a central composite design. Under the optimal conditions, the benzene derivatives' calibration curve was linear in the range of 0.1-200 Î¼g L-1. The limit of detection (LOD) ranged from 0.016 to 0.16 Î¼g L-1, and the limit of quantitation (LOQ) ranged from 0.046 to 0.50 Î¼g L-1. The enrichment factors (EFs) ranged from 254 to 1094. Intraday and interday precision were found to be in the range of 2.2-6.2% (n = 3) and 4.0-6.3% (n = 9), respectively. The relative recovery of the four aqueous samples ranged from 69% to 121%. These experimental results indicated that the proposed device is reliable. Furthermore, it is simple, convenient and high-throughput.
Zhiqiang Li, Zhian Guo, Xiaomei Chen, Jie Liu, Yidong Xu, Yi Wang, Jingchan Zhao
2671 related Products with: Development of a high-throughput device for liquid-phase microextraction coupled with gas chromatography-mass spectrometry for the determination of benzene derivatives in environmental water.400Tests100Tests0.2 mg20 1,000 tests 100ul1100μg
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