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#33090796   2020/10/22 To Up

Adsorption Characteristics of Synthesized Polyelectrolytes onto Alumina Nanoparticles and their Application in Antibiotic Removal.

The present study aims to investigate the adsorption of synthesized poly(2-acrylamide-2-methylpropane sulfonic acid) (PAMPs) onto alumina nanoparticles and their application in the removal of ciprofloxacin (CFX) antibiotic from a water environment. The PAMPs were successfully synthesized and characterized by nuclear magnetic resonance and gel-permeation chromatography methods. The number- and weight-average molecular weights of PAMPs were 6.76 × 10 and 7.28 × 10 g/mol, respectively. The charge reversal of nanoalumina after PAMPs modification from positive to -37.5 mV was determined by ζ-potential measurement, while the appearance of C ═ O and N-H functional groups in PAMPs observed by Fourier-transform infrared spectroscopy confirmed them as the main indicators for adsorption of PAMPs onto a nanoalumina surface. The maximum adsorption capacity of PAMPs onto nanoalumina in 100 mg/L KCl was about 10 mg/g. The adsorption isotherms were fitted well by a two-step adsorption model. Application of PAMPs-modified nanoalumina (PAMNA) in CFX removal was also thoroughly studied. The optimum conditions for CFX removal using PAMNA were found to be pH 6, 10 mM NaCl, contact time 90 min, and adsorption dosage 5 mg/mL. The CFX adsorption isotherms and kinetics were in accordance with the two-step and pseudo-second-order models, respectively. The application for CFX removal in actual hospital wastewater was greater than 80%. The results of this study demonstrate that PAMNA is a new and promising material for antibiotic removal from wastewater.
Thi-Huong Dao, Thi-Quynh-Mai Vu, Ngoc-Trung Nguyen, Thu-Thao Pham, Thi-Lien Nguyen, Shin-Ichi Yusa, Tien-Duc Pham

2231 related Products with: Adsorption Characteristics of Synthesized Polyelectrolytes onto Alumina Nanoparticles and their Application in Antibiotic Removal.

0.1ml (1mg/ml)100ug Lyophilized1mg0.1ml100ug Lyophilized 100ul 100ul 100ul100ug Lyophilized50ul 100ul0.1ml (1mg/ml)

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#33090488   2020/10/08 To Up

Scoparone alleviates hepatic fibrosis by inhibiting the TLR-4/NF-κB pathway.

The aim of this study was to investigate the role of scoparone (SCO) in hepatic fibrosis. For this, we conducted in vivo and in vitro experiments. In vivo rats that were divided into six groups, control, carbon tetrachloride, and colchicine, as well as SCO groups, SCO50, SCO100, and SCO200 treated with 50, 100, and 200 mg/kg SCO doses, respectively. Furthermore, SCO was shown to inhibit Toll-like receptor-4 (TLR-4)/nuclear factor kappa-B (NF-κB; TLR-4/NF-κB) signals by inhibiting TLR-4, which in turn downregulates the expression of MyD88, promotes NF-κB inhibitor-α, NF-κB inhibitor-β, and NF-κB inhibitor-ε activation, while inhibiting NF-κB inhibitor-ζ. Subsequently, the decrease of phosphorylation of nuclear factor-κB levels leads to the downregulation of the downstream inflammatory factors' tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and IL-1 beta, thus weakening hepatic fibrosis. Notably, the SCO200 treated group presented the most significant improvement. Hence, we conclude that SCO alleviates hepatic fibrosis by inhibiting TLR-4/NF-κB signals.
Ya Gao, Boting Xi, Jiani Li, Zimeng Li, Jie Xu, Mingli Zhong, Qiongmei Xu, Yuanyu Lian, Riming Wei, Liping Wang, Houkang Cao, Ling Jin, Kefeng Zhang, Jianghui Dong

1331 related Products with: Scoparone alleviates hepatic fibrosis by inhibiting the TLR-4/NF-κB pathway.

2 Pieces/Box500 Units2 Pieces/Box1 mg12 Pieces/Box10100 μg1.5x10(6) cells

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#33090073   2020/10/22 To Up

Optimization and efficacy study of synergistic vincristine coloaded liposomal doxorubicin against breast and lung cancer.

To improve the efficacy of poly-ethylene glycol (PEG)ylated liposomes coloaded with doxorubicin and vincristine against triple-negative breast cancer (TNBC) and non-small-cell lung cancer (NSCLC). The combinatorial index of the drugs was established using the Chou-Talalay method in MDA-MB-231 and A549 cell lines. The most effective ratio was co-encapsulated in factorial design optimized nanoliposomes which were characterized for similarity to clinical standard and evaluated and for therapeutic efficacy. The formulation exhibited more than 95% co-encapsulation, a size of 95.74 ± 2.65 nm and zeta potential of -9.17 ± 1.19 mV while having no significant differences in physicochemical and biochemical characteristics as compared with the clinical standard. Efficacy evaluation studies showed significantly improved cytotoxicity and tumor regression compared with liposomal doxorubicin indicating improvement in efficacy against TNBC and NSCLC.
Saikat Ghosh, Rohan Lalani, Kuntal Maiti, Shubhadeep Banerjee, Vivek Patel, Subhas Bhowmick, Ambikanandan Misra

1486 related Products with: Optimization and efficacy study of synergistic vincristine coloaded liposomal doxorubicin against breast and lung cancer.

1000 25 mg

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#33089432   2020/10/22 To Up

Development, optimization and in vitro evaluation of oxaliplatin loaded nanoparticles in non-small cell lung cancer.

Platinum-based chemotherapy in non-small cell lung cancer (NSCLC) has been demonstrated as a promising approach by many researchers. However, due to low bioavailability and several side effects, drug targeting to lungs by intravenous administration is not a common route of administration.
Ozgur Esim, Nurgul K Bakirhan, Nuray Yildirim, Meral Sarper, Ayhan Savaser, Sibel A Ozkan, Yalcin Ozkan

2800 related Products with: Development, optimization and in vitro evaluation of oxaliplatin loaded nanoparticles in non-small cell lung cancer.

1.00 flask

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#33088651   2020/09/26 To Up

Catalytic and physical features of a naturally immobilized lipase in cell debris (LipImDebri) displaying high thermostability.

Lipase activity (337 U/g dry weight of cell debris) was detected in cell debris after ultrasound treatment of cells cultivated in residual frying palm oil. It is a naturally immobilized lipase with protein content of 47%, herein called LipImDebri. This immobilized biocatalyst presents low hydrophobicity (8%), that can be increased adjusting pH and buffer type. Despite apparent intact cells, electron microscopy showed a shapeless and flat surface for LipImDebri and optical microscopy revealed no cell viability. Besides, an inferior mean diameter (3.4 mm) in relation to whole cells reveals structure modification. A high negative zeta potential value (- 33.86 mV) for pH 6 and 25 °C suggests that LipImDebri is a stable suspension in aqueous solution. Fourier Transform Infrared Spectra (FTIR) expose differences between LipImDebri and extracellular lipase extract signaling a physical interaction between enzyme and cell debris, which is possibly the reason for the high thermostability ( = 0.246 h;  = 2.82 h at 50 °C, pH 7.0). A good adjustment of LipImDebri kinetic data with Hill equation ( = 0.95) exposes an allosteric behavior related to the presence of more than one lipase isoform. These features reveal that LipImDebri can be a good catalyst for industrial applications.
Jully Lacerda Fraga, Adrian Chaves Beserra da Penha, Emília Akil, Kelly Alencar Silva, Priscilla Filomena Fonseca Amaral

2157 related Products with: Catalytic and physical features of a naturally immobilized lipase in cell debris (LipImDebri) displaying high thermostability.

2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box2 Pieces/Box100ug Lyophilized4 Membranes/Box1 L.2 Pieces/Box

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#33087964   2020/05/14 To Up

Preparation of functional rice cake by using β-carotene-loaded emulsion powder.

The purpose of this study was to apply a powdered β-carotene-loaded emulsion to a real food product, Korean traditional rice cakes (). β-Carotene was incorporated into the oil phase of a sodium caseinate-stabilized emulsion. Emulsion powder containing β-carotene was prepared using freeze-drying, and maltodextrin and gum arabic were used as wall materials. Oil/protein/maltodextrin weight ratios of 3:1:2 and 3:1:5 (core-to-wall ratios of 1:1 and 1:2) were used, and gum arabic was added by replacing the amount of maltodextrin for 0.1%, 0.2%, and 0.5% w/w. Manufactured emulsion powders prepared with wall material at a core-to-wall ratio of 1:2 remained stable after reconstitution in terms of particle diameter and ζ-potential. The encapsulation efficiency of the emulsion powder increased by 90% in the presence of maltodextrin at a core-to-wall ratio of 1:2. containing the emulsion powder was then manufactured and it was confirmed that β-carotene was not degraded during the manufacturing process of by using HPLC. The results from this study may be useful for rational designing of functional foods with lipophilic bioactive materials.
Junhee No, Malshick Shin, Saehun Mun

1026 related Products with: Preparation of functional rice cake by using β-carotene-loaded emulsion powder.

1 kit(96 Wells)100ug Lyophilized100gm20preparations100mg100gmBag100μg100gm

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#33087104   2020/10/21 To Up

Designed proteinoid polymers and nanoparticles encapsulating risperidone for enhanced antipsychotic activity.

Nanoparticles (NPs) incorporating drug formulations can be used to facilitate passage through biological barriers including the blood-brain barrier (BBB) and increase drug delivery and bioavailability. Hence, NP-based administration may enhance the efficiency of current antipsychotics. Encapsulation within NPs can resolve aqueous solubility problems that not only reduce permeability through the BBB but also affect targeting. The present study describes a new drug delivery system based on proteinoid NPs to explore the possibility of improving drug efficacy. Risperidone (RSP) is a commonly used atypical antipsychotic medication, and was therefore selected for encapsulation by proteinoid NPs.
L Lugasi, I Grinberg, S Rudnick-Glick, E Okun, H Einat, S Margel

1313 related Products with: Designed proteinoid polymers and nanoparticles encapsulating risperidone for enhanced antipsychotic activity.

1 kit 1 G40 assays96 wells (1 kit)100ug100ug100 assays

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#33086639   2020/10/19 To Up

Removal of Cd from Water by Use of Super-Macroporous Cryogels and Comparison to Commercial Adsorbents.

In this study amphoteric cryogels were synthesized by the use of free-radical co-polymerization of acrylate-based precursors (methacrylic acid and 2-acrylamido-2-methyl-1-propansulfonic acid) with allylamine at different ratios. The physico-chemical characteristics of the cryogels were examined using SEM/EDX, FT-IR, XPS and zeta potential measurements. The cryogels were tested toward Cd removal from aqueous solutions at various pH and initial concentrations. Equilibrium studies revealed a maximum sorption capacity in the range of 132-249 mg/g. Leaching experiments indicated the stability of Cd in the cryogel structure. Based on kinetics, equilibrium and characterization results, possible removal mechanisms are proposed, indicating a combination of ion exchange and complexation of Cd with the cryogels' surface functional groups. The cryogels were compared to commercially available adsorbents (zeolite Y and cation exchange resin) for the removal of Cd from various water matrices (ultrapure water, tap water and river water) and the results showed that, under the experimental conditions used, the cryogels can be more effective adsorbents.
Alzhan Baimenov, Dmitriy Berillo, Seitkhan Azat, Talgat Nurgozhin, Vassilis Inglezakis

2686 related Products with: Removal of Cd from Water by Use of Super-Macroporous Cryogels and Comparison to Commercial Adsorbents.

5 G50 100 100ug Lyophilized100ug Lyophilized25 100 100ug100ug Lyophilized50.5 mg5

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#33085055   2020/10/21 To Up

Nanodelivery of Resveratrol-Loaded PLGA Nanoparticles for Age-Related Macular Degeneration.

Age-related macular degeneration, precisely neovascular form, is the leading cause of vision loss and the key treatment includes intravitreal injections of anti-vascular endothelial growth factor (anti-VEGF) agents. A method to increase local concentration of drug at posterior segment of the eye and to reduce the frequency of intravitreal injections is an unmet need. Resveratrol, a naturally occurring antioxidant and anti-inflammatory polyphenol, was loaded in PLGA polymeric nanoparticles to study their sustained release property and effectiveness in reducing expression of VEGF protein in vitro. Nanoparticles were characterized using FTIR, DSC, size, encapsulation efficiency, TEM, and in vitro drug release studies. Using MTT assay, the cytotoxicity of formulation was evaluated on ARPE-19 cells. The cellular uptake and VEGF expression levels were also evaluated in in vitro settings. The optimized formulation had a particle size of 102.7 nm with - 47.30 mV of zeta potential. Entrapment efficiency was found to be 65.21%. The cell viability results suggested compatibility of developed formulation. Cellular uptake and VEGF expression levels for the formulated nanoparticles specified that the developed formulation showed potential cellular uptake and had displayed anti-angiogenic property by inhibiting VEGF expression in vitro. The results showed successful development of resveratrol-loaded nanoparticles which may be used for neovascular AMD treatment alone or in combination with anti-VEGF agents.
Priyanka Bhatt, Gulimirerouzi Fnu, Deepak Bhatia, Amna Shahid, Vijaykumar Sutariya

2287 related Products with: Nanodelivery of Resveratrol-Loaded PLGA Nanoparticles for Age-Related Macular Degeneration.

2 Pieces/Box 1 G 5 G100 1kit 1 G100 TESTS100μg1,000 tests 6 ml Ready-to-use 500 ml2x96 well plate

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